ACAD US Equity

ACADIA PHARMACEUTICALS INC

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Health Care · Pharmaceutical Preparations · CIK 1070494 · FYE 1231

$26.01

+0.62 (+2.44%)

USD · as of 2026-07-28 · marketstack

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Institutional ownership· 13F filers holding ACAD · 2026-Q1 methodology → sources →

338 holders

% of shares outstanding held

96.4%

Shares held (13F)

164,994,786

Reporting holders

338

Top holders

largest 100 of 338 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	BAKER BROS. ADVISORS LP	42,896,69042.9M	$955M	25.05%	—
2	BlackRock, Inc.	21,550,92121.6M	$480M	12.59%	ADD 4%
3	VANGUARD PORTFOLIO MANAGEMENT LLC	8,671,6458.7M	$193M	5.06%	NEW†
4	STATE STREET CORP	8,332,7718.3M	$185M	4.87%	ADD 5%
5	RTW INVESTMENTS, LP	7,144,5247.1M	$159M	4.17%	—
6	VANGUARD CAPITAL MANAGEMENT LLC	5,661,4005.7M	$126M	3.31%	NEW†
7	GEODE CAPITAL MANAGEMENT, LLC	3,464,6893.5M	$77M	2.02%	ADD 7%
8	FIRST TRUST ADVISORS LP	3,343,8683.3M	$74M	1.95%	ADD 47%
9	DIMENSIONAL FUND ADVISORS LP	3,155,1603.2M	$70M	1.84%	ADD 8%
10	Palo Alto Investors LP	2,872,6952.9M	$64M	1.68%	ADD 16%
11	Point72 Asset Management, L.P.	2,577,9162.6M	$57M	1.51%	TRIM -24%
12	BRAIDWELL LP	2,471,1992.5M	$55M	1.44%	ADD 22%
13	Pictet Asset Management Holding SA	2,026,0442.0M	$45M	1.18%	ADD 31%
14	RENAISSANCE TECHNOLOGIES LLC	1,724,1961.7M	$38M	1.01%	ADD 13%
15	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	1,569,4911.6M	$35M	0.92%	ADD 4%
16	GOLDMAN SACHS GROUP INC	1,557,8041.6M	$35M	0.91%	—
17	BANK OF AMERICA CORP /DE/	1,553,7701.6M	$35M	0.91%	ADD 27%
18	Frazier Life Sciences Management, L.P.	1,438,1981.4M	$32M	0.84%	ADD 11%
19	Artisan Partners Limited Partnership	1,331,8131.3M	$30M	0.78%	NEW
20	FRED ALGER MANAGEMENT, LLC	1,277,1511.3M	$28M	0.75%	TRIM -18%
21	NORTHERN TRUST CORP	1,272,6111.3M	$28M	0.74%	ADD 3%
22	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1,173,5601.2M	$26M	0.69%	—
23	MORGAN STANLEY	1,093,1511.1M	$24M	0.64%	TRIM -4%
24	Nuveen, LLC	1,036,9871.0M	$23M	0.61%	—
25	Rockefeller Capital Management L.P.	1,027,3571.0M	$23M	0.60%	TRIM -8%
26	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	1,019,8241.0M	$23M	0.60%	TRIM -5%
27	Allspring Global Investments Holdings, LLC	954,855954,855	$21M	0.56%	ADD 45%
28	Qube Research & Technologies Ltd	950,299950,299	$21M	0.55%	TRIM -21%
29	VANGUARD FIDUCIARY TRUST CO	875,720875,720	$19M	0.51%	NEW
30	DEUTSCHE BANK AG\	840,414840,414	$19M	0.49%	—
31	Invesco Ltd.	836,510836,510	$19M	0.49%	—
32	JANE STREET GROUP, LLC	803,265803,265	$18M	0.47%	NEW
33	TWO SIGMA INVESTMENTS, LP	775,121775,121	$17M	0.45%	TRIM -31%
34	PRINCIPAL FINANCIAL GROUP INC	768,224768,224	$17M	0.45%	ADD 3%
35	Logos Global Management LP	750,000750,000	$17M	0.44%	TRIM -12%
36	Bank of New York Mellon Corp	736,558736,558	$16M	0.43%	TRIM -2%
37	Fisher Asset Management, LLC	732,872732,872	$16M	0.43%	ADD 10%
38	D. E. Shaw & Co., Inc.	729,836729,836	$16M	0.43%	TRIM -29%
39	Allianz Asset Management GmbH	706,664706,664	$16M	0.41%	ADD 139%
40	MILLENNIUM MANAGEMENT LLC	705,461705,461	$16M	0.41%	ADD 27%
41	PANAGORA ASSET MANAGEMENT INC	688,649688,649	$15M	0.40%	—
42	Woodline Partners LP	676,401676,401	$15M	0.40%	NEW
43	PRICE T ROWE ASSOCIATES INC /MD/	634,662634,662	$14M	0.37%	ADD 3%
44	AMERIPRISE FINANCIAL INC	624,260624,260	$14M	0.36%	TRIM -6%
45	CITADEL ADVISORS LLC	622,760622,760	$14M	0.36%	TRIM -54%
46	RICE HALL JAMES & ASSOCIATES, LLC	617,489617,489	$14M	0.36%	ADD 2%
