TRVI US Equity

Trevi Therapeutics, Inc.

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Health Care · Pharmaceutical Preparations · CIK 1563880 · FYE 1231

$18.09

-0.34 (-1.84%)

USD · as of 2026-07-29 · marketstack

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Institutional ownership· 13F filers holding TRVI · 2026-Q1 methodology → sources →

198 holders

% of shares outstanding held

95.0%

Shares held (13F)

134,937,154

Reporting holders

198

Top holders

largest 100 of 198 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	NEA Management Company, LLC	13,222,22813.2M	$158M	9.31%	—
2	BlackRock, Inc.	10,240,18610.2M	$122M	7.21%	—
3	Frazier Life Sciences Management, L.P.	9,939,5479.9M	$119M	7.00%	TRIM -3%
4	FMR LLC	8,038,0618.0M	$96M	5.66%	ADD 24%
5	WELLINGTON MANAGEMENT GROUP LLP	5,189,0885.2M	$62M	3.65%	ADD 52%
6	Vivo Capital, LLC	5,094,6685.1M	$61M	3.59%	—
7	VANGUARD CAPITAL MANAGEMENT LLC	4,978,5675.0M	$59M	3.51%	NEW†
8	MARSHALL WACE, LLP	3,966,0194.0M	$47M	2.79%	TRIM -13%
9	Rubric Capital Management LP	3,712,3733.7M	$44M	2.61%	—
10	MPM BIOIMPACT LLC	3,298,4303.3M	$39M	2.32%	—
11	VIKING GLOBAL INVESTORS LPtracked	3,198,6443.2M	$38M	2.25%	—
12	ALLIANCEBERNSTEIN L.P.	2,845,4722.8M	$36M	2.00%	TRIM -8%
13	GEODE CAPITAL MANAGEMENT, LLC	2,778,2312.8M	$33M	1.96%	ADD 15%
14	STATE STREET CORP	2,665,3132.7M	$32M	1.88%	ADD 9%
15	EVENTIDE ASSET MANAGEMENT, LLC	2,622,3062.6M	$31M	1.85%	—
16	ORBIMED ADVISORS LLC	2,454,4002.5M	$29M	1.73%	TRIM -23%
17	Logos Global Management LP	2,400,0002.4M	$29M	1.69%	ADD 55%
18	Vestal Point Capital, LP	2,166,5042.2M	$26M	1.53%	NEW
19	ACORN CAPITAL ADVISORS, LLC	2,144,8442.1M	$26M	1.51%	—
20	Artia Global Partners LP	2,013,6022.0M	$24M	1.42%	—
21	Affinity Asset Advisors, LLC	2,000,1722.0M	$24M	1.41%	TRIM -7%
22	FRONTIER CAPITAL MANAGEMENT CO LLC	1,994,2922.0M	$24M	1.40%	ADD 80%
23	EMERALD ADVISERS, LLC	1,839,5661.8M	$22M	1.30%	TRIM -3%
24	Siren, L.L.C.	1,786,8671.8M	$21M	1.26%	TRIM -22%
25	Pictet Asset Management Holding SA	1,706,0481.7M	$20M	1.20%	ADD 11%
26	RAYMOND JAMES FINANCIAL INC	1,687,9771.7M	$20M	1.19%	TRIM -4%
27	Soleus Capital Management, L.P.	1,620,0001.6M	$19M	1.14%	ADD 80%
28	Pivotal bioVenture Partners Investment Advisor LLC	1,553,7261.6M	$19M	1.09%	ADD 24%
29	Octagon Capital Advisors LP	1,485,0001.5M	$18M	1.05%	TRIM -47%
30	EMERALD MUTUAL FUND ADVISERS TRUST	1,262,4921.3M	$15M	0.89%	—
31	GOLDMAN SACHS GROUP INC	1,227,7721.2M	$15M	0.86%	ADD 16%
32	BANK OF AMERICA CORP /DE/	1,216,9551.2M	$15M	0.86%	ADD 11%
33	CITADEL ADVISORS LLC	1,201,4891.2M	$14M	0.85%	ADD 686%
34	NAN FUNG TRINITY (HK) LTD	1,142,9501.1M	$14M	0.81%	ADD 25%
35	FLPUTNAM INVESTMENT MANAGEMENT CO	1,063,3011.1M	$13M	0.75%	—
36	Woodline Partners LP	1,000,7821.0M	$12M	0.70%	—
37	VANGUARD PORTFOLIO MANAGEMENT LLC	968,588968,588	$12M	0.68%	NEW
38	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	840,572840,572	$10M	0.59%	—
39	NORTHERN TRUST CORP	806,659806,659	$10M	0.57%	ADD 6%
40	Candriam S.C.A.	773,620773,620	$9M	0.54%	NEW
41	MORGAN STANLEY	731,255731,255	$9M	0.52%	TRIM -30%
42	VANGUARD FIDUCIARY TRUST CO	714,631714,631	$9M	0.50%	NEW
43	PANAGORA ASSET MANAGEMENT INC	625,578625,578	$7M	0.44%	TRIM -10%
44	SPHERA FUNDS MANAGEMENT LTD.	574,029574,029	$7M	0.40%	TRIM -4%
45	MILLENNIUM MANAGEMENT LLC	570,971570,971	$7M	0.40%	—
46	PEREGRINE CAPITAL MANAGEMENT LLC	530,451530,451	$6M	0.37%	ADD 4%
