| 1 | 1PRICE T ROWE ASSOCIATES INC /MD/ | 2,951,1163.0M | $47M | 7.53% | NEW† |
| 2 | 2JANUS HENDERSON GROUP PLC | 1,815,4741.8M | $29M | 4.63% | ADD 989% |
| 3 | 3Venrock Adviser, LLC | 1,675,2621.7M | $27M | 4.27% | NEW† |
| 4 | 4PERCEPTIVE ADVISORS LLC | 1,447,7821.4M | $23M | 3.69% | ADD 230% |
| 5 | 5Ikarian Capital, LLC | 1,017,6001.0M | $16M | 2.59% | ADD 5% |
| 6 | 6Stonepine Capital Management, LLC | 975,200975,200 | $16M | 2.49% | ADD 8106% |
| 7 | 7Logos Global Management LP | 625,000625,000 | $10M | 1.59% | NEW |
| 8 | 8MORGAN STANLEY | 596,564596,564 | $10M | 1.52% | — |
| 9 | 9Velan Capital Investment Management LP | 583,333583,333 | $9M | 1.49% | ADD 600% |
| 10 | 10ADAGE CAPITAL PARTNERS GP, L.L.C. | 540,126540,126 | $9M | 1.38% | ADD 548% |
| 11 | 11Point72 Asset Management, L.P. | 533,965533,965 | $9M | 1.36% | ADD 26% |
| 12 | 12MILLENNIUM MANAGEMENT LLC | 533,889533,889 | $9M | 1.36% | ADD 77% |
| 13 | 13ARMISTICE CAPITAL, LLC | 478,827478,827 | $8M | 1.22% | NEW |
| 14 | 14Avidity Partners Management LP | 481,868481,868 | $7M | 1.23% | NEW |
| 15 | 15Siren, L.L.C. | 427,141427,141 | $7M | 1.09% | — |
| 16 | 16TD Asset Management Inc | 399,184399,184 | $6M | 1.02% | NEW |
| 17 | 17UBS Group AG | 381,419381,419 | $6M | 0.97% | ADD 56323% |
| 18 | 18STEMPOINT CAPITAL LP | 377,400377,400 | $6M | 0.96% | NEW |
| 19 | 19RTW INVESTMENTS, LP | 370,246370,246 | $6M | 0.94% | TRIM -2% |
| 20 | 20BOOTHBAY FUND MANAGEMENT, LLC | 366,791366,791 | $6M | 0.94% | ADD 4% |
| 21 | 21MARSHALL WACE, LLP | 352,572352,572 | $6M | 0.90% | ADD 18% |
| 22 | 22BVF INC/IL | 339,549339,549 | $5M | 0.87% | — |
| 23 | 23GREAT POINT PARTNERS LLC | 327,307327,307 | $5M | 0.83% | NEW |
| 24 | 24Woodline Partners LP | 323,911323,911 | $5M | 0.83% | ADD 126% |
| 25 | 25FMR LLC | 322,600322,600 | $5M | 0.82% | ADD 129% |
| 26 | 26AMERIPRISE FINANCIAL INC | 279,537279,537 | $4M | 0.71% | NEW |
| 27 | 27VANGUARD CAPITAL MANAGEMENT LLC | 263,421263,421 | $4M | 0.67% | NEW |
| 28 | 28ADAR1 Capital Management, LLC | 213,462213,462 | $3M | 0.54% | ADD 235% |
| 29 | 29Vivo Capital, LLC | 208,333208,333 | $3M | 0.53% | — |
| 30 | 30BOONE CAPITAL MANAGEMENT LLC | 200,000200,000 | $3M | 0.51% | NEW |
| 31 | 31Balyasny Asset Management L.P. | 194,616194,616 | $3M | 0.50% | NEW |
| 32 | 32DIADEMA PARTNERS LP | 179,738179,738 | $3M | 0.46% | TRIM -26% |
| 33 | 33Integral Health Asset Management, LLC | 167,000167,000 | $3M | 0.43% | — |
| 34 | 34RENAISSANCE TECHNOLOGIES LLC | 152,600152,600 | $2M | 0.39% | ADD 22% |
| 35 | 35CITADEL ADVISORS LLC | 152,516152,516 | $2M | 0.39% | ADD 18% |
| 36 | 36SPHERA FUNDS MANAGEMENT LTD. | 136,015136,015 | $2M | 0.35% | TRIM -28% |
| 37 | 37ExodusPoint Capital Management, LP | 120,529120,529 | $2M | 0.31% | NEW |
| 38 | 38Sofinnova Investments, Inc. | 104,400104,400 | $2M | 0.27% | NEW |
| 39 | 39Verdad Advisers, LP | 95,33095,330 | $2M | 0.24% | NEW |
| 40 | 40GEODE CAPITAL MANAGEMENT, LLC | 69,16069,160 | $1M | 0.18% | ADD 24% |