47	VOYA INVESTMENT MANAGEMENT LLC	613,784613,784	$14M	0.36%	TRIM -4%
48	MANUFACTURERS LIFE INSURANCE COMPANY, THE	571,776571,776	$13M	0.33%	ADD 7%
49	AQR CAPITAL MANAGEMENT LLC	527,913527,913	$12M	0.31%	TRIM -13%
50	JUPITER ASSET MANAGEMENT LTD	491,093491,093	$11M	0.29%	TRIM -21%
51	STEMPOINT CAPITAL LP	485,132485,132	$11M	0.28%	NEW
52	UBS Group AG	448,549448,549	$10M	0.26%	TRIM -42%
53	Public Sector Pension Investment Board	447,930447,930	$10M	0.26%	ADD 3%
54	Hudson Bay Capital Management LP	445,506445,506	$10M	0.26%	ADD 536%
55	GLENMEDE TRUST CO NA	405,892405,892	$9M	0.24%	TRIM -11%
56	PRUDENTIAL FINANCIAL INC	387,650387,650	$9M	0.23%	TRIM -20%
57	Squarepoint Ops LLC	370,458370,458	$8M	0.22%	ADD 810%
58	RHUMBLINE ADVISERS	355,461355,461	$8M	0.21%	—
59	FMR LLC	350,340350,340	$8M	0.20%	TRIM -52%
60	Balyasny Asset Management L.P.	312,982312,982	$7M	0.18%	NEW
61	Connor, Clark & Lunn Investment Management Ltd.	294,265294,265	$7M	0.17%	TRIM -49%
62	Legal & General Group Plc	287,382287,382	$6M	0.17%	TRIM -9%
63	SPHERA FUNDS MANAGEMENT LTD.	256,202256,202	$6M	0.15%	ADD 21%
64	JPMORGAN CHASE & CO	263,091263,091	$6M	0.15%	TRIM -3%
65	LAZARD ASSET MANAGEMENT LLC	246,297246,297	$5M	0.14%	ADD 9%
66	GREAT LAKES ADVISORS, LLC	241,827241,827	$5M	0.14%	TRIM -23%
67	Trexquant Investment LP	235,946235,946	$5M	0.14%	TRIM -21%
68	Swiss National Bank	234,404234,404	$5M	0.14%	—
69	FRANKLIN RESOURCES INC	230,072230,072	$5M	0.13%	ADD 34%
70	ROYAL BANK OF CANADA	223,155223,155	$5M	0.13%	TRIM -23%
71	NORDEA INVESTMENT MANAGEMENT AB	228,125228,125	$5M	0.13%	TRIM -4%
72	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	206,884206,884	$5M	0.12%	—
73	Edgestream Partners, L.P.	191,328191,328	$4M	0.11%	TRIM -39%
74	Rafferty Asset Management, LLC	181,676181,676	$4M	0.11%	TRIM -8%
75	ALLIANCEBERNSTEIN L.P.	149,327149,327	$4M	0.09%	TRIM -4%
76	Birchview Capital, LP	171,000171,000	$4M	0.10%	—
77	ENVESTNET ASSET MANAGEMENT INC	169,954169,954	$4M	0.10%	ADD 12%
78	HUSSMAN STRATEGIC ADVISORS, INC.	168,000168,000	$4M	0.10%	ADD 14%
79	ALPS ADVISORS INC	162,820162,820	$4M	0.10%	ADD 3%
80	CONGRESS ASSET MANAGEMENT CO	160,794160,794	$4M	0.09%	NEW
81	STATE OF WISCONSIN INVESTMENT BOARD	156,422156,422	$3M	0.09%	ADD 4%
82	NEW YORK STATE COMMON RETIREMENT FUND	153,053153,053	$3M	0.09%	ADD 194%
83	Axecap Investments, LLC	152,910152,910	$3M	0.09%	ADD 12%
84	BESSEMER GROUP INC	150,498150,498	$3M	0.09%	ADD 21127%
85	Tetragon Partners GP Ltd	144,620144,620	$3M	0.08%	NEW
86	VICTORY CAPITAL MANAGEMENT INC	143,469143,469	$3M	0.08%	TRIM -19%
87	JACOBS LEVY EQUITY MANAGEMENT, INC	142,716142,716	$3M	0.08%	TRIM -62%
88	Bridgewater Associates, LP	141,812141,812	$3M	0.08%	ADD 3%
89	ALGERT GLOBAL LLC	140,462140,462	$3M	0.08%	TRIM -77%
90	MARTINGALE ASSET MANAGEMENT L P	139,964139,964	$3M	0.08%	ADD 28%
91	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	138,244138,244	$3M	0.08%	ADD 9%
92	Man Group plc	129,384129,384	$3M	0.08%	TRIM -63%
93	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	128,689128,689	$3M	0.08%	—
94	Erste Asset Management GmbH	133,700133,700	$3M	0.08%	—
95	Ishara Investments LP	123,000123,000	$3M	0.07%	TRIM -23%
96	SEGALL BRYANT & HAMILL, LLC	121,021121,021	$3M	0.07%	TRIM -4%
97	Caption Management, LLC	120,877120,877	$3M	0.07%	NEW
98	WELLS FARGO & COMPANY/MN	118,525118,525	$3M	0.07%	TRIM -43%
99	VANGUARD ASSET MANAGEMENT, Ltd	114,112114,112	$3M	0.07%	NEW
100	Emerald Investment Advisers, LLC	110,039110,039	$2M	0.06%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

