$99.15
+0.95 (+0.97%)
USD · as of 2026-08-18 · marketstack
Clinical trials
catalyst calendar across sponsors →Studies where ZBH is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
117 interventional · 157 observational · 1 expanded access · 83 with posted results
Held by 19 tracked-famous managers (Dodge & Cox, HARRIS ASSOCIATES L P, PRIMECAP MANAGEMENT CO/CA/, CITADEL ADVISORS LLC, Holocene Advisors, LP, +14 more) · FINRA short interest 4.9 days to cover (settled 2026-07-31) · insider 90d: 0 buys / 2 sells · government filings 180d: 0 congress / 3 executive
| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|
| G7 Freedom Constrained Vivacit-E LinersNCT05587244Survival of the study deviceOpen-label · Treatment | Not applicable | Enrolling by invitation | Device: Total Hip Arthroplasty with G7 Freedom Constrained Vivacit-E Liners | Osteoarthritis, Hip, Rheumatoid Arthritis, Non-Union Fracture, Trochanteric Fractures, Femoral Neck Fractures, Avascular Necrosis, Dislocation, Hip | 202 | Dec 2037 | ≤ 4,152 d | 2025-10-20 |
| G7 Dual Mobility With Vivacit-E or Longevity PMCFNCT05548972Survival of the implant systemNon-randomized · Open-label · Treatment | Not applicable | Enrolling by invitation | Device: G7 Dual Mobility with Vivacit-E bearing, G7 Dual Mobility Longevity bearing | Hip Osteoarthritis, Rheumatoid Arthritis, Joint Diseases, Avascular Necrosis, Dislocation, Hip, Femoral Neck Fractures, Trochanteric Fractures, Revision Surgeries | 358 | Jan 2037 | ≤ 3,818 d | 2025-06-15 |
| OsseoFit Stemless Shoulder System (Anatomic)NCT07421245observationalthe American Shoulder and Elbow Surgeons (ASES) Shoulder Score | — | Not yet recruiting | Device: OsseoFit Stemless Inlay, OsseoFit Stemless Onlay | Shoulder Injuries, Shoulder Pain, Shoulder Fractures, Shoulder Arthritis, Shoulder Disease | 136 | Jan 2036 | ≤ 3,452 d | 2026-07-09 |
| Clinical Outcomes Study of the Nexel Total ElbowNCT02469662SurvivorshipNon-randomized · Open-label · Treatment | Not applicable | Recruiting | Device: Nexel Total Elbow | Elbow Joint Destruction, Post-traumatic Lesions, Ankylosed Joints, Advanced Rheumatoid Arthritis, Joint Instability or Loss of Motion, Acute Comminuted Articular Fracture of Elbow Joint Surfaces, Bone Loss Contributing to Elbow Instability, Bilateral Ankylosis From Causes Other Than Active Sepsis, Post-traumatic Arthritis, Degenerative Arthritis | 134 | Dec 2035 | ≤ 3,421 d | 2026-07-09 |
| Comprehensive Segmental Revision SystemNCT03270982observationalImplant survivorship assessed according to the implant revisions | — | Active, not recruiting | Device: Comprehensive SRS Replacement | Degenerative Disease, Oncology, Revision Surgery, Trauma, Rheumatoid Arthritis | 105 | Dec 2035 | ≤ 3,421 d | 2026-06-09 |
| MDR - Comprehensive Primary Revision Stems PMCFNCT06788717observationalImplant Survivorship at 10 years follow-up (Kaplan Meier) | — | Enrolling by invitation | Device: Comprehensive Primary Revision Stems | Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Disease, Shoulder Arthritis | 59 | Jul 2035 | ≤ 3,268 d | 2026-07-09 |
| Avenir Complete Post-Market Clinical Follow-Up StudyNCT04731077Survival of the study device; whether or not it is still implanted in the subjectOpen-label · Treatment | Not applicable | Active, not recruiting | Device: Avenir Complete Femoral Stem | Osteoarthritis, Hip, Avascular Necrosis of Hip, Avascular Necrosis of the Femoral Head, Post-traumatic; Arthrosis | 275 | 2035-06-01 | in 3,208 d | 2025-06-18 |
| MDR - Comprehensive Reverse/Versa Dial Ti GlenosphereNCT04003272observationalProduct Safety assessed through the incidence and frequency of revisions, complications and adverse events | — | Enrolling by invitation | Device: Comprehensive Reverse Versa-Dial Titanium Glenosphere | Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Arthritis, Shoulder Disease | 59 | 2034-08-19 | in 2,922 d | 2026-02-06 |
| Persona Ti-Nidium Post-Market Clinical Follow-upNCT04817969Oxford Knee Score (OKS)Open-label · Treatment | Not applicable | Active, not recruiting | Device: Zimmer Biomet Persona Ti-Nidium Total Knee System | Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of the Knee, Avascular Necrosis, Patellofemoral Osteoarthritis | 240 | May 2034 | ≤ 2,842 d | 2026-08-17 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the Anatomical Shoulder 2.0 Fracture SystemNCT05351112observationalIncidence and frequency of revisions [Product safety based on implant survivorship] | — | Recruiting | — | Proximal Humerus Fracture, Posttraumatic Arthrosis After Humeral Head Fracture, Posttraumatic Necrosis of the Humeral Head | 78 | 2034-01-21 | in 2,712 d | 2025-08-17 |
| G7 Acetabular System With Vivacit-E or Longevity Liner PMCF StudyNCT04754087Survival of the study device (liner); whether or not it is still implanted in the subjectOpen-label · Treatment | Not applicable | Active, not recruiting | Device: Vivacit-E and Longevity (HXLPE) Liners | Total Hip Arthroplasty, Degenerative Joint Disease of Hip, Avascular Necrosis of Hip, Rheumatoid Arthritis of Hip, Osteoarthritis, Hip, Osteoarthritis of Hip, Fractures, Hip, Fracture of Hip | 300 | 2033-12-31 | in 2,691 d | 2026-07-16 |
| Persona Revision Knee System OutcomesNCT04821154observationalKnee Society Clinical Rating System objective knee score (KS-KS) | — | Recruiting | Device: Persona Revision Knee System | Arthroplasty Complications, Infection, Knee Disease, Knee Osteoarthritis | 380 | 2033-12-31 | in 2,691 d | 2026-07-10 |
| Zimmer Biomet Shoulder Arthroplasty PMCFNCT04984291Implant Survivorship at 10 years follow-up (Kaplan Meier)Open-label · Treatment | Not applicable | Recruiting | Device: Alliance Glenoid, Identity Stem | Shoulder Fractures, Shoulder Arthritis, Shoulder Osteoarthritis, Shoulder Deformity, Shoulder Injuries, Shoulder Pain | 584 | 2033-08-15 | in 2,553 d | 2026-04-28 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the Anatomical Shoulder Bipolar SystemNCT05358574observationalIncidence and frequency of revisions [Product safety based on implant survivorship] | — | Recruiting | — | Revision of a Shoulder Prosthesis | 40 | 2033-07-16 | in 2,523 d | 2025-11-25 |
| Anatomical Shoulder Domelock System StudyNCT03312465observationalImplant Survivorship | — | Active, not recruiting | Device: AS Domelock System | Avascular Necrosis, Revision Surgery, Conditions Consequent to Earlier Operations, Arthritis, Rheumatoid, Arthritis, Degenerative, Arthritis;Traumatic | 73 | 2032-12-09 | in 2,304 d | 2026-03-25 |
| Cemented vs Cementless Persona Keel RCTNCT05630053Oxford Knee Score (OKS)Randomized · Single-masked · Treatment | Not applicable | Active, not recruiting | Device: Cementless Persona Knee System, Cemented Persona Knee System | Knee Pain Chronic, Rheumatoid Arthritis, Osteoarthritis, Traumatic Arthritis, Polyarthritis, Avascular Necrosis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee | 300 | May 2032 | ≤ 2,112 d | 2026-04-27 |
| MDR - PMCF Study for Taperloc Complete StemsNCT04028687observationalDevice Safety assessed through the frequency and incidence of revisions, complications and Adverse Events. | — | Recruiting | Device: Taperloc Complete Stem | Hip Arthritis, Hip Disease, Hip Fractures, Hip Injuries, Hip Pain Chronic | 820 | 2032-02-12 | in 2,003 d | 2025-03-11 |
| A Prospective, Clinical Investigation of the Vanguard 360 Revision KneeNCT01542580observationalAMERICAN KNEE SOCIETY KNEE SCORE | — | Active, not recruiting | Device: Vanguard SSK 360 with PS Bearing, Vanguard SSK 360 with PSC bearing, Vanguard DA 360, Vanguard 360 TiNbN Femur with PS bearing, Vanguard 360 TiNbN Femur with PSC bearing | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Post Traumatic Deformity, Complications; Arthroplasty, Deformity of Limb | 255 | Dec 2031 | ≤ 1,960 d | 2025-11-25 |
| Avenir® Cemented Hip Stem - PMCFNCT03396224observationalImplant survival based on removal or intended removal of the device and determined using the Kaplan-Meier method | — | Active, not recruiting | — | Primary Osteoarthritis, Post-Traumatic Osteoarthritis of Hip, Femoral Neck Fractures, Femoral Head Necrosis, Sequelae From Previous Hip Surgery, Osteotomies, Congenital Hip Dysplasia | 100 | Nov 2030 | ≤ 1,564 d | 2025-11-25 |
| Persona Partial Knee Clinical Outcomes StudyNCT03034811Oxford Knee ScoreOpen-label · Treatment | Not applicable | Active, not recruiting | Device: Persona Partial Knee system | Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Conditional Tibial Condyle or Plateau Fractures, Conditional Revision of the Articular Surface | 757 | Sep 2030 | ≤ 1,503 d | 2026-04-22 |
| Comprehensive Nano - Post Market Clinical Follow-Up StudyNCT03423953observationalSurvivorship | — | Active, not recruiting | Device: Comprehensive Nano | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Revision, Correction of Functional Deformity | 194 | 2030-07-31 | in 1,442 d | 2026-04-21 |
| A 3-Arm Study on G7 Acetabular Cup With Echo BiMetric Stem in Total Hip ArthroplastyNCT02518269Difference in osteolytic volume at 5 years postoperatively measured by CT scan.Randomized · Single-masked · Treatment | Not applicable | Active, not recruiting | Procedure: Hip Arthroplasty | Osteoarthrosis, Pain, Arthritis | 360 | Jun 2030 | ≤ 1,411 d | 2025-11-25 |
| Post-Market Study of Comprehensive Reverse Augmented Glenoid and Mini Humeral Tray in Total Shoulder ArthroplastyNCT03726554Implant SurvivorshipNon-randomized · Open-label · Treatment | Not applicable | Active, not recruiting | Device: Comprehensive Reverse Porous Augmented Glenoid, Comprehensive Mini Humeral Tray | Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects, Post-Traumatic Arthritis | 99 | Feb 2030 | ≤ 1,289 d | 2026-07-09 |
| G7 BiSpherical Acetabular Shell PMCF StudyNCT03266874observationalImplant survivorship is assessed counting the number of implant revisions | — | Active, not recruiting | — | Rheumatoid Arthritis, Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Correction of Functional Deformity, Non-Union Fracture, Femoral Neck Fractures, Trochanteric Fractures | 160 | Dec 2029 | ≤ 1,230 d | 2025-06-25 |
| Persona SoluTion PPS Femur PMCFNCT07286513observationalChange in KOOS JR Score between pre-op and 2 years post-op | — | Enrolling by invitation | Device: Total knee arthroplasty | Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis, Collagen Disorders, Avascular Necrosis of Femoral Condyle, Valgus Deformity, Varus Deformity, Flexion Deformity of Knee | 200 | Dec 2029 | ≤ 1,230 d | 2026-08-17 |
| BC Study of G7 Cup and Compatible Femoral StemsNCT03456622observationalSurvival of the implant system | — | Active, not recruiting | — | Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis | 230 | Jun 2029 | ≤ 1,046 d | 2025-11-25 |
| Zimmer Biomet Shoulder Arthroplasty PMCF StudyNCT06920459observationalAmerican Shoulder and Elbow Surgeons (ASES) | — | Recruiting | Device: Alliance™ Glenoid | Shoulder Fractures, Shoulder Arthritis Osteoarthritis, Shoulder Injury, Shoulder Pain, Degenerative Joint Disease, Arthritis Shoulder | 50 | Jun 2029 | ≤ 1,046 d | 2026-06-08 |
| Persona Cohort Nordic Multicenter StudyNCT03495232observationalEvaluate patient reported outcome measures following primary total knee replacement using Persona Total Knee system | — | Active, not recruiting | Device: Zimmer Biomet Persona total knee system | Knee Arthropathy | 700 | 2029-04-07 | in 962 d | 2025-12-18 |
| Z1 Hip System: Post-Market Clinical Follow Up StudyNCT07104279observational2 Year Survivorship | — | Recruiting | Device: Z1 Femoral Hip System | Hip Osteoarthritis, Acute Traumatic Fracture of the Femoral Head or Neck, Avascular Necrosis of the Femoral Head | 150 | Aug 2028 | ≤ 743 d | 2025-11-10 |
| MDR - Comprehensive Primary/Micro Stem & Versa-Dial Ti Humeral HeadNCT04003311observationalDevice Safety assessed through the frequency and incidence of revisions, complications and Adverse Events | — | Enrolling by invitation | Device: Comprehensive Primary Micro Stem, Comprehensive Anatomic Versa-Dial Titanium Humeral Head | Shoulder Pain, Shoulder Injuries, Shoulder Fractures, Shoulder Disease, Shoulder Arthritis | 146 | 2028-07-29 | in 710 d | 2025-10-30 |
