| 1 | 1Artisan Partners Limited Partnership | 6,367,7776.4M | $303M | 10.23% | ADD 9% |
| 2 | 2ARK Investment Management LLC | 6,342,7336.3M | $301M | 10.19% | TRIM -16% |
| 3 | 3BlackRock, Inc. | 5,554,3625.6M | $264M | 8.92% | TRIM -6% |
| 4 | 4EdgePoint Investment Group Inc. | 5,382,5215.4M | $256M | 8.64% | — |
| 5 | 5WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 5,269,7185.3M | $250M | 8.46% | TRIM -11% |
| 6 | 6STATE STREET CORP | 3,670,6823.7M | $174M | 5.89% | — |
| 7 | 7VANGUARD PORTFOLIO MANAGEMENT LLC | 2,649,1012.6M | $126M | 4.25% | NEW† |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 2,639,0442.6M | $125M | 4.24% | NEW† |
| 9 | 9Invesco Ltd. | 2,171,8982.2M | $103M | 3.49% | ADD 68% |
| 10 | 10FMR LLC | 1,889,9451.9M | $90M | 3.04% | ADD 2642% |
| 11 | 11GOLDMAN SACHS GROUP INC | 1,705,5461.7M | $81M | 2.74% | — |
| 12 | 12GEODE CAPITAL MANAGEMENT, LLC | 1,519,7131.5M | $72M | 2.44% | ADD 4% |
| 13 | 13Sumitomo Mitsui Trust Group, Inc. | 1,496,0991.5M | $71M | 2.40% | TRIM -21% |
| 14 | 14Amova Asset Management Americas, Inc. | 1,496,0991.5M | $71M | 2.40% | TRIM -21% |
| 15 | 15FARALLON CAPITAL MANAGEMENT LLC | 1,427,6501.4M | $68M | 2.29% | ADD 18562% |
| 16 | 16Thrivent Financial for Lutherans | 1,312,5441.3M | $62M | 2.11% | TRIM -4% |
| 17 | 17Soleus Capital Management, L.P. | 1,226,6291.2M | $58M | 1.97% | TRIM -34% |
| 18 | 18CITADEL ADVISORS LLC | 1,220,4001.2M | $58M | 1.96% | ADD 3708% |
| 19 | 19BAILLIE GIFFORD & CO | 1,215,1511.2M | $58M | 1.95% | TRIM -5% |
| 20 | 20First Light Asset Management, LLC | 878,848878,848 | $42M | 1.41% | TRIM -23% |
| 21 | 21Tao Capital Management LP | 828,815828,815 | $39M | 1.33% | — |
| 22 | 22UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 823,976823,976 | $39M | 1.32% | TRIM -30% |
| 23 | 23DIMENSIONAL FUND ADVISORS LP | 781,618781,618 | $37M | 1.26% | TRIM -4% |
| 24 | 24WELLINGTON MANAGEMENT GROUP LLP | 738,629738,629 | $35M | 1.19% | TRIM -9% |
| 25 | 25Balyasny Asset Management L.P. | 726,288726,288 | $35M | 1.17% | ADD 25% |
| 26 | 26NEW YORK STATE COMMON RETIREMENT FUND | 673,987673,987 | $32M | 1.08% | ADD 14% |
| 27 | 27Point72 Asset Management, L.P. | 669,732669,732 | $32M | 1.08% | NEW |
| 28 | 28JENNISON ASSOCIATES LLC | 605,188605,188 | $29M | 0.97% | TRIM -2% |
| 29 | 29BNP PARIBAS FINANCIAL MARKETS | 604,047604,047 | $29M | 0.97% | ADD 45% |
| 30 | 30JANE STREET GROUP, LLC | 601,163601,163 | $29M | 0.97% | NEW |
| 31 | 31Driehaus Capital Management LLC | 584,696584,696 | $28M | 0.94% | NEW |
| 32 | 32BANK OF AMERICA CORP /DE/ | 584,261584,261 | $28M | 0.94% | ADD 46% |
| 33 | 33MORGAN STANLEY | 546,845546,845 | $26M | 0.88% | TRIM -37% |