47	Burkehill Global Management, LP	525,000525,000	$6M	0.37%	—
48	SILVERARC CAPITAL MANAGEMENT, LLC	511,127511,127	$6M	0.36%	TRIM -6%
49	AMERIPRISE FINANCIAL INC	504,836504,836	$6M	0.36%	ADD 56%
50	Balyasny Asset Management L.P.	473,849473,849	$6M	0.33%	ADD 171%
51	Ensign Peak Advisors, Inc	464,746464,746	$6M	0.33%	NEW
52	UBS Group AG	446,192446,192	$5M	0.31%	ADD 62%
53	KVP Capital Advisors, LP	414,000414,000	$5M	0.29%	—
54	Jones Hill Capital LP	370,175370,175	$4M	0.26%	NEW
55	Invesco Ltd.	352,984352,984	$4M	0.25%	TRIM -29%
56	Opaleye Management Inc.	345,100345,100	$4M	0.24%	—
57	GMT Capital Corp	317,700317,700	$4M	0.22%	NEW
58	Swiss Life Asset Management Ltd	21,42821,428	$4M	0.02%	NEW
59	Bank of New York Mellon Corp	260,161260,161	$3M	0.18%	—
60	SUPERSTRING CAPITAL MANAGEMENT LP	251,566251,566	$3M	0.18%	ADD 70%
61	J. Goldman & Co LP	236,959236,959	$3M	0.17%	TRIM -47%
62	F/m Investments LLC	231,602231,602	$3M	0.16%	TRIM -4%
63	SUSQUEHANNA INTERNATIONAL GROUP, LLP	227,688227,688	$3M	0.16%	TRIM -72%
64	Propel Bio Management, LLC	223,802223,802	$3M	0.16%	NEW
65	Nuveen, LLC	188,182188,182	$2M	0.13%	ADD 3%
66	D. E. Shaw & Co., Inc.	181,344181,344	$2M	0.13%	ADD 28%
67	Swiss National Bank	168,200168,200	$2M	0.12%	—
68	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	154,168154,168	$2M	0.11%	ADD 10%
69	STATE OF WISCONSIN INVESTMENT BOARD	134,731134,731	$2M	0.09%	ADD 12%
70	TRUST CO OF TOLEDO NA /OH/	131,502131,502	$2M	0.09%	ADD 260%
71	FIFTH THIRD BANCORP	128,325128,325	$2M	0.09%	NEW
72	RHUMBLINE ADVISERS	109,061109,061	$1M	0.08%	ADD 3%
73	Squarepoint Ops LLC	103,967103,967	$1M	0.07%	NEW
74	OPPENHEIMER & CO INC	100,027100,027	$1M	0.07%	—
75	LMR Partners LLP	100,000100,000	$1M	0.07%	—
76	CITIGROUP INC	99,94999,949	$1M	0.07%	TRIM -19%
77	WEXFORD CAPITAL LP	90,75290,752	$1M	0.06%	ADD 11%
78	DEUTSCHE BANK AG\	84,75584,755	$1M	0.06%	ADD 20%
79	Erste Asset Management GmbH	90,00090,000	$1M	0.06%	—
80	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	83,39183,391	$994,855	0.06%	—
81	LPL Financial LLC	80,88380,883	$964,934	0.06%	ADD 53%
82	ExodusPoint Capital Management, LP	79,85979,859	$952,718	0.06%	NEW
83	PFS Partners, LLC	79,00079,000	$942,470	0.06%	—
84	SECTORAL ASSET MANAGEMENT INC	74,44674,446	$939,499	0.05%	TRIM -12%
85	SEI INVESTMENTS CO	78,22278,222	$933,187	0.06%	TRIM -47%
86	Russell Investments Group, Ltd.	68,12068,120	$812,680	0.05%	ADD 15%
87	JPMORGAN CHASE & CO	70,63170,631	$790,362	0.05%	ADD 19%
88	Simplify Asset Management Inc.	65,41265,412	$780,365	0.05%	NEW
89	MAI Capital Management	65,12565,125	$776,942	0.05%	TRIM -16%
90	PRICE T ROWE ASSOCIATES INC /MD/	64,70364,703	$772,000	0.05%	ADD 29%
91	TUDOR INVESTMENT CORP ET AL	64,52464,524	$769,771	0.05%	TRIM -6%
92	Legal & General Group Plc	63,81963,819	$761,361	0.04%	TRIM -22%
93	WealthTrust Axiom LLC	61,50061,500	$733,695	0.04%	—
94	KENNEDY CAPITAL MANAGEMENT LLC	61,29861,298	$731,285	0.04%	ADD 9%
95	Zurcher Kantonalbank (Zurich Cantonalbank)	59,86259,862	$714,154	0.04%	ADD 28%
96	Vanguard Global Advisers, LLC	58,90058,900	$702,677	0.04%	NEW
97	BARCLAYS PLC	53,58553,585	$639,268	0.04%	TRIM -91%
98	HighVista Strategies LLC	53,52553,525	$638,553	0.04%	TRIM -50%
99	VANGUARD ASSET MANAGEMENT, Ltd	53,25453,254	$635,320	0.04%	NEW
100	MetLife Investment Management, LLC	51,81451,814	$618,141	0.04%	ADD 3%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