| Zimmer Continuum Metal on Polyethylene (MoP) PostMarket Clinical Followup (PMCF) StudyNCT01307384observationalSurvivorship | — | Active, not recruiting | Device: Continuum Metal on Polyethylene Acetabular System | Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis | 165 | Dec 2027 | ≤ 499 d | 2025-06-18 |
| G7 Dual Mobility System Used in Total Hip Arthroplasty for the Treatment of Femoral Neck FractureNCT04031209observationalImplant dislocation rate | — | Active, not recruiting | Device: G7 Acetabular System | Hip Fractures | 275 | Dec 2027 | ≤ 499 d | 2024-12-18 |
| ZNN Bactiguard Retrograde Femoral Nails PMCF StudyNCT05276674observationalRate of fracture healing 12 months after fracture fixation | — | Recruiting | Device: ZNN Bactiguard Retrograde Femoral Nail | Femoral Fracture | 100 | Dec 2027 | ≤ 499 d | 2026-02-03 |
| MDR Vivacit-E Elevated StudyNCT07150221observationalSurvival of the Implant System via Adverse Events | — | Enrolling by invitation | Device: Vivacit-E Elevated Liners | Osteoarthritis (OA) of the Hip, Avascular Necrosis of Bone of Hip, Protrusio Acetabuli, Traumatic Arthropathy-Hip, Slipped Capital Femoral Epiphyses, Fused Hip, Fracture of Pelvis, Diastrophic Variant | 52 | Dec 2027 | ≤ 499 d | 2026-04-01 |
| Zimmer Trabecular Metal Total Ankle PMCFNCT02038140SurvivorshipOpen-label · Treatment | Not applicable | Active, not recruiting | Device: Zimmer Trabecular Metal Total Ankle System | Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis | 120 | Sep 2027 | ≤ 407 d | 2026-07-09 |
| Affixus Natural Nail System Humeral Nail PMCFNCT05019664observationalBone Union | — | Active, not recruiting | Device: humeral fracture | Humeral Fractures, Proximal, Humeral Fractures | 100 | Aug 2027 | ≤ 377 d | 2026-05-20 |
| Zimmer Biomet-RibFix TitanNCT07485829observationalEvaluation of Patient Safety | — | Recruiting | Device: The RibFix Titan™ device should be used within this arm of the study. | Rib Fracture, Rib Fracture Multiple | 54 | Jul 2027 | ≤ 346 d | 2026-04-21 |
| Prospective G7 Dual Mobility Total Hip PMCFNCT03308929observationalSurvivorship of the study device | — | Active, not recruiting | Device: G7 Dual Mobility hip | Clinical Outcomes, Functional Outcomes, Radiological Outcomes, Survivorship, Safety | 250 | 2027-07-01 | in 316 d | 2025-06-15 |
| AVANTAGE® RELOAD Double Mobility Acetabular Cup -Clinical StudyNCT03357445SurvivorshipRandomized · Single-masked · Other | Not applicable | Active, not recruiting | Other: Avantage Reload cup | Primary Osteoarthritis, Post-Traumatic Arthritis, Inflammatory Joint Disease, Femoral Neck Fracture, Femoral Head Necrosis, Sequelae From Previous Hip Surgery, Osteotomies, Congenital Hip Dysplasia | 500 | 2027-04-27 | in 251 d | 2024-11-14 |
| MDR - PMCF Study for RingLoc Bipolar Acetabular Cup and Endo II Femoral HeadsNCT05199870observationalDevice safety assessed through the frequency and incidence of revisions, complications, and Adverse Events. | — | Enrolling by invitation | Device: RingLoc Bipolar Acetabular Cup, Endo II Femoral Head | Hip Arthritis, Hip Disease, Hip Fractures, Hip Injuries, Hip Pain Chronic | 116 | Mar 2027 | ≤ 224 d | 2026-03-19 |
| PMCF Study on the Safety and Performance of the Zimmer® Maxera™ Acetabular System in Total Hip ArthroplastyNCT03372278observationalImplant survival based on removal or intended removal of the device and determined using the Kaplan-Meier method | — | Active, not recruiting | — | Rheumatoid Arthritis With Adequate Bone Quality, Inflammatory Arthritis, Osteoarthritis, Hip, Avascular Necrosis, Post-traumatic; Arthrosis, Congenital Hip Dysplasia | 250 | Jan 2027 | ≤ 165 d | 2025-06-15 |
| ZNN Bactiguard Antegrade Femoral Nails PMCF StudyNCT05339360observationalPerformance of the study device | — | Recruiting | Procedure: Femoral fixation with intramedullary nails | Femur Fracture, Osteotomy | 100 | Jan 2027 | ≤ 165 d | 2025-11-25 |
| ROSA Knee Intraoperative Planning Flexibility StudyNCT05966519observationalThe mean absolute difference between X-Atlas image based pre-op plan & intra-op final plan | — | Recruiting | Device: Total Knee Replacement (TKR) | Osteo Arthritis Knee, Rheumatoid Arthritis | 80 | Jan 2027 | ≤ 165 d | 2026-04-08 |
| Outcomes Study of the Trabecular Metal (TM) Reverse Shoulder SystemNCT01480440observationalSurvivorship | — | Active, not recruiting | Device: Trabecular Metal Reverse Shoulder System | Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Ununited Humeral Head Fracture, Irreducible 3-and 4-part Proximal Humeral Fractures, Avascular Necrosis, Gross Rotator Cuff Deficiency, Revision Total Shoulder Arthroplasty | 200 | Dec 2026 | ≤ 134 d | 2026-04-28 |
| Comprehensive Reverse Shoulder Data CollectionNCT03404778observationalPain Score | — | Enrolling by invitation | Device: Biomet Comprehensive Reverse Shoulder | Arthropathy of Shoulder Region, Grossly Deficient Rotator Cuff, Osteoarthritis of the Shoulder, Rheumatoid Arthritis Without Humeral Metaphyseal Defects, Post-Traumatic Arthitis | 175 | Dec 2026 | ≤ 134 d | 2025-10-30 |
| Database Retrieval for the Comprehensive ShoulderNCT03409718observationalImplant survivorship is assessed counting the number of implant revisions | — | Active, not recruiting | Device: Biomet Comprehensive Shoulder System | Osteoarthritis of the Shoulder, Avascular Necrosis, Rheumatoid Arthritis, Prior Failed Revision, Correction of Functional Deformity, Fracture of Proximal End of Humerus, Cuff Tear Arthropathy | 160 | Dec 2026 | ≤ 134 d | 2026-07-10 |
| Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating SystemNCT03626038Re-operationOpen-label · Treatment | Not applicable | Active, not recruiting | Device: A.L.P.S. Proximal Humerus Plating System | Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Psoriatic Arthritis, Proximal Humeral Fracture | 135 | Dec 2026 | ≤ 134 d | 2026-02-13 |
| A.L.P.S. Clavicle Plating System PMCFNCT05327959Number of subjects with fracture healingOpen-label · Treatment | Not applicable | Active, not recruiting | Device: Clavicle open reduction and internal fixation | Clavicle Fracture, Clavicle Injury | 98 | Dec 2026 | ≤ 134 d | 2026-02-13 |
| Persona IQ Cohort StudyNCT06089291observationalmymobility platform data compared to most common AEs. | — | Active, not recruiting | Device: Persona IQ | Osteo Arthritis Knee, Knee Arthritis, Monitoring Orthopedic Devices, Total Knee Arthroplasty, Total Knee Replacement | 200 | Dec 2026 | ≤ 134 d | 2026-06-04 |
| Comprehensive SRS Regenerex Tissue AttachmentNCT06615739observationalKaplan Meier Implant Survivorship | — | Active, not recruiting | Device: Regenerex Tissue Attachment Augments | Arthroplasty Complications, Osteo Arthritis Shoulders | 22 | 2026-12-31 | in 134 d | 2025-10-29 |
| Embody Post-Market Clinical Follow-Up StudyNCT05735119observationalSubscapularis repair integrity | — | Active, not recruiting | Device: Tapestry Biointegrative Implant | Tendon Injuries- Subscapularis | 100 | Nov 2026 | ≤ 103 d | 2026-05-22 |
| Hi-Fatigue G Bone Cement Retrospective StudyNCT06699134observationalRadiographic evaluation | — | Recruiting | Device: Total knee arthroplasty, Total Hip arthroplasty | Total Hip and Knee Arthroplasties | 90 | Oct 2026 | ≤ 73 d | 2025-12-02 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the ComposiTCPNCT07080450observationalAssessment of performance by analyzing soft tissue to bone healing in the shoulder (rotator cuff) | — | Recruiting | — | Rotator Cuff Repairs | 43 | Aug 2026 | ≤ 12 d | 2026-02-03 |
| MDR ExploR Radial Head System PMCFNCT05583448observationalDevice Survivorship | — | Enrolling by invitation | Device: ExploR Radial Head | Elbow Injury | 93 | 2026-08-16 | — | 2026-02-04 |
| Zimmer® Natural Nail® (ZNN) Bactiguard Tibia Post-Market Clinical Follow-up StudyNCT05022485observationalFracture related infection (FRI) rate in investigational and control group | — | Recruiting | Device: ZNN Bactiguard tibia | Tibial Fractures, Fracture Infection | 500 | Jul 2026 | — | 2025-11-25 |
| Persona OsseoTi Keel Compatibility Study (Total Knee Arthroplasty)NCT05787821observationalOxford Knee Score (OKS) | — | Active, not recruiting | Device: Total Knee Arthroplasty | Knee Pain Chronic, Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Varus Deformity, Valgus Deformity, Flexion Deformity of Knee, Avascular Necrosis | 760 | 2026-06-30actual | — | 2026-07-10 |
| MDR - Biomet Cannulated ScrewsNCT04002518observationalDevice Safety Assessed Through the Incidence and Frequency of Revisions, Complications, and Adverse Events | — | Active, not recruiting | Device: Biomet Cannulated Screw: 3.0, 4.0, 5.0, 6.5, and 8.0mm screws. | Fractures, Bone, Fracture Multiple | 51 | 2026-06-18actual | — | 2026-07-09 |
| DenCT Shoulder Bone Quality EvaluationNCT06032416CT scan data acquisitionOpen-label · Basic science | Not applicable | Not yet recruiting | Radiation: Preoperative CT Scan | Osteoarthritis Shoulder, Rotator Cuff Tears | 200 | Apr 2026 | — | 2025-02-10 |
| JuggerStitch Post Market Clinical Follow-up StudyNCT04228367Clinical SuccessOpen-label · Treatment | Not applicable | Recruiting | Device: JuggerStitch Meniscal Repair Device | Meniscus Tear, Tibial, Meniscus Lesion | 104 | 2026-03-31 | — | 2025-11-12 |
| Vivacit-E Post-market Follow-up StudyNCT03226808Survival of the study device; whether or not it is still implanted in the subjectOpen-label · Treatment | Not applicable | Active, not recruiting | Device: Vivacit-E Liner | Osteoarthritis, Avascular Necrosis of Bone of Hip, Post-traumatic; Arthrosis, Congenital Hip Dysplasia | 258 | 2026-03-02 | — | 2025-01-01 |
| Persona Total Knee Arthroplasty Outcomes StudyNCT02255383Knee Society ScoreOpen-label · Treatment | Not applicable | Active, not recruiting | Device: Zimmer Persona Total Knee System | Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Moderate Varus, Valgus or Flexion Deformities, Avascular Necrosis of the Femoral Condyle | 737 | Dec 2025actual | — | 2026-03-10 |
| RibFix Blu Thoracic Fixation System Versus Non-surgical Treatment in Non-flail Chest Rib FracturesNCT05146986observationalThoracic pain as assessed by numeric Rating Scale (NRS) | — | Recruiting | Device: Non surgical and Surgical | Rib; Fracture | 167 | 2025-12-30 | — | 2024-03-07 |
| Continuum Ceramic on Ceramic Bearing Post Market Clinical Follow-Up StudyNCT03343171observationalSafety will be evaluated by adverse events reporting. | — | Active, not recruiting | — | Osteoarthritis, Avascular Necrosis, Inflammatory Arthritis, Post-traumatic Arthritis | 203 | Feb 2025 | — | 2025-01-31 |
| Exception Cementless Hip StemNCT04349046observationalImplant survival based on removal or intended removal of the device and determined using the Kaplan-Meier method | — | Active, not recruiting | Device: Total hip arthoplasty (THA) | Osteoarthritis, Hip, Rheumatoid Arthritis, Inflammatory Arthritis, Congenital Hip Dysplasia, Avascular Necrosis of Hip, Femoral Neck Fractures | 332 | 2024-05-01actual | — | 2025-06-18 |
| A Multicenter Prospective Randomized Control Study on Persona Total Knee System vs NexGenNCT03073941results2025-01-17Oxford Knee ScoreRandomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Active, not recruiting | Device: Persona total knee system, Nexgen total knee system | Osteoarthritis, Knee | 332 | 2021-11-23actual | — | 2026-05-12 |
| Clinical Evaluation of Vanguard DD RPNCT04076202PerformanceOpen-label · Treatment | Not applicable | Active, not recruiting | Device: Cementless Vanguard DD RP | Knee Osteoarthritis, Post-traumatic Osteoarthritis, Rheumatoid Arthritis | 113 | 2018-08-26actual | — | 2024-05-17 |
| Investigation to Determine Safety of Taperloc Stems With BioGuard Coating When Used in Cementless Total Hip ArthroplastyNCT02263209Change in normalised peri-implant BMD as measured by DXARandomized · Double-masked · Treatment | Not applicable | Active, not recruiting | Device: Bioguard Group, Control Group | Osteoarthritis of Hip | 50 | Nov 2015actual | — | 2024-08-16 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the NexGen TM Augmentation PatellaNCT05253976observationalThe incidence and frequency of revisions, complications and adverse events. | — | Withdrawnsponsor's stated reason: Study had to be terminated before first patient got enrolled due to insufficient case number. | — | Rheumatoid Arthritis, Non-inflammatory Degenerative Joint Disease, Functional Deformity, Revision Total Knee Arthroplasty | 0 | 2034-12-31 | in 3,056 d | 2024-12-24 |
