| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 9,082,0009.1M | $178M | 15.83% | ADD 18% |
| 2 | SR One Capital Management, LP | 5,037,8545.0M | $98M | 8.78% | — |
| 3 | NEA Management Company, LLC | 4,023,2194.0M | $79M | 7.01% | ADD 14% |
| 4 | ENAVATE SCIENCES GP, LLC | 3,919,1593.9M | $77M | 6.83% | — |
| 5 | FEDERATED HERMES, INC. | 3,127,0313.1M | $61M | 5.45% | ADD 15% |
| 6 | Polar Capital Holdings Plc | 2,548,4442.5M | $50M | 4.44% | ADD 141% |
| 7 | Capital International Investors | 2,434,0002.4M | $48M | 4.24% | NEW† |
| 8 | Fairmount Funds Management LLC | 2,359,0252.4M | $46M | 4.11% | ADD 7% |
| 9 | BlackRock, Inc. | 2,037,5482.0M | $40M | 3.55% | ADD 15% |
| 10 | NVP ASSOCIATES, LLC | 1,838,4821.8M | $36M | 3.21% | — |
| 11 | ALLIANCEBERNSTEIN L.P. | 897,321897,321 | $33M | 1.56% | ADD 4790% |
| 12 | STATE STREET CORP | 1,470,9231.5M | $29M | 2.56% | ADD 236% |
| 13 | WELLINGTON MANAGEMENT GROUP LLP | 1,246,0531.2M | $24M | 2.17% | ADD 46% |
| 14 | VANGUARD CAPITAL MANAGEMENT LLC | 1,245,3911.2M | $24M | 2.17% | NEW |
| 15 | SILVERARC CAPITAL MANAGEMENT, LLC | 1,135,9351.1M | $22M | 1.98% | NEW |
| 16 | EcoR1 Capital, LLC | 789,500789,500 | $15M | 1.38% | — |
| 17 | Balyasny Asset Management L.P. | 667,070667,070 | $13M | 1.16% | ADD 245% |
| 18 | ArrowMark Colorado Holdings LLC | 658,909658,909 | $13M | 1.15% | TRIM -12% |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 655,785655,785 | $13M | 1.14% | ADD 11% |
| 20 | Pivotal bioVenture Partners Investment Advisor LLC | 591,991591,991 | $12M | 1.03% | — |
| 21 | Woodline Partners LP | 590,525590,525 | $12M | 1.03% | NEW |
| 22 | GREAT POINT PARTNERS LLC | 524,066524,066 | $10M | 0.91% | NEW |
| 23 | Rock Springs Capital Management LP | 502,077502,077 | $10M | 0.88% | — |
| 24 | MARSHALL WACE, LLP | 501,928501,928 | $10M | 0.88% | ADD 6969% |
| 25 | MILLENNIUM MANAGEMENT LLC | 476,818476,818 | $9M | 0.83% | ADD 870% |
| 26 | NEXTBio Capital Management LP | 426,736426,736 | $8M | 0.74% | ADD 33% |
| 27 | BANK OF AMERICA CORP /DE/ | 388,347388,347 | $8M | 0.68% | ADD 723% |
| 28 | GOLDMAN SACHS GROUP INC | 381,461381,461 | $7M | 0.67% | ADD 192% |
| 29 | UBS Group AG | 367,405367,405 | $7M | 0.64% | ADD 429% |
| 30 | PRICE T ROWE ASSOCIATES INC /MD/ | 357,266357,266 | $7M | 0.62% | TRIM -3% |
| 31 | Sio Capital Management, LLC | 331,730331,730 | $6M | 0.58% | NEW |
| 32 | TWO SIGMA INVESTMENTS, LP | 275,056275,056 | $5M | 0.48% | ADD 1722% |
| 33 | VANGUARD PORTFOLIO MANAGEMENT LLC | 251,410251,410 | $5M | 0.44% | NEW |
| 34 | JENNISON ASSOCIATES LLC | 250,000250,000 | $5M | 0.44% | NEW |
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 224,402224,402 | $4M | 0.39% | ADD 5% |
| 36 | Jefferies Financial Group Inc. | 219,947219,947 | $4M | 0.38% | NEW |
| 37 | iA Global Asset Management Inc. | 215,830215,830 | $4M | 0.38% | NEW |
| 38 | SPHERA FUNDS MANAGEMENT LTD. | 214,334214,334 | $4M | 0.37% | NEW |
| 39 | Vestal Point Capital, LP | 200,000200,000 | $4M | 0.35% | NEW |
| 40 | NORTHERN TRUST CORP | 194,640194,640 | $4M | 0.34% | ADD 25% |
| 41 | VANGUARD FIDUCIARY TRUST CO | 179,388179,388 | $4M | 0.31% | NEW |
| 42 | SEB Asset Management AB | 163,860163,860 | $3M | 0.29% | NEW |
| 43 | Monashee Investment Management LLC | 150,000150,000 | $3M | 0.26% | NEW |
| 44 | Maven Securities LTD | 150,000150,000 | $3M | 0.26% | NEW |
| 45 | Walleye Capital LLC | 125,232125,232 | $2M | 0.22% | NEW |
| 46 | Invesco Ltd. | 113,479113,479 | $2M | 0.20% | TRIM -40% |
| 47 | Atom Investors LP | 107,016107,016 | $2M | 0.19% | NEW |