NEA Management Company, LLC

11.4M

13.2M

$158M

BlackRock, Inc.

3.9M

5.3M

8.2M

9.9M

10.1M

10.2M

$122M

Frazier Life Sciences Management, L.P.

10.7M

10.3M

9.9M

$119M

FMR LLC

369K

3.3M

6.5M

8.0M

$96M

WELLINGTON MANAGEMENT GROUP LLP

—

127K

172K

3.3M

3.4M

5.2M

$62M

Vivo Capital, LLC

3.5M

4.5M

5.1M

$61M

VANGUARD CAPITAL MANAGEMENT LLC

—

5.0M

$59M

MARSHALL WACE, LLP

43K

2.6M

2.5M

4.8M

4.6M

4.0M

$47M

Rubric Capital Management LP

4.2M

4.5M

8.5M

3.8M

3.7M

$44M

MPM BIOIMPACT LLC

3.1M

3.4M

3.3M

$39M

VIKING GLOBAL INVESTORS LPtracked

4.4M

3.2M

1.5M

5.1M

3.2M

$38M

ALLIANCEBERNSTEIN L.P.

15K

22K

4.3M

3.1M

2.8M

$36M

GEODE CAPITAL MANAGEMENT, LLC

1.3M

1.6M

1.8M

2.2M

2.4M

2.8M

$33M

STATE STREET CORP

1.2M

1.4M

1.8M

2.2M

2.4M

2.7M

$32M

EVENTIDE ASSET MANAGEMENT, LLC

—

1.4M

2.6M

$31M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	198	134,937,154	95.0%	$1.6B
2025-Q4	184	130,341,496	91.8%	$1.6B
2025-Q3	164	129,382,778	91.1%	$1.2B
2025-Q2	154	115,477,319	81.3%	$632M
2025-Q1	137	88,150,165	62.1%	$554M
2024-Q4	110	79,497,051	56.0%	$330M
2024-Q3	93	58,220,491	41.0%	$194M
2024-Q2	77	58,738,070	41.4%	$175M
2024-Q1

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · TRVI

Activists — 13D, active intent

New Enterprise Associates 16, L.P.10.5%▼ -1.1ppSCHEDULE 13D/A · Amd 9 · event 2026-05-05SEC →

15,074,080 shares · 13 reporting persons

“The Funds acquired the Firm Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer, including shares that may be acquired upon exercise of the NEA 16 Warrants prior to expiration. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acq”

Large holders — 13G, passive (top 5 of 9 by % of class)

Holder	% of class	Type	As of
Frazier Life Sciences Public Fund, L.P.	7%	Passive	2025-09-30	SEC →
FMR LLC	6.3%	QII	2026-03-31	SEC →

