| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 13,011,84913.0M | $26M | 9.89% | NEW† |
| 2 | TCG Crossover Management, LLC | 13,011,84913.0M | $26M | 9.89% | NEW† |
| 3 | venBio Partners LLC | 12,884,63812.9M | $26M | 9.79% | ADD 33% |
| 4 | Redmile Group, LLC | 7,964,1888.0M | $16M | 6.05% | ADD 144% |
| 5 | Blackstone Inc. | 5,826,5445.8M | $12M | 4.43% | NEW† |
| 6 | Driehaus Capital Management LLC | 5,734,6205.7M | $11M | 4.36% | ADD 303% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 4,179,7364.2M | $8M | 3.18% | NEW† |
| 8 | MARSHALL WACE, LLP | 3,757,2163.8M | $8M | 2.85% | ADD 14145% |
| 9 | Vivo Capital, LLC | 3,184,7133.2M | $6M | 2.42% | NEW† |
| 10 | Almitas Capital LLC | 3,173,8343.2M | $6M | 2.41% | ADD 25% |
| 11 | 5AM Venture Management, LLC | 3,057,3253.1M | $6M | 2.32% | NEW† |
| 12 | ORBIMED ADVISORS LLC | 2,866,2562.9M | $6M | 2.18% | NEW† |
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,000,0002.0M | $4M | 1.52% | NEW |
| 14 | MILLENNIUM MANAGEMENT LLC | 1,988,5592.0M | $4M | 1.51% | TRIM -38% |
| 15 | TWO SIGMA INVESTMENTS, LP | 1,587,8331.6M | $3M | 1.21% | ADD 148% |
| 16 | Squadron Capital Management LLC | 1,460,0001.5M | $3M | 1.11% | NEW |
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,328,9071.3M | $3M | 1.01% | ADD 780% |
| 18 | ACADIAN ASSET MANAGEMENT LLC | 1,101,0251.1M | $2M | 0.84% | TRIM -20% |
| 19 | Ensign Peak Advisors, Inc | 950,550950,550 | $2M | 0.72% | NEW |
| 20 | UBS Group AG | 914,754914,754 | $2M | 0.70% | ADD 6% |
| 21 | RENAISSANCE TECHNOLOGIES LLC | 732,599732,599 | $1M | 0.56% | ADD 73% |
| 22 | BANK OF AMERICA CORP /DE/ | 577,783577,783 | $1M | 0.44% | ADD 9% |
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 493,437493,437 | $989,757 | 0.37% | ADD 40% |
| 24 | BlackRock, Inc. | 447,799447,799 | $897,836 | 0.34% | — |
| 25 | VANGUARD FIDUCIARY TRUST CO | 294,478294,478 | $590,428 | 0.22% | NEW |
| 26 | STATE STREET CORP | 175,828175,828 | $352,535 | 0.13% | ADD 42% |
| 27 | GOLDMAN SACHS GROUP INC | 138,593138,593 | $277,879 | 0.11% | ADD 703% |
| 28 | NORTHERN TRUST CORP | 136,964136,964 | $274,613 | 0.10% | TRIM -8% |
| 29 | Qube Research & Technologies Ltd | 107,647107,647 | $215,832 | 0.08% | NEW |
| 30 | BANK OF NOVA SCOTIA | 105,858105,858 | $212,245 | 0.08% | — |
| 31 | MORGAN STANLEY | 98,83598,835 | $198,164 | 0.08% | ADD 18% |
| 32 | VANGUARD PORTFOLIO MANAGEMENT LLC | 97,88197,881 | $196,251 | 0.07% | NEW |
| 33 | JANE STREET GROUP, LLC | 95,10195,101 | $190,678 | 0.07% | TRIM -49% |
| 34 | IEQ CAPITAL, LLC | 92,23392,233 | $184,927 | 0.07% | — |
| 35 | Brevan Howard Capital Management LP | 79,38979,389 | $159,175 | 0.06% | NEW |
