$30.19
+0.51 (+1.72%)
USD · as of 2026-08-18 · marketstack
Clinical trials
catalyst calendar across sponsors →Studies where SNN is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
61 interventional · 70 observational · 53 with posted results
Held by 9 tracked-famous managers (MILLENNIUM MANAGEMENT LLC, D. E. Shaw & Co., Inc., JANE STREET GROUP, LLC, Bridgewater Associates, LP, CITADEL ADVISORS LLC, +4 more) · FINRA short interest 2.6 days to cover (settled 2026-07-31) · government filings 180d: none disclosed
| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|
| A Multi-Center Study Assessing the Safety and Efficacy of the LEGION Medial Stabilized (MS) Insert in Patients Undergoing a Total Knee Arthroplasty (TKA)NCT07199738observationalImplant Survivorship at 10 Years | — | Recruiting | Device: Cemented CoCr, Cemented Oxinium, Cementless | Inflammatory Arthritis, Primary Total Knee Arthroplasty Due to Degenerative Joint Disease (Primary Diagnosis of Osteoarthritis), Post-traumatic Arthritis | 144 | Dec 2036 | ≤ 3,787 d | 2026-08-06 |
| A Multicenter, Post-Market Clinical Follow-up Study of Subjects With the REDAPT™ System Monolithic Sleeveless/Sleeved Stem and/or Fully Porous Acetabular Shell With XLPE Liner and/or Modular Shell Components Previously ImplantedNCT03610789observationalRevision rate | — | Enrolling by invitation | Device: REDAPT | Hip Replacement | 220 | 2034-07-01 | in 2,873 d | 2025-01-06 |
| Safety and Performance Study of the Legion Porous System in Total Knee ArthroplastyNCT03720782observationalImplant survivorship 10 years post-surgery | — | Active, not recruiting | Device: LEGION Porous HA Tibial Baseplate and/or the LEGION Porous HA CR Femoral Component | Total Knee Arthroplasty | 118 | 2031-01-23 | in 1,618 d | 2026-04-23 |
| Evaluation Of Outcomes Following Rotator Cuff Repair Using the REGENETEN Bioinductive ImplantNCT06857084observationalEuroQol 5 Dimension 5 Level (EQ-5D-5L) Score | — | Recruiting | Device: Arthroscopic rotator cuff repair with REGENETEN Bioinductive Implant augmentation | Rotator Cuff Injuries | 400 | 2029-12-31 | in 1,230 d | 2026-06-01 |
| Post Market Clinical Follow Up of LEGION™ Primary TKS With VERILAST™NCT02380092observationalSurvival | — | Active, not recruiting | Device: LEGION™ Primary TKS with VERILAST™ Bearing Surface | Degenerative Joint Disease | 163 | May 2029 | ≤ 1,016 d | 2025-12-15 |
| Ten Year Implant Survivorship of the ANTHEM™ PS Total Knee SystemNCT03078543observationalTen year Anthem knee implant survivorship | — | Active, not recruiting | Device: ANTHEM™ PS Total Knee System implant | Arthroplasty, Replacement, Knee | 148 | 2029-04-30 | in 985 d | 2026-03-11 |
| JOURNEY II XR Safety and Effectiveness PMCFNCT03136887observationalImplant survival rate | — | Active, not recruiting | Device: JOURNEY II XR Total Knee System | Rheumatoid Vasculitis With Rheumatoid Arthritis of Knee, Unilateral Post-Traumatic Osteoarthritis of Knee, Knee Osteoarthritis, Degenerative Arthritis Peripheral Joint, Failed Osteotomies, Failed Unicompartmental Replacement | 176 | Apr 2029 | ≤ 985 d | 2024-08-12 |
| JOURNEY™ II CR Total Knee SystemNCT02440672observationalEquivalence in 1 year post-operative mean Range of Motion (ROM) in subjects receiving the J II CR TKS as compared to the literature reference mean ROM | — | Active, not recruiting | Device: JOURNEY™ II CR Total Knee System (J II CR TKS) | Osteoarthritis, Knee | 170 | Jun 2028 | ≤ 681 d | 2026-06-12 |
| LEGION Hinge Safety and Efficacy StudyNCT02445443observationalOriginal Knee Society Clinical Score© (KSCS) | — | Active, not recruiting | Device: LEGION Hinge Knee System | Knee Arthroplasty, Total | 47 | 2027-12-31 | in 499 d | 2024-11-27 |
| A Multi-Centre Study in Patients Undergoing Total Hip Arthroplasty With the Smith+Nephew CATALYSTEM™ Primary Hip SystemNCT06564636observationalCollared CATALYSTEM™ femoral stem implant survivorship 2 years post-operatively | — | Active, not recruiting | Device: CATALYSTEM | Total Hip Arthroplasty (THA), Osteoarthritis, Degenerative Joint Disease, Inflammatory Arthritis, Avascular Necrosis, Post-traumatic Arthritis, Congenital Hip Dysplasia | 119 | Dec 2027 | ≤ 499 d | 2026-03-12 |
| Safety and Performance Using Legion™ CR Oxinium and CoCr Femoral Implants Combined With Legion™/Genesis™ II XLPE High Flex Tibial InsertsNCT03687593observationalImplant survival 10 years postoperatively | — | Active, not recruiting | Device: Legion™ CR Oxinium and CoCr Femoral Implants combined with Legion™/Genesis™ II XLPE High Flex Tibial Inserts | Total Knee Arthroplasty | 126 | 2027-10-01 | in 408 d | 2026-01-29 |
| AETOS Shoulder SystemNCT06319911observationalImplant Survivorship | — | Recruiting | Device: AETOS | Shoulder Osteoarthritis, Shoulder Arthritis | 220 | 2027-08-30 | in 376 d | 2024-05-07 |
| A Post Approval Multicenter 10 Year Follow-up Observational Trial of Marketed Product - MP01 vs. Surgical Standard of Care (SSOC) Used for the Treatment of Joint Surface Lesions of the KneeNCT06916728observationalChange from Baseline in Overall Knee Injury and Osteoarthritis Outcome Score (KOOS) at 7 Years | — | Enrolling by invitation | Device: Marketed Product - MP01 · Procedure: Surgical Standard of Care | Knee Injuries, Joint Surface Knee Lesions | 170 | 2027-02-05 | in 170 d | 2026-07-16 |
