% of shares outstanding suppressed: the summed institutional 13F holdings (99,681,756) exceed the latest reported shares-outstanding count (85,029,624) by more than securities-lending double counting can explain (FINRA short interest 11,287,439 shares at 2026-04-30), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | BlackRock, Inc. | 7,170,8687.2M | $158M | — | ADD 57% |
| 2 | Deep Track Capital, LP | 6,772,5956.8M | $149M | — | NEW† |
| 3 | SAMSARA BIOCAPITAL, LLC | 6,345,2196.3M | $140M | — | ADD 10% |
| 4 | Foresite Capital Management V, LLC | 5,896,9955.9M | $130M | — | ADD 2% |
| 5 | venBio Partners LLC | 4,528,4084.5M | $100M | — | — |
| 6 | Foresite Capital Management VI LLC | 4,247,6704.2M | $94M | — | — |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 4,032,2664.0M | $89M | — | NEW† |
| 8 | Cormorant Asset Management, LP | 3,949,2413.9M | $87M | — | ADD 9% |
| 9 | Nextech Invest, Ltd. | 3,540,9983.5M | $78M | — | ADD 21% |
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,286,7533.3M | $72M | — | ADD 6418% |
| 11 | Saturn V Capital Management LP | 3,202,0753.2M | $71M | — | ADD 2% |
| 12 | UBS Group AG | 3,054,8653.1M | $67M | — | ADD 2580% |
| 13 | Octagon Capital Advisors LP | 2,830,7002.8M | $62M | — | ADD 12% |
| 14 | MPM BIOIMPACT LLC | 2,386,5292.4M | $53M | — | — |
| 15 | JANUS HENDERSON GROUP PLC | 2,124,4082.1M | $47M | — | NEW† |
| 16 | BAKER BROS. ADVISORS LP | 2,012,5002.0M | $44M | — | ADD 29% |
| 17 | SR One Capital Management, LP | 1,959,8962.0M | $43M | — | — |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 1,918,4151.9M | $42M | — | ADD 29% |
| 19 | STATE STREET CORP | 1,801,8121.8M | $40M | — | ADD 43% |
| 20 | Invesco Ltd. | 1,511,5371.5M | $33M | — | ADD 258% |
| 21 | Ikarian Capital, LLC | 1,213,5481.2M | $27M | — | NEW |
| 22 | MARSHALL WACE, LLP | 1,172,7491.2M | $26M | — | ADD 214% |
| 23 | Weiss Asset Management LP | 1,097,4171.1M | $24M | — | NEW |
| 24 | PRINCIPAL FINANCIAL GROUP INC | 1,058,0511.1M | $23M | — | NEW |
| 25 | FMR LLC | 973,782973,782 | $21M | — | ADD 3960% |
| 26 | GREAT POINT PARTNERS LLC | 856,061856,061 | $19M | — | NEW |
| 27 | Integral Health Asset Management, LLC | 800,000800,000 | $18M | — | NEW |
| 28 | JPMORGAN CHASE & CO | 861,575861,575 | $17M | — | ADD 142% |
| 29 | Yu Fan | 776,845776,845 | $17M | — | — |
| 30 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 749,099749,099 | $17M | — | NEW |
| 31 | GOLDMAN SACHS GROUP INC | 718,040718,040 | $16M | — | ADD 68% |
| 32 | VANGUARD PORTFOLIO MANAGEMENT LLC | 712,608712,608 | $16M | — | NEW |
| 33 | TWO SIGMA INVESTMENTS, LP | 658,115658,115 | $14M | — | ADD 121% |
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 635,389635,389 | $14M | — | ADD 26% |
| 35 | MILLENNIUM MANAGEMENT LLC | 606,284606,284 | $13M | — | TRIM -47% |
| 36 | D. E. Shaw & Co., Inc. | 572,129572,129 | $13M | — | ADD 147% |
| 37 | NORTHERN TRUST CORP | 563,522563,522 | $12M | — | ADD 35% |
| 38 | Opaleye Management Inc. | 550,000550,000 | $12M | — | ADD 3% |
| 39 | ORBIMED ADVISORS LLC | 548,163548,163 | $12M | — | TRIM -50% |
| 40 | PRUDENTIAL FINANCIAL INC | 538,733538,733 | $12M | — | NEW |
