| 1 | 1BML Capital Management, LLC | 14,250,00014.3M | $53M | 10.20% | — |
| 2 | 2Deep Track Capital, LP | 9,345,0009.3M | $35M | 6.69% | NEW† |
| 3 | 3BlackRock, Inc. | 7,407,0657.4M | $28M | 5.30% | ADD 9% |
| 4 | 4RA CAPITAL MANAGEMENT, L.P. | 6,804,0726.8M | $26M | 4.87% | NEW† |
| 5 | 5Vivo Capital, LLC | 6,666,6666.7M | $25M | 4.77% | TRIM -25% |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 5,167,4695.2M | $19M | 3.70% | NEW† |
| 7 | 7Frazier Life Sciences Management, L.P. | 4,925,3744.9M | $18M | 3.53% | NEW† |
| 8 | 8Rock Springs Capital Management LP | 4,472,6504.5M | $17M | 3.20% | — |
| 9 | 9Decheng Capital LLC | 4,041,7364.0M | $15M | 2.89% | — |
| 10 | 10ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,871,0003.9M | $15M | 2.77% | ADD 15% |
| 11 | 11Balyasny Asset Management L.P. | 3,361,3283.4M | $13M | 2.41% | NEW† |
| 12 | 12Kalehua Capital Management LLC | 3,169,9213.2M | $12M | 2.27% | NEW† |
| 13 | 13MORGAN STANLEY | 2,746,3022.7M | $10M | 1.97% | TRIM -20% |
| 14 | 14GEODE CAPITAL MANAGEMENT, LLC | 2,423,6912.4M | $9M | 1.74% | — |
| 15 | 15CITADEL ADVISORS LLC | 2,249,3192.2M | $8M | 1.61% | ADD 87% |
| 16 | 16STATE STREET CORP | 2,008,7462.0M | $8M | 1.44% | ADD 33% |
| 17 | 17BRAIDWELL LP | 1,699,1161.7M | $6M | 1.22% | NEW |
| 18 | 18VANGUARD PORTFOLIO MANAGEMENT LLC | 1,656,0661.7M | $6M | 1.19% | NEW |
| 19 | 19Palo Alto Investors LP | 1,613,4301.6M | $6M | 1.16% | ADD 3% |
| 20 | 20ACADIAN ASSET MANAGEMENT LLC | 1,539,7911.5M | $6M | 1.10% | TRIM -27% |
| 21 | 21Woodline Partners LP | 1,485,6231.5M | $6M | 1.06% | ADD 100% |
| 22 | 22Connor, Clark & Lunn Investment Management Ltd. | 1,418,3601.4M | $5M | 1.02% | — |
| 23 | 23DEUTSCHE BANK AG\ | 997,850997,850 | $4M | 0.71% | — |
| 24 | 24Aldebaran Capital, LLC | 947,162947,162 | $4M | 0.68% | — |
| 25 | 25D. E. Shaw & Co., Inc. | 900,804900,804 | $3M | 0.64% | TRIM -57% |
| 26 | 26MILLENNIUM MANAGEMENT LLC | 756,127756,127 | $3M | 0.54% | TRIM -28% |
| 27 | 27NORTHERN TRUST CORP | 728,225728,225 | $3M | 0.52% | ADD 10% |
| 28 | 28Three Bridge Wealth Advisors, LLC | 714,823714,823 | $3M | 0.51% | — |
| 29 | 29MARSHALL WACE, LLP | 712,984712,984 | $3M | 0.51% | ADD 47% |
| 30 | 30VANGUARD FIDUCIARY TRUST CO | 628,859628,859 | $2M | 0.45% | NEW |
| 31 | 31GOLDMAN SACHS GROUP INC | 588,691588,691 | $2M | 0.42% | TRIM -7% |
| 32 | 32DIMENSIONAL FUND ADVISORS LP | 511,461511,461 | $2M | 0.37% | ADD 89% |
| 33 | 33RENAISSANCE TECHNOLOGIES LLC | 502,631502,631 | $2M | 0.36% | TRIM -55% |
| 34 | 34PANAGORA ASSET MANAGEMENT INC | 502,290502,290 | $2M | 0.36% | ADD 637% |
| 35 | 35Monashee Investment Management LLC | 500,000500,000 | $2M | 0.36% | NEW |