| Post-Market Clinical Study to Evaluate the Safety and Effectiveness of REFLEX ULTRA 45 for Coblation Inferior Turbinate Reduction in ChinaNCT07025304Nasal Obstruction Symptom Evaluation (NOSE) score at 3 MonthsOpen-label · Treatment | Not applicable | Recruiting | Device: REFLEX ULTRA 45 | Nasal Obstruction Due to Inferior Turbinate Hypertrophy | 105 | 2026-09-30 | in 42 d | 2026-01-07 |
| Use of the REGENETEN™ Bioinductive Implant System in High Grade Partial-thickness TearsNCT05444465Change in Western Ontario Rotator Cuff (WORC)Randomized · Single-masked · Treatment | Not applicable | Recruiting | Device: Isolated Bioinductive Repair · Procedure: Completion and Repair | Rotator Cuff Injuries | 234 | 2026-08-15 | — | 2026-08-05 |
| A Global Clinical Study Investigating the Safety and Effectiveness of Smith and Nephew's Porous Knee System in Patients Who Need a Total Knee Replacement Due to Degenerative Arthritis, Post-traumatic Arthritis or Inflammatory ArthritisNCT05197036observationalImplant Survivorship (femoral and/or tibial component) 2 Years Post-Surgery | — | Active, not recruiting | Procedure: Total Knee Arthroplasty | Osteoarthritis, Post-traumatic Arthritis, Rheumatoid Arthritis | 299 | 2026-06-11actual | — | 2026-08-11 |
| Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) ProcedureNCT04848896Post-operative Leg AlignmentRandomized · Open-label · Treatment | Not applicable | Recruiting | Device: CORI Robotics · Procedure: Conventional Procedure | Arthroplasty, Replacement, Knee | 140 | 2026-04-17 | — | 2026-03-11 |
| Safety and Effectiveness Study of OR3O™ Dual Mobility System in THANCT04325022observationalSurvivorship of Primary Total Hip Arthroplasty (THA) | — | Active, not recruiting | Device: Primary Total Hip Arthroplasty, Revision Total Hip Arthroplasty | Advanced Degeneration of the Hip Joint, Revision of the Hip Joint | 177 | 2026-02-23actual | — | 2026-07-02 |
| Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center RegistryNCT05915078observationalProcedure Success | — | Recruiting | Combination product: Iontophoresis and tube placement | Otitis Media With Effusion, Acute Otitis Media, Otitis Media | 200 | 2025-03-30 | — | 2024-07-23 |
| OXINIUM◊ DH Total Hip Arthroplasty Pivotal StudyNCT02353377results2026-03-19Overall Success at 730 Days Post-operative in Participants With a Unilateral Hip ImplantRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | — | Active, not recruiting | Device: OXINIUM DH Hip System, BIOLOX◊ | Hip Osteoarthritis | 413 | 2021-09-21actual | — | 2026-03-19 |
| REDAPT Revision System Study to Assess 5 Year Revision Rate & up to 10 Year Revision Rate and Safety and EffectivenessNCT02344160observationalStem revision | — | Withdrawnsponsor's stated reason: Unable to recruit subjects | Other: Phlebotomy | Total Hip Arthroplasty (THA) | 0 | Dec 2028 | ≤ 865 d | 2016-12-16 |
| Study to Evaluate Patient Outcomes and Safety and Effectiveness of Robotic Assisted Unicompartmental Knee Replacements Versus Conventional Unicompartmental Knee for Subjects With Primary Arthritis of the Knee Joint Involving One (UKA) Compartment (Medial or Lateral)NCT06036212Forgotten Joint Score 12 (FJS-12) at 12 Months Post OperativeRandomized · Single-masked · Treatment | Not applicable | Withdrawnsponsor's stated reason: Terminated post suspension, no subjects enrolled | Device: Robotic System, Conventional | Arthroplasty, Replacement, Knee, Unicompartmental Knee Arthroplasty | 0 | 2027-03-15 | in 208 d | 2025-11-17 |
| A Clinical Study on New Negative Pressure Wound Therapy Dressing in the Management of Chronic & Acute WoundsNCT06306716observationalWound Healing Status | — | Terminatedsponsor's stated reason: The primary reason for this early termination is insufficient enrollment, compounded by recruitment challenges and Impending Expiry of Study Product | Device: RENASYS Film with AIRLOCK Technology | Chronic Wounds, Acute Wounds | 7 | 2025-10-31actual | — | 2025-11-04 |
| PICO Venous Leg Ulcers (VLU) Reimbursement StudyNCT06510777Number of Venous Leg Ulcers (VLUs) confirmed healed by or at 12 weeksRandomized · Single-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: Early terminated due to protocol design issues with inability to correct at this stage. | Device: PICO Treatment, Standard of Care (SOC) Treatment | Venous Insufficiency, Venous Leg Ulcer | 142 | 2025-10-24actual | — | 2026-01-08 |
| To Evaluate the Performance of the CORI™ KNEE TENSIONER as an Accessory to the CORI™ Surgical System.NCT04849884results2026-06-30EuroQol 5-Dimension 5-Level Visual Analogue Scale (EQ-5D-5L VAS) Score Change From Baseline to 6 Weeks, 6 Months, and 12 MonthsOpen-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: CORI™ KNEE TENSIONER | Arthroplasty, Replacement, Knee | 77 | 2025-06-04actual | — | 2026-06-30 |
| Safety and Performance of the Journey™ II UNI Unicompartmental Knee SystemNCT03768128observationalImplant survival 5 years postoperatively | — | Completed | Device: Journey™ II UNI Unicompartmental Knee System | Non-inflammatory Degenerative Joint Disease (NIDJD) of the Knee | 154 | 2025-05-19actual | — | 2026-02-27 |
