| 1 | 1FMR LLC | 16,630,54116.6M | $231M | 14.96% | — |
| 2 | 2BlackRock, Inc. | 8,828,8368.8M | $123M | 7.94% | TRIM -2% |
| 3 | 3PERCEPTIVE ADVISORS LLC | 8,284,8828.3M | $115M | 7.45% | — |
| 4 | 4TCG Crossover Management, LLC | 6,243,8126.2M | $87M | 5.62% | — |
| 5 | 5Commodore Capital LP | 5,650,0005.7M | $79M | 5.08% | — |
| 6 | 6JANUS HENDERSON GROUP PLC | 4,986,0735.0M | $69M | 4.48% | ADD 12% |
| 7 | 7Saturn V Capital Management LP | 4,349,8854.3M | $60M | 3.91% | TRIM -3% |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 4,141,5754.1M | $58M | 3.72% | NEW† |
| 9 | 9ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,560,7643.6M | $49M | 3.20% | ADD 28% |
| 10 | 10First Light Asset Management, LLC | 3,190,6453.2M | $44M | 2.87% | TRIM -5% |
| 11 | 11Driehaus Capital Management LLC | 2,987,1473.0M | $42M | 2.69% | TRIM -4% |
| 12 | 12GOLDMAN SACHS GROUP INC | 2,625,9912.6M | $37M | 2.36% | — |
| 13 | 13STATE STREET CORP | 2,363,1612.4M | $33M | 2.13% | ADD 14% |
| 14 | 14FRANKLIN RESOURCES INC | 2,261,5692.3M | $31M | 2.03% | ADD 88% |
| 15 | 15GEODE CAPITAL MANAGEMENT, LLC | 2,210,9322.2M | $31M | 1.99% | ADD 2% |
| 16 | 16MORGAN STANLEY | 2,175,5472.2M | $30M | 1.96% | TRIM -8% |
| 17 | 17Almitas Capital LLC | 2,122,5972.1M | $30M | 1.91% | — |
| 18 | 18GREAT POINT PARTNERS LLC | 1,750,0001.8M | $24M | 1.57% | — |
| 19 | 19Jones Hill Capital LP | 1,598,7941.6M | $22M | 1.44% | NEW |
| 20 | 20683 Capital Management, LLC | 1,530,0001.5M | $21M | 1.38% | TRIM -7% |
| 21 | 21EVENTIDE ASSET MANAGEMENT, LLC | 1,513,9581.5M | $21M | 1.36% | — |
| 22 | 22STEMPOINT CAPITAL LP | 1,339,3701.3M | $19M | 1.20% | ADD 137% |
| 23 | 23BANK OF AMERICA CORP /DE/ | 1,330,6891.3M | $18M | 1.20% | — |
| 24 | 24DEUTSCHE BANK AG\ | 1,267,7851.3M | $18M | 1.14% | TRIM -5% |
| 25 | 25Siren, L.L.C. | 1,230,0001.2M | $17M | 1.11% | NEW |
| 26 | 26Balyasny Asset Management L.P. | 1,107,2711.1M | $15M | 1.00% | ADD 29% |
| 27 | 27ADAR1 Capital Management, LLC | 1,000,6041.0M | $14M | 0.90% | ADD 12% |
| 28 | 28BARCLAYS PLC | 971,854971,854 | $14M | 0.87% | ADD 229% |
| 29 | 29VANGUARD PORTFOLIO MANAGEMENT LLC | 944,781944,781 | $13M | 0.85% | NEW |
| 30 | 30DIMENSIONAL FUND ADVISORS LP | 903,192903,192 | $13M | 0.81% | ADD 17% |
| 31 | 31Connor, Clark & Lunn Investment Management Ltd. | 868,325868,325 | $12M | 0.78% | TRIM -14% |
| 32 | 32Woodline Partners LP | 845,800845,800 | $12M | 0.76% | — |
| 33 | 33Boxer Capital Management, LLC | 800,000800,000 | $11M | 0.72% | — |
| 34 | 34NORTHERN TRUST CORP | 779,908779,908 | $11M | 0.70% | TRIM -17% |
| 35 | 35CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 716,225716,225 | $10M | 0.64% | — |