Institutional ownership· 13F filers holding TRVI · 2026-Q1 methodology → sources →

198 holders

% of shares outstanding held

95.0%

Shares held (13F)

134,937,154

Reporting holders

198

Top holders

largest 100 of 198 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	NEA Management Company, LLC	13,222,22813.2M	$158M	9.31%	—
2	BlackRock, Inc.	10,240,18610.2M	$122M	7.21%	—
3	Frazier Life Sciences Management, L.P.	9,939,5479.9M	$119M	7.00%	TRIM -3%
4	FMR LLC	8,038,0618.0M	$96M	5.66%	ADD 24%
5	WELLINGTON MANAGEMENT GROUP LLP	5,189,0885.2M	$62M	3.65%	ADD 52%
6	Vivo Capital, LLC	5,094,6685.1M	$61M	3.59%	—
7	VANGUARD CAPITAL MANAGEMENT LLC	4,978,5675.0M	$59M	3.51%	NEW†
8	MARSHALL WACE, LLP	3,966,0194.0M	$47M	2.79%	TRIM -13%
9	Rubric Capital Management LP	3,712,3733.7M	$44M	2.61%	—
10	MPM BIOIMPACT LLC	3,298,4303.3M	$39M	2.32%	—
11	VIKING GLOBAL INVESTORS LPtracked	3,198,6443.2M	$38M	2.25%	—
12	ALLIANCEBERNSTEIN L.P.	2,845,4722.8M	$36M	2.00%	TRIM -8%
13	GEODE CAPITAL MANAGEMENT, LLC	2,778,2312.8M	$33M	1.96%	ADD 15%
14	STATE STREET CORP	2,665,3132.7M	$32M	1.88%	ADD 9%
15	EVENTIDE ASSET MANAGEMENT, LLC	2,622,3062.6M	$31M	1.85%	—
16	ORBIMED ADVISORS LLC	2,454,4002.5M	$29M	1.73%	TRIM -23%
17	Logos Global Management LP	2,400,0002.4M	$29M	1.69%	ADD 55%
18	Vestal Point Capital, LP	2,166,5042.2M	$26M	1.53%	NEW
19	ACORN CAPITAL ADVISORS, LLC	2,144,8442.1M	$26M	1.51%	—
20	Artia Global Partners LP	2,013,6022.0M	$24M	1.42%	—
21	Affinity Asset Advisors, LLC	2,000,1722.0M	$24M	1.41%	TRIM -7%
22	FRONTIER CAPITAL MANAGEMENT CO LLC	1,994,2922.0M	$24M	1.40%	ADD 80%
23	EMERALD ADVISERS, LLC	1,839,5661.8M	$22M	1.30%	TRIM -3%
24	Siren, L.L.C.	1,786,8671.8M	$21M	1.26%	TRIM -22%
25	Pictet Asset Management Holding SA	1,706,0481.7M	$20M	1.20%	ADD 11%
26	RAYMOND JAMES FINANCIAL INC	1,687,9771.7M	$20M	1.19%	TRIM -4%
27	Soleus Capital Management, L.P.	1,620,0001.6M	$19M	1.14%	ADD 80%
28	Pivotal bioVenture Partners Investment Advisor LLC	1,553,7261.6M	$19M	1.09%	ADD 24%
29	Octagon Capital Advisors LP	1,485,0001.5M	$18M	1.05%	TRIM -47%
30	EMERALD MUTUAL FUND ADVISERS TRUST	1,262,4921.3M	$15M	0.89%	—
31	GOLDMAN SACHS GROUP INC	1,227,7721.2M	$15M	0.86%	ADD 16%
32	BANK OF AMERICA CORP /DE/	1,216,9551.2M	$15M	0.86%	ADD 11%
33	CITADEL ADVISORS LLC	1,201,4891.2M	$14M	0.85%	ADD 686%
34	NAN FUNG TRINITY (HK) LTD	1,142,9501.1M	$14M	0.81%	ADD 25%
35	FLPUTNAM INVESTMENT MANAGEMENT CO	1,063,3011.1M	$13M	0.75%	—
36	Woodline Partners LP	1,000,7821.0M	$12M	0.70%	—
37	VANGUARD PORTFOLIO MANAGEMENT LLC	968,588968,588	$12M	0.68%	NEW
38	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	840,572840,572	$10M	0.59%	—
39	NORTHERN TRUST CORP	806,659806,659	$10M	0.57%	ADD 6%
40	Candriam S.C.A.	773,620773,620	$9M	0.54%	NEW
41	MORGAN STANLEY	731,255731,255	$9M	0.52%	TRIM -30%
42	VANGUARD FIDUCIARY TRUST CO	714,631714,631	$9M	0.50%	NEW
43	PANAGORA ASSET MANAGEMENT INC	625,578625,578	$7M	0.44%	TRIM -10%
44	SPHERA FUNDS MANAGEMENT LTD.	574,029574,029	$7M	0.40%	TRIM -4%
45	MILLENNIUM MANAGEMENT LLC	570,971570,971	$7M	0.40%	—
46	PEREGRINE CAPITAL MANAGEMENT LLC	530,451530,451	$6M	0.37%	ADD 4%
47	Burkehill Global Management, LP	525,000525,000	$6M	0.37%	—
48	SILVERARC CAPITAL MANAGEMENT, LLC	511,127511,127	$6M	0.36%	TRIM -6%