| A Safety and Efficacy Study of the Birmingham Hip Resurfacing SystemNCT00611585observationalProportion of Participants with Revision by 10 Years | — | Completed | Device: Birmingham Hip Resurfacing | Arthritis | 329 | 2025-05-12actual | — | 2026-04-15 |
| LEGION™ Revision Metal Hypersensitivity StudyNCT02412813Major modified Lymphocyte Transformation Tests (Cobalt, Chromium and Nickel) measurementsRandomized · Open-label · Treatment | Not applicable | Withdrawnsponsor's stated reason: Overhaul of Study Design | Device: LEGION OXINIUM, LEGION Cobalt Chrome | Total Knee Replacement Revision | 0 | Apr 2025 | — | 2016-03-09 |
| Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)NCT03142958observationalImplant Survivorship | — | Suspendedsponsor's stated reason: Prematurely terminated -Sponsor decision not due to adverse events, complications, or device issues. Final data collection underway. | Device: Integra Cadence Total Ankle System | Rheumatoid Arthritis, Degenerative Arthritis, Post Traumatic Arthritis | 132 | 2025-04-30 | — | 2024-11-12 |
| Journey™ UNI Post Market Clinical Follow-UpNCT03442231observationalImplant survival rate | — | Unknown status | Device: Journey UNI Unicompartmental Knee System | Non-inflammatory Degenerative Joint Disease | 147 | 2025-04-11 | — | 2024-02-20 |
| Human Participant Study of a Prototype Multilayer Foam Dressing on Intact Skin.NCT06831448results2026-06-09Acceptable Dressing Presence at Day 7Randomized · Open-label · OtherStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Prototype dressing, Marketed dressing 1, Marketed dressing 2 | Healthy | 120 | 2025-03-17actual | — | 2026-06-09 |
| Human Participant Study of Prototype Non-medicated Multilayer Foam Dressings on Intact SkinNCT06700850results2026-04-02Number of Participants With Acceptable Dressing Presence at Day 7Randomized · Open-label · OtherStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Prototype dressing rectangle, Marketed dressing rectangle, Prototype dressing square, Marketed dressing square | Healthy | 135 | 2025-01-21actual | — | 2026-04-02 |
| Safety and Performance Study of the FAST-FIX FLEX System for Meniscal Repairs and Meniscal TransplantationsNCT04903106results2026-03-18observationalReoperations at 12 MonthsStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: FAST-FIX FLEX Meniscal Repair System, FAST-FIX FLEX Meniscal Repair System | Meniscus Tear | 63 | 2024-11-26actual | — | 2026-03-18 |
| Agili-C™ Implant Performance EvaluationNCT03299959results2025-12-05Overall Knee Injury and Osteoarthritis Outcome Score (KOOS) Change From Baseline to 60 MonthsRandomized · Open-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Agili-C implant · Procedure: SSOC | Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis | 251 | 2024-11-14actual | — | 2025-12-05 |
| Safety and Performance of MICRORAPTOR™ Suture Anchors in Shoulder and HipNCT03985839results2026-07-13observationalRepair Failure Rate at 6 MonthsStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: MICRORAPTOR™ REGENESORB™ Suture Anchor, MICRORAPTOR™ Knotless REGENESORB™ Suture Anchor, MICRORAPTOR™ Knotless PEEK Suture Anchor | Labral Tear, Glenoid, Acetabular Labrum Tear, Bankart Lesions, Anterior Shoulder Instability, SLAP Lesion, Rotator Cuff Tears | 298 | 2024-08-08actual | — | 2026-07-13 |
| Safety of Treatment of Shoulder RepairNCT04552119results2026-04-16observationalClinical Success Rate at 6 MonthsStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: HEALICOIL Knotless PEEK, HEALICOIL Knotless REGENESORB | Rotator Cuff | 138 | 2024-05-24actual | — | 2026-04-16 |
| Circumferential Compression STITCH Repairs of Complex and Horizontal Cleavage Meniscal TearsNCT04361487results2026-02-24observationalRate of Freedom From Reoperation at 12 Months After SurgeryStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Slow enrollment resulted in the decision to prematurely terminate the study | Device: NOVOSTITCH™ PRO Meniscal Repair System | Meniscus Tear, Retention; Meniscus | 33 | 2024-04-25actual | — | 2026-02-24 |
| Evaluate the Performance of JOURNEY II CR in TKA PopulationsNCT04818840results2025-08-20observationalOxford Knee Score (OKS) at 2 YearsStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: It was terminated by sponsor for updated evidence needs | Device: Resurfaced Patella · Procedure: Un-resurfaced Patella | Arthroplasty, Replacement, Knee | 62 | 2024-03-15actual | — | 2025-08-20 |
| TITAN™ Reverse Shoulder SystemNCT02204228observationalSurvival (lack of implant component removal or revision) | — | Terminatedsponsor's stated reason: Business reasons not related to safety | Device: TITAN™ Reverse Shoulder System (TRS) | Osteoarthritis of the Shoulder | 151 | 2023-12-14actual | — | 2026-03-13 |
| REGENETEN™ Bioinductive Implant System in Full-thickness TearsNCT04450342results2025-05-23Retear Rate at 6 MonthsRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Sponsor decision not related to safety. | Device: Arthroscopic rotator cuff repair with REGENETEN™ Bioinductive Implant augmentation, Arthroscopic rotator cuff repair for revision surgery · Procedure: Arthroscopic rotator cuff repair | Rotator Cuff Injuries | 119 | 2023-10-31actual | — | 2025-05-23 |
| Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Knee Arthroplasty ProceduresNCT04786119results2025-01-13Post-Operative Leg AlignmentOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: CORI Robotics | Arthroplasty, Replacement, Knee | 126 | 2023-10-27actual | — | 2025-10-31 |
| A Multi-center Outcomes Clinical Study of the PyroTITAN™ HRA Shoulder Implant in Humeral Head ResurfacingNCT02405208results2025-12-24observationalDevice SurvivalStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: PyroTITAN HRA | Arthritis | 156 | Sep 2023actual | — | 2025-12-24 |
| Study to Evaluate the Safety and Effectiveness of REAL INTELLIGENCE™ CORI™ in Unicondylar Knee Arthroplasty (UKA) ProceduresNCT04797897results2025-03-25Post-operative Leg AlignmentRandomized · Open-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: The Study terminated prematurely due to very low patient enrollment in the study. | Device: CORI, Conventional | Non-inflammatory Degenerative Joint Disease, Osteoarthritis, Avascular Necrosis, Requires Correction of Functional Deformity, Fracture, Knee | 4 | 2023-09-29actual | — | 2025-03-25 |
| Treatment of Partial-Thickness Rotator Cuff TearsNCT03734536results2024-11-19American Shoulder and Elbow Surgeons (ASES) ScoreNon-randomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Business reasons not related to patient safety | Device: REGENETEN™ Bioinductive Implant, Arthroscopic repair of the high-grade (>50%) partial-thickness | Arthroscopic Surgical Treatment of High-grade (>50%) Partialthickness | 168 | 2023-09-11actual | — | 2024-11-19 |
| Long Term Follow-up of Integra® Cadence™ Total Ankle System in Primary Ankle Joint ReplacementNCT03247023results2026-06-22observationalImplant Survivorship at 2 YearsStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Sponsor decision not related to safety | Device: Implantation of Integra Cadence Total Ankle System | Degenerative Arthritis, Rheumatoid Arthritis, Traumatic Arthritis | 65 | 2023-09-06actual | — | 2026-06-22 |
| Safety and Efficacy of the Journey II BCS Total Knee SystemNCT01705067observationalRate of ITB Friction Pain | — | Completed | Device: TKA with Journey II BCS Total Knee System | Osteoarthritis, Knee | 209 | 2023-07-31actual | — | 2024-06-13 |
| R3 Delta Ceramic Acetabular System PAS U.S.NCT03056534results2025-04-13observationalOverall Study Success at 3 Years PostoperativeStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: R3 Biolox Delta Ceramic Acetabular System | Degenerative Joint Disease | 189 | 2023-05-31actual | — | 2025-04-13 |
| Ankle Joint Replacement Outcomes StudyNCT00503438observationalSurvivorship of Salto Talaris Ankle Implant | — | Completed | Device: Salto Talaris Ankle | Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Septic Arthritis, Prior Ankle Fusion | 76 | 2023-04-21actual | — | 2024-01-24 |
| Clinical Evaluation of the Integra® Titan™ Modular Shoulder System Generation 2.5 for Primary Shoulder Joint ReplacementNCT03250767observationalImplant Survivorship | — | Terminatedsponsor's stated reason: Sponsor decision not due to adverse events, complications, or device issues. | Device: Integra Titan Modular Shoulder System 2.5 | Osteo Arthritis Shoulders, Traumatic Arthritis, Rheumatoid Arthritis | 58 | 2023-03-10actual | — | 2023-11-09 |
| PyroTITAN Humeral Resurfacing Arthroplasty (HRA)NCT02983292results2024-11-04observationalDevice Survival: Kaplan-Meir EstimateStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: PyroTITAN™ HRA | Arthritis | 137 | 2023-02-08actual | — | 2024-11-04 |
| Evaluate the Performance of JOURNEY II CR and JOURNEY II BCS in TKA PopulationsNCT04822259Oxford Knee Score (OKS) at 2 yearsNon-randomized · Open-label · Treatment | Not applicable | Withdrawnsponsor's stated reason: Study design is not reasonable and sponsor decided to terminate the study. No patient enrolled by now | Device: JOURNEY II BCS Total Knee System, JOURNEY II CR Total Knee System | Arthroplasty, Replacement, Knee | 0 | 2022-12-31 | — | 2022-06-07 |
| Pilot Study Evaluating the Safety and Efficacy of a New Hard-on-Hard Total Hip Replacement SystemNCT02154516results2024-12-06Number of Participants With Device-Related RevisionsNon-randomized · Open-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: ODH Hip System | Arthritis, Degenerative | 26 | 2022-10-18actual | — | 2024-12-06 |
| Study to Evaluate the PICO 14 Negative Pressure Wound Therapy System in the Management of Acute and Chronic WoundsNCT05234632results2025-01-28observationalDelivery of Nominal -80mmHg Negative PressureStudy Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Due to enrolment issues with dehisced and DFU's wounds | Device: PICO 14 single-use Negative Pressure Wound Therapy System | Surgical Incision, Ulcer Foot, Ulcer Venous, Ulcer, Leg, Pressure Ulcer, Wound Dehiscence | 45 | 2022-09-23actual | — | 2025-06-06 |
| Performance, Safety and Efficacy of NPWT DeviceNCT04102865results2024-11-21Negative Pressure Maintenance at Nominal 80 mmHgNon-randomized · Open-label · PreventionStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Negative-Pressure Wound Therapy (NPWT) | Wound Healing and Prevention | 90 | 2022-07-06actual | — | 2024-12-11 |
