| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 8,101,5638.1M | $73M | 14.89% | ADD 8% |
| 2 | ORBIMED ADVISORS LLC | 5,693,5895.7M | $51M | 10.46% | — |
| 3 | BlackRock, Inc. | 3,370,6893.4M | $30M | 6.19% | — |
| 4 | Decheng Capital LLC | 2,724,8682.7M | $25M | 5.01% | TRIM -13% |
| 5 | ENAVATE SCIENCES GP, LLC | 2,459,7032.5M | $22M | 4.52% | — |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 1,873,5741.9M | $17M | 3.44% | NEW† |
| 7 | Y-Intercept (Hong Kong) Ltd | 1,000,6311.0M | $9M | 1.84% | ADD 2049% |
| 8 | FEDERATED HERMES, INC. | 979,758979,758 | $9M | 1.80% | ADD 203169% |
| 9 | GEODE CAPITAL MANAGEMENT, LLC | 950,617950,617 | $9M | 1.75% | ADD 12% |
| 10 | MILLENNIUM MANAGEMENT LLC | 937,323937,323 | $8M | 1.72% | ADD 81% |
| 11 | SEB Asset Management AB | 878,473878,473 | $8M | 1.61% | NEW |
| 12 | Bain Capital Life Sciences Investors, LLC | 867,211867,211 | $8M | 1.59% | TRIM -35% |
| 13 | Woodline Partners LP | 831,481831,481 | $7M | 1.53% | ADD 9% |
| 14 | D. E. Shaw & Co., Inc. | 820,480820,480 | $7M | 1.51% | ADD 2929% |
| 15 | Parkman Healthcare Partners LLC | 786,783786,783 | $7M | 1.45% | TRIM -6% |
| 16 | SAMSARA BIOCAPITAL, LLC | 736,047736,047 | $7M | 1.35% | — |
| 17 | Pictet Asset Management Holding SA | 733,431733,431 | $7M | 1.35% | TRIM -5% |
| 18 | VANGUARD PORTFOLIO MANAGEMENT LLC | 727,711727,711 | $7M | 1.34% | NEW |
| 19 | STATE STREET CORP | 705,350705,350 | $6M | 1.30% | TRIM -47% |
| 20 | HSBC HOLDINGS PLC | 640,326640,326 | $6M | 1.18% | NEW |
| 21 | Qube Research & Technologies Ltd | 619,321619,321 | $6M | 1.14% | NEW |
| 22 | MORGAN STANLEY | 552,609552,609 | $5M | 1.02% | ADD 353% |
| 23 | JPMORGAN CHASE & CO | 463,001463,001 | $4M | 0.85% | ADD 320% |
| 24 | Nantahala Capital Management, LLC | 400,000400,000 | $4M | 0.74% | TRIM -19% |
| 25 | Altshuler Shaham Ltd | 380,061380,061 | $3M | 0.70% | TRIM -72% |
| 26 | SPHERA FUNDS MANAGEMENT LTD. | 358,000358,000 | $3M | 0.66% | NEW |
| 27 | Propel Bio Management, LLC | 341,779341,779 | $3M | 0.63% | NEW |
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 342,353342,353 | $3M | 0.63% | TRIM -62% |
| 29 | Jump Financial, LLC | 319,400319,400 | $3M | 0.59% | NEW |
| 30 | GOLDMAN SACHS GROUP INC | 316,587316,587 | $3M | 0.58% | TRIM -5% |
| 31 | Alyeska Investment Group, L.P. | 298,329298,329 | $3M | 0.55% | — |
| 32 | NORTHERN TRUST CORP | 260,992260,992 | $2M | 0.48% | ADD 10% |
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 257,729257,729 | $2M | 0.47% | TRIM -10% |
| 34 | Prosight Management, LP | 241,123241,123 | $2M | 0.44% | NEW |
| 35 | UBS Group AG | 231,254231,254 | $2M | 0.42% | TRIM -87% |
| 36 | VANGUARD FIDUCIARY TRUST CO | 224,157224,157 | $2M | 0.41% | NEW |
| 37 | XTX Topco Ltd | 209,277209,277 | $2M | 0.38% | ADD 1287% |
| 38 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 185,087185,087 | $2M | 0.34% | NEW |
| 39 | TCG Crossover Management, LLC | 181,063181,063 | $2M | 0.33% | TRIM -76% |
| 40 | DEUTSCHE BANK AG\ | 180,889180,889 | $2M | 0.33% | ADD 42% |
| 41 | Point72 Asset Management, L.P. | 178,168178,168 | $2M | 0.33% | NEW |
| 42 | Trexquant Investment LP | 176,657176,657 | $2M | 0.32% | ADD 469% |
| 43 | Schonfeld Strategic Advisors LLC | 161,349161,349 | $1M | 0.30% | ADD 39% |
