| 1 | 1QVT Financial LP | 4,615,7094.6M | $16M | 9.33% | — |
| 2 | 2ORBIMED ADVISORS LLC | 4,166,0004.2M | $14M | 8.42% | — |
| 3 | 3SUVRETTA CAPITAL MANAGEMENT, LLC | 3,700,0003.7M | $13M | 7.48% | — |
| 4 | 4ACUTA CAPITAL PARTNERS, LLC | 3,410,4023.4M | $12M | 6.90% | — |
| 5 | 5Avoro Capital Advisors LLC | 2,849,4022.8M | $10M | 5.76% | — |
| 6 | 6KVP Capital Advisors, LP | 2,165,9972.2M | $7M | 4.38% | — |
| 7 | 7Siren, L.L.C. | 2,082,0002.1M | $7M | 4.21% | — |
| 8 | 8Yu Fan | 2,070,0002.1M | $7M | 4.19% | — |
| 9 | 9STEMPOINT CAPITAL LP | 1,878,7381.9M | $6M | 3.80% | ADD 29% |
| 10 | 10VANGUARD CAPITAL MANAGEMENT LLC | 1,315,7701.3M | $5M | 2.66% | NEW† |
| 11 | 11ACORN CAPITAL ADVISORS, LLC | 1,139,3631.1M | $4M | 2.30% | — |
| 12 | 12Ally Bridge Group (NY) LLC | 817,939817,939 | $3M | 1.65% | — |
| 13 | 13Balyasny Asset Management L.P. | 550,441550,441 | $2M | 1.11% | NEW |
| 14 | 14GEODE CAPITAL MANAGEMENT, LLC | 457,540457,540 | $2M | 0.93% | ADD 8% |
| 15 | 15RENAISSANCE TECHNOLOGIES LLC | 428,622428,622 | $1M | 0.87% | TRIM -3% |
| 16 | 16AMES NATIONAL CORP | 4,5714,571 | $1M | 0.01% | NEW |
| 17 | 17BlackRock, Inc. | 351,385351,385 | $1M | 0.71% | ADD 18% |
| 18 | 18MILLENNIUM MANAGEMENT LLC | 309,674309,674 | $1M | 0.63% | NEW |
| 19 | 19Eversept Partners, LP | 306,800306,800 | $1M | 0.62% | ADD 18% |
| 20 | 20Woodline Partners LP | 281,497281,497 | $971,165 | 0.57% | NEW |
| 21 | 21TWO SIGMA INVESTMENTS, LP | 273,482273,482 | $943,513 | 0.55% | TRIM -12% |
| 22 | 22BRIDGEWAY CAPITAL MANAGEMENT, LLC | 215,284215,284 | $742,730 | 0.44% | — |
| 23 | 23VANGUARD FIDUCIARY TRUST CO | 214,827214,827 | $741,153 | 0.43% | NEW |
| 24 | 24SUSQUEHANNA INTERNATIONAL GROUP, LLP | 203,465203,465 | $701,954 | 0.41% | ADD 85% |
| 25 | 25STATE STREET CORP | 160,382160,382 | $553,318 | 0.32% | ADD 10% |
| 26 | 26JANE STREET GROUP, LLC | 151,110151,110 | $521,330 | 0.31% | ADD 116% |
| 27 | 27ADAR1 Capital Management, LLC | 128,503128,503 | $443,335 | 0.26% | ADD 66% |
| 28 | 28Verdad Advisers, LP | 115,484115,484 | $398,420 | 0.23% | NEW |
| 29 | 29NORTHERN TRUST CORP | 107,266107,266 | $370,067 | 0.22% | ADD 4% |
| 30 | 30CITADEL ADVISORS LLC | 91,85291,852 | $316,889 | 0.19% | TRIM -7% |
| 31 | 31ACADIAN ASSET MANAGEMENT LLC | 70,10170,101 | $239,000 | 0.14% | ADD 185% |
| 32 | 32Hudson Bay Capital Management LP | 57,59757,597 | $198,710 | 0.12% | NEW |
| 33 | 33GOLDMAN SACHS GROUP INC | 56,91256,912 | $196,346 | 0.12% | NEW |
| 34 | 34Seven Fleet Capital Management LP | 54,29654,296 | $187,321 | 0.11% | NEW |
| 35 | 35BANK OF AMERICA CORP /DE/ | 52,86152,861 | $182,370 | 0.11% | ADD 12762% |
| 36 | 36Qube Research & Technologies Ltd | 48,30748,307 | $166,659 | 0.10% | TRIM -33% |
| 37 | 37HRT FINANCIAL LP | 34,93534,935 | $120,000 | 0.07% | NEW |
| 38 | 38BAILARD, INC. | 31,39831,398 | $108,323 | 0.06% | NEW |
| 39 | 39DIMENSIONAL FUND ADVISORS LP | 30,09030,090 | $103,810 | 0.06% | ADD 5% |
| 40 | 40Point72 Asset Management, L.P. | 28,02628,026 | $96,690 | 0.06% | NEW |
| 41 | 41Catalyst Funds Management Pty Ltd | 27,01127,011 | $93,188 | 0.05% | NEW |
| 42 | 42OCCUDO QUANTITATIVE STRATEGIES LP | 22,29122,291 | $89,387 | 0.05% | NEW |
| 43 | 43XTX Topco Ltd | 22,98322,983 | $79,291 | 0.05% | ADD 46% |
| 44 | 44Vanguard Global Advisers, LLC | 20,17720,177 | $69,611 | 0.04% | NEW |
| 45 | 45Brevan Howard Capital Management LP | 12,58912,589 | $43,432 | 0.03% | NEW |
| 46 | 46OMERS ADMINISTRATION Corp | 11,50011,500 | $39,675 | 0.02% | NEW |
| 47 | 47UBS Group AG | 11,43811,438 | $39,461 | 0.02% | TRIM -62% |
| 48 | 48PRELUDE CAPITAL MANAGEMENT, LLC | 10,28310,283 | $35,476 | 0.02% | TRIM -45% |
| 49 | 49MORGAN STANLEY | 8,3428,342 | $28,780 | 0.02% | ADD 24% |
| 50 | 50CITIGROUP INC | 6,1596,159 | $21,249 | 0.01% | NEW |
| 51 | 51US BANCORP \DE\ | 3,3333,333 | $11,499 | 0.01% | — |
| 52 | 52OSAIC HOLDINGS, INC. | 1,6391,639 | $5,654 | 0.00% | TRIM -47% |
| 53 | 53BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,3331,333 | $5,545 | 0.00% | — |
| 54 | 54BARCLAYS PLC | 647647 | $2,232 | 0.00% | NEW |
| 55 | 55Russell Investments Group, Ltd. | 386386 | $1,332 | 0.00% | — |
| 56 | 56ROYAL BANK OF CANADA | 177177 | $1,000 | 0.00% | NEW |
| 57 | 57TD Waterhouse Canada Inc. | 232232 | $814 | 0.00% | — |
| 58 | 58BNP PARIBAS FINANCIAL MARKETS | 202202 | $697 | 0.00% | ADD 26% |
| 59 | 59JPMORGAN CHASE & CO | 121121 | $397 | 0.00% | — |
| 60 | 60CWM, LLC | 2525 | $86 | 0.00% | — |
| 61 | 61SBI Securities Co., Ltd. | 2323 | $79 | 0.00% | ADD 21% |
| 62 | 62Parallel Advisors, LLC | 88 | $28 | 0.00% | — |