| Clinical Evaluation of the TITAN™ Total Shoulder SystemNCT03245320observationalImplant survival at 2 years | — | Terminatedsponsor's stated reason: Terminated by the Sponsor. Decision not due to adverse events, complications, or device issues. | Device: Integra TITAN™ Total Shoulder Generation 1.0 | Arthritis, Arthritis, Degenerative, Rheumatoid Arthritis, Post-traumatic Arthrosis of Other Joints, Shoulder Region, Rotator Cuff Syndrome of Shoulder and Allied Disorders, Fracture, Avascular Necrosis, Joint Instability, Joint Trauma, Dislocation, Shoulder, Pain, Shoulder | 50 | 2022-03-22actual | — | 2023-12-21 |
| Safety and Performance of the TFCC FastFix in the WristNCT03756714observationalRate (%) of clinical success of six months post-operative. Clinical success is defined as wrists without signs of device failure and/or re-intervention after assessment by surgeon | — | Completed | — | Suture Retention Device to Facilitate Triangular Fibrocartilage Complex (TFCC) Repair | 88 | 2021-09-29actual | — | 2021-10-05 |
| Safety and Effectiveness of BIOSURE RG in Cruciate Ligaments Reconstruction in ChineseNCT04012567results2025-03-25Lysholm Knee Scoring Scale 12 Months After OperationRandomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Investigational device: Biosure Regenesorb Interference Screw, Control device: BIOSURE HA Interference Screw | Cruciate Ligament Reconstruction, Knee | 140 | 2021-09-11actual | — | 2025-03-25 |
| Safety and Performance of ENTACT Septal Staple System for SeptoplastyNCT04392583results2022-05-18observationalPercentage of Participants With Clinical Success of the ENTACT Septal Staple System by Examining the Participant's Nasal Cavity at the 21 Day Follow-up VisitStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: ENTACT Septal Staple system | Septoplasty | 40 | 2021-06-02actual | — | 2022-06-15 |
| Retro-prospective Study of Safety & Performance of Round XTENDOBUTTON™ Fixation Device Post Knee RepairNCT04211857observationalSuccess of the Round XTENDOBUTTON™ Fixation | — | Completed | Device: Round XTENDOBUTTON Fixation Device used in suture fixation of ligaments and tendons in conjunction with an ULTRABUTTON™ product or ENDOBUTTON™ device. | Knee Reconstruction | 40 | 2021-02-17actual | — | 2022-05-10 |
| LEGION™ Primary Safety and EfficacyNCT04040985results2024-10-10Implant Survivorship PercentageOpen-label · OtherStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: There is no regulatory or otherwise commitment to continue to follow up to the 10-year time point. The study data had met the primary objectives. After a business review, Smith+Nephew had decided to terminate the study prematurely. | Procedure: Total Knee Arthroplasty using LEGION™ Total Knee System | Osteo Arthritis Knee, Total Knee Replacement | 128 | 2020-12-17actual | — | 2024-10-10 |
| POLARSTEM Cementless Hip StemNCT02648152results2026-01-21observationalKaplan-Meier Estimate: Overall Survivorship of POLARSTEMStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: Total Hip Arthroplasty | Osteoarthritis | 218 | Nov 2020actual | — | 2026-01-21 |
| Post-Market Evaluation of the Rotation Medical Rotator Cuff SystemNCT02200939results2022-03-02Change in Tendon ThicknessNon-randomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Bioinductive implant, Surgical repair | Partial Thickness Supraspinatus Tendon Tear, Full Thickness Supraspinatus Tendon Tear | 148 | 2020-11-24actual | — | 2022-03-02 |
| BIOSURE™ RG Knee Safety & Performance StudyNCT03519555observationalGraft fixation survival | — | Completed | — | ACL Repair, Posterior Cruciate Ligament (PCL) Repair, Medial Collateral Ligament (MCL), Lateral Collateral Ligament (LCL), Posterior Oblique Ligament (POL), Patellar Realignment and Tendon Repairs, Vastus Medialis Obliquus Advancement, Iliotibial Band Tenodesis, Extra-capsular Repairs, Knee Repair | 60 | 2020-10-05actual | — | 2021-07-08 |
| Safety and Performance of Journey II XR Total Knee SystemNCT03798847observationalRevision of one or more study device components | — | Completed | Device: Journey II XR TKA | Journey II XR Total Knee System | 683 | 2020-09-10actual | — | 2023-07-14 |
| Safety and Performance of JOURNEY™ II Cruciate Retaining (CR) Total Knee System (TKS)NCT03885531observationalNumber of adverse events reported per ISO 14155 guidelines | — | Completed | Device: Total knee arthroplasty with Journey II CR Total Knee System | Journey II CR Total Knee System | 586 | 2020-06-30actual | — | 2024-01-03 |
| A Clinical Study to Evaluate the Safety and Efficacy of Q-Fix Trial in Chinese PatientsNCT03765515The Constant-Murley score at 6 months after operation.Randomized · Open-label · Treatment | Not applicable | Completed | Device: Twinfix Ti, Q-Fix | Arthroscopy | 128 | 2020-06-28actual | — | 2021-08-05 |
| REDAPT Retrospective-Prospective Modular Stem StudyNCT02661620observationalModular stem revision | — | Terminatedsponsor's stated reason: The study was prematurely terminated by S+N due to business reasons. After an extensive review of all ongoing studies with the focus on which studies are still required for regulatory obligations S+N took the decision to close the REDAPT 15 study. | Device: REDAPT Revision Femoral System modular stem | Arthroplasties, Hip Replacement | 140 | 2020-04-16actual | — | 2024-04-02 |