| Refobacin Revision-3 Bone Cement Post-Market StudyNCT06699160observationalSurvivorship | — | Withdrawnsponsor's stated reason: The study was discontinued upon availability of relevant data through bespoke reporting, which fulfilled the study's primary objectives | Device: Revision arthroplasty | Revision Arthroplasty | 0 | Dec 2030 | ≤ 1,595 d | 2025-11-25 |
| Tapestry Rotator Cuff Repair PMCFNCT06287853observationalRe-tear rate after arthroscopic rotator cuff repair | — | Suspendedsponsor's stated reason: Sponsor has elected to place the Tapestry RC PMCF study on hold. The Tapestry RC product line is being enhanced, and we have chosen to delay data collection on this product until the new devices are available. Study is anticipated to resume in 2026. | Device: Tapestry Biointegrative Implant | Rotator Cuff Tears, Rotator Cuff Injuries | 170 | 2030-12-30 | in 1,594 d | 2025-11-21 |
| A Randomized Controlled Trial for Partial Knee ArthroplastyNCT05037734Accuracy of implant positionRandomized · Single-masked · Treatment | Not applicable | Withdrawnsponsor's stated reason: Relaunch at later date with updated product. | Device: Persona Partial Knee System | Degenerative Joint Disease of Knee, Osteoarthritis, Traumatic Arthritis, Varus Deformity, Knee Pain Chronic | 0 | Jun 2030 | ≤ 1,411 d | 2023-06-05 |
| MDR - G7 Neutral and G7 Freedom Constrained Neutral Acetabular LinersNCT04093739observationalDevice Safety assessed through the frequency and incidence of revisions, complications and adverse events | — | Withdrawnsponsor's stated reason: Manufacturer decided not to proceed with study. | Device: G7 Freedom Constrained Liners | Hip Osteoarthritis, Hip Disease, Hip Fractures, Hip Injuries | 0 | 2029-12-31 | in 1,230 d | 2023-12-13 |
| Mymobility Knee ROMNCT06863428observationalActive knee flexion | — | Completed | — | Knee Range of Motion | 41 | 2026-03-09actual | — | 2026-07-10 |
| TESS V3 Modular Total Shoulder System PMCFNCT05002959observationalImplant survival at 10 years | — | Terminatedsponsor's stated reason: Termination of PMCF study due to product discontinuation (commercial reasons) | Device: Anatomic TESS V3, Reverse TESS V3 | Osteoarthritis Shoulder, Rheumatoid Arthritis, Rheumatoid Arthritis Shoulder, Avascular Necrosis, Revision, Rotator Cuff Tears, Osteonecrosis, Rotator Cuff Tear Arthropathy, Proximal Humeral Fracture, Malunion of Fracture, Shoulder Region | 67 | 2026-03-05actual | — | 2026-06-09 |
| ROSA® Knee System V1.5 Pilot StudyNCT07009912Incidence of Procedure-Emergent Adverse Events, to assess the Safety of the ROSA® Knee System v1.5 SystemOpen-label · Other | Not applicable | Completed | Device: Total Knee Arthroplasty | Knee Arthroplasty, Total, Robotic Surgical Procedures, Joint Diseases, Knee Osteoarthritis | 40 | 2026-02-17actual | — | 2026-02-27 |
| ZNN Bactiguard Cephalomedullary Nails PMCF StudyNCT05362864observationalPerformance of the study device by analyzing fracture/osteotomy healing at 12 months after fracture fixation. | — | Completed | Procedure: Fracture fixation via Intramedullary Nailing | Osteotomy, Trochanteric Fractures, Sub-trochanteric Fractures, Femoral Shaft Fracture | 149 | 2025-12-17actual | — | 2026-05-22 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the XtraFix® Small External Fixation SystemNCT05943574observationalPerformance: Fracture healing assessed radiographically or clinically. | — | Completed | — | Wrist Fracture, Proximal Humerus Fracture | 91 | 2025-11-14actual | — | 2026-04-23 |
| A Prospective, Single Center, Observational Study to Assess the Rapid Recovery After Cardiac Surgery Using SternaLock XPNCT05578651observationalIncidence of sternal wound infection | — | Withdrawnsponsor's stated reason: Zimmer Biomet has no current plans to market this product in EMEA. | Device: SternaLock XP | Rigid Plate Fixation, Median Sternotomy | 0 | Sep 2025 | — | 2025-01-16 |
| Infection Consortium Study#1NCT06153446observationalPositive/Negative Percent Agreement between PJI RISC Panel and Clinical Guidelines | — | Completed | Diagnostic test: Synovasure® Comprehensive Infection Panel | PJI | 810 | 2025-09-04actual | — | 2025-10-27 |
| ROSA Total Knee Post Market Study EMEANCT04338893results2026-01-21Alignment AccuracyNon-randomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Procedure: Device: Persona Total Knee, Device: NexGen Total Knee, Device: Vanguard Total Knee | Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis | 252 | 2025-08-22actual | — | 2026-05-12 |
| Allofit® IT With HXPE in Total Hip ArthroplastyNCT03672929results2026-01-27observationalSurvival of the Implant SystemStudy Protocol, Statistical Analysis Plan, and Informed Consent Form ↗ | — | Completed | — | Avascular Necrosis, Osteoarthritis, Hip, Inflammatory Arthritis, Post-Traumatic Osteoarthritis of Hip | 197 | 2025-07-03actual | — | 2026-01-27 |
| A Prospective Multicenter Longitudinal Cohort Study of the Mymobility PlatformNCT03737149results2026-03-23Phase II (RCT): ReadmissionsRandomized · Open-label · Supportive careStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Other: mymobility with Apple Watch | Osteoarthritis, Knee, Osteoarthritis, Hip | 6,559 | 2025-04-15actual | — | 2026-03-23 |
| Multicentre Prospective Study to Evaluate Long-term Clinical Outcomes of the Sirius Cemented Femoral StemNCT02371382observationalHarris Hip Score | — | Unknown status | Device: Arthroplasty hip | Arthroplasty, Replacement, Hip | 250 | Mar 2025 | — | 2024-07-01 |
| A Multicentre Observational Study to Evaluate Clinical Outcomes of the G7 Acetabular SystemNCT02036931results2025-12-19observationalHarris Hip ScoreStudy Protocol ↗ | — | Completed | Device: Metal on Polyethylene articulation, Ceramic on Polyethylene articulation, Ceramic on Ceramic articulation | Noninflammatory Degenerative Joint Disease, Rheumatoid Arthritis | 162 | Dec 2024actual | — | 2025-12-19 |
| Vanguard Rocc Post Market SurveillanceNCT03664791observationalFunctional outcomes assessment | — | Unknown status | Procedure: Vanguard Rocc | Osteoarthritis, Knee, Rheumatoid Arthritis, Traumatic Arthritis, Posttraumatic Deformity, Varus Deformity, Valgus Deformity, Osteotomy, Arthrodesis | 450 | 2024-12-31 | — | 2024-04-10 |
| ROSA® Hip System THA PMCFNCT05497206Accuracy of implant positionOpen-label · Treatment | Not applicable | Terminatedsponsor's stated reason: The data needed for regulatory submissions based on the current pace of the study, will not be available in the foreseeable future. | Device: One of the following hip implants may be used within this arm of the study: G7 Acetabular System, Taperloc Complete System, Avenir and Avenir Complete Systems, and Echo Bi-Metric System | Osteoarthritis, Hip, Avascular Necrosis of Hip | 12 | 2024-12-12actual | — | 2025-02-05 |
| RISC Panel Remnant Sample CollectionNCT05778162observationalRate of agreement | — | Completed | Diagnostic test: Synovasure® RISC™ Panel | Arthritis, Inflammatory | 1,000 | 2024-11-12actual | — | 2025-10-24 |
| MDR - M/L Taper With Kinectiv Technology Stems and NecksNCT04027140observationalDevice safety assessed through the frequency and incidence of revisions, complications and adverse events | — | Terminatedsponsor's stated reason: Zimmer Biomet no longer intends to market the M/L Taper with Kinectiv in the European Union and therefore has terminated study MDRG2017-89MS-56H. | Device: M/L Taper with Kinectiv Technology Stems and Necks | Hip Disease, Hip Fractures, Hip Injuries, Hip Arthritis, Hip Pain Chronic | 36 | 2024-11-05actual | — | 2024-12-31 |
| MDR - Longevity IT Oblique and Offset LinersNCT05980234observationalIncidence of treatment-emergent Adverse Events (safety) | — | Terminatedsponsor's stated reason: Zimmer Biomet received the CE mark for the Continuum and Trilogy IT Acetabular System, which includes the Longevity IT Offset and Oblique Liners, in June 2024. | Device: Total Hip Arthroplasty with Longevity IT Oblique Liners, Total Hip Arthroplasty with Longevity IT Offset Liners | Non-inflammatory Degenerative Joint Disease (NIDJD), Avascular Necrosis, Protrusio Acetabuli, Traumatic Arthritis, Slipped Capital Femoral Epiphyses, Fracture of the Pelvis, Diastrophic Variant, Osteoarthritis, Fused Hip | 6 | 2024-11-02actual | — | 2024-12-27 |
| Oxford UKA and HTO Post-market Clinical StudyNCT04518111observationalOxford Knee Score | — | Unknown status | — | Knee Osteoarthritis | 370 | 2024-09-30 | — | 2024-05-23 |
| PMCF Study of MOTIVATION HIP System in THANCT03892005observationalImplant survivorship based on revision rate | — | Suspendedsponsor's stated reason: No plan to extend CE Mark | Procedure: Total Hip Arthroplasty using MOTIVATION HIP Total Hip System | Total Hip Arthroplasty | 500 | 2024-08-31 | — | 2024-07-24 |
| PMCF Study of MPS-Flex® Knee System in TKANCT04427722observationalImplant survivorship based on revision | — | Suspendedsponsor's stated reason: No plan to extend CE mark | Device: MPS-Flex Total Knee Joint Prostheses | Total Knee Arthroplasty | 250 | 2024-08-31 | — | 2024-07-24 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the Quattro X BroadbandNCT05690776results2025-09-10observationalAssessment of Performance by Analyzing Soft Tissue to Bone Healing in the Shoulder (Rotator Cuff)Study Protocol and Statistical Analysis Plan ↗ | — | Completed | — | Rotator Cuff Tears, Rotator Cuff Injuries | 106 | 2024-08-09actual | — | 2025-09-10 |
| Embody Insertional Achilles TendinopathyNCT05998785observationalPain/VAS | — | Terminatedsponsor's stated reason: Administrative issues with IRB, none of which impacted the health/safety/welfare of the subjects, has resulted in enrollment suspension and subsequent study termination. | Device: TAPESTRY Biointegrative Implant | Insertional Achilles Tendinopathy | 8 | 2024-08-01actual | — | 2024-12-20 |
| Gender Solutions Natural Knee Post-Market StudyNCT01463566observationalSurvivorship | — | Withdrawnsponsor's stated reason: Suspended pending internal review/direction of the company's focus. | Device: Zimmer Gender(R) Solutions(TM) Natural-Knee(R) Flex System | Osteoarthritis, Inflammatory Arthritis, Post-traumatic Arthritis, Rheumatoid Arthritis, Osteonecrosis, Varus or Valgus Deformities | 0 | Jul 2024 | — | 2019-01-09 |
| FastFrame Knee Spanning and Damage Control Kit PMCFNCT04730739results2025-02-10Number of Participants With Device-related Adverse Events and Device DeficienciesOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Product will not be taken to EU, thus no PMCF requirements. | Device: FastFrame External Fixation System - Knee Spanning or Damage Control Kit | Fracture, Fractures, Bone, Fractures, Closed, Fractures, Open | 33 | 2024-06-30actual | — | 2025-02-10 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the ToggleLoc™ 2.9mm and JuggerLoc™ in the ShoulderNCT05584553results2025-11-28observationalNumber of Participants With Evidence of Soft Tissue-to-Bone Healing in the ShoulderStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: ToggleLoc 2.9 mm soft tissue device, JuggerLoc soft tissue device | Bankart Lesions, SLAP Lesion, Acromioclavicular; Dislocation, Capsular Shift/Capsulolabral Reconstruction, Deltoid Repair, Rotator Cuff Tear Repair, Biceps Tendon Disorder | 214 | 2024-06-30actual | — | 2025-11-28 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the Zimmer® Reconstruction SystemNCT05215626results2026-03-10observationalPerformance: Fracture HealingStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | — | Acetabulum Fracture, Pelvic Ring Fracture | 78 | 2024-06-16actual | — | 2026-03-10 |
| Prospective Clinical Follow-up of the Echo Bi-Metric Microplasty Stem for Total Hip ArthroplastyNCT04326010observationalImplant Survival | — | Terminatedsponsor's stated reason: Data collected up to this point has provided sufficient follow-up and will allow for a reasonable estimate of the five-year survivorship rate for the Echo Bi-Metric Microplasty stem in primary total hip arthroplasty. | Device: Surgery | Hip Osteoarthritis | 206 | 2024-06-14actual | — | 2025-02-05 |