BAKER BROS. ADVISORS LP

42.9M

$955M

BlackRock, Inc.

12.7M

21.4M

20.7M

20.3M

20.8M

21.6M

$480M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

8.7M

$193M

STATE STREET CORP

4.5M

7.0M

6.2M

7.3M

7.9M

8.3M

$185M

RTW INVESTMENTS, LP

8.7M

8.5M

9.0M

7.1M

$159M

VANGUARD CAPITAL MANAGEMENT LLC

—

5.7M

$126M

GEODE CAPITAL MANAGEMENT, LLC

2.9M

3.0M

3.1M

3.2M

3.5M

$77M

FIRST TRUST ADVISORS LP

2.7M

2.4M

1.9M

2.3M

3.3M

$74M

DIMENSIONAL FUND ADVISORS LP

1.1M

1.7M

2.4M

2.8M

2.9M

3.2M

$70M

Palo Alto Investors LP

2.7M

2.6M

2.5M

2.9M

$64M

Point72 Asset Management, L.P.

2.2M

4.6M

3.2M

1.5M

3.4M

2.6M

$57M

BRAIDWELL LP

—

2.4M

2.0M

2.5M

$55M

Pictet Asset Management Holding SA

467K

435K

1.6M

1.5M

2.0M

$45M

RENAISSANCE TECHNOLOGIES LLC

1.2M

1.5M

1.4M

1.5M

1.7M

$38M

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

—

336K

1.6M

1.5M

1.6M

$35M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	338	164,994,786	96.4%	$3.7B
2025-Q4

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · ACAD

Activists — 13D, active intent

BAKER BROS. ADVISORS LP25.4%NEWSCHEDULE 13D/A · Amd 17 · event 2026-02-24SEC →

43,294,373 shares · 5 reporting persons

Large holders — 13G, passive (top 4 by % of class)

Holder	% of class	Type	As of
BlackRock, Inc.	11.9%	QII	2025-01-31	SEC →
VANGUARD PORTFOLIO MANAGEMENT LLC	5.15%	QII	2026-03-31	SEC →
RTW INVESTMENTS, LP	4.2%	QII	2025-09-30	SEC →