| Safety Study of Treatment of Leg FracturesNCT03881241observationalReoperation rate for any reason of the lower extremity fractures treated operatively with the EVOS SMALL Plating System | — | Terminatedsponsor's stated reason: Difficulty with enrollment | — | Tibial Fractures | 2 | 2020-03-24actual | — | 2020-04-10 |
| A Safety Follow Up Study in Australian Subjects Implanted With the SMF Short Modular Femoral Stem Hip SystemNCT03646513results2024-03-19observationalMetal Ion LevelStudy Protocol and Statistical Analysis Plan ↗ | — | Terminatedsponsor's stated reason: Product recalled. Sponsor decision to discontinue study. | Device: SMF Short Modular Femoral Hip System | Total Hip Arthroplasty (THA) | 4 | 2020-03-12actual | — | 2024-03-19 |
| A Clinical Study to Assess the Safety and Clinical Performance of a New Dressing (PICO7Y) in Breast Surgery PatientsNCT03835845Clinical performance PICO 7Y NPWT system within 7 days of surgeryOpen-label · Treatment | Not applicable | Completed | Device: PICO7Y | Oncoplastic Breast Surgery, Bilateral Surgery | 40 | 2020-02-29actual | — | 2022-06-21 |
| Safety Study of Femoral Neck Fracture SystemNCT03721835results2023-09-25Reoperation Rate at One Year Post-operationOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Slow enrollment | Device: CONQUEST FN Femoral Neck Fracture System | Femoral Neck Fractures | 15 | 2020-02-11actual | — | 2023-09-25 |
| Clinical Outcome Following Total Hip Arthroplasty With the SMF StemNCT02471703observationalRevision of the study device | — | Terminatedsponsor's stated reason: The study was prematurely terminated by S+N due to business reasons. After an extensive review of all ongoing studies with the focus on which studies are still required for regulatory obligations S+N took the decision to close the SMF S\&E study. | Device: Total hip arthroplasty | Joint Diseases | 126 | 2020-02-01actual | — | 2021-02-21 |
| Rotation Medical Bioinductive Implant Database RegistryNCT02784600observationalShoulder pain | — | Completed | Device: Bioinductive implant | Rotator Cuff Tear | 483 | 2020-01-16actual | — | 2021-10-18 |
| S&P of Q-Fix™ All-Suture Anchor SystemNCT03594071results2021-02-09observationalClinical Success Rate, Defined as Participant Joints Without Reintervention at 6 Months Post-operative, as Assessed by the SurgeonStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: The Q-Fix™ All-Suture Anchor | Bankart Lesion, Acetabular Labrum Tear, SLAP Lesion, Acromioclavicular Sprain, Capsular Shift/Capsulolabral Reconstruction, Deltoid Repair, Rotator Cuff Repair, Bicep Tendinitis, Extra-capsular Repair, Medial Collateral Ligament, Lateal Collateral Ligament, Posterior Oblique Ligament, IBT, Vastus Medialis, Obliquus Advancement, Joint Capsule Closure | 294 | 2019-12-11actual | — | 2021-02-09 |
| Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral DefectsNCT02423629• The KOOS Pain Subscale relative to baselineOpen-label · Treatment | Not applicable | Completed | Device: Agili-C™ implantation procedure | Cartilage or Osteochondral Defects in the Knee | 143 | 2019-11-19actual | — | 2025-03-06 |
| Study of Suture Repair of Torn Meniscus in the KneeNCT02237001results2020-10-27Freedom From Re-operation of the Index Meniscus Repair Site (Incidence of Subjects Requiring Re-operation)Open-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Suture-based meniscal repair | Meniscal Tear, Meniscus Tear | 30 | 2019-11-18actual | — | 2020-12-04 |
| A Study of the Safety and Performance of the MINITAC◊ Titanium 2.0 Suture AnchorNCT04186481results2021-02-26observationalClinical Success Rate (%) of the MINITAC◊ Ti 2.0 Suture Anchor in Extremities at 6 Months Post-operativeStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | Device: MINITAC Ti 2.0 suture anchor | Hallux Valgus Repairs, Medial or Lateral Instability Repairs/Reconstructions, Achilles Tendon Repairs/Reconstructions, Midfoot Reconstructions, Metatarsal Ligament/Tendon Repairs/Reconstructions, Scapholunate Ligament Reconstructions, Ulnar or Radial Collateral Ligament Reconstructions, Lateral Epicondylitis Repair, Biceps Tendon Reattachment | 32 | 2019-11-08actual | — | 2021-02-26 |
| Safety and Performance of PEEK Anchors in ExtremitiesNCT03782298results2024-09-24observationalNumber of Participants With Clinical Success of the Study Devices in the Extremity Over a Time Period of 6 Months After InterventionStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Spyromite, Dynomite, Raptomite, Footprint Ultra PK SL | Medial or Lateral Instability Repairs/Reconstructions, Hallux Valgus Repairs, Achilles Tendon Repairs/Reconstructions, Midfoot Reconstructions, Metatarsal Ligament/Tendon Repairs/Reconstructions, Bunionectomy, Scapholunate Ligament Reconstructions, Ulnar, Lateral Epicondylitis Repair, Bicep Tendon Reattachments | 140 | 2019-10-10actual | — | 2024-10-01 |
| Achilles Tendon Repair With Bioinductive ImplantNCT02811003results2022-11-04New Tissue ThicknessOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Rotation Medical Bioinductive Implant | Tendinopathy | 20 | 2019-09-17actual | — | 2022-11-04 |