| Anaverse™ Glenoid System and Its InstrumentationNCT05215600results2025-03-20observationalSurvival of Implant System (Kaplan Meier)Study Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Termination of PMCF study due to product discontinuation. | Device: Anaverse Shoulder System | Rotator Cuff Injuries, Shoulder Pain, Arthropathy, Arthroplasty Complications | 20 | 2024-04-23actual | — | 2025-04-08 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the Zimmer® Plates and Screws SystemNCT05215613results2025-02-25observationalPerformance: Fracture HealingStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | — | Proximal Humeral Fracture, Proximal Tibia Fractures, Diaphyseal Fracture | 57 | 2024-03-27actual | — | 2025-02-25 |
| MDR EZ Pass and Precision Flexible ReamerNCT03914703results2025-07-01observationalPerformance of Instruments (EZ Pass Suture Passer and Precision Flexible Reamer)Study Protocol and Statistical Analysis Plan ↗ | — | Completed | Procedure: EZ Pass Suture Passer | Anterior Cruciate Ligament Injury, Rotator Cuff Tear | 73 | 2023-12-31actual | — | 2025-07-01 |
| RibFix Advantage™ Post-Market Follow-UpNCT05179005observationalRate of re-operation | — | Terminatedsponsor's stated reason: Sponsor Terminated | Device: RibFix Advantage | Rib Fractures | 1 | 2023-12-31actual | — | 2024-01-29 |
| ASHCOM Shoulder System and Its Related InstrumentsNCT04258605results2025-04-03observationalSurvival of Implant System (Kaplan Meier)Study Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Termination of PMCF study due to product discontinuation. | Device: ASHCOM Shoulder System | Rotator Cuff Injuries, Shoulder Pain, Arthropathy; Traumatic, Arthroplasty Complications | 24 | 2023-12-18actual | — | 2025-04-03 |
| Patello-Femoral Joint Post Market Clinical Follow-up Within the Knee RegistryNCT01469806observationalLong-term Device survivorship for publication | — | Withdrawnsponsor's stated reason: Suspended pending internal review/direction of the company's focus. No sites ever engaged or collected data. | Device: Zimmer Gender Solutions PFJ Knee Prosthesis | Arthritis | 0 | Oct 2023 | — | 2016-09-27 |
| Evaluation on Safety and Effectiveness of the An All-inside, All-suture Meniscal Repair DeviceNCT06899659Lysholm Knee ScoreRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: JuggerStitch™ Meniscal Repair Device, Fast-Fix 360 Meniscal Repair System | Meniscal Tears | 94 | 2023-10-30actual | — | 2025-03-28 |
| SCP Hip Outcomes StudyNCT03494660results2026-04-21observationalOverall Group Mean Improvement From Baseline of the Modified Harris Hip Score (mHHS) at 2 YearsStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Subchondroplasty Procedure with AccuFill | Subchondral Cysts, Subchondral Bone Edema, Bone Marrow Edema, Insufficiency Fractures, Avascular Necrosis of Hip, Femoroacetabular Impingement, Dysplasia; Hip | 77 | 2023-10-23actual | — | 2026-04-21 |
| PMCF Study on the Safety, Performance and Clinical Benefits Data of the ToggleLoc™ 2.9mm in the ElbowNCT05519228results2024-11-12observationalSoft Tissue to Bone Healing in the Elbow - Hook TestStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: ToggleLoc 2.9 mm Soft Tissue System | Epicondylitis of the Elbow, Biceps Tendon Disorder | 83 | 2023-09-27actual | — | 2025-01-30 |
| ROSA Robot Used in Total Knee Replacement Post Market StudyNCT03969654results2024-05-03Clinical PerformanceNon-randomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: PERSONA Total Knee, Vanguard Total Knee, NexGen Total Knee | Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis | 181 | 2023-09-22actual | — | 2024-05-03 |
| A Post Market Clinical Follow-up Study on Biomet Microfixation HTR PEKK (Midface), Facial & Mandibular Plates.NCT04931056observationalSurvival of implant at 1 year post operative | — | Completed | Device: Titanium Facial Plates, Titanium Mandibular Plates, Add-on Condyle, HTR-PEKK | Tumor, Facial Fracture, Mandibular Fractures, Fibrous Dysplasia, Osteoma of Mandibular Condyle, Neuroma, Cleft Face, Hemifacial Microsomia, Treacher Collins Syndrome, Miller Syndrome, Nager Syndrome | 91 | 2023-09-01actual | — | 2024-01-29 |
| A Longitudinal Outcomes Study of the Subchondroplasty® Procedure in the Foot/AnkleNCT03087396results2026-04-09observationalFoot Function Index-Revised (FFI-R) Short Form Score at 24 MonthsStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Treatment of insufficiency fractures | Insufficiency Fractures, Stress Fracture, Stress Fracture, Ankle, Foot and Toes | 148 | 2023-08-23actual | — | 2026-04-09 |
| Subchondroplasty® Knee RCTNCT03112200results2026-05-14Composite Clinical SuccessRandomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Procedure: Subchondroplasty with Arthroscopy, Arthroscopy Alone | Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis | 131 | 2023-08-23actual | — | 2026-05-14 |
| Prospective Multi-centre Outcomes Study of Persona Knee System in Total Knee ArthroplastyNCT04461626observationalImplant Survivorship | — | Completed | Device: Persona fixed bearing knee system (All patients will receive Persona fixed bearing knee system) | Knee Osteoarthritis | 1,017 | 2023-06-30actual | — | 2024-08-22 |
| Fitmore Hip Stem PMCF Study: A Multi-centre, Non-comparative, Prospective Post-market Clinical Follow-up Study.NCT03411044results2024-10-17observationalHarris Hip ScoreStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Fitmore Hip Stem | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Prosthesis Failure | 420 | 2023-06-10actual | — | 2024-11-05 |
| Metasul Monoblock Component™ Cup in a Hip Resurfacing Application With the Durom® Hip Resurfacing Femoral ComponentNCT03681639results2024-12-03Implant SurvivalOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Diagnostic test: Serum Metal ion levels determined to monitor changes in chromium and cobalt levels | Avascular Necrosis of Hip, Osteoarthritis, Hip, Rheumatoid Arthritis, Inflammatory Arthritis, Post-traumatic; Arthrosis | 45 | 2023-05-22actual | — | 2024-12-03 |
| Allofit® IT Ceramic Bearing System in Total Hip ArthroplastyNCT03672916results2025-02-12observationalSurvivorshipStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | — | Avascular Necrosis of Hip, Osteoarthritis, Hip, Inflammatory Arthritis, Post-Traumatic Osteoarthritis of Hip | 185 | Apr 2023actual | — | 2025-02-12 |
| NexGen TM Tibia Clinical Outcomes StudyNCT03272373results2024-12-05Radiograph Assessment of Progressive Tibial RadiolucenciesNon-randomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: NexGen TM Monoblock Tibia, NexGen TM Modular Tibia | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Collagen Disorders and/or Avascular Necrosis of the Femoral Condyle, Post-traumatic Loss of Joint Configuration, Moderate Valgus, Varus, or Flexion Deformities | 160 | 2023-03-30actual | — | 2024-12-30 |
| Subchondroplasty Procedure in Patients With Bone Marrow LesionsNCT03430219observationalKnee Injury and Osteoarthritis Outcome Score (KOOS) pain subscale | — | Completed | Device: Subchondroplasty Procedure | Bone Marrow Lesions, Bone Marrow Edema | 93 | 2023-03-16actual | — | 2023-06-22 |
| Microplasty Tibial Tray Data CollectionNCT00754637observationalKnee Society Score | — | Withdrawnsponsor's stated reason: The study was withdrawn because it no longer fit the business need. | — | Joint Disease | 0 | Dec 2022 | — | 2017-06-21 |
| 10 Year Clinical Evaluation of Primoris Hip ComponentNCT01326832observationalRSA | — | Unknown status | Device: Primoris | Coxarthrosis | 350 | Dec 2022actual | — | 2024-07-01 |
| Robotic-assisted Versus Conventional Total Knee ArthroplastyNCT04982198Mechanical axis alignmentRandomized · Open-label · Treatment | Not applicable | Completed | Procedure: ROSA assisted TKA | Total Knee Arthoplasty | 99 | 2022-12-30actual | — | 2023-06-26 |
| Persona TM Tibia Clinical Outcomes StudyNCT03589300results2024-07-23Radiograph Assessment of Progressive Tibial RadiolucenciesOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Persona TM Tibia | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Polyarthritis, Collagen Disorders and/or Avascular Necrosis of the Femoral Condyle, Post-traumatic Loss of Joint Configuration, Moderate Valgus, Varus, or Flexion Deformities | 148 | 2022-11-30actual | — | 2024-07-23 |
| MDR SureLock All-Suture AnchorNCT04093700observationalDevice Performance and Benefits assessed through improvements in shoulder function | — | Terminatedsponsor's stated reason: The Sponsor decided that the CE marking would not be renewed, and therefore there was no longer a need to continue the study as the data was no longer necessary. | Device: SureLock All-Suture Anchor | Shoulder Pain, Shoulder Injuries, Shoulder Disease, Shoulder Pain Chronic, Shoulder Syndrome, Labral Tear, Glenoid | 24 | 2022-11-08actual | — | 2023-08-14 |
| Continuum™ Metal Bearing System in Total Hip ArthroplastyNCT03382652results2024-12-16observationalImplant Survival at 10 YearsStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Metal-on-Metal Articulation | Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Post-traumatic; Arthrosis, Total Hip Arthroplasty | 83 | 2022-10-22actual | — | 2025-01-03 |
| MDR-JuggerKnot Mini Soft Anchor in Maxillofacial TMJNCT04033692observationalDevice Safety Assessed Through the Incidence and Frequency of Revisions, Complications, and Adverse Events | — | Withdrawnsponsor's stated reason: Manufacturer decided not to proceed with study. | Device: JuggerKnot Mini Soft Anchor | TMJ Disc Disorder, TMJ Pain, TMJ Sounds on Opening/Closing the Jaw, TMJ Disease | 0 | 2022-10-01 | — | 2022-01-27 |
| Vanguard™ Deep Dish Rotating Platform Knee Clinical EvaluationNCT00753090results2025-01-30Knee Society ScoreRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Vanguard™ Deep Dish Rotating Platform Knee, Vanguard™ Cruciate Retaining Knee | Osteoarthritis | 326 | 2022-07-15actual | — | 2025-01-30 |
| Exceed ABT Acetabular Cup Cementless SystemNCT04255394results2024-07-26observationalHarris Hip ScoreStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | — | Osteoarthritis, Rheumatoid Arthritis, Correction of Functional Deformity | 677 | 2022-02-28actual | — | 2024-07-26 |
| A Study Comparing Ceramic-on-metal Articulation to Metal-on-metal Articulation in Cementless Primary Hip ArthroplastyNCT00754520results2024-10-02Composite Clinical Success (CCS) Rate as Defined in the ProtocolRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Ceramic On Metal, Metal on Metal | Osteoarthritis | 213 | Dec 2021actual | — | 2024-10-02 |
| Zimmer POLAR - Total Knee Arthroplasty (TKA)NCT01859130results2023-10-13Knee Society ScoresOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Zimmer Persona Total Knee System | Osteoarthritis, RheumatoId Arthritis, Traumatic Arthritis, Polyarthritis | 299 | 2021-12-31actual | — | 2023-10-13 |
| Hydroxyapatite (HA) Coating Versus Plasma Porous Spray (PPS) in Press-fit Acetabular Components Early Outcomes With DEXANCT02447653Bone Remodelling (DEXA analysis)Randomized · Open-label · Treatment | Not applicable | Completed | Device: G7 HA Acetabular Component, G7 PPS Acetabular Component | Osteoarthritis | 50 | 2021-12-31actual | — | 2022-01-28 |
| ROSA Total Knee Investigational Testing Authorization StudyNCT03970629EQ-5D questionnaireNon-randomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Challenging enrollment due to COVID-19. | Device: PERSONA Total Knee | Knee Pain, Chronic Osteoarthritis, Avascular Necrosis of Femoral Condyle, Moderate Varus, Valgus or Flexion Deformities, Rheumatoid Arthritis | 19 | 2021-11-23actual | — | 2022-05-19 |
| PMCF Study on the Safety, Performance and Clinical Benefits of the DVR Plating SystemNCT04653051results2024-11-20observationalFracture Healing Based on Clinical Measures and X-raysStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | — | Distal Radius Fracture, Distal Ulna Fracture, Osteotomy | 111 | 2021-10-03actual | — | 2024-11-20 |
| Arcos Revision Stem: Evaluation of Clinical PerformanceNCT01820611results2025-01-20observationalSurvivorshipStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Arcos Revision Stem System | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Deformity, Fracture, Complications; Arthroplasty | 74 | 2021-06-14actual | — | 2025-01-20 |
| BioWick SureLock Clinical Outcomes StudyNCT03199391results2022-05-25Number of Participants Not Requiring Removal or Reoperation of the ImplantOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: BioWick SureLock Implant | Rotator Cuff Tear | 71 | 2021-05-05actual | — | 2022-07-07 |
