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EW vs ISRG

Edwards Lifesciences Corp (EW) and Intuitive Surgical Inc (ISRG) are both filed with the SEC under Orthopedic, Prosthetic & Surgical Appliances & Supplies. ISRG is 2.5× EW's size by market cap ($129.7B against $51.8B); EW trades at the higher fiscal-year P/E (49.2× against 46.6×); ISRG reports the higher net margin (26.1% against 17.7%); ISRG grew sales faster over three years (+18.4% against +10.8%); and over the past year EW returned +11.1% against ISRG's -21.4%.

EWISRG
Last close$90.21$372.60
Market cap$51.8B$129.7B
P/E (FY)49.2×46.6×
P/S8.5×11.9×
EV/EBITDA33.9×
Gross margin78.0%60.7%
Operating margin20.8%26.9%
Net margin17.7%26.1%
Return on equity10.6%16.7%
Sales growth (3y)+10.8%+18.4%
EPS growth (3y)-9.1%+29.2%
1-year return+11.1%-21.4%

Screener snapshot — prices as of 2026-08-28. Each side's last close is the most recent session the snapshot holds for that company, which can be an earlier one, and its 1-year return is measured to that close. Market caps struck on 2026-08-27. Last close, market cap and the 1-year return are price figures; every other row is computed over the company's latest filed fiscal year — FY2025 (ended 2025-12-31) for both. — not published for this company. A ratio goes unpublished for more than one reason: a component the calculation needs is not on file, the filing does not tag the line it is read from, or the calculation is not defined on the filed basis — EV/EBITDA is not printed on non-positive EBITDA, and return on equity is not computed on a zero or negative equity base.

Who holds them, and who has traded them

EWISRG
Institutional holders (13F)1,2872,290
Insider buyers − sellers (180d)-5-5
Congressional trades disclosed (180d)11
Executive-branch officials on file — trades disclosed (180d)416

Counts only. The congressional figures count transactions dated in the trailing 180 days and disclosed in STOCK Act periodic transaction reports; amounts are filed as ranges and are never summed. The executive-branch figures count the same window of transactions, and they are scoped to one roster. The officials OGE posts for direct download. Insider buyers − sellers counts distinct people filing open-market Form 4 purchases minus distinct people filing open-market sales over the trailing 180 days, capped at ±5.

EW vs ISRG: common questions

Is EW bigger than ISRG?
ISRG carries the larger market cap — $129.7B against $51.8B, both struck on 2026-08-27.
Which trades at a higher P/E, EW or ISRG?
EW, at a fiscal-year 49.2× against 46.6× for ISRG. Both are price ÷ latest full-year diluted earnings per share, not a trailing-twelve-month P/E.
How have EW and ISRG performed over the past year?
EW returned +11.1% and ISRG -21.4%, measured on the trailing calendar year to the last close.
How many institutions hold EW and ISRG?
1,287 13F filers report a position in EW and 2,290 in ISRG, on the latest quarter in the panel.
Are EW and ISRG in the same industry?
Both are filed with the SEC under Orthopedic, Prosthetic & Surgical Appliances & Supplies, which is the classification this pairing is built on.

EW overview · ISRG overview · EW institutional ownership · ISRG institutional ownership · Congress and EW · Congress and ISRG · Executive branch and EW · Executive branch and ISRG

More in Orthopedic, Prosthetic & Surgical Appliances & Supplies: ALGN vs EW · ALGN vs ISRG · ALGN vs STE · ALGN vs ZBH

Stock comparisons lists every pair this site publishes.

Source: SPZCO — https://spzco.com/vs/ew-vs-isrg