| 48 | SEVEN GRAND MANAGERS, LLC | 100,000100,000 | $2M | 0.17% | NEW |
| 49 | MORGAN STANLEY | 93,39693,396 | $2M | 0.16% | TRIM -27% |
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 85,00585,005 | $2M | 0.15% | ADD 521% |
| 51 | Exome Asset Management LLC | 80,73080,730 | $2M | 0.14% | NEW |
| 52 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 77,49377,493 | $2M | 0.14% | TRIM -42% |
| 53 | Birchview Capital, LP | 70,00070,000 | $1M | 0.12% | NEW |
| 54 | Nuveen, LLC | 67,77067,770 | $1M | 0.12% | ADD 33% |
| 55 | CITADEL ADVISORS LLC | 66,87066,870 | $1M | 0.12% | ADD 173% |
| 56 | Bank of New York Mellon Corp | 60,86460,864 | $1M | 0.11% | ADD 17% |
| 57 | Jump Financial, LLC | 60,00160,001 | $1M | 0.10% | NEW |
| 58 | AQR CAPITAL MANAGEMENT LLC | 50,97150,971 | $996,483 | 0.09% | TRIM -35% |
| 59 | Rafferty Asset Management, LLC | 48,16948,169 | $941,704 | 0.08% | NEW |
| 60 | ALPS ADVISORS INC | 43,69443,694 | $854,218 | 0.08% | — |
| 61 | Squarepoint Ops LLC | 42,87442,874 | $838,187 | 0.07% | ADD 176% |
| 62 | DAFNA Capital Management LLC | 42,50042,500 | $830,875 | 0.07% | NEW |
| 63 | Burkehill Global Management, LP | 40,00040,000 | $782,000 | 0.07% | NEW |
| 64 | J. Goldman & Co LP | 36,79736,797 | $719,381 | 0.06% | NEW |
| 65 | Swiss National Bank | 31,60031,600 | $617,780 | 0.06% | — |
| 66 | SCHRODER INVESTMENT MANAGEMENT GROUP | 33,69733,697 | $614,128 | 0.06% | TRIM -33% |
| 67 | Voleon Capital Management LP | 29,61229,612 | $578,915 | 0.05% | ADD 191% |
| 68 | BARCLAYS PLC | 29,61029,610 | $578,875 | 0.05% | TRIM -14% |
| 69 | JACOBS LEVY EQUITY MANAGEMENT, INC | 27,53227,532 | $538,251 | 0.05% | NEW |
| 70 | RHUMBLINE ADVISERS | 26,81326,813 | $524,187 | 0.05% | ADD 22% |
| 71 | HRT FINANCIAL LP | 25,74925,749 | $503,000 | 0.04% | NEW |
| 72 | JPMORGAN CHASE & CO | 25,10925,109 | $457,612 | 0.04% | ADD 16% |
| 73 | PROFUND ADVISORS LLC | 21,41621,416 | $418,683 | 0.04% | NEW |
| 74 | Quantinno Capital Management LP | 21,12621,126 | $413,013 | 0.04% | NEW |
| 75 | Vanguard Global Advisers, LLC | 20,84020,840 | $407,422 | 0.04% | NEW |
| 76 | STATE OF WISCONSIN INVESTMENT BOARD | 20,81420,814 | $406,914 | 0.04% | ADD 104% |
| 77 | XTX Topco Ltd | 19,31119,311 | $377,530 | 0.03% | ADD 59% |
| 78 | DEUTSCHE BANK AG\ | 19,26619,266 | $376,650 | 0.03% | ADD 51% |
| 79 | Aquatic Capital Management LLC | 18,64018,640 | $364,412 | 0.03% | NEW |
| 80 | ALLSTATE CORP | 18,22318,223 | $356,260 | 0.03% | NEW |
| 81 | Schonfeld Strategic Advisors LLC | 17,63817,638 | $344,821 | 0.03% | ADD 93% |
| 82 | Corient Private Wealth LLC | 16,84516,845 | $329,320 | 0.03% | NEW |
| 83 | PRELUDE CAPITAL MANAGEMENT, LLC | 16,64516,645 | $325,410 | 0.03% | NEW |
| 84 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,81915,819 | $309,261 | 0.03% | — |
| 85 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 15,52315,523 | $303,475 | 0.03% | ADD 85% |
| 86 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,38614,386 | $276,806 | 0.03% | ADD 64% |
| 87 | China Universal Asset Management Co., Ltd. | 13,52613,526 | $264,433 | 0.02% | — |
| 88 | Scientech Research LLC | 12,95212,952 | $253,212 | 0.02% | NEW |
| 89 | MetLife Investment Management, LLC | 12,90912,909 | $252,371 | 0.02% | ADD 28% |
| 90 | Creative Planning | 12,65812,658 | $247,464 | 0.02% | ADD 3% |
| 91 | FOX RUN MANAGEMENT, L.L.C. | 13,33113,331 | $242,957 | 0.02% | NEW |
| 92 | SEI INVESTMENTS CO | 12,38612,386 | $242,142 | 0.02% | NEW |
| 93 | VANGUARD ASSET MANAGEMENT, Ltd | 10,64210,642 | $208,051 | 0.02% | NEW |
| 94 | Legal & General Group Plc | 10,43210,432 | $203,946 | 0.02% | TRIM -20% |