| Maxera Large Cups - CanadaNCT04348968observationalImplant survival based on removal or intended removal of the device and determined using the Kaplan-Meier method | — | Terminatedsponsor's stated reason: The notified body does not require data anymore and recruitment did not start. The study was thus terminated after approval from the investigator and the local ethical committee. | Device: Total hip arthroplasty | Degenerative Joint Disease of Hip, Osteoarthritis, Hip, Avascular Necrosis of Hip, Post-Traumatic Osteoarthritis of Hip, Congenital Dysplasia of the Hip, Joint Diseases, Rheumatoid Arthritis of Hip | 20 | 2021-03-25actual | — | 2021-04-05 |
| N-Force Screws Augmented With N-Force Blue in Hip FracturesNCT03807349results2022-06-08Number of Participants With a ReoperationOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Sponsor will not pursue CE mark for this product, which precludes need for large PMCF study. | Device: N-Force Screws Augmented with N-Force Blue | Intracapsular Proximal Femur Fracture, Garden Grade I Subcapital Fracture of Femoral Neck, Garden Grade II Subcapital Fracture of Femoral Neck | 12 | 2021-03-11actual | — | 2022-06-08 |
| THP Hip Fracture Plating System StudyNCT03870477results2022-05-12Number of Participants With a RevisionOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Business decision to remove product from portfolio. | Device: THP Hip Fracture Plating System with telescoping lag screws | Femur Fracture, Femur Fracture Intertrochanteric, Garden Grade I Subcapital Fracture of Femoral Neck, Garden Grade II Subcapital Fracture of Femoral Neck, Garden Grade III Subcapital Fracture of Femoral Neck, Garden Grade IV Subcapital Fracture of Femoral Neck | 1 | 2021-03-10actual | — | 2022-05-12 |
| A Clinical Investigation of the Vanguard™ Complete Knee SystemNCT00698854observationalKSS | — | Completed | Device: Vanguard™ Complete Knee System, Vanguard™ Patient-Specific Femur | Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Lower Limb Deformity, Complications, Arthroplasty | 552 | Jan 2021actual | — | 2024-09-19 |
| Randomized Controlled Clinical Outcomes of the Vanguard XP Bicruciate Knee SystemNCT02175576results2023-02-21Number of Knees Reported as "Feels Normal" on a Single Assessment Numeric Evaluation (SANE)Randomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Data no longer required to meet regulatory requirements. | Device: Vanguard XP Bicruciate Knee System, Vanguard CR Knee System | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Lower Limb Deformity, Post-traumatic Deformity, Complications, Arthroplasty | 50 | Dec 2020actual | — | 2023-02-21 |
| Biologically Assisted Core Decompression of the Femoral Head Using the PerFuse Instrument and BioCUENCT02662881observationalHarris Hip Score | — | Unknown status | Device: PerFuse Percutaneous Decompression System, BioCUE Platelet Concentration System | Avascular Necrosis of the Femoral Head | 100 | 2020-12-08actual | — | 2021-10-20 |
| Safety and Efficacy of the Oxford Cementless Partial Knee SystemNCT01473134results2024-09-19Radiographic SuccessRandomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Oxford Cementless Partial Knee, Oxford Cemented Partial Knee | Osteoarthritis, Knee, Avascular Necrosis of the Medial Femoral Condyle | 320 | 2020-11-30actual | — | 2025-08-11 |
| Randomized Controlled RSA Study Comparing the Taperloc Complete Versus the Taperloc Complete Microplasty.NCT03409666results2022-07-14Stability Over a Period of Two Year Measured by Migration With Röntgen Stereophotogrammetric Analysis (RSA)Randomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Taperloc Complete Microplasty stem, Taperloc Complete Reduced Distal stem | Hip Osteoarthritis, Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Correction of Functional Deformity, Rheumatoid Arthritis | 50 | 2020-11-06actual | — | 2022-07-14 |
| Comparison of ARPE Prosthesis With the LiteratureNCT01904019results2021-08-23observationalGrip StrengthStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | — | Arthritis | 100 | Oct 2020actual | — | 2021-10-18 |
| Stereotactic, Robot-assisted Intracerebral Hemorrhage Clot EvacuationNCT03414307Hematoma volume reductionOpen-label · Other | Not applicable | Withdrawnsponsor's stated reason: COVID 19 Pandemic | Procedure: Intracerebral catheter placement · Device: Robot-assisted intracerebral catheter | Intracerebral Hematoma | 0 | 2020-09-30actual | — | 2021-07-23 |
| SCP® Observational Study of the KneeNCT03110224results2025-08-27observationalChange From Baseline Visual Analog Scale (VAS) Pain Scale at 12 MonthsStudy Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Enrollment of 500 subjects was met and Sponsor decided to discontinue enrollment as of July 2018. Sponsor believes enrollment number will provide us with sufficient follow-up to submit a substantial manuscript with minimum of 2 year follow-up data. | Device: Subchondroplasty Procedure with AccuFill | Bone Marrow Edema | 516 | 2020-09-16actual | — | 2025-10-28 |
| Minimal Invasive Approach for Surgical Repair of Rib Fractures With a Novel Intrathoracic DeviceNCT04163224observationalFracture stability | — | Withdrawnsponsor's stated reason: Sponsor strategy change | Device: RibFix Advantage | Rib Fracture Multiple | 0 | 2020-08-30 | — | 2020-09-01 |
| Sidus(TM) Post Market Clinical Follow-up (PMCF) StudyNCT01700543observationalFunctional Performance (Constant & Murley Score) | — | Completed | Procedure: Shoulder Arthroplasty | Non-inflammatory Degenerative Joint Disease (NIDJD), Avascular Necrosis, Osteoarthritis, Inflammatory Joint Disease (IJD), Rheumatoid Arthritis | 152 | Jul 2020actual | — | 2026-06-08 |
| Safety and Efficacy Study of Spinal TetheringNCT02897453observationalCobb angle measurement of the patient's coronal deformity | — | Unknown status | Device: The Spinal Tethering System | Adolescent Idiopathic Scoliosis | 56 | 2020-07-19actual | — | 2020-08-20 |
| Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing KneeNCT00854295results2023-02-14Group 2 - Total Knee Society Score (KSS)Non-randomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: NexGen LPS-Flex Mobile Bearing Knee | Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus, Valgus, Flexion Deformities | 266 | Jun 2020actual | — | 2023-02-14 |
| A Prospective Study to Evaluate Long-term Clinical Outcomes of the GTS Cementless Femoral StemNCT02851992results2023-12-01Mean Harris Hip ScoreOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Zimmer Biomet is prioritizing specific products within its portfolio and has chosen not to extend the CE mark for the GTS stem under MDR requirements, leading to the premature termination of the GTS study in 2024. | Device: GTS cementless stem | Osteoarthritis, Hip | 303 | May 2020actual | — | 2026-08-10 |
| Clinical Outcomes in Patients Treated With SternaLock BluNCT03709693observationalDeep Sternal Wound Infection Rate | — | Terminatedsponsor's stated reason: COVID 19 Pandemic | Device: SternaLock Blu | Cardiac Surgical Procedures, Coronary Artery Disease, Heart Valve Diseases | 156 | 2020-05-13actual | — | 2021-07-23 |
| CM Asia Nail With AS2 Without AS2 （AS2 Study）NCT03196193results2020-09-29Number of Patient With and Without Excessive Lag Screw Sliding DistanceRandomized · Quadruple-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Procedure: Open Reduction and Internal Fixation · Device: ZNN CM Asia, Anterior Support Screw | Trochanteric Fracture of Femur | 240 | 2020-04-02actual | — | 2020-09-29 |
| Long Term Sidus PMCFNCT04063943Safety: Monitoring frequency of AE, SAE and UADEs.Open-label · Treatment | Not applicable | Withdrawnsponsor's stated reason: Sponsor has decided there is not a business need for this study and is not required to complete. | Device: Sidus Stem-Free Shoulder | Osteoarthritis, Post-traumatic; Arthrosis | 0 | 2020-01-31actual | — | 2021-05-13 |
| Zimmer® MotionLoc® in Distal Tibia FracturesNCT02717546results2021-08-04observationalAverage Clinical Fracture Healing of the Tibia Using the Function Index for Trauma (FIX-IT) Score at 3 Months Follow-upStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Zimmer MotionLoc Screw | Distal Tibia Fractures | 32 | 2019-12-05actual | — | 2021-08-04 |
| Persona TKA With iASSIST Knee System and iASSIST Knee SystemNCT03227692results2020-03-19Number of Participants With Alignment Accuracy of the Knee Femoral Components in Coronal PlainRandomized · Quadruple-masked · Supportive careStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Persona Knee System, iAssist Knee · Procedure: Total Knee Arthroplasty | Osteoarthritis, Knee | 93 | 2019-11-14actual | — | 2020-07-02 |
| TESS Shoulder Arthroplasty Data CollectionNCT00751673observationalChange in Constant Murley Score | — | Terminatedsponsor's stated reason: No more data collected. | — | Arthritis | 600 | Oct 2019actual | — | 2019-10-08 |
| nSTRIDE APS Versus Hyaluronic Acid for Knee OsteoarthritisNCT03182374results2024-09-19Change From Baseline to 12 Months Post-injection in Mean WOMAC LK3.1 Pain Score in Both Arms of the Study (nSTRIDE APS and Synvisc One)Randomized · Quadruple-masked · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: nSTRIDE APS, Synvisc-One | Osteoarthritis, Knee | 252 | 2019-09-30actual | — | 2024-09-19 |
| Saline-Controlled Study of nSTRIDE APS for Knee OsteoarthritisNCT02905240results2023-10-19Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Likert (LK) 3.1 Pain Subscale Change From Baseline to 12 MonthsRandomized · Quadruple-masked · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: nSTRIDE APS, Saline | Osteoarthritis | 332 | Jul 2019actual | — | 2023-11-07 |
| Prospective Post-Market Data Collection on Patients With Knee OA and Treated With nSTRIDE APSNCT02580643observationalKnee pain and function | — | Completed | Biological: APS | Osteoarthritis, Knee | 78 | 2019-06-30actual | — | 2020-06-11 |
| Avenir Müller Hip Stem Post Market Surveillance StudyNCT04079127results2020-06-23observationalEvaluation of Pain and Functional Performance Determined by the Harris Hip ScoreStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Patients who met the inclusion/exclusion criteria to receive the Avenir Müller stem. | Osteoarthritis, Hip, Rheumatoid Arthritis, Fracture of Hip, Dislocated Hip, Osteonecrosis, Post-traumatic; Arthrosis, Subluxation Hip | 150 | 2019-06-29actual | — | 2021-05-14 |
| PMCF Study on the Safety and Performance of the Alloclassic Variall Cup Ceramic Bearing System in Total Hip ArthroplastyNCT03672370results2021-01-14observationalClinical Success Will be Based on the Harris Hip Scoring SystemStudy Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Study terminated as CE marks of the devices used have not been renewed. | — | Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Posttraumatic Arthritis | 100 | 2019-05-14actual | — | 2021-01-14 |
| COMPREHENSIVE® REVERSE SHOULDER Mini BasePlateNCT02084693observationalSurvivorshipStudy Protocol ↗ | — | Completed | Device: COMPREHENSIVE | Rotator Cuff Tear Arthropathy, Osteoporosis, Osteomalacia, Joint; Destruction, Sacroiliac | 100 | Apr 2019actual | — | 2019-07-05 |
| PMCF Study of the CLS Brevius Stem With Kinectiv TechnologyNCT03410940observationalImplant survivorship is assessed counting the number of implant revisions | — | Terminatedsponsor's stated reason: The production of the device was stopped due to economic reasons. Basic post-market surveillance activities will be continued. | Device: CLS Brevius stem with Kinectiv technology | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Femoral Neck Fractures, Prosthesis Failure | 223 | 2019-04-08actual | — | 2020-12-17 |
| A Prospective Multi-center Study on Total Hip Arthroplasty With E1NCT01883492results2020-02-17Polyethylene Wear Between Immediate Postoperative and 2 Year Postoperative PeriodRandomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Enrollment of the subject could not reach statistically required number. | Device: Femoral Stem, Acetabular Cup, Acetabular Liner | Hip Osteoarthritis | 153 | 2019-02-06actual | — | 2020-02-17 |
| A Cohort Study for Clinical Evaluation of OmniMax MMF SystemNCT03075865observationalRoot Damage | — | Completed | Device: OmniMax MMF system | Mandibular Fractures | 39 | 2019-01-10actual | — | 2021-07-19 |