| 36 | 36Qube Research & Technologies Ltd | 702,236702,236 | $10M | 0.63% | ADD 70% |
| 37 | 37Logos Global Management LP | 700,000700,000 | $10M | 0.63% | TRIM -26% |
| 38 | 38Parkman Healthcare Partners LLC | 621,458621,458 | $9M | 0.56% | ADD 63% |
| 39 | 39JUPITER ASSET MANAGEMENT LTD | 592,654592,654 | $8M | 0.53% | ADD 3705% |
| 40 | 40VANGUARD FIDUCIARY TRUST CO | 586,152586,152 | $8M | 0.53% | NEW |
| 41 | 41Nantahala Capital Management, LLC | 535,684535,684 | $7M | 0.48% | TRIM -36% |
| 42 | 42Rock Springs Capital Management LP | 499,764499,764 | $7M | 0.45% | — |
| 43 | 43CITADEL ADVISORS LLC | 411,532411,532 | $6M | 0.37% | ADD 19% |
| 44 | 44FEDERATED HERMES, INC. | 363,546363,546 | $5M | 0.33% | TRIM -21% |
| 45 | 45HighVista Strategies LLC | 352,085352,085 | $5M | 0.32% | ADD 47% |
| 46 | 46Cormorant Asset Management, LP | 350,000350,000 | $5M | 0.31% | TRIM -13% |
| 47 | 47UBS Group AG | 324,319324,319 | $5M | 0.29% | TRIM -40% |
| 48 | 48Tetragon Partners GP Ltd | 317,877317,877 | $4M | 0.29% | ADD 17% |
| 49 | 49iA Global Asset Management Inc. | 304,786304,786 | $4M | 0.27% | NEW |
| 50 | 50Nuveen, LLC | 264,897264,897 | $4M | 0.24% | TRIM -7% |
| 51 | 51Bank of New York Mellon Corp | 251,104251,104 | $3M | 0.23% | ADD 16% |
| 52 | 52WELLINGTON MANAGEMENT GROUP LLP | 241,552241,552 | $3M | 0.22% | ADD 7% |
| 53 | 53SummitTX Capital, L.P. | 227,010227,010 | $3M | 0.20% | ADD 4% |
| 54 | 54Aldebaran Capital, LLC | 197,892197,892 | $3M | 0.18% | — |
| 55 | 55Invesco Ltd. | 171,620171,620 | $2M | 0.15% | TRIM -2% |
| 56 | 56TWO SIGMA INVESTMENTS, LP | 161,945161,945 | $2M | 0.15% | TRIM -53% |
| 57 | 57UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 157,089157,089 | $2M | 0.14% | ADD 59% |
| 58 | 58ACUTA CAPITAL PARTNERS, LLC | 151,067151,067 | $2M | 0.14% | TRIM -55% |
| 59 | 59JPMORGAN CHASE & CO | 159,663159,663 | $2M | 0.14% | ADD 140% |
| 60 | 60PFM Health Sciences, LP | 145,275145,275 | $2M | 0.13% | ADD 8% |
| 61 | 61Alpha Wave Global, LP | 142,336142,336 | $2M | 0.13% | TRIM -55% |
| 62 | 62Swiss National Bank | 130,300130,300 | $2M | 0.12% | TRIM -19% |
| 63 | 63PRICE T ROWE ASSOCIATES INC /MD/ | 121,439121,439 | $2M | 0.11% | ADD 13% |
| 64 | 64Squarepoint Ops LLC | 114,877114,877 | $2M | 0.10% | ADD 50% |
| 65 | 65Elmind Capital, LP | 112,000112,000 | $2M | 0.10% | — |
| 66 | 66RHUMBLINE ADVISERS | 108,467108,467 | $2M | 0.10% | ADD 9% |
| 67 | 67Point72 Asset Management, L.P. | 106,535106,535 | $1M | 0.10% | TRIM -68% |
| 68 | 68ALPS ADVISORS INC | 89,98389,983 | $1M | 0.08% | — |
| 69 | 69SEI INVESTMENTS CO | 85,27985,279 | $1M | 0.08% | ADD 61% |