| 41 | 41TWO SIGMA INVESTMENTS, LP | 68,58868,588 | $1M | 0.17% | ADD 105% |
| 42 | 42DIMENSIONAL FUND ADVISORS LP | 62,78662,786 | $1M | 0.16% | NEW |
| 43 | 43Persistent Asset Partners Ltd | 58,18258,182 | $930,330 | 0.15% | TRIM -11% |
| 44 | 44Vestal Point Capital, LP | 53,43953,439 | $854,490 | 0.14% | — |
| 45 | 45Trexquant Investment LP | 50,71250,712 | $810,885 | 0.13% | NEW |
| 46 | 46XTX Topco Ltd | 47,85147,851 | $765,137 | 0.12% | NEW |
| 47 | 47Creek Drive Management Group LLC | 45,00045,000 | $719,550 | 0.11% | NEW |
| 48 | 48BRIDGEWAY CAPITAL MANAGEMENT, LLC | 44,90044,900 | $717,951 | 0.11% | — |
| 49 | 49Artia Global Partners LP | 42,08042,080 | $672,859 | 0.11% | — |
| 50 | 50HRT FINANCIAL LP | 41,81941,819 | $668,000 | 0.11% | NEW |
| 51 | 51JANE STREET GROUP, LLC | 33,62833,628 | $537,712 | 0.09% | NEW |
| 52 | 52VANGUARD FIDUCIARY TRUST CO | 33,43033,430 | $534,546 | 0.09% | NEW |
| 53 | 53GOLDMAN SACHS GROUP INC | 31,85431,854 | $509,345 | 0.08% | ADD 42% |
| 54 | 54MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,33631,336 | $501,063 | 0.08% | NEW |
| 55 | 55BNP PARIBAS FINANCIAL MARKETS | 30,64730,647 | $490,046 | 0.08% | ADD 100% |
| 56 | 56STATE STREET CORP | 28,99028,990 | $463,550 | 0.07% | NEW |
| 57 | 57SUSQUEHANNA INTERNATIONAL GROUP, LLP | 28,97728,977 | $463,342 | 0.07% | NEW |
| 58 | 58Qube Research & Technologies Ltd | 28,28528,285 | $452,277 | 0.07% | NEW |
| 59 | 59BANK OF AMERICA CORP /DE/ | 18,56918,569 | $296,918 | 0.05% | ADD 391% |
| 60 | 60BlackRock, Inc. | 16,97716,977 | $271,462 | 0.04% | — |
| 61 | 61BARCLAYS PLC | 16,69816,698 | $267,001 | 0.04% | NEW |
| 62 | 62Quadrature Capital Ltd | 15,47215,472 | $247,397 | 0.04% | TRIM -25% |
| 63 | 63Verition Fund Management LLC | 13,58913,589 | $217,288 | 0.03% | NEW |
| 64 | 64Corient Private Wealth LLC | 12,38812,388 | $198,084 | 0.03% | TRIM -50% |
| 65 | 65NORTHERN TRUST CORP | 12,04912,049 | $192,664 | 0.03% | NEW |
| 66 | 66LETKO, BROSSEAU & ASSOCIATES INC | 10,65010,650 | $170,294 | 0.03% | — |
| 67 | 67JPMORGAN CHASE & CO | 9,4189,418 | $131,946 | 0.02% | ADD 944% |
| 68 | 68ACADIAN ASSET MANAGEMENT LLC | 4,5024,502 | $71,000 | 0.01% | NEW |
| 69 | 69Vanguard Global Advisers, LLC | 3,2993,299 | $52,751 | 0.01% | NEW |
| 70 | 70Rockefeller Capital Management L.P. | 2,5012,501 | $39,991 | 0.01% | ADD 250000% |
| 71 | 71Tower Research Capital LLC (TRC) | 1,1001,100 | $17,589 | 0.00% | ADD 453% |
| 72 | 72Caitong International Asset Management Co., Ltd | 5757 | $911 | 0.00% | NEW |
| 73 | 73CITIGROUP INC | 11 | $16 | 0.00% | — |
| 74 | 74MAI Capital Management | 11 | $16 | 0.00% | NEW |
| 75 | 75Allworth Financial LP | 11 | $16 | 0.00% | — |
| 76 | 76Physician Wealth Advisors, Inc. | 11 | $16 | 0.00% | — |
| 77 | 77Titiun Yejiel | 11 | $16 | 0.00% | — |
| 78 | 78JONES FINANCIAL COMPANIES LLLP | 11 | $15 | 0.00% | — |
| 79 | 79Union Bancaire Privee, UBP SA | 11 | $11 | 0.00% | — |
| 80 | 80ROYAL BANK OF CANADA | 44 | $0 | 0.00% | NEW |