| 34 | 34CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 537,111537,111 | $26M | 0.86% | TRIM -2% |
| 35 | 35NORTHERN TRUST CORP | 527,966527,966 | $25M | 0.85% | ADD 5% |
| 36 | 36LOOMIS SAYLES & CO L P | 492,290492,290 | $23M | 0.79% | NEW |
| 37 | 37Allspring Global Investments Holdings, LLC | 455,446455,446 | $23M | 0.73% | NEW |
| 38 | 38CITIGROUP INC | 460,287460,287 | $22M | 0.74% | ADD 15% |
| 39 | 39UBS Group AG | 452,526452,526 | $22M | 0.73% | TRIM -32% |
| 40 | 40VANGUARD FIDUCIARY TRUST CO | 423,115423,115 | $20M | 0.68% | NEW |
| 41 | 41SEI INVESTMENTS CO | 354,420354,420 | $17M | 0.57% | ADD 31% |
| 42 | 42MILLENNIUM MANAGEMENT LLC | 350,604350,604 | $17M | 0.56% | TRIM -77% |
| 43 | 43Holocene Advisors, LP | 344,758344,758 | $16M | 0.55% | NEW |
| 44 | 44Nuveen, LLC | 293,655293,655 | $14M | 0.47% | — |
| 45 | 45IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 284,589284,589 | $14M | 0.46% | TRIM -23% |
| 46 | 46Blue Water Life Science Advisors, LP | 276,000276,000 | $13M | 0.44% | TRIM -28% |
| 47 | 47Freshford Capital Management, LLC | 258,982258,982 | $12M | 0.42% | TRIM -38% |
| 48 | 48Schonfeld Strategic Advisors LLC | 258,604258,604 | $12M | 0.42% | ADD 85% |
| 49 | 49SILVERCREST ASSET MANAGEMENT GROUP LLC | 244,025244,025 | $12M | 0.39% | TRIM -9% |
| 50 | 50Meridiem Capital Partners LP | 239,669239,669 | $11M | 0.38% | ADD 1030% |
| 51 | 51PEREGRINE CAPITAL MANAGEMENT LLC | 220,079220,079 | $10M | 0.35% | TRIM -24% |
| 52 | 52OSTERWEIS CAPITAL MANAGEMENT INC | 211,158211,158 | $10M | 0.34% | TRIM -18% |
| 53 | 53Duquesne Family Office LLC | 206,000206,000 | $10M | 0.33% | NEW |
| 54 | 54JPMORGAN CHASE & CO | 205,767205,767 | $9M | 0.33% | TRIM -4% |
| 55 | 55Bank of New York Mellon Corp | 180,817180,817 | $9M | 0.29% | — |
| 56 | 56Pictet Asset Management Holding SA | 185,992185,992 | $8M | 0.30% | TRIM -16% |
| 57 | 57Trexquant Investment LP | 170,107170,107 | $8M | 0.27% | TRIM -14% |
| 58 | 58Squarepoint Ops LLC | 153,526153,526 | $7M | 0.25% | ADD 330% |
| 59 | 59STATE OF MICHIGAN RETIREMENT SYSTEM | 153,172153,172 | $7M | 0.25% | — |
| 60 | 60NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 152,687152,687 | $7M | 0.25% | ADD 90% |
| 61 | 61PERCEPTIVE ADVISORS LLC | 150,000150,000 | $7M | 0.24% | NEW |
| 62 | 62ODDO BHF ASSET MANAGEMENT SAS | 145,960145,960 | $7M | 0.23% | ADD 8% |
| 63 | 63Universal- Beteiligungs- und Servicegesellschaft mbH | 131,265131,265 | $6M | 0.21% | ADD 102% |
| 64 | 64Legal & General Group Plc | 128,075128,075 | $6M | 0.21% | TRIM -25% |
| 65 | 65AQR CAPITAL MANAGEMENT LLC | 124,753124,753 | $6M | 0.20% | TRIM -4% |