| 36 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 76,07276,072 | $152,524 | 0.06% | — |
| 37 | OMERS ADMINISTRATION Corp | 75,00075,000 | $150,375 | 0.06% | NEW |
| 38 | GSA CAPITAL PARTNERS LLP | 68,98768,987 | $138,000 | 0.05% | TRIM -26% |
| 39 | XTX Topco Ltd | 44,14144,141 | $88,503 | 0.03% | NEW |
| 40 | Point72 Asset Management, L.P. | 41,09541,095 | $82,396 | 0.03% | ADD 103% |
| 41 | Graham Capital Management, L.P. | 37,73937,739 | $75,667 | 0.03% | NEW |
| 42 | WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 37,99737,997 | $74,854 | 0.03% | — |
| 43 | HC Advisors, LLC | 22,90022,900 | $45,915 | 0.02% | TRIM -4% |
| 44 | Callan Family Office, LLC | 22,41922,419 | $44,950 | 0.02% | TRIM -21% |
| 45 | CAXTON CORP | 20,94620,946 | $41,996 | 0.02% | NEW |
| 46 | NINE MASTS CAPITAL Ltd | 20,62320,623 | $41,349 | 0.02% | ADD 33% |
| 47 | JSF Financial, LLC | 17,50017,500 | $35,088 | 0.01% | — |
| 48 | MONETA GROUP INVESTMENT ADVISORS LLC | 15,19615,196 | $30,468 | 0.01% | — |
| 49 | Lido Advisors, LLC | 13,22013,220 | $26,506 | 0.01% | — |
| 50 | FMR LLC | 12,98612,986 | $26,037 | 0.01% | — |
| 51 | Abel Hall, LLC | 12,59812,598 | $25,259 | 0.01% | — |
| 52 | Beacon Pointe Advisors, LLC | 12,50012,500 | $25,063 | 0.01% | NEW |
| 53 | TWO SIGMA SECURITIES, LLC | 10,99310,993 | $22,041 | 0.01% | NEW |
| 54 | Invesco Ltd. | 10,98010,980 | $22,014 | 0.01% | NEW |
| 55 | BARCLAYS PLC | 10,51510,515 | $21,083 | 0.01% | — |
| 56 | HSBC HOLDINGS PLC | 10,10510,105 | $20,463 | 0.01% | TRIM -50% |
| 57 | Vanguard Global Advisers, LLC | 9,9689,968 | $19,986 | 0.01% | NEW |
| 58 | ROYAL BANK OF CANADA | 1,8791,879 | $4,000 | 0.00% | ADD 95% |
| 59 | NISA INVESTMENT ADVISORS, LLC | 1,1061,106 | $2,218 | 0.00% | — |
| 60 | Bradley & Co. Private Wealth Management, LLC | 1,0001,000 | $2,005 | 0.00% | — |
| 61 | EverSource Wealth Advisors, LLC | 905905 | $1,815 | 0.00% | NEW |
| 62 | BNP PARIBAS FINANCIAL MARKETS | 466466 | $934 | 0.00% | TRIM -3% |
| 63 | PNC FINANCIAL SERVICES GROUP, INC. | 100100 | $201 | 0.00% | — |
| 64 | JPMORGAN CHASE & CO | 9999 | $189 | 0.00% | — |
| 65 | CWM, LLC | 6565 | $130 | 0.00% | TRIM -32% |
| 66 | Optiver Holding B.V. | 2727 | $54 | 0.00% | — |
| 67 | CITIGROUP INC | 1717 | $34 | 0.00% | NEW |
| 68 | SBI Securities Co., Ltd. | 1414 | $28 | 0.00% | TRIM -97% |
| 69 | Caitong International Asset Management Co., Ltd | 66 | $12 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | — | — | — | — | — | 13.0M | $26M |
| RA CAPITAL MANAGEMENT, L.P. | — | — | — | — | — | 13.0M | $26M |
| venBio Partners LLC | 9.7M | 9.7M | 9.7M | 9.7M | 9.7M | 12.9M | $26M |
| Redmile Group, LLC | 3.7M | 3.6M | 3.4M | 3.3M | 3.3M | 8.0M | $16M |