| 36 | 36Logos Global Management LP | 500,000500,000 | $2M | 0.36% | TRIM -17% |
| 37 | 37JPMORGAN CHASE & CO | 486,633486,633 | $2M | 0.35% | TRIM -22% |
| 38 | 38Aisling Capital Management LP | 434,455434,455 | $2M | 0.31% | — |
| 39 | 39Bollard Group LLC | 431,631431,631 | $2M | 0.31% | TRIM -46% |
| 40 | 40TWO SIGMA INVESTMENTS, LP | 395,637395,637 | $1M | 0.28% | TRIM -31% |
| 41 | 41MPM BIOIMPACT LLC | 391,918391,918 | $1M | 0.28% | NEW |
| 42 | 42SUSQUEHANNA INTERNATIONAL GROUP, LLP | 379,930379,930 | $1M | 0.27% | TRIM -59% |
| 43 | 43SUPERSTRING CAPITAL MANAGEMENT LP | 366,490366,490 | $1M | 0.26% | NEW |
| 44 | 44BRIDGEWAY CAPITAL MANAGEMENT, LLC | 330,019330,019 | $1M | 0.24% | — |
| 45 | 45Russell Investments Group, Ltd. | 308,165308,165 | $1M | 0.22% | ADD 3049% |
| 46 | 46HighTower Advisors, LLC | 305,836305,836 | $1M | 0.22% | — |
| 47 | 47RAYMOND JAMES FINANCIAL INC | 266,448266,448 | $999,181 | 0.19% | — |
| 48 | 48CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 260,990260,990 | $978,713 | 0.19% | TRIM -8% |
| 49 | 49WELLINGTON MANAGEMENT GROUP LLP | 257,156257,156 | $964,335 | 0.18% | TRIM -3% |
| 50 | 50SEI INVESTMENTS CO | 217,154217,154 | $814,328 | 0.16% | NEW |
| 51 | 51Invesco Ltd. | 214,935214,935 | $806,007 | 0.15% | ADD 2% |
| 52 | 52MACKENZIE FINANCIAL CORP | 213,405213,405 | $800,269 | 0.15% | NEW |
| 53 | 53Bank of New York Mellon Corp | 207,024207,024 | $776,339 | 0.15% | — |
| 54 | 54UBS Group AG | 206,814206,814 | $775,553 | 0.15% | TRIM -43% |
| 55 | 55Verdad Advisers, LP | 197,042197,042 | $738,908 | 0.14% | NEW |
| 56 | 56Qube Research & Technologies Ltd | 194,510194,510 | $729,413 | 0.14% | TRIM -57% |
| 57 | 57Informed Momentum Co LLC | 178,378178,378 | $668,918 | 0.13% | NEW |
| 58 | 58Assenagon Asset Management S.A. | 177,283177,283 | $664,811 | 0.13% | ADD 15% |
| 59 | 59FMR LLC | 176,353176,353 | $661,324 | 0.13% | ADD 285% |
| 60 | 60PRICE T ROWE ASSOCIATES INC /MD/ | 156,725156,725 | $588,000 | 0.11% | ADD 12% |
| 61 | 61Creative Planning | 152,088152,088 | $570,330 | 0.11% | ADD 197% |
| 62 | 62ADAR1 Capital Management, LLC | 132,426132,426 | $496,598 | 0.09% | TRIM -78% |
| 63 | 63AMERICAN CENTURY COMPANIES INC | 118,702118,702 | $445,133 | 0.08% | ADD 53% |
| 64 | 64Nuveen, LLC | 118,020118,020 | $442,575 | 0.08% | TRIM -50% |
| 65 | 65ALPS ADVISORS INC | 98,17598,175 | $368,156 | 0.07% | ADD 10% |
| 66 | 66XTX Topco Ltd | 97,77497,774 | $366,653 | 0.07% | TRIM -13% |
| 67 | 67BANK OF AMERICA CORP /DE/ | 79,53979,539 | $298,271 | 0.06% | ADD 23% |
| 68 | 68RHUMBLINE ADVISERS | 75,40175,401 | $282,749 | 0.05% | ADD 5% |