| Outcomes Study of the TM Humeral Stem Used in Primary, Total or Hemi Shoulder ArthroplastyNCT01480453observationalSurvivorship | — | Terminatedsponsor's stated reason: Business decision was made to remove the CE mark from this product, thus prompting the closing of this study. | Device: Trabecular Metal Humeral Stem | Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Ununited Humeral Head Fracture, Irreducible 3- and 4-part Proximal Humeral Fractures, Avascular Necrosis | 67 | 2018-12-31actual | — | 2019-03-26 |
| Evaluating Bactisure Wound Lavage in Orthopedic WoundsNCT03192124observationalReduction WBC | — | Completed | Device: Bactisure | Infection of Total Knee Joint Prosthesis | 40 | 2018-12-22actual | — | 2020-01-27 |
| Regenerex Tibial Tray Multi-Center Data CollectionNCT00859963observationalKnee Society Score | — | Completed | — | Pain, Arthritis | 102 | Nov 2018actual | — | 2021-10-27 |
| Comprehensive Shoulder System Nano IDENCT01936259results2020-01-13American Shoulder and Elbow Surgeon's Score (ASES)Randomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Mini Stem, Nano | Joint Disease | 258 | 2018-11-21actual | — | 2020-01-13 |
| Vanguard TKA With KneeAlign 2 and Without KneeAlign 2NCT02695329results2019-10-03Proportion of Subjects That Have Alignment Within 2 Degrees From Neutral on TibiaRandomized · Single-masked · Supportive careStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: KneeAlign 2 | Osteoarthritis, Knee | 100 | 2018-10-03actual | — | 2020-02-12 |
| Post-Market Surveillance Study of the TM Ardis Interbody Fusion SystemNCT02429908Improvement in ODI scoreOpen-label · Treatment | Phase 4 | Completed | Device: TM-Ardis Interbody | Degenerative Disc Disease | 80 | 2018-09-14actual | — | 2019-03-15 |
| nSTRIDE APS in Females With Primary Patellofemoral OsteoarthritisNCT02610192results2019-12-02Pain Measured With Knee Injury and Osteoarthritis Outcome Score (KOOS) Questionnaire Subscale Pain at 1, 3, 6 and 12 MonthsOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: nSTRIDE Autologous Protein Solution (APS) Kit | Patellofemoral Osteoarthritis | 52 | Jun 2018actual | — | 2020-06-12 |
| Sidus Stem-Free Shoulder IDE StudyNCT01878253results2019-07-15Pain and Function as Measured by the American Society of Shoulder and Elbow Surgeons QuestionnaireOpen-label · TreatmentStudy Protocol ↗ | Not applicable | Completed | Device: Sidus Stem-Free Total Shoulder Arthroplasty System | Osteoarthritis, Posttraumatic Arthrosis, Rheumatoid Arthritis | 95 | May 2018actual | — | 2019-07-15 |
| Zimmer CAS PSI X-Ray Knee in TKA (Total Knee Arthroplasty)NCT02504112observationalassess the positioning accuracy and precision of customized X-RAY PSI guides using the Sesamoid Optical Navigation system in Total Knee Arthroplasty | — | Completed | Other: there is no intervention | Total Knee Arthroplasty / Position of Customized X-Ray PSI Guides Using Optical Navigation | 9 | May 2018actual | — | 2018-06-25 |
| MaxAn Post Market Surveillance ValidationNCT01343693results2020-01-06observationalNumber of Participants With Differing Severity of Adjacent Level OssificationStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | — | DDD, Deformity, Tumor, Fracture | 119 | Jan 2018actual | — | 2020-01-06 |
| Cellentra Viable Cell Bone Matrix (VCBM) Anterior Cervical Discectomy and Fusion Outcomes Study (VCBM/MaxAn)NCT02182843results2019-03-15Change in NDI From BaselineOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Biological: Cellentra VCBM | Cervical Disc Degenerative Disorder | 81 | Jan 2018actual | — | 2019-03-15 |
| Evaluation of Subchondroplasty™ for Defects Associated With Bone Marrow LesionsNCT01621893observationalKnee Injury Osteoarthritis Outcomes Score (KOOS) Pain Subscore | — | Completed | Procedure: Subchondroplasty | Bone Marrow Edema | 70 | 2018-01-17actual | — | 2021-09-24 |
| Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient PopulationNCT02087449observationalHHS scoreStudy Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Sponsor decided to terminate study. | Device: E1-Hip Bearing | Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis, Legg-perthes Disease | 100 | Dec 2017actual | — | 2025-04-02 |
| Metal-on-metal Hip Replacement MRI StudyNCT03409640observationalMRI Scoring change in soft tissue mass size | — | Completed | — | Hip Athroplasty Using M2a Magnum | 100 | 2017-12-31actual | — | 2018-01-24 |
| Recover L-PRP in Lateral Epicondylitis (REGP-11-00)NCT02588040observationalThe primary objective of the study will be to measure number of patients who achieve resolution of chronic LE symptoms at 6 months following initial injection with Recover L-PRP. | — | Terminatedsponsor's stated reason: Not enough sites available to complete enrollment in a timely manner | Biological: Leukocyte- and Platelet-Rich Plasma (L-PRP) | Lateral Epicondylitis | 18 | Sep 2017actual | — | 2018-01-10 |
| Sternal Closure With SternaLock 360: First in Man StudyNCT02686099Sternal Bone HealingRandomized · Single-masked · Treatment | Not applicable | Completed | Device: SternaLock 360, Wire Cerclage | Sternal Fracture | 50 | 2017-09-05actual | — | 2018-01-18 |
| Post-market Surveillance Study With the HYPERION Hip Endoprosthesis System in Defect ReconstructionNCT03382665results2020-08-21observationalPain and Walking Ability Determined by a Merle d' Aubigné Score Increase of >4 Points.Study Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: CE mark will not be renewed, PMCF data no longer required | — | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis, Functional Deformities, Pseudoarthrosis, Revision of Endoprosthesis-treated Hips, Fracture, Proximal Humeral, Provision of Non-endoprosthetic Previous Operations of the Hip Joint (e.g., Transposition Osteotomies), Femur Fracture, Pseudarthrosis, Trochanteric Fractures, Bridging of Large Bone Defects, Revisions | 70 | Aug 2017actual | — | 2023-04-07 |
| A Prospective Munti-center Study on VANGUARD™ PS Total Knee Replacement SystemNCT01906177observationalAmerican Knee Society Score | — | Completed | — | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Posttraumatic Deformity | 100 | Jul 2017actual | — | 2018-06-26 |
| Dynesys Spinal System Post Market 522 StudyNCT01528072results2020-01-29Fusion RatesOpen-label · TreatmentStudy Protocol, Statistical Analysis Plan, and Informed Consent Form ↗ | Not applicable | Terminatedsponsor's stated reason: Terminated at request of FDA | Device: Dynesys Spinal System | Degenerative Spondylolisthesis, Pseudoarthrosis | 153 | Apr 2017actual | — | 2020-01-29 |
| Anatomical Shoulder™ Fracture PMCF StudyNCT02465398results2025-06-12Functional PerformanceOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Procedure: Fracture Shoulder Arthroplasty | Fracture | 52 | 2017-03-29actual | — | 2025-06-12 |
| A Study on M2a Magnum Total Hip ArthroplastyNCT01010763results2019-06-21Range of MotionRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Total Hip Arthroplasty | Degenerative Joint Disease, Avascular Necrosis | 184 | 2017-02-28actual | — | 2019-06-21 |
| Post Market Clinical Follow-Up of the Zimmer Stafit Acetabular SystemNCT04079114results2020-06-30observationalImplant SurvivalStudy Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Stafit Acetabular System not CE marked anymore | Device: Patients who received the Stafit Acetabular System | Osteoarthritis, Hip, Fracture of Hip, Avascular Necrosis of Hip, Dislocated Hip, Osteonecrosis, Post-traumatic; Arthrosis, Rheumatoid Arthritis, Subluxation Hip | 166 | 2017-01-24actual | — | 2020-06-30 |
| ArCom® and ArComXL® Polyethylene Data CollectionNCT00565786observationalPolyethylene wear rates | — | Completed | Device: ArCom® Polyethylene, ArComXL® Polyethylene | Osteoarthritis of Hip | 150 | 2017-01-17actual | — | 2025-06-11 |
| Safety of NStride Autologous Protein Solution in the Treatment of Knee Osteoarthritis (PROGRESS I)NCT02262364results2019-02-15Adverse EventsOpen-label · Treatment | Phase 1 | Completed | Biological: APS | Osteoarthritis, Knee | 11 | Oct 2016actual | — | 2019-02-15 |
| BOLD MRI as a Surrogate of Improved Muscle Oxygenation Following Endovascular Therapy for the Treatment of CLINCT02601430Enhanced oxygen reperfusion of the index foot assessed by BOLD MRI before and after endovascular intervention.Open-label · Other | Not applicable | Completed | Other: BOLD-MRI | Peripheral Arterial Disease, Critical Limb Ischemia | 5 | Oct 2016actual | — | 2017-10-12 |
| S.E.S Shoulder Arthroplasty Data CollectionNCT00754416observationalConstance and oxford Scores | — | Terminatedsponsor's stated reason: Product no more sold | — | Arthritis | 100 | Sep 2016actual | — | 2017-03-07 |
| Signature Personalised Patient Care System With the Vanguard Knee System StudyNCT01092312Mechanical Axial AlignmentRandomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: No difference in outcome between the two groups | Procedure: Vanguard Knee System with Signature Knee Guide, Vanguard Knee System with conventional Instruments | Arthroplasty, Replacement, Knee | 325 | Sep 2016actual | — | 2017-09-05 |
| Discovery Elbow Long-Term SurvivorshipNCT01308463results2017-05-01observationalPatient Derived American Shoulder and Elbow Society (ASES) Pain Score | — | Terminatedsponsor's stated reason: Study terminated due to change in sponsorship | Device: Discovery elbow minimally constrained | Survivorship, Pain | 29 | Sep 2016actual | — | 2017-05-01 |
| Oxford Signature vs. Conventional Global StudyNCT01763684results2021-04-23Percentage of Knees Achieving Optimal AlignmentRandomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Due to slow enrollment and not being able to reach the primary endpoint | Device: Signature Custom Guides · Procedure: Conventional Instrumentation | Osteoarthritis, Osteoarthritis, Knee, Osteonecrosis | 266 | Aug 2016actual | — | 2021-04-23 |
| An MRI Investigation of Soft Tissues in Total Hip ArthroplastyNCT01750606results2026-02-20observationalAsymptomatic vs Symptomatic Metal-on-Metal and Metal-on-Poly Patients (Via a Proportion) With a Soft Tissue Mass | — | Completed | — | Tissue Reaction, Elevated Blood Ion Levels | 397 | Jul 2016actual | — | 2026-02-20 |
| Signature Acetabular Posterior/Lateral Data CollectionNCT02220478results2022-10-25Operative Room TimeNon-randomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Unable to engage surgeons to participate in the study | Device: Posterior Lateral Approach Total Hip Arthroplasty | Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Rheumatoid Arthritis | 24 | Jul 2016actual | — | 2022-10-25 |
| Safety and Efficacy Study of Autologous Concentrated Bone Marrow Aspirate (cBMA) for Critical Limb Ischemia (CLI)NCT01049919results2021-05-28Occurrence of Major Amputation or DeathRandomized · Double-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: Primary endpoint not met, remaining long-term follow-up not needed. | Device: Bone marrow concentration device · Procedure: Placebo procedure (sham) | Critical Limb Ischemia, Peripheral Arterial Disease, Peripheral Vascular Disease | 153 | Jun 2016actual | — | 2021-05-28 |
| G7 Acetabular System vs. Exceed ABT Acetabular System in THANCT02340390the safety and effectiveness of patients (Harris Hip Score)Randomized · Double-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: G7, Exceed ABT | Osteoarthritis Arthritis, Rheumatoid Arthritis | 160 | Jun 2016actual | — | 2019-03-26 |
| Signature Versus Computer Assisted Surgery StudyNCT01256216Mechanical AlignmentNon-randomized · Open-label · Treatment | Not applicable | Completed | Device: Total Knee Replacement with Vanguard Total Knee | Joint Disease | 60 | May 2016actual | — | 2017-06-19 |
| Cementless Oxford Partial Knee Controlled Observational StudyNCT02350049observationalComposite Endpoint- Safety & Efficacy (Radiographic Success, American Knee Society Score, Absence of Revision / Removal / Unanticipated Adverse Device Affects) | — | Completed | — | Osteoarthritis, Avascular Necrosis | 391 | Mar 2016actual | — | 2017-12-08 |
| Platelet Rich Plasma to Treat Plantar FasciitisNCT00758641Percentage of successfully treated patientsRandomized · Quadruple-masked · Treatment | Phase 4 | Completed | Device: L-PRP Injection · Drug: Corticosteroid Injection | Plantar Fasciitis | 115 | Jan 2016actual | — | 2017-03-14 |