| 44 | Boxer Capital Management, LLC | 150,000150,000 | $1M | 0.28% | — |
| 45 | BNP PARIBAS FINANCIAL MARKETS | 126,000126,000 | $1M | 0.23% | ADD 2432% |
| 46 | ALLIANCEBERNSTEIN L.P. | 31,01031,010 | $841,922 | 0.06% | — |
| 47 | ExodusPoint Capital Management, LP | 91,43191,431 | $822,879 | 0.17% | ADD 21% |
| 48 | AMERICAN CENTURY COMPANIES INC | 87,62487,624 | $788,616 | 0.16% | — |
| 49 | Bank of New York Mellon Corp | 81,38381,383 | $732,447 | 0.15% | TRIM -4% |
| 50 | DIMENSIONAL FUND ADVISORS LP | 80,00280,002 | $719,492 | 0.15% | NEW |
| 51 | Simplify Asset Management Inc. | 77,79377,793 | $700,137 | 0.14% | NEW |
| 52 | Nuveen, LLC | 75,53675,536 | $679,824 | 0.14% | TRIM -4% |
| 53 | EntryPoint Capital, LLC | 73,56873,568 | $662,112 | 0.14% | NEW |
| 54 | AQR CAPITAL MANAGEMENT LLC | 72,17172,171 | $649,539 | 0.13% | ADD 137% |
| 55 | MARSHALL WACE, LLP | 66,77066,770 | $600,930 | 0.12% | TRIM -81% |
| 56 | RENAISSANCE TECHNOLOGIES LLC | 62,10062,100 | $558,900 | 0.11% | ADD 279% |
| 57 | Quantinno Capital Management LP | 49,38949,389 | $444,501 | 0.09% | ADD 220% |
| 58 | BANK OF AMERICA CORP /DE/ | 48,46048,460 | $436,140 | 0.09% | TRIM -44% |
| 59 | Swiss National Bank | 48,10048,100 | $432,900 | 0.09% | ADD 81% |
| 60 | Squarepoint Ops LLC | 44,62644,626 | $401,634 | 0.08% | NEW |
| 61 | ALPS ADVISORS INC | 43,99243,992 | $395,928 | 0.08% | — |
| 62 | STATE OF WISCONSIN INVESTMENT BOARD | 41,67141,671 | $375,039 | 0.08% | NEW |
| 63 | RHUMBLINE ADVISERS | 41,20341,203 | $370,827 | 0.08% | — |
| 64 | Invesco Ltd. | 40,51040,510 | $364,590 | 0.07% | TRIM -75% |
| 65 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,66139,661 | $356,949 | 0.07% | ADD 171% |
| 66 | GSA CAPITAL PARTNERS LLP | 39,23239,232 | $353,000 | 0.07% | NEW |
| 67 | Stonepine Capital Management, LLC | 35,00035,000 | $315,000 | 0.06% | NEW |
| 68 | ADAR1 Capital Management, LLC | 35,00035,000 | $315,000 | 0.06% | NEW |
| 69 | Aquatic Capital Management LLC | 31,48431,484 | $283,356 | 0.06% | NEW |
| 70 | Bleakley Financial Group, LLC | 28,86428,864 | $259,776 | 0.05% | NEW |
| 71 | AXQ CAPITAL, LP | 27,50327,503 | $247,527 | 0.05% | NEW |
| 72 | Mariner, LLC | 27,31427,314 | $245,834 | 0.05% | ADD 131% |
| 73 | PRICE T ROWE ASSOCIATES INC /MD/ | 26,43426,434 | $238,000 | 0.05% | ADD 35% |
| 74 | TUDOR INVESTMENT CORP ET AL | 26,41226,412 | $237,708 | 0.05% | NEW |
| 75 | MARTINGALE ASSET MANAGEMENT L P | 26,22326,223 | $236,007 | 0.05% | NEW |
| 76 | VICTORY CAPITAL MANAGEMENT INC | 25,86625,866 | $232,794 | 0.05% | NEW |
| 77 | BARCLAYS PLC | 24,72024,720 | $222,480 | 0.05% | TRIM -95% |
| 78 | DNB Asset Management AS | 23,51523,515 | $211,635 | 0.04% | ADD 84% |
| 79 | Entropy Technologies, LP | 23,33623,336 | $210,024 | 0.04% | NEW |
| 80 | DIADEMA PARTNERS LP | 21,60921,609 | $194,481 | 0.04% | ADD 5% |
| 81 | Man Group plc | 21,15421,154 | $190,386 | 0.04% | NEW |
| 82 | NISA INVESTMENT ADVISORS, LLC | 19,55819,558 | $176,022 | 0.04% | ADD 4790% |
| 83 | MetLife Investment Management, LLC | 19,38019,380 | $174,420 | 0.04% | — |
| 84 | WELLS FARGO & COMPANY/MN | 18,40218,402 | $165,618 | 0.03% | TRIM -50% |
| 85 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,96115,961 | $143,649 | 0.03% | TRIM -71% |