| 70 | 70Schonfeld Strategic Advisors LLC | 77,79477,794 | $1M | 0.07% | ADD 270% |
| 71 | 71WELLS FARGO & COMPANY/MN | 75,08375,083 | $1M | 0.07% | TRIM -49% |
| 72 | 72D. E. Shaw & Co., Inc. | 74,23074,230 | $1M | 0.07% | — |
| 73 | 73STATE OF WISCONSIN INVESTMENT BOARD | 72,06172,061 | $1M | 0.06% | TRIM -14% |
| 74 | 74ALLIANCEBERNSTEIN L.P. | 80,80080,800 | $976,064 | 0.07% | ADD 13% |
| 75 | 75CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,00265,002 | $903,528 | 0.06% | TRIM -18% |
| 76 | 76Walleye Capital LLC | 61,71161,711 | $857,783 | 0.06% | ADD 975% |
| 77 | 77Russell Investments Group, Ltd. | 59,34659,346 | $824,907 | 0.05% | TRIM -9% |
| 78 | 78Legal & General Group Plc | 55,77355,773 | $775,244 | 0.05% | TRIM -23% |
| 79 | 79Campbell & CO Investment Adviser LLC | 54,42254,422 | $756,466 | 0.05% | TRIM -31% |
| 80 | 80Informed Momentum Co LLC | 53,25653,256 | $740,258 | 0.05% | — |
| 81 | 81MetLife Investment Management, LLC | 51,58751,587 | $717,059 | 0.05% | ADD 4% |
| 82 | 82Maven Securities LTD | 50,00050,000 | $695,000 | 0.04% | NEW |
| 83 | 83Numerai GP LLC | 48,55348,553 | $674,887 | 0.04% | TRIM -57% |
| 84 | 84Vanguard Global Advisers, LLC | 47,85147,851 | $665,129 | 0.04% | NEW |
| 85 | 85VANGUARD ASSET MANAGEMENT, Ltd | 43,28343,283 | $601,634 | 0.04% | NEW |
| 86 | 86MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,55342,553 | $591,487 | 0.04% | ADD 3% |
| 87 | 87Zurcher Kantonalbank (Zurich Cantonalbank) | 40,79040,790 | $566,981 | 0.04% | ADD 14% |
| 88 | 88SUSQUEHANNA INTERNATIONAL GROUP, LLP | 39,80239,802 | $553,248 | 0.04% | TRIM -42% |
| 89 | 89MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,78138,781 | $539,056 | 0.03% | ADD 44% |
| 90 | 90Optimize Financial Inc | 32,00132,001 | $444,814 | 0.03% | NEW |
| 91 | 91CITIGROUP INC | 31,78231,782 | $441,770 | 0.03% | TRIM -16% |
| 92 | 92TUDOR INVESTMENT CORP ET AL | 31,33431,334 | $435,543 | 0.03% | ADD 40% |
| 93 | 93AQR CAPITAL MANAGEMENT LLC | 29,08929,089 | $404,338 | 0.03% | ADD 4% |
| 94 | 94Integrated Quantitative Investments LLC | 27,23427,234 | $378,553 | 0.02% | — |
| 95 | 95GUGGENHEIM CAPITAL LLC | 25,51325,513 | $354,631 | 0.02% | — |
| 96 | 96INTECH INVESTMENT MANAGEMENT LLC | 24,92124,921 | $346,402 | 0.02% | TRIM -22% |
| 97 | 97Vanguard Personalized Indexing Management, LLC | 24,07224,072 | $334,601 | 0.02% | ADD 16% |
| 98 | 98Police & Firemen's Retirement System of New Jersey | 23,75223,752 | $330,153 | 0.02% | — |
| 99 | 99State of New Jersey Common Pension Fund D | 22,51922,519 | $313,014 | 0.02% | NEW |
| 100 | 100NEW YORK STATE COMMON RETIREMENT FUND | 21,90021,900 | $304,410 | 0.02% | — |