| 95 | BNP PARIBAS FINANCIAL MARKETS | 9,9999,999 | $195,480 | 0.02% | ADD 40% |
| 96 | CITIGROUP INC | 9,8889,888 | $193,310 | 0.02% | ADD 321% |
| 97 | WELLS FARGO & COMPANY/MN | 8,8858,885 | $173,702 | 0.02% | TRIM -58% |
| 98 | Tower Research Capital LLC (TRC) | 7,2357,235 | $141,444 | 0.01% | ADD 810% |
| 99 | Zurcher Kantonalbank (Zurich Cantonalbank) | 6,7776,777 | $132,490 | 0.01% | NEW |
| 100 | Virtus Investment Advisers, LLC | 6,7176,717 | $131,317 | 0.01% | ADD 2% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | 1.8M | 2.9M | 3.3M | 4.8M | 7.7M | 9.1M | $178M |
| SR One Capital Management, LP | 4.9M | 4.9M | 4.9M | 4.9M | 5.0M | 5.0M | $98M |
| NEA Management Company, LLC | 2.6M | 2.6M | 2.7M | 2.7M | 3.5M | 4.0M | $79M |
| ENAVATE SCIENCES GP, LLC | 3.8M | 3.8M | 3.8M | 3.8M | 3.9M | 3.9M | $77M |
| FEDERATED HERMES, INC. | 1.2M | 1.2M | 1.9M | 1.9M | 2.7M | 3.1M | $61M |
| Polar Capital Holdings Plc | — | — | — | — | 1.1M | 2.5M | $50M |
| Capital International Investors | — | — | — | — | — | 2.4M | $48M |
| Fairmount Funds Management LLC | 1.9M | 1.9M | 1.9M | 1.9M | 2.2M | 2.4M | $46M |
| BlackRock, Inc. | 1.0M | 1.0M | 1.1M | 1.2M | 1.8M | 2.0M | $40M |
| NVP ASSOCIATES, LLC | 1.8M | 1.8M | 1.8M | 1.8M | 1.8M | 1.8M | $36M |
| ALLIANCEBERNSTEIN L.P. | — | — | 16K | 18K | 18K | 897K | $33M |
| STATE STREET CORP | 212K | 266K | 310K | 377K | 438K | 1.5M | $29M |
| WELLINGTON MANAGEMENT GROUP LLP | 1.1M | 874K | 879K | 858K | 855K | 1.2M | $24M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.2M | $24M |
| SILVERARC CAPITAL MANAGEMENT, LLC | — | — | — | — | — | 1.1M | $22M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 139 | 55,396,702 | 96.6% | $1.1B |
| 2025-Q4 | 118 | 41,561,367 | 77.4% | $1.5B |
| 2025-Q3 | 80 | 34,832,289 | 82.7% | $775M |
| 2025-Q2 | 73 | 34,056,527 | 81.4% | $330M |
| 2025-Q1 | 67 | 32,489,883 | 77.7% | $257M |
| 2024-Q4 | 65 | 31,716,256 | 75.9% | $260M |
| 2024-Q3 | 44 | 24,771,152 | 59.3% | $419M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The Funds acquired their respective shares for investment purposes. Depending on market conditions, their continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of s”
“The information set forth in Item 3 of this Statement is incorporated herein by reference. Mr. Moulder serves as the Chairman of the Issuer's Board of Directors and as its Chief Executive Officer. In such capacity, Mr. Moulder has influence over the corporate activities of the Issuer, including activities that may relate to items described in subparagraphs (a) through (j) of Item 4 of Schedule 13D. Except as described herein, the Reporting Persons have no present plans or proposals that relate t”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| Capital International Investors | +2,434,000 | $48M | OPEN |
| Polar Capital Holdings Plc | +1,490,835 | $29M | ADD |
| FMR LLC | +1,377,745 | $27M | ADD |
| VANGUARD CAPITAL MANAGEMENT LLC | +1,245,391 | $24M | OPEN |
| SILVERARC CAPITAL MANAGEMENT, LLC | +1,135,935 | $22M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −1,453,065 | $28M | CLOSE |
| NOVO HOLDINGS A/S | −1,450,000 | $28M | CLOSE |
| Vivo Capital, LLC | −853,495 | $17M | CLOSE |
| Point72 Asset Management, L.P. | −368,400 | $7M | CLOSE |
| Skandinaviska Enskilda Banken AB (publ) | −163,860 | $3M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
“The information set forth in Item 4 of the Original Schedule 13D is incorporated herein by reference.”
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