| Efficacy of the Aspen Spinous Process System in Anterior Lumbar Interbody Fusion (ALIF)NCT01016314Oswestry Disability Index (ODI)Randomized · Open-label · Treatment | Not applicable | Withdrawnsponsor's stated reason: Protocol amended to NCT01549366 and participants rolled into study | Device: Aspen Spinous Process System, Pedicle Screw Fixation | Degenerative Disc Disease | 0 | Jan 2016actual | — | 2019-01-23 |
| The Metaphyseal Hip Prosthesis - Total HipNCT01501955results2018-08-13RSA Translation XRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Metaphyseal Hip Prosthesis, Stanmore | Osteoarthritis of the Hip | 20 | Jan 2016actual | — | 2024-12-18 |
| Comparison of the Aspen Device Versus Pedicle Screws for Supplemental Posterior Fixation in Lumbar Interbody FusionNCT01549366Absolute change in Oswestry Disability Index (ODI)Randomized · Open-label · Treatment | Not applicable | Completed | Device: Aspen Spinous Process Fixation Device, Pedicle Screws | Degeneration of Lumbar Intervertebral Disc | 64 | Jan 2016actual | — | 2018-03-07 |
| A Clinical Investigation of ArComXL® Polyethylene in Total Hip ReplacementNCT00698152observationalIncidence of revisions and removals | — | Completed | — | Osteoarthritis, Avascular Necrosis, Rheumatoid Arthritis | 149 | 2016-01-15actual | — | 2020-03-30 |
| Enhanced Metal Reduction Techniques for Definitive CT Scanning to Assess Spinal Fusion With TM-ArdisNCT02170558observationalCT scan to determine if the study software can reduce metal scatter on the scan. | — | Withdrawn | Device: TM- Ardis implant and Metal Reduction CT software | Degenerative Disc Disease | 0 | Dec 2015 | — | 2019-01-24 |
| Multi Centre Study on TESS V2 Shoulder SystemNCT03431857results2021-10-19observationalConstant Shoulder ScoreStudy Protocol ↗ | — | Completed | Device: TESS V2 | Osteoarthritis Shoulder, Fracture, Rheumatoid Arthritis, Avascular Necrosis, Rotator Cuff Tear, Revision | 106 | 2015-12-31actual | — | 2021-10-19 |
| APSS-33-00: A Multicenter, Pilot Study of Autologous Protein Solution (APS) in Knee Osteoarthritis (OA)NCT02138890results2019-04-12Change From Baseline to 6 Months in Pain Measured With WOMAC Questionnaire (Day 1, Week 2, Month 1, 3 and 6)Randomized · Quadruple-masked · Treatment | Not applicable | Completed | Device: APS, Saline | Osteoarthritis, Knee | 46 | Oct 2015actual | — | 2021-02-05 |
| Aspen Spinous Process Fixation System for Use in PLF in Patients With SpondylolisthesisNCT01560273observationalAbsolute change in Oswestry Disability Index (ODI) | — | Terminatedsponsor's stated reason: Will answer study question through other research means. | Device: Aspen Spinous Process Fixation Device | Spondylolisthesis | 25 | Sep 2015actual | — | 2019-01-09 |
| A Multicentre Trial to Compare Two Articulating Bearing Surfaces as Used in Cementless Primary Hip ArthroplastyNCT01247038Metal ion concentration in blood and urineRandomized · Single-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: Biomet's focus has changed and we no longer expect further developments | Device: Metal on ceramic articulation, Metal-on-Metal | Osteoarthritis | 130 | 2015-07-10actual | — | 2017-06-21 |
| A Clinical Study of the Dynesys(R) Spinal SystemNCT00759057Overall Clinical Success (VAS Leg Pain, ODI, Major Complications, Additional Surgical Procedures, Neurological Status)Randomized · Single-masked · Treatment | Phase 3 | Terminatedsponsor's stated reason: PMA not approved. FDA granted permission to close the study. | Device: Posterior Pedicle Screw System | Degenerative Spondylolisthesis or Retrolisthesis, Spinal Stenosis, Stenosing Lesion. | 399 | Jun 2015 | — | 2012-06-28 |
| An Evaluation of Rigid Sternal Fixation in Supporting Bone Healing and Improving Postoperative RecoveryNCT01783483results2017-09-08Sternal Healing Score at 3 Month Post op, as Defined by a 6-point Scale to Evaluate Bone HealingRandomized · Single-masked · Supportive care | Not applicable | Completed | Device: SternaLock Blue closure system, Suture Wire | Coronary Artery Disease, Angina Pectoris, Cardiac Valve Disease | 236 | Jun 2015actual | — | 2017-09-08 |
| Oxford Partial Knee Comparative Instrument Pilot StudyNCT01410786Oxford Knee ScoreNon-randomized · Open-label · Basic science | Not applicable | Completed | Procedure: Conventional Instrumentation, Signature Custom Guides | Osteoarthritis, Knee | 35 | May 2015actual | — | 2017-08-02 |
| A Comparison Between Signature Total Knee Arthroplasty (TKA) to Conventional TKA and Computer Assisted TKANCT01145157Mechanical Axial AlignmentRandomized · Open-label · Treatment | Not applicable | Completed | Device: Signature Knee Guide, Conventional Instrumentation, Computer Assisted Navigation | Joint Disease | 150 | Dec 2014actual | — | 2017-08-02 |
| Prospective Multi-Center Study on Vanguard With E1 BearingNCT02088372observationalKnee Society ScoreStudy Protocol ↗ | — | Terminatedsponsor's stated reason: All 4 sites were terminated due to low follow-up of patients and low interest in the study | Device: Vanguard with E1 PS Bearing | Varus Deformity, Valgus Deformity, Posttraumatic Deformity, Osteoarthritis, Knee, Unspecified Disorder of Knee Joint | 200 | Dec 2014actual | — | 2022-10-21 |
| Short-Term Clinical Outcome of Total Hip Arthroplasty Using Larger Diameter of 4th Generation Ceramic BearingNCT01103882observationalDislocation | — | Completed | — | Arthropathy of Hip | 277 | Aug 2014actual | — | 2018-06-26 |
| Taperloc Complete Microplasty vs Taperloc Complete Standard: Randomized Controlled Study on Bone Mineral DensityNCT02087436Bone Mineral DensityRandomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Taperloc Complete Microplasty, Taperloc Complete Standard | Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis, Legg-Perthes Disease | 100 | Jul 2014actual | — | 2020-01-09 |
| Evaluation of Intra-articular Injection of Autologous Protein Solution ("APS(TM)") for the Treatment of Osteoarthritis (OA)NCT01773226results2016-06-15Number of Adverse EventsOpen-label · Treatment | Not applicable | Completed | Device: Autologous Protein Solution "APS(TM)" | Gonarthrosis, Knee Osteoarthritis, Osteoarthritis | 11 | Jun 2014actual | — | 2018-02-05 |
| A Clinical Evaluation of Metal Ion Release From Metal-on-Metal Cementless Total Hip ArthroplastyNCT00757354concentration of Cobalt, Chromium and Molybdenum ions in urineOpen-label · Treatment | Not applicable | Completed | Procedure: Metal on Metal cementless hip | Osteoarthritis, Avascular Necrosis, Traumatic Arthritis, Rheumatoid Arthritis | 77 | Mar 2014actual | — | 2017-06-19 |
| Post Market Surveillance to Evaluate the Effectiveness the Polaris Deformity Spinal SystemNCT01220505observationalMaintenance of Deformity Correction | — | Completed | Procedure: Surgery | Spinal Deformity | 66 | Jan 2014actual | — | 2019-12-19 |
| Data Collection on ReCap/Magnum in Total Hip Replacement and ResurfacingNCT00758355observationalPostel-Merle d'Aubigné (PMA), Harris Hip Score | — | Completed | — | Total Hip Resurfacing | 150 | Dec 2013actual | — | 2017-02-23 |
| Randomized Controlled Clinical Evaluation to Compare Vanguard Cruciate Retaining and AGC Total Condylar Knee ImplantsNCT01064063American Knee Society Knee ScoreRandomized · Single-masked · Treatment | Not applicable | Completed | Device: Vanguard CR, AGC knee | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis | 150 | 2013-12-15actual | — | 2025-11-26 |
| A Clinical Registry to Collect Patient Outcome Date for the BIOMET® Stimulator SystemsNCT01750840results2016-06-14observationalRadiographic Assessment of Healing | — | Terminatedsponsor's stated reason: Slow enrollment and poor patient follow-up following enrollment | Device: Biomet® EBI Bone Healing System, Biomet Orthopak® Non-Invasive Bone Growth Stimulator System, Biomet SpinalPak® Non-Invasive Spine Fusion Stimulator | Fusion of Spine (Disease), Fractures, Ununited | 8 | Oct 2013actual | — | 2017-06-19 |
| A Comparison of Two Different Surgical Techniques for Total Hip ResurfacingNCT00750984RSARandomized · Open-label · Treatment | Not applicable | Completed | Procedure: Anterolateral approach, Posterior approach · Device: ReCap Total Hip Resurfacing, ReCap Total Hip Resurfacing | Arthritis, Avascular Necrosis | 49 | Jul 2013actual | — | 2018-01-11 |
| Pro Osteon Bone Void Filler StudyNCT00858598observationalRadiographic Evaluation | — | Withdrawnsponsor's stated reason: Study never started. Study suspended indefinitely. | — | Osteoarthritis, Revision Arthroplasty | 0 | Jul 2013 | — | 2017-06-21 |
| Pediatric Locking Nail for the Treatment of Femoral Fractures in ChildrenNCT00725894observationallimb alignment | — | Completed | Device: Pediatric Locking Nail | Femur Fracture | 33 | May 2013actual | — | 2017-06-21 |
| Avascular Necrosis (AVN) Long-Term Follow-upNCT00833430observationalSafety, Efficacy and longevity of device with patient as opposed to conventional total hip replacement | — | Terminated | — | Avascular Necrosis, Femoral Head Collapse | 35 | Feb 2013actual | — | 2016-02-19 |
| Vanguard Complete Knee Versus Vanguard High Flex Rotating Platform (RP) Knee StudyNCT01010269American Knee Society Knee ScoreNon-randomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Vanguard Complete Knee, Vanguard High Flex RP | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis | 300 | Oct 2012actual | — | 2018-06-26 |
| CopiOs Posterolateral Fusion ProcedureNCT01123850results2015-05-27Fusion AssessmentOpen-label · Treatment | Phase 2 | Terminatedsponsor's stated reason: Slow enrollment | Device: Copios | Spondylolisthesis, Stenosis | 45 | Oct 2012actual | — | 2015-05-27 |
| Clinical Outcomes of the Trinica(R) Anterior Lumbar Plate: Fixed Screws vs. Variable ScrewsNCT00762723results2014-03-26Clinical Outcomes (Oswestry Disability Index, SF-12, Numeric Pain Rating Scale, Surgeon Assessment, Patient Self Assessment, Radiological Assessment)Randomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Study was stopped due to slow enrollment | Device: Trinica Anterior Lumbar Plate System | Degenerative Disc Disease, Spinal Stenosis, Spondylolisthesis | 19 | Sep 2012actual | — | 2014-04-17 |
| Evaluate Effectiveness of the Biomet Lumbar Spinal Fusion SystemNCT00758719observationalRadiographic Fusion | — | Completed | — | Degenerative Disc Disease | 53 | Aug 2012actual | — | 2020-02-24 |
| A Prospective Randomized Study on Vanguard Cruciate Retaining Versus Vanguard High Flex Posterior Stabilized Total Knee System in the Early Range of MotionNCT00763113Knee Society ScoreRandomized · Open-label · Treatment | Not applicable | Completed | Device: Vanguard PS Knee, Vanguard CR Knee | Total Knee Arthroplasty | 173 | Jul 2012actual | — | 2017-06-16 |
| Trilogy AB Acetabular Hip System Post Approval StudyNCT00715026results2014-11-26Harris Hip ScoreOpen-label · Treatment | Phase 4 | Terminatedsponsor's stated reason: Sponsor business decision unrelated to clinical performance. | Device: Trilogy AB Acetabular Hip Implant System | Osteoarthritis, Avascular Necrosis, Congenital Hip Dysplasia, Traumatic Arthritis | 31 | Jun 2012actual | — | 2014-11-26 |
| Study Comparing BoneMaster Hydroxyapatite Coating With Plasma-sprayed Hydroxyapatite Coating on Acetabular CupsNCT00859976results2019-02-08Record and Measure Bone Density Using DEXA Scans at 24 Months.Randomized · Open-label · Treatment | Not applicable | Completed | Device: BoneMaster coated acetabular shell., Plasma Coated Acetabular Shell | Arthropathy of Hip | 167 | Jun 2012actual | — | 2019-03-05 |
| Study of Root Coverage With Acellular Dermal Matrix: Puros® Dermis Versus Alloderm®NCT00881959results2015-05-27Non -Inferiority of Dermis to AllodermRandomized · Single-masked · Treatment | Not applicable | Completed | Device: Puros® Dermis versus Alloderm® | Gingival Recession | 80 | Apr 2012actual | — | 2015-05-27 |
| Review on Minimally Invasive Skin Incision in Vanguard PS Artificial Knee Joint SystemNCT01010828Force from femoral and tibial side to retract and bring visual field into viewRandomized · Open-label · Treatment | Not applicable | Completed | Procedure: Incision technique, Incision technique | Gonarthrosis Patients Who Need Artificial Knee Joint Total Replacement | 72 | 2012-03-31actual | — | 2019-03-27 |