Institutional ownership· 13F filers holding ACAD · 2026-Q1 methodology → sources →

338 holders

% of shares outstanding held

96.4%

Shares held (13F)

164,994,786

Reporting holders

338

Top holders

largest 100 of 338 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	BAKER BROS. ADVISORS LP	42,896,69042.9M	$955M	25.05%	—
2	BlackRock, Inc.	21,550,92121.6M	$480M	12.59%	ADD 4%
3	VANGUARD PORTFOLIO MANAGEMENT LLC	8,671,6458.7M	$193M	5.06%	NEW†
4	STATE STREET CORP	8,332,7718.3M	$185M	4.87%	ADD 5%
5	RTW INVESTMENTS, LP	7,144,5247.1M	$159M	4.17%	—
6	VANGUARD CAPITAL MANAGEMENT LLC	5,661,4005.7M	$126M	3.31%	NEW†
7	GEODE CAPITAL MANAGEMENT, LLC	3,464,6893.5M	$77M	2.02%	ADD 7%
8	FIRST TRUST ADVISORS LP	3,343,8683.3M	$74M	1.95%	ADD 47%
9	DIMENSIONAL FUND ADVISORS LP	3,155,1603.2M	$70M	1.84%	ADD 8%
10	Palo Alto Investors LP	2,872,6952.9M	$64M	1.68%	ADD 16%
11	Point72 Asset Management, L.P.	2,577,9162.6M	$57M	1.51%	TRIM -24%
12	BRAIDWELL LP	2,471,1992.5M	$55M	1.44%	ADD 22%
13	Pictet Asset Management Holding SA	2,026,0442.0M	$45M	1.18%	ADD 31%
14	RENAISSANCE TECHNOLOGIES LLC	1,724,1961.7M	$38M	1.01%	ADD 13%
15	ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	1,569,4911.6M	$35M	0.92%	ADD 4%
16	GOLDMAN SACHS GROUP INC	1,557,8041.6M	$35M	0.91%	—
17	BANK OF AMERICA CORP /DE/	1,553,7701.6M	$35M	0.91%	ADD 27%
18	Frazier Life Sciences Management, L.P.	1,438,1981.4M	$32M	0.84%	ADD 11%
19	Artisan Partners Limited Partnership	1,331,8131.3M	$30M	0.78%	NEW
20	FRED ALGER MANAGEMENT, LLC	1,277,1511.3M	$28M	0.75%	TRIM -18%
21	NORTHERN TRUST CORP	1,272,6111.3M	$28M	0.74%	ADD 3%
22	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	1,173,5601.2M	$26M	0.69%	—
23	MORGAN STANLEY	1,093,1511.1M	$24M	0.64%	TRIM -4%
24	Nuveen, LLC	1,036,9871.0M	$23M	0.61%	—
25	Rockefeller Capital Management L.P.	1,027,3571.0M	$23M	0.60%	TRIM -8%
26	MASSACHUSETTS FINANCIAL SERVICES CO /MA/	1,019,8241.0M	$23M	0.60%	TRIM -5%
27	Allspring Global Investments Holdings, LLC	954,855954,855	$21M	0.56%	ADD 45%
28	Qube Research & Technologies Ltd	950,299950,299	$21M	0.55%	TRIM -21%
29	VANGUARD FIDUCIARY TRUST CO	875,720875,720	$19M	0.51%	NEW
30	DEUTSCHE BANK AG\	840,414840,414	$19M	0.49%	—
31	Invesco Ltd.	836,510836,510	$19M	0.49%	—
32	JANE STREET GROUP, LLC	803,265803,265	$18M	0.47%	NEW
33	TWO SIGMA INVESTMENTS, LP	775,121775,121	$17M	0.45%	TRIM -31%
34	PRINCIPAL FINANCIAL GROUP INC	768,224768,224	$17M	0.45%	ADD 3%
35	Logos Global Management LP	750,000750,000	$17M	0.44%	TRIM -12%
36	Bank of New York Mellon Corp	736,558736,558	$16M	0.43%	TRIM -2%
37	Fisher Asset Management, LLC	732,872732,872	$16M	0.43%	ADD 10%
38	D. E. Shaw & Co., Inc.	729,836729,836	$16M	0.43%	TRIM -29%
39	Allianz Asset Management GmbH	706,664706,664	$16M	0.41%	ADD 139%
40	MILLENNIUM MANAGEMENT LLC	705,461705,461	$16M	0.41%	ADD 27%
41	PANAGORA ASSET MANAGEMENT INC	688,649688,649	$15M	0.40%	—
42	Woodline Partners LP	676,401676,401	$15M	0.40%	NEW
43	PRICE T ROWE ASSOCIATES INC /MD/	634,662634,662	$14M	0.37%	ADD 3%
44	AMERIPRISE FINANCIAL INC	624,260624,260	$14M	0.36%	TRIM -6%
45	CITADEL ADVISORS LLC	622,760622,760	$14M	0.36%	TRIM -54%
46	RICE HALL JAMES & ASSOCIATES, LLC	617,489617,489	$14M	0.36%	ADD 2%
47	VOYA INVESTMENT MANAGEMENT LLC	613,784613,784	$14M	0.36%	TRIM -4%
48	MANUFACTURERS LIFE INSURANCE COMPANY, THE	571,776571,776	$13M	0.33%	ADD 7%