| PMCF Study on PEEK Suture Anchors for Hip IndicationsNCT03814044results2024-10-15observationalNumber of Participants With Clinical Success of the Study Devices in the Hip Over a Time Period of 6 Months After InterventionStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: PEEK Suture Anchors | Soft Tissue to Bone Fixation | 149 | 2019-09-10actual | — | 2024-10-15 |
| PMCF Study on PEEK Suture Anchors for Shoulder IndicationsNCT03826667results2022-04-12observationalNumber of Participants With Clinical Success of the Study Devices in the Shoulder Over a Time Period of 6 Months After InterventionStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Polyetheretherketone (PEEK) Shoulder Suture Anchors | Soft Tissue to Bone Fixation | 464 | 2019-08-28actual | — | 2022-04-12 |
| Safety and Performance of Journey II BCS Total Knee System Patient Reported Outcome MeasuresNCT03903731observationalRevision of one or more study device components | — | Completed | Device: Total knee arthroplasty with Journey II BCS Total Knee System | Journey II BCS Total Knee System | 600 | 2019-08-08actual | — | 2020-11-12 |
| Agili-CTM Implant Performance Evaluation in the Treatment of Osteoarthritis of the Great ToeNCT02831244Foot and Ankle Ability Measure (FAAM) scoreOpen-label · Treatment | Not applicable | Completed | Device: Agili-CTM | Osteoarthritis of Multiple Joints of Ankle or Foot | 20 | 2019-06-23actual | — | 2025-03-06 |
| DURAFIBER Ag Post-Market Clinical Follow-UpNCT03277131Change in the mean log10 bacterial count in tissue biopsies from baseline to week 8Open-label · Treatment | Not applicable | Completed | Device: DURAFIBER Ag | Wounds and Injuries, Venous Leg Ulcer, Infection | 20 | 2019-06-19actual | — | 2022-03-02 |
| Performance, Safety and Efficacy of PICO Device.NCT03698968Functional clinical performance of the PICO 7 NPWT system through delivery of negative pressureOpen-label · Prevention | Not applicable | Completed | Device: Negative Pressure Wound Therapy | Wound Heal | 50 | 2019-06-18actual | — | 2019-09-18 |
| Use of Santyl Within an Accountable Care OrganizationNCT02716519Target Ulcer ComplicationsRandomized · Open-label · Treatment | Phase 4 | Withdrawnsponsor's stated reason: Business Decision | Biological: Santyl · Other: Standard Care | Pressure Ulcer, Foot Ulcer, Diabetic | 0 | Dec 2018 | — | 2017-03-15 |
| Evaluation of the Agili-C Biphasic Implant in the Knee JointNCT01471236improvement in KOOS pain subscalesOpen-label · Treatment | Not applicable | Completed | Device: Agili-C Bi-phasic Implant · Procedure: mini-arthrotomy | Cartilage Diseases, Osteochondritis Dissecans | 65 | 2018-11-19actual | — | 2025-03-06 |
| Navio With Total Knee ArthroplastyNCT03317834results2024-10-08observationalCount of Participants With Post-operative Mechanical AlignmentStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: Navio ™ Robotic-assisted Surgical System | Total Knee Arthroplasty, Arthroplasty of Knee | 122 | 2018-10-25actual | — | 2024-10-08 |
| Evaluation Of An Advanced Borderless DressingNCT03146845results2023-05-10Change in the Cardiff Wound Impact Schedule-Physical Symptoms of Daily Living (CWIS-PSDL) Scale Score From Baseline to the Week 6 VisitRandomized · Open-label · Supportive careStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: ALLEVYN Life Non-Bordered, Standard Care | Pressure Ulcer, Leg Ulcer, Diabetic Foot Ulcer | 40 | 2018-06-12actual | — | 2023-05-10 |
| Predictors of Early Success From Circumferential Compression STITCH Meniscal RepairsNCT03097744observationalReoperation Rate | — | Completed | Device: Ceterix NovoStitch | Knee Medial Meniscus Tears, Meniscus Lesion, Meniscus; Rupture, Bucket Handle, Meniscus Disorder | 23 | 2018-04-20actual | — | 2020-09-07 |
| Journey II Bi-Cruciate Stabilized (BCS) Total Knee System Retrospective StudyNCT03292003observationalRevision Rate of Total Knee System | — | Completed | Device: Journey II BCS Total Knee System | Total Knee Arthroplasty | 1,694 | 2018-01-30actual | — | 2019-03-28 |
| Non-Comparative Study of Open Abdomen That Require the Use of Negative Pressure Wound Therapy (NPWT) for Temporary Abdominal ClosureNCT03431220To determine the number of days taken to achieve delayed primary fascial closure.Open-label · Treatment | Not applicable | Withdrawn | Device: RENASYS® TOUCH Negative Pressure Wound Therapy (NPWT) Device | Abdomenal Wound Trauma | 0 | Nov 2017 | — | 2018-02-13 |
| A Retrospective Study of the Navio Robotic-assisted Surgical SystemNCT03072459results2022-05-02observationalEvaluate the Navio™ System for Revisions at 2+ Years Post-surgical Implantation SurvivorshipStudy Protocol ↗ · Statistical Analysis Plan ↗ | — | Completed | — | Surgical Robotics, Knee Replacement | 128 | 2017-11-29actual | — | 2022-05-25 |
| ACTICOAT™ for the Treatment of Burns and Chronic WoundsNCT02852148Change in EQ-5D 5L mean single index utility scores (EuroQol Research Foundation 2015).Open-label · Treatment | Not applicable | Completed | Device: ACTICOAT | Wounds and Injuries, Burns, Pressure Ulcer, Foot Ulcer | 25 | 2017-11-28actual | — | 2019-04-04 |