| 86 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,60815,608 | $140,472 | 0.03% | TRIM -11% |
| 87 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,33815,338 | $138,042 | 0.03% | ADD 51% |
| 88 | FRANKLIN RESOURCES INC | 14,58914,589 | $131,301 | 0.03% | NEW |
| 89 | Vanguard Global Advisers, LLC | 13,05913,059 | $117,531 | 0.02% | NEW |
| 90 | Corient Private Wealth LLC | 12,15712,157 | $109,413 | 0.02% | NEW |
| 91 | Creative Planning | 10,85010,850 | $97,650 | 0.02% | TRIM -8% |
| 92 | Virtus Investment Advisers, LLC | 10,04610,046 | $90,414 | 0.02% | ADD 2% |
| 93 | Shay Capital LLC | 10,00010,000 | $90,000 | 0.02% | NEW |
| 94 | STRS OHIO | 9,8009,800 | $88,200 | 0.02% | — |
| 95 | Legal & General Group Plc | 9,6099,609 | $86,481 | 0.02% | TRIM -30% |
| 96 | China Universal Asset Management Co., Ltd. | 9,5909,590 | $86,310 | 0.02% | ADD 9% |
| 97 | Police & Firemen's Retirement System of New Jersey | 9,4569,456 | $85,104 | 0.02% | — |
| 98 | VANGUARD ASSET MANAGEMENT, Ltd | 9,2509,250 | $83,250 | 0.02% | NEW |
| 99 | KLP KAPITALFORVALTNING AS | 5,9005,900 | $53,100 | 0.01% | ADD 103% |
| 100 | Persistent Asset Partners Ltd | 5,4955,495 | $49,455 | 0.01% | TRIM -38% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7.2M | 7.3M | 7.9M | 8.1M | 7.5M | 8.1M | $73M |
| ORBIMED ADVISORS LLC | 5.7M | 5.7M | 5.7M | 5.7M | 5.7M | 5.7M | $51M |
| BlackRock, Inc. | 1.1M | 1.2M | 2.1M | 2.6M | 3.3M | 3.4M | $30M |
| Decheng Capital LLC | 3.3M | 3.3M | 3.3M | 3.3M | 3.1M | 2.7M | $25M |
| ENAVATE SCIENCES GP, LLC | 2.5M | 2.5M | 2.5M | 2.5M | 2.5M | 2.5M | $22M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.9M | $17M |
| Y-Intercept (Hong Kong) Ltd | — | — | — | — | 47K | 1.0M | $9M |
| FEDERATED HERMES, INC. | — | — | — | — | 482 | 980K | $9M |
| GEODE CAPITAL MANAGEMENT, LLC | 363K | 411K | 647K | 817K | 852K | 951K | $9M |
| MILLENNIUM MANAGEMENT LLC | — | 62K | — | 40K | 517K | 937K | $8M |
| SEB Asset Management AB | — | — | — | — | — | 878K | $8M |
| Bain Capital Life Sciences Investors, LLC | 2.3M | 2.3M | 2.4M | 2.4M | 1.3M | 867K | $8M |
| Woodline Partners LP | 527K | 557K | 558K | 602K | 760K | 831K | $7M |
| D. E. Shaw & Co., Inc. | — | — | — | — | 27K | 820K | $7M |
| Parkman Healthcare Partners LLC | — | 234K | 716K | 844K | 835K | 787K | $7M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 140 | 44,886,514 | 82.5% | $404M |
| 2025-Q4 | 133 | 51,176,318 | 94.7% | $1.4B |
| 2025-Q3 | 95 | 44,491,763 | 82.5% | $837M |
| 2025-Q2 | 83 | 48,356,864 | 89.9% | $531M |
| 2025-Q1 | 79 | 46,279,367 | 86.3% | $267M |
| 2024-Q4 | 70 | 42,074,592 | 78.5% | $690M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +1,873,574 | $17M | OPEN |
| FEDERATED HERMES, INC. | +979,276 | $9M | ADD |
| Y-Intercept (Hong Kong) Ltd | +954,072 | $9M | ADD |
| SEB Asset Management AB | +878,473 | $8M | OPEN |
| D. E. Shaw & Co., Inc. | +793,389 | $7M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| NORGES BANK | −2,882,647 | $26M | CLOSE |
| VANGUARD GROUP INC | −2,388,439 | $21M | CLOSE |
| UBS Group AG | −1,574,989 | $14M | TRIM |
| JANUS HENDERSON GROUP PLC | −1,527,958 | $14M | CLOSE |
| Omega Fund Management, LLC | −1,326,293 | $12M | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Passive |
| 2025-09-30 |
| SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