49	AMERIPRISE FINANCIAL INC	504,836504,836	$6M	0.36%	ADD 56%
50	Balyasny Asset Management L.P.	473,849473,849	$6M	0.33%	ADD 171%
51	Ensign Peak Advisors, Inc	464,746464,746	$6M	0.33%	NEW
52	UBS Group AG	446,192446,192	$5M	0.31%	ADD 62%
53	KVP Capital Advisors, LP	414,000414,000	$5M	0.29%	—
54	Jones Hill Capital LP	370,175370,175	$4M	0.26%	NEW
55	Invesco Ltd.	352,984352,984	$4M	0.25%	TRIM -29%
56	Opaleye Management Inc.	345,100345,100	$4M	0.24%	—
57	GMT Capital Corp	317,700317,700	$4M	0.22%	NEW
58	Swiss Life Asset Management Ltd	21,42821,428	$4M	0.02%	NEW
59	Bank of New York Mellon Corp	260,161260,161	$3M	0.18%	—
60	SUPERSTRING CAPITAL MANAGEMENT LP	251,566251,566	$3M	0.18%	ADD 70%
61	J. Goldman & Co LP	236,959236,959	$3M	0.17%	TRIM -47%
62	F/m Investments LLC	231,602231,602	$3M	0.16%	TRIM -4%
63	SUSQUEHANNA INTERNATIONAL GROUP, LLP	227,688227,688	$3M	0.16%	TRIM -72%
64	Propel Bio Management, LLC	223,802223,802	$3M	0.16%	NEW
65	Nuveen, LLC	188,182188,182	$2M	0.13%	ADD 3%
66	D. E. Shaw & Co., Inc.	181,344181,344	$2M	0.13%	ADD 28%
67	Swiss National Bank	168,200168,200	$2M	0.12%	—
68	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	154,168154,168	$2M	0.11%	ADD 10%
69	STATE OF WISCONSIN INVESTMENT BOARD	134,731134,731	$2M	0.09%	ADD 12%
70	TRUST CO OF TOLEDO NA /OH/	131,502131,502	$2M	0.09%	ADD 260%
71	FIFTH THIRD BANCORP	128,325128,325	$2M	0.09%	NEW
72	RHUMBLINE ADVISERS	109,061109,061	$1M	0.08%	ADD 3%
73	Squarepoint Ops LLC	103,967103,967	$1M	0.07%	NEW
74	OPPENHEIMER & CO INC	100,027100,027	$1M	0.07%	—
75	LMR Partners LLP	100,000100,000	$1M	0.07%	—
76	CITIGROUP INC	99,94999,949	$1M	0.07%	TRIM -19%
77	WEXFORD CAPITAL LP	90,75290,752	$1M	0.06%	ADD 11%
78	DEUTSCHE BANK AG\	84,75584,755	$1M	0.06%	ADD 20%
79	Erste Asset Management GmbH	90,00090,000	$1M	0.06%	—
80	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	83,39183,391	$994,855	0.06%	—
81	LPL Financial LLC	80,88380,883	$964,934	0.06%	ADD 53%
82	ExodusPoint Capital Management, LP	79,85979,859	$952,718	0.06%	NEW
83	PFS Partners, LLC	79,00079,000	$942,470	0.06%	—
84	SECTORAL ASSET MANAGEMENT INC	74,44674,446	$939,499	0.05%	TRIM -12%
85	SEI INVESTMENTS CO	78,22278,222	$933,187	0.06%	TRIM -47%
86	Russell Investments Group, Ltd.	68,12068,120	$812,680	0.05%	ADD 15%
87	JPMORGAN CHASE & CO	70,63170,631	$790,362	0.05%	ADD 19%
88	Simplify Asset Management Inc.	65,41265,412	$780,365	0.05%	NEW
89	MAI Capital Management	65,12565,125	$776,942	0.05%	TRIM -16%
90	PRICE T ROWE ASSOCIATES INC /MD/	64,70364,703	$772,000	0.05%	ADD 29%
91	TUDOR INVESTMENT CORP ET AL	64,52464,524	$769,771	0.05%	TRIM -6%
92	Legal & General Group Plc	63,81963,819	$761,361	0.04%	TRIM -22%
93	WealthTrust Axiom LLC	61,50061,500	$733,695	0.04%	—
94	KENNEDY CAPITAL MANAGEMENT LLC	61,29861,298	$731,285	0.04%	ADD 9%
95	Zurcher Kantonalbank (Zurich Cantonalbank)	59,86259,862	$714,154	0.04%	ADD 28%
96	Vanguard Global Advisers, LLC	58,90058,900	$702,677	0.04%	NEW
97	BARCLAYS PLC	53,58553,585	$639,268	0.04%	TRIM -91%
98	HighVista Strategies LLC	53,52553,525	$638,553	0.04%	TRIM -50%
99	VANGUARD ASSET MANAGEMENT, Ltd	53,25453,254	$635,320	0.04%	NEW
100	MetLife Investment Management, LLC	51,81451,814	$618,141	0.04%	ADD 3%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