| LPS Flex Porous Femoral ComponentsNCT01462240observationalSurvivorship | — | Withdrawnsponsor's stated reason: Suspended pending internal review/direction of the company's focus. | Device: LPS Flex Porous Femoral Components | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Poly Arthritis, Collagen Disorders, Avascular Necrosis of Femoral Condyle | 0 | Mar 2012 | — | 2021-08-24 |
| Feasibility Study of Anti-inflammatory Cytokines in Whole Blood in Osteoarthritis PatientsNCT01050894observationalMeasure anti-inflammatory cytokines | — | Completed | — | Osteoarthritis | 105 | Jan 2012actual | — | 2017-03-21 |
| Prospective Data Collection on Cementless Oxford Partial KneeNCT00760188observationalAmerican Knee Society Score | — | Withdrawnsponsor's stated reason: No patients recruited into study. | Device: Cementless Oxford Partial Knee | Arthroplasty, Replacement, Knee | 0 | Dec 2011actual | — | 2017-09-05 |
| CopiOs® Pericardium Membrane for Localized Alveolar Ridge AugmentationNCT00889265results2014-08-07Change in Horizontal Ridge Widths From Baseline to 6 MonthsOpen-label · Treatment | Not applicable | Completed | Device: CopiOs Pericardium Membrane | Alveolar Ridge Defect | 51 | Dec 2011actual | — | 2014-08-11 |
| A Double-Blind Study on Adjunctive Use of PEMF in the Treatment of 5th Metatarsal Non-Union FracturesNCT00586170results2016-05-16Percentage of Successful 5th Metatarsal Unions Achieved.Randomized · Quadruple-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: Slow enrollment | Device: EBI Bone Healing System, Placebo Device · Procedure: Surgery | Nonunion of Fracture of Fifth Metatarsal | 8 | Aug 2011actual | — | 2017-06-21 |
| Clinical Study on BiHapro Total Hip System With Different Surface CoatingsNCT00755001observationalHarris Hip Score | — | Terminatedsponsor's stated reason: The site decided to stop the study | Device: BiHapro hip stem with PPS Ti+Plasma HA, BiHapro hip stem with PPS Ti+BoneMaster HA | Osteoarthritis | 40 | May 2011actual | — | 2017-07-07 |
| Durom(R) Hip Resurfacing System Multicenter TrialNCT00746616Device SurvivalOpen-label · Treatment | Phase 3 | Completed | Device: Durom Hip Resurfacing System | Advanced Hip Disease | 40 | Mar 2011actual | — | 2013-04-10 |
| Posterior Lateral Fusion (PLF) With DynesysNCT00791180observationalClinical Outcomes | — | Completed | — | Spondylolisthesis | 38 | Mar 2011actual | — | 2011-09-29 |
| A Randomized Control Trial to Assess Early Clinical and Functional Outcome of the ROCC and LCS Total Knee Implant DesignsNCT00755144American Knee Society ScoreRandomized · Open-label · Treatment | Not applicable | Completed | Device: LCS Knee, ROCC Knee | Osteoarthritis | 200 | Jan 2011actual | — | 2017-06-20 |
| Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and PainNCT00819286results2012-03-15CT Scan Evaluation of Sternal Bone HealingRandomized · Single-masked · Treatment | Not applicable | Completed | Device: SternaLock Rigid Fixation Plates, wire (control) | Sternal Wound Infection, Sternal Non-union, Pain, Mediastinitis | 140 | Jan 2011actual | — | 2018-02-13 |
| ROCC Knee Data CollectionNCT00758901observationalAmerican Knee Score | — | Terminatedsponsor's stated reason: Site Decision | Device: Knee Replacement (with ROCC Knee prosthesis) | Arthritis of Knee | 200 | Dec 2010actual | — | 2017-03-10 |
| A Study to Compare the NexGen CR and CR-Flex Knee ImplantsNCT00761956results2012-07-16Postoperative Range of Motion (ROM)Randomized · Single-masked · Treatment | Not applicable | Completed | Device: NexGen CR-Flex Fixed Bearing Knee, NexGen CR Knee | Total Knee Arthroplasty, Osteoarthritis | 189 | Dec 2010actual | — | 2012-07-16 |
| ChonDux for Filling Full Thickness Cartilage Defects in the Femoral Condyle of the KneeNCT01110070Defect fill at 6 months determined by magnetic resonance imaging (MRI)Randomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Enrollment suspended; follow up continue | Device: ChonDux, ChonDux | Cartilage Defect | 21 | Dec 2010actual | — | 2017-07-07 |
| Vanguard Knee Anterior Stabilized Versus Posterior Stabilized Bearing StudyNCT01308515Objective Knee ScoreRandomized · Open-label · Treatment | Not applicable | Withdrawnsponsor's stated reason: Could not find interested researchers/clinicians to complete study protocol. | Device: Vanguard Knee System with AS Bearing, Vanguard Knee System with PS Bearing | Osteoarthritis, Degenerative Arthritis | 0 | Sep 2010 | — | 2017-06-21 |
| Clinical Evaluation on HA Coated Dynamic Hip Screws for Trochanteric Femoral FracturesNCT00756431Harris Hip ScoreRandomized · Double-masked · Treatment | Not applicable | Withdrawnsponsor's stated reason: No data so far | Device: Hip Fracture reduction Screw without HA Coating (Hiploc), Hip Fracture reduction Screw with HA Coating (Hiploc) | Osteoarthritis | 0 | Jun 2010actual | — | 2017-06-19 |
| Platelet-Rich and Concentrated Platelet-Poor Plasma to Reduce Air Leak Post-Lobectomy: A Randomized Controlled TrialNCT00665912Duration of postoperative air leakRandomized · Double-masked · Treatment | Not applicable | Completed | Procedure: Standard post-lobectomy wound care plus use of PRP and PPPc prepared by GPS and Plasmax respectively, Standard post-lobectomy wound care | Lung Cancer | 204 | May 2010actual | — | 2017-03-13 |
| Oxford Unicompartmental Knee Arthroplasty With and Without Navigational UnitNCT00862316Operative recordRandomized · Open-label · Treatment | Not applicable | Completed | Device: Oxford Unicompartmental Knee | Knee Arthritis | 48 | May 2010actual | — | 2017-06-16 |
| Retrospective Data Review of ReCap Total Hip ResurfacingNCT00758329observationalSurvival rate | — | Withdrawnsponsor's stated reason: No further contact with the site | Device: ReCap Total Hip Resurfacing | Osteoarthritis of the Hip | 0 | Apr 2010actual | — | 2017-06-19 |
| ReCap Total Hip Resurfacing Prospective Data CollectionNCT00758472observationalsurvival rate | — | Terminated | Device: ReCap Total Hip Resurfacing | Arthritis | 82 | Mar 2010actual | — | 2017-06-19 |
| Retrieval Study and Histological Examination Of A Hip Femoral Components With Hydroxyapatite CoatingsNCT00757653Adverse EventRandomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: slow enrollment | Device: Hip stem with plasma sprayed porous Ti 6Al4V alloy + plasma sprayed HA, Hip stem with plasma spayed porous Titanium 6Al4V alloy + Bonemaster HA, Hip stem with Interloc Titanium surface + Bonemaster H.A | Femoral Neck Fractures | 57 | Dec 2009actual | — | 2017-06-20 |
| A Study to Compare the NexGen LPS and LPS-Flex Knee ImplantsNCT00763386results2012-05-25Postoperative Range of Motion (ROM)Randomized · Single-masked · Treatment | Not applicable | Completed | Device: NexGen LPS-Flex Fixed Bearing Knee, NexGen Legacy Posterior Stabilized Knee | Total Knee Arthroplasty, Osteoarthritis | 331 | Dec 2009actual | — | 2012-06-04 |
| Patient Outcomes Evaluation of the EBI Vuelock™ Anterior Cervical Plate SystemNCT00726128observationalProportion of Patients with radiographic fusion | — | Completed | Device: VueLock™ Anterior Cervical Plate | Trauma, Tumor, Pseudarthrosis, Scoliosis, Degenerative Disc Disease | 371 | Sep 2009actual | — | 2020-02-24 |
| Evaluation Of Spinelink® Fixation In The Treatment Of Degenerative Spondylolisthesis And Spinal InstabilityNCT00726310observationalPercentage of successful fusions achieved | — | Completed | Device: SpineLink® , SpineLink® II | Degenerative Disc Disease, Degenerative Spondylolisthesis | 202 | Jul 2009actual | — | 2020-02-13 |
| Outcome Analysis of the Oxford Partial Knee ArthroplastyNCT00759616WOMAC, SF12, oxford Knee,KSCRSOpen-label · Treatment | Not applicable | Completed | Device: Oxford Partial Knee | Knee Arthroplasty | 156 | Jun 2009actual | — | 2017-06-16 |
| OsseoFit™ Prospective Data CollectionNCT00708474Site repair grade by MRI analysisRandomized · Single-masked · Treatment | Not applicable | Withdrawnsponsor's stated reason: Planning new study protocol | Device: OsseoFit™ Porous Tissue Matrix™ | Bone Graft, Knee | 0 | Feb 2009 | — | 2019-01-10 |
| The Value of Platelet-Rich Plasma in Chronic Midportion Achilles Tendinopathy: a Double-blind Randomized Clinical TrialNCT00761423VISA-A ScoreRandomized · Double-masked · Treatment | Phase 4 | Completed | Biological: PRP Injection with eccentric exercises, Placebo Injection with eccentric exercises | Achilles Tendinopathy | 81 | Feb 2009actual | — | 2017-05-18 |
| Performance of the Hedrocel(R) Cervical Fusion DeviceNCT00758758results2013-08-12Overall Clinical Success (NDI, Fusion, Additional Surgical Procedures)Randomized · Single-masked · Treatment | Phase 3 | Completed | Device: Anterior Cervical Discectomy and Fusion, Anterior Cervical Discectomy and Fusion, Anterior Cervical Discectomy and Fusion | Symptomatic Cervical Disc Disease | 231 | Jan 2009actual | — | 2013-08-23 |
| Evaluate Use of Gravitational Platelet Separation System on Leg Wound Healing in Coronary Bypass SurgeryNCT00514241Presence/absence of leg wound infection, General wound healing - picture evaluationRandomized · Double-masked · Treatment | Phase 1 | Completed | Device: The GPS™ II Platelet Concentrate Separation Kit | Coronary Heart Failure | 140 | Aug 2008actual | — | 2017-05-19 |
| Total Temporomandibular Joint Replacement System Post Approval StudyNCT00762944observationalTime to Revision | — | Completed | Device: Biomet TMJ Replacement System | Arthroplasty | 93 | 2008-08-25actual | — | 2024-06-21 |
| Slotted Hole Versus Fixed Hole C-TekNCT00585923results2010-03-26Fusion SuccessRandomized · Single-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: Due to lack of follow-up information | Device: Fixed hole C-Tek™ Plate, Slotted hole C-Tek™ Plate | Herniated Disc, Radiculopathy, Spondylolysis | 115 | May 2008actual | — | 2019-03-05 |
| Study to Analyze the Effects of EBI OsteoGen™ on the Surgical Reconstruction of Tibia Non-unionsNCT00726193observationalThe primary outcome measure for this trial will be the percentage of successful tibia unions achieved | — | Terminatedsponsor's stated reason: Slow enrollment, lack of follow up | Device: OsteoGen | Tibia Fracture Non Union Bone | 4 | Apr 2008actual | — | 2019-01-24 |
| Platelet-rich-plasma Treating Tennis ElbowNCT00757289Visual Analog Score - PainRandomized · Double-masked · Treatment | Not applicable | Completed | Biological: PRP Injection, Corticosteroid Injection | Pain | 106 | Jan 2008actual | — | 2017-05-19 |
| CopiOs(TM) Bone Void Filler in the Post-Harvest Iliac CrestNCT00768924observationalData obtained by this study will provide valuable insight on the ability of CopiOs to fill the post-harvest iliac crest bone void created by a surgeon during spinal fusion. | — | Completed | — | Spinal Fusions | 35 | Dec 2007actual | — | 2011-09-30 |
| Spine Patient Outcomes Registry for Biomet/EBI (Electro-Biology, Inc)NCT00726284observationalFusion Status | — | Completed | — | Degenerative Disc Disease, Spinal Stenosis | 651 | 2007-12-06actual | — | 2020-02-24 |
| A Prospective Clinical Study On A Total Hip Resurfacing SystemNCT00604734Harris Hip Score, Device Revision/Removal, Radiographic EvaluationOpen-label · Treatment | Not applicable | Completed | Device: ReCap Total Hip Resurfacing System | Arthritis, Avascular Necrosis | 280 | Oct 2007actual | — | 2019-02-11 |
| Total Knee Replacement Using Simplex® or Cobalt™ Bone CementNCT00589485observationalRadiographic analysis and Knee Society Score | — | Withdrawnsponsor's stated reason: Sponsor did not fund the study | Device: Simplex® Bone Cement, Cobalt™ Bone Cement | Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis, Knee Arthritis | 0 | Nov 2006actual | — | 2017-06-21 |
| MIS MiLIF Versus OpenNCT00792129observationalClinical Outcomes | — | Completed | Device: The Atavi System | Chronic Low Back Pain, Leg Pain | 113 | Mar 2006actual | — | 2012-02-16 |
| Retrospective Study on Cenos Stem With BoneMaster HANCT00761046observationalComplication Rate | — | Withdrawnsponsor's stated reason: No data have been obtained at all in this time. | — | Osteoarthritis | 0 | — | — | 2017-07-07 |
| Safety and Efficacy of Autologous Concentrated Bone Marrow Aspirate for Critical Limb Ischemia - Continued AccessNCT02474121expanded access | — | No longer available | Device: Bone marrow concentration device | Peripheral Arterial Disease, Peripheral Vascular Diseases, Critical Limb Ischemia | — | — | — | 2020-03-27 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19