ALGN vs ISRG
Align Technology Inc (ALGN) and Intuitive Surgical Inc (ISRG) are both filed with the SEC under Orthopedic, Prosthetic & Surgical Appliances & Supplies. ISRG is 11.5× ALGN's size by market cap ($129.7B against $11.3B); ISRG trades at the higher fiscal-year P/E (46.6× against 28.1×); ISRG reports the higher net margin (26.1% against 10.1%); ISRG grew sales faster over three years (+18.4% against +2.7%); and over the past year ALGN returned +11.7% against ISRG's -21.4%.
| ALGN | ISRG | |
|---|---|---|
| Last close | $157.58 | $372.60 |
| Market cap | $11.3B | $129.7B |
| P/E (FY) | 28.1× | 46.6× |
| P/S | 2.8× | 11.9× |
| Gross margin | 66.7% | 60.7% |
| Operating margin | 13.4% | 26.9% |
| Net margin | 10.1% | 26.1% |
| Return on equity | 10.4% | 16.7% |
| Sales growth (3y) | +2.7% | +18.4% |
| EPS growth (3y) | +7.0% | +29.2% |
| 1-year return | +11.7% | -21.4% |
Screener snapshot — prices as of 2026-08-28. Each side's last close is the most recent session the snapshot holds for that company, which can be an earlier one, and its 1-year return is measured to that close. Market caps struck on 2026-08-27. Last close, market cap and the 1-year return are price figures; every other row is computed over the company's latest filed fiscal year — FY2025 (ended 2025-12-31) for both.
Who holds them, and who has traded them
| ALGN | ISRG | |
|---|---|---|
| Institutional holders (13F) | 687 | 2,290 |
| Insider buyers − sellers (180d) | — | -5 |
| Congressional trades disclosed (180d) | 0 | 1 |
| Executive-branch officials on file — trades disclosed (180d) | 1 | 16 |
Counts only. The congressional figures count transactions dated in the trailing 180 days and disclosed in STOCK Act periodic transaction reports; amounts are filed as ranges and are never summed. The executive-branch figures count the same window of transactions, and they are scoped to one roster. The officials OGE posts for direct download. Insider buyers − sellers counts distinct people filing open-market Form 4 purchases minus distinct people filing open-market sales over the trailing 180 days, capped at ±5. — no open-market Form 4 purchases or sales in the window.
ALGN vs ISRG: common questions
- Is ALGN bigger than ISRG?
- ISRG carries the larger market cap — $129.7B against $11.3B, both struck on 2026-08-27.
- Which trades at a higher P/E, ALGN or ISRG?
- ISRG, at a fiscal-year 46.6× against 28.1× for ALGN. Both are price ÷ latest full-year diluted earnings per share, not a trailing-twelve-month P/E.
- How have ALGN and ISRG performed over the past year?
- ALGN returned +11.7% and ISRG -21.4%, measured on the trailing calendar year to the last close.
- How many institutions hold ALGN and ISRG?
- 687 13F filers report a position in ALGN and 2,290 in ISRG, on the latest quarter in the panel.
- Are ALGN and ISRG in the same industry?
- Both are filed with the SEC under Orthopedic, Prosthetic & Surgical Appliances & Supplies, which is the classification this pairing is built on.
ALGN overview → · ISRG overview → · ALGN institutional ownership → · ISRG institutional ownership → · Congress and ISRG → · Executive branch and ALGN → · Executive branch and ISRG →
More in Orthopedic, Prosthetic & Surgical Appliances & Supplies: ALGN vs EW · ALGN vs STE · ALGN vs ZBH · EW vs ISRG
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Source: SPZCO — https://spzco.com/vs/algn-vs-isrg