| 41 | VANGUARD FIDUCIARY TRUST CO | 527,305527,305 | $12M | — | NEW |
| 42 | ROYCE & ASSOCIATES LP | 476,392476,392 | $10M | — | NEW |
| 43 | STEMPOINT CAPITAL LP | 459,132459,132 | $10M | — | NEW |
| 44 | Spruce Street Capital LP | 392,574392,574 | $9M | — | NEW |
| 45 | Point72 Asset Management, L.P. | 362,985362,985 | $8M | — | NEW |
| 46 | CITADEL ADVISORS LLC | 351,507351,507 | $8M | — | ADD 195% |
| 47 | BOOTHBAY FUND MANAGEMENT, LLC | 346,131346,131 | $8M | — | NEW |
| 48 | Artia Global Partners LP | 325,046325,046 | $7M | — | NEW |
| 49 | Nuveen, LLC | 319,188319,188 | $7M | — | ADD 88% |
| 50 | Exome Asset Management LLC | 279,176279,176 | $6M | — | TRIM -4% |
| 51 | ExodusPoint Capital Management, LP | 266,243266,243 | $6M | — | ADD 2278% |
| 52 | Omega Fund Management, LLC | 241,255241,255 | $5M | — | TRIM -63% |
| 53 | WELLINGTON MANAGEMENT GROUP LLP | 239,231239,231 | $5M | — | ADD 41% |
| 54 | MORGAN STANLEY | 225,072225,072 | $5M | — | TRIM -56% |
| 55 | BARCLAYS PLC | 222,658222,658 | $5M | — | ADD 82% |
| 56 | TOWERVIEW LLC | 222,294222,294 | $5M | — | TRIM -55% |
| 57 | STIFEL FINANCIAL CORP | 209,729209,729 | $5M | — | — |
| 58 | Bank of New York Mellon Corp | 206,729206,729 | $5M | — | ADD 29% |
| 59 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 194,355194,355 | $4M | — | TRIM -7% |
| 60 | Hudson Bay Capital Management LP | 193,395193,395 | $4M | — | NEW |
| 61 | Trium Capital LLP | 191,391191,391 | $4M | — | TRIM -79% |
| 62 | TD Asset Management Inc | 191,202191,202 | $4M | — | NEW |
| 63 | ACT CAPITAL MANAGEMENT, LLC | 174,250174,250 | $4M | — | NEW |
| 64 | Susquehanna Portfolio Strategies, LLC | 172,779172,779 | $4M | — | — |
| 65 | Ensign Peak Advisors, Inc | 169,497169,497 | $4M | — | NEW |
| 66 | Ally Bridge Group (NY) LLC | 166,959166,959 | $4M | — | NEW |
| 67 | Burkehill Global Management, LP | 165,000165,000 | $4M | — | NEW |
| 68 | Russell Investments Group, Ltd. | 162,180162,180 | $4M | — | ADD 979% |
| 69 | ALGERT GLOBAL LLC | 157,826157,826 | $3M | — | NEW |
| 70 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 154,634154,634 | $3M | — | ADD 776% |
| 71 | AQR CAPITAL MANAGEMENT LLC | 146,682146,682 | $3M | — | ADD 6% |
| 72 | Elmind Capital, LP | 130,000130,000 | $3M | — | NEW |
| 73 | BANK OF AMERICA CORP /DE/ | 127,812127,812 | $3M | — | TRIM -8% |
| 74 | Swiss National Bank | 127,800127,800 | $3M | — | NEW |
| 75 | Quantinno Capital Management LP | 127,095127,095 | $3M | — | TRIM -6% |
| 76 | SCHRODER INVESTMENT MANAGEMENT GROUP | 137,347137,347 | $3M | — | NEW |
| 77 | Squarepoint Ops LLC | 114,198114,198 | $3M | — | NEW |
| 78 | HighVista Strategies LLC | 112,929112,929 | $2M | — | NEW |
| 79 | TUDOR INVESTMENT CORP ET AL | 106,376106,376 | $2M | — | NEW |
| 80 | AMERICAN CENTURY COMPANIES INC | 102,456102,456 | $2M | — | ADD 893% |
| 81 | Ghisallo Capital Management LLC | 100,000100,000 | $2M | — | NEW |
| 82 | Harvest Investment Services, LLC | 99,85099,850 | $2M | — | NEW |
| 83 | CITIGROUP INC | 98,92498,924 | $2M | — | ADD 603% |
| 84 | WELLS FARGO & COMPANY/MN | 86,71886,718 | $2M | — | TRIM -33% |
| 85 | RHUMBLINE ADVISERS | 84,29284,292 | $2M | — | ADD 22% |
| 86 | Informed Momentum Co LLC | 83,18783,187 | $2M | — | NEW |