| 69 | 69Quadrature Capital Ltd | 72,54072,540 | $272,025 | 0.05% | ADD 26% |
| 70 | 70AQR CAPITAL MANAGEMENT LLC | 72,40872,408 | $271,530 | 0.05% | TRIM -30% |
| 71 | 71Vanguard Global Advisers, LLC | 68,79368,793 | $257,974 | 0.05% | NEW |
| 72 | 72CenterBook Partners LP | 66,59866,598 | $249,743 | 0.05% | NEW |
| 73 | 73MetLife Investment Management, LLC | 43,87043,870 | $164,513 | 0.03% | ADD 71% |
| 74 | 74MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,58943,589 | $163,459 | 0.03% | ADD 2% |
| 75 | 75Cambridge Investment Research Advisors, Inc. | 41,87341,873 | $157,000 | 0.03% | — |
| 76 | 76Susquehanna Portfolio Strategies, LLC | 39,70139,701 | $148,879 | 0.03% | — |
| 77 | 77WELLS FARGO & COMPANY/MN | 36,26236,262 | $135,983 | 0.03% | TRIM -65% |
| 78 | 78EntryPoint Capital, LLC | 33,00733,007 | $123,776 | 0.02% | NEW |
| 79 | 79Diversified Trust Co | 29,45529,455 | $110,456 | 0.02% | NEW |
| 80 | 80NEW YORK STATE COMMON RETIREMENT FUND | 27,30027,300 | $102,375 | 0.02% | — |
| 81 | 81SG Americas Securities, LLC | 26,76726,767 | $100,000 | 0.02% | ADD 74% |
| 82 | 82MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,39825,398 | $95,243 | 0.02% | TRIM -12% |
| 83 | 83Vontobel Holding Ltd. | 25,00025,000 | $93,750 | 0.02% | TRIM -4% |
| 84 | 84TWO SIGMA SECURITIES, LLC | 22,47122,471 | $84,266 | 0.02% | ADD 95% |
| 85 | 85NEUBERGER BERMAN GROUP LLC | 22,06222,062 | $82,733 | 0.02% | ADD 16% |
| 86 | 86BARCLAYS PLC | 21,50821,508 | $80,654 | 0.02% | TRIM -85% |
| 87 | 87BNP PARIBAS FINANCIAL MARKETS | 21,44521,445 | $80,419 | 0.02% | — |
| 88 | 88China Universal Asset Management Co., Ltd. | 21,40121,401 | $80,254 | 0.02% | ADD 21% |
| 89 | 89Police & Firemen's Retirement System of New Jersey | 19,70019,700 | $73,875 | 0.01% | — |
| 90 | 90INTECH INVESTMENT MANAGEMENT LLC | 19,19619,196 | $71,985 | 0.01% | TRIM -59% |
| 91 | 91ProShare Advisors LLC | 18,69618,696 | $70,109 | 0.01% | TRIM -13% |
| 92 | 92Engineers Gate Manager LP | 18,29418,294 | $68,603 | 0.01% | NEW |
| 93 | 93CRA Financial Services, LLC | 17,78217,782 | $66,683 | 0.01% | — |
| 94 | 94Vanguard Personalized Indexing Management, LLC | 17,55817,558 | $65,843 | 0.01% | NEW |
| 95 | 95CIBC Asset Management Inc | 17,42817,428 | $65,355 | 0.01% | — |
| 96 | 96ExodusPoint Capital Management, LP | 16,89516,895 | $63,356 | 0.01% | NEW |
| 97 | 97Hudson Bay Capital Management LP | 16,82016,820 | $63,075 | 0.01% | NEW |
| 98 | 98VOYA INVESTMENT MANAGEMENT LLC | 16,31116,311 | $61,166 | 0.01% | TRIM -5% |
| 99 | 99STRS OHIO | 16,00016,000 | $60,000 | 0.01% | NEW |
| 100 | 100PRUDENTIAL FINANCIAL INC | 13,38013,380 | $50,175 | 0.01% | NEW |