49	AQR CAPITAL MANAGEMENT LLC	527,913527,913	$12M	0.31%	TRIM -13%
50	JUPITER ASSET MANAGEMENT LTD	491,093491,093	$11M	0.29%	TRIM -21%
51	STEMPOINT CAPITAL LP	485,132485,132	$11M	0.28%	NEW
52	UBS Group AG	448,549448,549	$10M	0.26%	TRIM -42%
53	Public Sector Pension Investment Board	447,930447,930	$10M	0.26%	ADD 3%
54	Hudson Bay Capital Management LP	445,506445,506	$10M	0.26%	ADD 536%
55	GLENMEDE TRUST CO NA	405,892405,892	$9M	0.24%	TRIM -11%
56	PRUDENTIAL FINANCIAL INC	387,650387,650	$9M	0.23%	TRIM -20%
57	Squarepoint Ops LLC	370,458370,458	$8M	0.22%	ADD 810%
58	RHUMBLINE ADVISERS	355,461355,461	$8M	0.21%	—
59	FMR LLC	350,340350,340	$8M	0.20%	TRIM -52%
60	Balyasny Asset Management L.P.	312,982312,982	$7M	0.18%	NEW
61	Connor, Clark & Lunn Investment Management Ltd.	294,265294,265	$7M	0.17%	TRIM -49%
62	Legal & General Group Plc	287,382287,382	$6M	0.17%	TRIM -9%
63	SPHERA FUNDS MANAGEMENT LTD.	256,202256,202	$6M	0.15%	ADD 21%
64	JPMORGAN CHASE & CO	263,091263,091	$6M	0.15%	TRIM -3%
65	LAZARD ASSET MANAGEMENT LLC	246,297246,297	$5M	0.14%	ADD 9%
66	GREAT LAKES ADVISORS, LLC	241,827241,827	$5M	0.14%	TRIM -23%
67	Trexquant Investment LP	235,946235,946	$5M	0.14%	TRIM -21%
68	Swiss National Bank	234,404234,404	$5M	0.14%	—
69	FRANKLIN RESOURCES INC	230,072230,072	$5M	0.13%	ADD 34%
70	ROYAL BANK OF CANADA	223,155223,155	$5M	0.13%	TRIM -23%
71	NORDEA INVESTMENT MANAGEMENT AB	228,125228,125	$5M	0.13%	TRIM -4%
72	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	206,884206,884	$5M	0.12%	—
73	Edgestream Partners, L.P.	191,328191,328	$4M	0.11%	TRIM -39%
74	Rafferty Asset Management, LLC	181,676181,676	$4M	0.11%	TRIM -8%
75	ALLIANCEBERNSTEIN L.P.	149,327149,327	$4M	0.09%	TRIM -4%
76	Birchview Capital, LP	171,000171,000	$4M	0.10%	—
77	ENVESTNET ASSET MANAGEMENT INC	169,954169,954	$4M	0.10%	ADD 12%
78	HUSSMAN STRATEGIC ADVISORS, INC.	168,000168,000	$4M	0.10%	ADD 14%
79	ALPS ADVISORS INC	162,820162,820	$4M	0.10%	ADD 3%
80	CONGRESS ASSET MANAGEMENT CO	160,794160,794	$4M	0.09%	NEW
81	STATE OF WISCONSIN INVESTMENT BOARD	156,422156,422	$3M	0.09%	ADD 4%
82	NEW YORK STATE COMMON RETIREMENT FUND	153,053153,053	$3M	0.09%	ADD 194%
83	Axecap Investments, LLC	152,910152,910	$3M	0.09%	ADD 12%
84	BESSEMER GROUP INC	150,498150,498	$3M	0.09%	ADD 21127%
85	Tetragon Partners GP Ltd	144,620144,620	$3M	0.08%	NEW
86	VICTORY CAPITAL MANAGEMENT INC	143,469143,469	$3M	0.08%	TRIM -19%
87	JACOBS LEVY EQUITY MANAGEMENT, INC	142,716142,716	$3M	0.08%	TRIM -62%
88	Bridgewater Associates, LP	141,812141,812	$3M	0.08%	ADD 3%
89	ALGERT GLOBAL LLC	140,462140,462	$3M	0.08%	TRIM -77%
90	MARTINGALE ASSET MANAGEMENT L P	139,964139,964	$3M	0.08%	ADD 28%
91	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	138,244138,244	$3M	0.08%	ADD 9%
92	Man Group plc	129,384129,384	$3M	0.08%	TRIM -63%
93	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	128,689128,689	$3M	0.08%	—
94	Erste Asset Management GmbH	133,700133,700	$3M	0.08%	—
95	Ishara Investments LP	123,000123,000	$3M	0.07%	TRIM -23%
96	SEGALL BRYANT & HAMILL, LLC	121,021121,021	$3M	0.07%	TRIM -4%
97	Caption Management, LLC	120,877120,877	$3M	0.07%	NEW
98	WELLS FARGO & COMPANY/MN	118,525118,525	$3M	0.07%	TRIM -43%
99	VANGUARD ASSET MANAGEMENT, Ltd	114,112114,112	$3M	0.07%	NEW
100	Emerald Investment Advisers, LLC	110,039110,039	$2M	0.06%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

