| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | TCG Crossover Management, LLC | 1,473,1011.5M | $43M | 12.69% | NEW† |
| 2 | Kalehua Capital Management LLC | 770,356770,356 | $22M | 6.64% | ADD 100% |
| 3 | Boxer Capital Management, LLC | 766,318766,318 | $22M | 6.60% | ADD 84% |
| 4 | MILLENNIUM MANAGEMENT LLC | 731,138731,138 | $21M | 6.30% | — |
| 5 | STEMPOINT CAPITAL LP | 721,620721,620 | $19M | 6.22% | ADD 16% |
| 6 | Venrock Adviser, LLC | 632,931632,931 | $18M | 5.45% | — |
| 7 | Spruce Street Capital LP | 432,040432,040 | $13M | 3.72% | — |
| 8 | BRAIDWELL LP | 396,100396,100 | $12M | 3.41% | TRIM -16% |
| 9 | 5AM Venture Management, LLC | 387,500387,500 | $11M | 3.34% | — |
| 10 | Vestal Point Capital, LP | 338,611338,611 | $10M | 2.92% | NEW† |
| 11 | Vivo Capital, LLC | 260,000260,000 | $8M | 2.24% | — |
| 12 | PERCEPTIVE ADVISORS LLC | 229,393229,393 | $7M | 1.98% | NEW |
| 13 | Woodline Partners LP | 227,848227,848 | $7M | 1.96% | — |
| 14 | Balyasny Asset Management L.P. | 203,888203,888 | $6M | 1.76% | ADD 7% |
| 15 | Ikarian Capital, LLC | 173,107173,107 | $5M | 1.49% | ADD 163% |
| 16 | ACUTA CAPITAL PARTNERS, LLC | 172,847172,847 | $5M | 1.49% | TRIM -3% |
| 17 | VANGUARD CAPITAL MANAGEMENT LLC | 169,092169,092 | $5M | 1.46% | NEW |
| 18 | AMERIPRISE FINANCIAL INC | 159,711159,711 | $5M | 1.38% | ADD 143% |
| 19 | SILVERARC CAPITAL MANAGEMENT, LLC | 144,255144,255 | $4M | 1.24% | TRIM -8% |
| 20 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 133,207133,207 | $4M | 1.15% | TRIM -50% |
| 21 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 88,65388,653 | $3M | 0.76% | — |
| 22 | Euclidean Capital LLC | 87,69687,696 | $3M | 0.76% | — |
| 23 | FRED ALGER MANAGEMENT, LLC | 71,69771,697 | $2M | 0.62% | TRIM -28% |
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 65,84965,849 | $2M | 0.57% | — |
| 25 | Eversept Partners, LP | 58,62458,624 | $2M | 0.50% | TRIM -38% |
| 26 | ArrowMark Colorado Holdings LLC | 55,12355,123 | $2M | 0.47% | — |
| 27 | RENAISSANCE TECHNOLOGIES LLC | 49,12649,126 | $1M | 0.42% | ADD 117% |
| 28 | BOOTHBAY FUND MANAGEMENT, LLC | 47,29947,299 | $1M | 0.41% | ADD 158% |
| 29 | TWO SIGMA INVESTMENTS, LP | 39,48239,482 | $1M | 0.34% | NEW |
| 30 | CITADEL ADVISORS LLC | 35,46935,469 | $1M | 0.31% | ADD 141% |
| 31 | VANGUARD FIDUCIARY TRUST CO | 35,39035,390 | $1M | 0.30% | NEW |
| 32 | Stonepine Capital Management, LLC | 33,00533,005 | $961,436 | 0.28% | TRIM -71% |
| 33 | 683 Capital Management, LLC | 33,00033,000 | $961,290 | 0.28% | TRIM -21% |
| 34 | BlackRock, Inc. | 27,85127,851 | $811,299 | 0.24% | ADD 7% |
| 35 | STATE STREET CORP | 27,72627,726 | $807,658 | 0.24% | ADD 14% |
| 36 | GOLDMAN SACHS GROUP INC | 25,85125,851 | $753,040 | 0.22% | — |
| 37 | LMR Partners LLP | 23,55723,557 | $686,215 | 0.20% | — |
| 38 | MORGAN STANLEY | 22,44622,446 | $653,851 | 0.19% | TRIM -39% |
| 39 | PRICE T ROWE ASSOCIATES INC /MD/ | 21,71521,715 | $633,000 | 0.19% | — |
| 40 | UBS Group AG | 21,24721,247 | $618,925 | 0.18% | ADD 35912% |