| 66 | 66Swiss National Bank | 119,000119,000 | $6M | 0.19% | — |
| 67 | 67Vestmark Advisory Solutions, Inc. | 109,266109,266 | $5M | 0.18% | TRIM -16% |
| 68 | 68NEUBERGER BERMAN GROUP LLC | 108,300108,300 | $5M | 0.17% | TRIM -20% |
| 69 | 69Clearstead Advisors, LLC | 107,303107,303 | $5M | 0.17% | ADD 1239% |
| 70 | 70PRINCIPAL FINANCIAL GROUP INC | 106,712106,712 | $5M | 0.17% | NEW |
| 71 | 71FIRST TRUST ADVISORS LP | 104,650104,650 | $5M | 0.17% | NEW |
| 72 | 72Metavasi Capital LP | 100,000100,000 | $5M | 0.16% | NEW |
| 73 | 73LORD, ABBETT & CO. LLC | 99,63099,630 | $5M | 0.16% | NEW |
| 74 | 74Man Group plc | 96,47096,470 | $5M | 0.15% | NEW |
| 75 | 75Rafferty Asset Management, LLC | 96,25596,255 | $5M | 0.15% | TRIM -16% |
| 76 | 76FRED ALGER MANAGEMENT, LLC | 95,78395,783 | $5M | 0.15% | — |
| 77 | 77SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,31990,319 | $4M | 0.15% | ADD 28% |
| 78 | 78RHUMBLINE ADVISERS | 90,04490,044 | $4M | 0.14% | — |
| 79 | 79STEMPOINT CAPITAL LP | 86,22086,220 | $4M | 0.14% | TRIM -83% |
| 80 | 80MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 79,07879,078 | $4M | 0.13% | ADD 4% |
| 81 | 81Ensign Peak Advisors, Inc | 75,01275,012 | $4M | 0.12% | TRIM -65% |
| 82 | 82Aberdeen Group plc | 73,61973,619 | $3M | 0.12% | TRIM -76% |
| 83 | 83CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 70,34870,348 | $3M | 0.11% | ADD 21% |
| 84 | 84PRICE T ROWE ASSOCIATES INC /MD/ | 70,30570,305 | $3M | 0.11% | ADD 19% |
| 85 | 85Russell Investments Group, Ltd. | 66,56566,565 | $3M | 0.11% | ADD 197% |
| 86 | 86ENVESTNET ASSET MANAGEMENT INC | 65,55665,556 | $3M | 0.11% | ADD 70% |
| 87 | 87DEUTSCHE BANK AG\ | 64,53664,536 | $3M | 0.10% | ADD 16% |
| 88 | 88LAZARD ASSET MANAGEMENT LLC | 57,62857,628 | $3M | 0.09% | TRIM -13% |
| 89 | 89BLAIR WILLIAM & CO/IL | 57,41757,417 | $3M | 0.09% | TRIM -30% |
| 90 | 90LPL Financial LLC | 56,89056,890 | $3M | 0.09% | ADD 7% |
| 91 | 91Conestoga Capital Advisors, LLC | 56,78556,785 | $3M | 0.09% | — |
| 92 | 92Baird Financial Group, Inc. | 53,86753,867 | $3M | 0.09% | NEW |
| 93 | 93VANGUARD ASSET MANAGEMENT, Ltd | 52,22152,221 | $2M | 0.08% | NEW |
| 94 | 94FRANKLIN RESOURCES INC | 51,96051,960 | $2M | 0.08% | TRIM -4% |
| 95 | 95IEQ CAPITAL, LLC | 51,18451,184 | $2M | 0.08% | — |
| 96 | 96D. E. Shaw & Co., Inc. | 46,64446,644 | $2M | 0.07% | ADD 69% |
| 97 | 97VICTORY CAPITAL MANAGEMENT INC | 45,41145,411 | $2M | 0.07% | ADD 21% |
| 98 | 98ALLIANCEBERNSTEIN L.P. | 67,43767,437 | $2M | 0.11% | — |
| 99 | 99PROFUND ADVISORS LLC | 43,03943,039 | $2M | 0.07% | — |
| 100 | 100Mitsubishi UFJ Asset Management Co., Ltd. | 42,41842,418 | $2M | 0.07% | TRIM -5% |