| Blackstone Inc. | — | — | — | — | — | 5.8M | $12M |
| Driehaus Capital Management LLC | — | — | — | 796K | 1.4M | 5.7M | $11M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 4.2M | $8M |
| MARSHALL WACE, LLP | — | 271K | 106K | 40K | 26K | 3.8M | $8M |
| Vivo Capital, LLC | — | — | — | — | — | 3.2M | $6M |
| Almitas Capital LLC | 1.2M | 1.4M | 2.5M | 5.1M | 2.5M | 3.2M | $6M |
| 5AM Venture Management, LLC | — | — | — | — | — | 3.1M | $6M |
| ORBIMED ADVISORS LLC | — | — | — | — | — | 2.9M | $6M |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | — | — | — | — | — | 2.0M | $4M |
| MILLENNIUM MANAGEMENT LLC | 2.1M | 944K | 493K | 2.6M | 3.2M | 2.0M | $4M |
| TWO SIGMA INVESTMENTS, LP | 704K | 543K | 478K | 607K | 640K | 1.6M | $3M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held |
|---|
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| BlackRock, Inc. | 5.4% | QII | 2026-06-30 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| TCG Crossover Management, LLC | +13,011,849 | $26M | OPEN |
| RA CAPITAL MANAGEMENT, L.P. | +13,011,849 | $26M | OPEN |
| Blackstone Inc. | +5,826,544 | $12M | OPEN |
| Redmile Group, LLC | +4,699,470 | $9M | ADD |
| Driehaus Capital Management LLC | +4,311,738 | $9M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −1,630,940 | $3M | CLOSE |
| MILLENNIUM MANAGEMENT LLC | −1,216,060 | $2M | TRIM |
| TWO SIGMA ADVISERS, LP | −710,400 | $1M | CLOSE |
| BANK OF MONTREAL /CAN/ | −474,781 | $951,936 | CLOSE |
| ACADIAN ASSET MANAGEMENT LLC | −273,248 | $547,862 | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| % shares out |
|---|
| Value held |
|---|
| 2026-Q1 | 69 | 94,268,985 | 71.6% | $189M |
| 2025-Q4 | 57 | 29,216,768 | 53.9% | $33M |
| 2025-Q3 | 61 | 30,384,300 | 56.7% | $56M |
| 2025-Q2 | 61 | 29,078,913 | 54.4% | $13M |
| 2025-Q1 | 85 | 34,806,413 | 65.2% | $22M |
| 2024-Q4 | 87 | 41,070,800 | 77.9% | $69M |
| 2024-Q3 | 92 | 45,500,313 | 86.4% | $83M |
| 2024-Q2 | 111 | 48,599,750 | 93.3% | $293M |
| 2024-Q1 | 106 | 46,514,471 | 92.7% | $519M |
| 2023-Q4 | 93 | 46,226,199 | 92.8% | $688M |
| 2023-Q3 | 76 | 33,283,236 | 80.9% | $160M |
| 2023-Q2 | 75 | 34,295,149 | 83.9% | $258M |
| 2023-Q1 | 86 | 41,827,112 | 102.4% | $189M |
| 2022-Q4 | 87 | 36,433,949 | 89.4% | $410M |
| 2022-Q3 | 99 | 36,439,912 | 89.4% | $349M |
| 2022-Q2 | 97 | 35,931,583 | 88.3% | $291M |
| 2022-Q1 | 96 | 36,919,026 | 90.9% | $624M |
| 2021-Q4 | 108 | 36,346,753 | 89.7% | $781M |
| 2021-Q3 | 115 | 34,512,039 | 85.5% | $2.5B |
| 2021-Q2 | 105 | 33,424,390 | 83.1% | $1.8B |
| 2021-Q1 | 94 | 33,516,525 | 83.5% | $2.5B |
| 2020-Q4 | 89 | 32,299,237 | 87.0% | $2.8B |
| 2020-Q3 | 57 | 27,250,796 | 73.7% | $1.0B |