| 41 | MARSHALL WACE, LLP | 18,93018,930 | $551,431 | 0.16% | ADD 73% |
| 42 | Qube Research & Technologies Ltd | 14,51614,516 | $422,851 | 0.13% | NEW |
| 43 | NORTHERN TRUST CORP | 12,26512,265 | $357,279 | 0.11% | TRIM -9% |
| 44 | HRT FINANCIAL LP | 12,15512,155 | $354,000 | 0.10% | NEW |
| 45 | ADAR1 Capital Management, LLC | 12,00012,000 | $349,560 | 0.10% | NEW |
| 46 | Alyeska Investment Group, L.P. | 10,18810,188 | $296,776 | 0.09% | — |
| 47 | Hudson Bay Capital Management LP | 8,6538,653 | $252,062 | 0.07% | NEW |
| 48 | BNP PARIBAS FINANCIAL MARKETS | 7,3257,325 | $213,377 | 0.06% | ADD 191% |
| 49 | Persistent Asset Partners Ltd | 7,1437,143 | $208,076 | 0.06% | ADD 64% |
| 50 | JANE STREET GROUP, LLC | 7,0917,091 | $206,561 | 0.06% | TRIM -74% |
| 51 | Vanguard Global Advisers, LLC | 2,5702,570 | $74,864 | 0.02% | NEW |
| 52 | China Universal Asset Management Co., Ltd. | 2,5002,500 | $72,825 | 0.02% | ADD 67% |
| 53 | BARCLAYS PLC | 1,8881,888 | $54,998 | 0.02% | NEW |
| 54 | ACADIAN ASSET MANAGEMENT LLC | 1,5081,508 | $43,000 | 0.01% | — |
| 55 | JPMORGAN CHASE & CO | 1,1191,119 | $30,717 | 0.01% | NEW |
| 56 | ROYAL BANK OF CANADA | 625625 | $18,000 | 0.01% | ADD 862% |
| 57 | FEDERATED HERMES, INC. | 2929 | $845 | 0.00% | NEW |
| 58 | Tower Research Capital LLC (TRC) | 11 | $29 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | — | — | — | — | — | 1.5M | $43M |
| Kalehua Capital Management LLC | — | — | — | — | 385K | 770K | $22M |
| Boxer Capital Management, LLC | — | — | — | — | 416K | 766K | $22M |
| MILLENNIUM MANAGEMENT LLC | — | — | — | 110K | 721K | 731K | $21M |
| STEMPOINT CAPITAL LP | 351K | 241K | 687K | 713K | 620K | 722K | $19M |
| Venrock Adviser, LLC | — | 633K | 633K | 633K | 633K | 633K | $18M |
| Spruce Street Capital LP | — | — | — | — | 432K | 432K | $13M |
| BRAIDWELL LP | — | — | 140K | 140K | 470K | 396K | $12M |
| 5AM Venture Management, LLC | — | 310K | 310K | 310K | 388K | 388K | $11M |
| Vestal Point Capital, LP | — | — | — | — | — | 339K | $10M |
| Vivo Capital, LLC | — | 260K | 260K | 260K | 260K | 260K | $8M |
| PERCEPTIVE ADVISORS LLC | — | — | — | — | — | 229K | $7M |
| Woodline Partners LP | — | — | — | 48K | 231K | 228K | $7M |
| Balyasny Asset Management L.P. | — | — | — | 71K | 190K | 204K | $6M |
| Ikarian Capital, LLC | — | — | — | — | 66K | 173K | $5M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 58 | 9,514,375 | 81.9% | $275M |
| 2025-Q4 | 54 | 7,274,913 | 62.7% | $156M |
| 2025-Q3 | 35 | 4,975,753 | 42.9% | $64M |
| 2025-Q2 | 30 | 4,662,512 | 40.2% | $42M |
| 2025-Q1 | 29 | 3,947,648 | 34.0% | $46M |
| 2024-Q4 | 23 | 1,659,393 | 14.3% | $24M |
| 2024-Q3 | 22 | 1,320,606 | 11.4% | $16M |
| 2024-Q2 | 20 | 1,482,355 | 12.8% | $16M |
| 2024-Q1 | 15 | 411,169 | 3.5% | $6M |
| 2023-Q4 | 16 | 447,547 | 3.9% | $4M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| TCG Crossover GP II, LLC | 9.9% | Passive | 2026-07-22 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