| 87 | VICTORY CAPITAL MANAGEMENT INC | 82,65482,654 | $2M | — | NEW |
| 88 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 82,07482,074 | $2M | — | NEW |
| 89 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 80,84580,845 | $2M | — | ADD 2222% |
| 90 | RENAISSANCE TECHNOLOGIES LLC | 75,16775,167 | $2M | — | TRIM -31% |
| 91 | PRELUDE CAPITAL MANAGEMENT, LLC | 74,75874,758 | $2M | — | TRIM -15% |
| 92 | VOYA INVESTMENT MANAGEMENT LLC | 73,90973,909 | $2M | — | NEW |
| 93 | Mariner, LLC | 73,12373,123 | $2M | — | TRIM -50% |
| 94 | FIRST TRUST ADVISORS LP | 66,09966,099 | $1M | — | NEW |
| 95 | DEUTSCHE BANK AG\ | 58,15858,158 | $1M | — | ADD 41% |
| 96 | Legal & General Group Plc | 50,59550,595 | $1M | — | ADD 921% |
| 97 | STATE OF WISCONSIN INVESTMENT BOARD | 44,51044,510 | $980,555 | — | NEW |
| 98 | VANGUARD ASSET MANAGEMENT, Ltd | 42,24442,244 | $930,635 | — | NEW |
| 99 | Vanguard Global Advisers, LLC | 42,24442,244 | $930,635 | — | NEW |
| 100 | MOORE CAPITAL MANAGEMENT, LP | 41,37041,370 | $911,381 | — | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 1.1M | 1.5M | 4.2M | 4.2M | 4.6M | 7.2M | $158M |
| Deep Track Capital, LP | — | — | — | — | — | 6.8M | $149M |
| SAMSARA BIOCAPITAL, LLC | 3.3M | 3.3M | 4.8M | 4.8M | 5.8M | 6.3M | $140M |
| Foresite Capital Management V, LLC | 5.8M | 5.8M | 5.8M | 5.8M | 5.8M | 5.9M | $130M |
| venBio Partners LLC | 2.8M | 2.8M | 4.6M | 4.6M | 4.6M | 4.5M | $100M |
| Foresite Capital Management VI LLC | 4.2M | 4.2M | 4.2M | 4.2M | 4.2M | 4.2M | $94M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 4.0M | $89M |
| Cormorant Asset Management, LP | 2.1M | 2.1M | 2.1M | 2.1M | 3.6M | 3.9M | $87M |
| Nextech Invest, Ltd. | — | 1.5M | 2.9M | 2.9M | 2.9M | 3.5M | $78M |
| PRICE T ROWE ASSOCIATES INC /MD/ | — | — | 28K | 28K | 50K | 3.3M | $72M |
| Saturn V Capital Management LP | — | — | — | — | 3.1M | 3.2M | $71M |
| UBS Group AG | 48K | 96K | 1.2M | 763K | 114K | 3.1M | $67M |
| Octagon Capital Advisors LP | — | — | — | — | 2.5M | 2.8M | $62M |
| MPM BIOIMPACT LLC | — | — | — | — | 2.4M | 2.4M | $53M |
| JANUS HENDERSON GROUP PLC | — | — | — | — | — | 2.1M | $47M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 196 | 99,681,756 | — | $2.2B |
| 2025-Q4 | 134 | 79,075,279 | 93.0% | $771M |
| 2025-Q3 | 130 | 78,265,741 | 92.0% | $312M |
| 2025-Q2 | 112 | 78,333,292 | 92.1% | $235M |
| 2025-Q1 | 72 | 40,203,345 | 47.3% | $247M |
| 2024-Q4 | 64 | 40,271,542 | 47.4% | $317M |
| 2024-Q3 | 52 | 35,240,585 | 41.4% | $376M |
| 2024-Q2 | 29 | 28,575,030 | 33.6% | $380M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The Reporting Persons hold their securities of the Issuer for investment purposes. Depending on the factors discussed herein, the Reporting Persons may, from time to time, acquire additional shares of Common Stock and/or retain and/or sell all or a portion of the Common Stock held by the Reporting Persons in the open market or in privately negotiated transactions, and/or may distribute the Common Stock held by the Reporting Persons to their respective members or limited partners. Any actions the”
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