NEA Management Company, LLC

11.4M

13.2M

$158M

BlackRock, Inc.

3.9M

5.3M

8.2M

9.9M

10.1M

10.2M

$122M

Frazier Life Sciences Management, L.P.

10.7M

10.3M

9.9M

$119M

FMR LLC

369K

3.3M

6.5M

8.0M

$96M

WELLINGTON MANAGEMENT GROUP LLP

—

127K

172K

3.3M

3.4M

5.2M

$62M

Vivo Capital, LLC

3.5M

4.5M

5.1M

$61M

VANGUARD CAPITAL MANAGEMENT LLC

—

5.0M

$59M

MARSHALL WACE, LLP

43K

2.6M

2.5M

4.8M

4.6M

4.0M

$47M

Rubric Capital Management LP

4.2M

4.5M

8.5M

3.8M

3.7M

$44M

MPM BIOIMPACT LLC

3.1M

3.4M

3.3M

$39M

VIKING GLOBAL INVESTORS LPtracked

4.4M

3.2M

1.5M

5.1M

3.2M

$38M

ALLIANCEBERNSTEIN L.P.

15K

22K

4.3M

3.1M

2.8M

$36M

GEODE CAPITAL MANAGEMENT, LLC

1.3M

1.6M

1.8M

2.2M

2.4M

2.8M

$33M

STATE STREET CORP

1.2M

1.4M

1.8M

2.2M

2.4M

2.7M

$32M

EVENTIDE ASSET MANAGEMENT, LLC

—

1.4M

2.6M

$31M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	198	134,937,154	95.0%	$1.6B
2025-Q4	184	130,341,496	91.8%	$1.6B
2025-Q3	164	129,382,778	91.1%	$1.2B
2025-Q2	154	115,477,319	81.3%	$632M
2025-Q1	137	88,150,165	62.1%	$554M
2024-Q4	110	79,497,051	56.0%	$330M
2024-Q3	93	58,220,491	41.0%	$194M
2024-Q2	77	58,738,070	41.4%	$175M
2024-Q1

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · TRVI

Activists — 13D, active intent

New Enterprise Associates 16, L.P.10.5%▼ -1.1ppSCHEDULE 13D/A · Amd 9 · event 2026-05-05SEC →

15,074,080 shares · 13 reporting persons

Large holders — 13G, passive (top 5 of 9 by % of class)

Holder	% of class	Type	As of
Frazier Life Sciences Public Fund, L.P.	7%	Passive	2025-09-30	SEC →
FMR LLC	6.3%	QII	2026-03-31	SEC →

TRVI US Equity☆

Institutional ownership· 13F filers holding TRVI · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · TRVI

Institutional ownership· 13F filers holding TRVI · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · TRVI

TRVI US Equity