BAKER BROS. ADVISORS LP

42.9M

$955M

BlackRock, Inc.

12.7M

21.4M

20.7M

20.3M

20.8M

21.6M

$480M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

8.7M

$193M

STATE STREET CORP

4.5M

7.0M

6.2M

7.3M

7.9M

8.3M

$185M

RTW INVESTMENTS, LP

8.7M

8.5M

9.0M

7.1M

$159M

VANGUARD CAPITAL MANAGEMENT LLC

—

5.7M

$126M

GEODE CAPITAL MANAGEMENT, LLC

2.9M

3.0M

3.1M

3.2M

3.5M

$77M

FIRST TRUST ADVISORS LP

2.7M

2.4M

1.9M

2.3M

3.3M

$74M

DIMENSIONAL FUND ADVISORS LP

1.1M

1.7M

2.4M

2.8M

2.9M

3.2M

$70M

Palo Alto Investors LP

2.7M

2.6M

2.5M

2.9M

$64M

Point72 Asset Management, L.P.

2.2M

4.6M

3.2M

1.5M

3.4M

2.6M

$57M

BRAIDWELL LP

—

2.4M

2.0M

2.5M

$55M

Pictet Asset Management Holding SA

467K

435K

1.6M

1.5M

2.0M

$45M

RENAISSANCE TECHNOLOGIES LLC

1.2M

1.5M

1.4M

1.5M

1.7M

$38M

ARROWSTREET CAPITAL, LIMITED PARTNERSHIP

—

336K

1.6M

1.5M

1.6M

$35M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	338	164,994,786	96.4%	$3.7B
2025-Q4

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · ACAD

Activists — 13D, active intent

BAKER BROS. ADVISORS LP25.4%NEWSCHEDULE 13D/A · Amd 17 · event 2026-02-24SEC →

43,294,373 shares · 5 reporting persons

Large holders — 13G, passive (top 4 by % of class)

Holder	% of class	Type	As of
BlackRock, Inc.	11.9%	QII	2025-01-31	SEC →
VANGUARD PORTFOLIO MANAGEMENT LLC	5.15%	QII	2026-03-31	SEC →
RTW INVESTMENTS, LP	4.2%	QII	2025-09-30	SEC →

ACAD US Equity☆

Institutional ownership· 13F filers holding ACAD · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · ACAD

Institutional ownership· 13F filers holding ACAD · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · ACAD

ACAD US Equity