| Single-Use Negative Pressure Wound Therapy System vs. Traditional Negative Pressure Wound Therapy System (tNPWT)NCT02470806results2020-04-06Change in Ulcer Area From Baseline to the End of the Treatment PeriodRandomized · Open-label · OtherStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: PICO System, tNPWT System | Venous Leg Ulcers, Diabetic Foot Ulcers | 164 | 2017-11-14actual | — | 2020-04-06 |
| A Retro-prospective Study of Total Hip Arthroplasty With EMPERION Modular Primary Stem in Australian Centres (HISTORIC)NCT02435420observationalSurvivorship of stem | — | Terminatedsponsor's stated reason: Commercial decision | Device: EMPERION Modular Primary Stem | Osteoarthritis, Hip, Arthritis, Degenerative | 25 | 2017-11-09actual | — | 2018-02-05 |
| Managing Wounds With Allevyn Life in a Home Health Care EnvironmentNCT02776800Number of home health clinician visits in each groupRandomized · Open-label · Supportive care | Not applicable | Withdrawnsponsor's stated reason: Business Decision | Device: Allevyn Life, Foam dressing with an integrated adhesive border | Wounds and Injuries | 0 | Jul 2017 | — | 2017-02-09 |
| Visionaire Health Economics Study Comparing Economic Outcomes Between Visionaire and Standard InstrumentationNCT02158819Cost of the episode of care from admission to hospital to dischargeNon-randomized · Open-label · Treatment | Not applicable | Completed | Device: Total knee arthroplasty with Visionaire | Osteoarthritis, Knee | 52 | 2017-05-15actual | — | 2019-01-08 |
| Mechanical vs. Radiofrequency-Based Debridement in the Treatment of Articular Cartilage LesionsNCT01803880results2019-03-28Change From Baseline in Knee and Osteoarthritis Outcomes Scores (KOOS) at Week 52 Post-operativeRandomized · Double-masked · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Unable to meet enrollment goals | Device: Mechanical Debridement, RF-Based Debridement | Chondral Lesion Plus Partial Medial Meniscectomy | 148 | 2017-05-04actual | — | 2019-03-28 |
| Journey II BCS CMS Total Knee System Compared to Other PS Total Knee Systems in PT SettingNCT02820766observationalDifference in Knee Range of Motion (ROM) at the first outpatient Physical Therapy (PT) visit (≤7 days of surgery) between the 2 treatment groups | — | Terminatedsponsor's stated reason: Logistics of study did not allow for consistent data collection | — | Osteoarthritis, Degenerative Arthritis, Traumatic Arthritis | 22 | 2017-04-27actual | — | 2017-08-10 |
| R3® Acetabular System in Patients With Degenerative Hip DiseaseNCT01407029observationalEffectiveness will be measured using the Harris Hip Score (HHS), The HOOS self assessment questionnaire, and radiographic assessment. Radiographic measures consist of radiolucencies, component position changes, and bony changes. | — | Completed | — | Osteoarthritis | 158 | 2017-03-14actual | — | 2017-04-25 |
| Study of SANTYL® vs Hydrogel (SoloSite®) for Pressure UlcersNCT02718625results2020-03-10Proportion of Ulcers With Complete DebridementRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Phase 4 | Terminatedsponsor's stated reason: Business Decision | Biological: Santyl, SoloSite® | Pressure Ulcer | 3 | 2017-03-09actual | — | 2020-03-10 |
| Comparison of Surgical Incision Complications in Patients Receiving PICO or Standard Care Following Colorectal SurgeryNCT02883010Number of complications in each groupRandomized · Open-label · Prevention | Not applicable | Withdrawnsponsor's stated reason: Business decision | Device: PICO Softport V1.6 · Other: Standard Care | Wounds and Injuries | 0 | Jan 2017actual | — | 2019-04-01 |
| Use of Santyl in Diabetic Foot UlcersNCT02581488results2018-08-01Mean Percent Change in Ulcer Area From Baseline to the End of the Treatment.Randomized · Open-label · Treatment | Phase 4 | Completed | Biological: Santyl · Other: Product containing silver | Diabetic Foot, Foot Ulcer, Diabetic | 102 | 2017-01-12actual | — | 2018-08-01 |
| BIOSURE™ HEALICOIL™ PK Bone In-growth StudyNCT02382341observationalBone In-growth measured by CT scans | — | Completed | Device: BIOSURE™ HEALICOIL™ PK Interference Screw | Deficiency of Anterior Cruciate Ligament | 12 | 2017-01-04actual | — | 2020-09-07 |
| Pilot Study of the Use of ULTRABRAID PLUS SUTURE in the Repair of Tears of the Rotator CuffNCT01767740Rotator Cuff IntegrityRandomized · Single-masked · Treatment | Not applicable | Completed | Device: ULTRABRAID PLUS SUTURE, ULTRABRAID SUTURE | Rotator Cuff Tear | 82 | Nov 2016actual | — | 2017-10-06 |
| Research Study to Compare the Addition of Topaz Micro Debridement to the Standard of Care SurgeryNCT01562366Modified Harris Hip ScoreRandomized · Double-masked · Health services research | Not applicable | Completed | Device: Topaz · Procedure: Iliotibial band release and trochanteric bursectomy | Greater Trochanteric Pain Syndrome, Hip Pain Chronic | 66 | Oct 2016actual | — | 2017-05-25 |
| The Clinical Efficacy of RENASYS TOUCH NPWT System in the Management of Acute, Sub-acute and Chronic WoundsNCT02565043The time to achieve the point where the reference wound is ready to be closed either by surgical intervention (STSG, simple flap or suturing) or by secondary intentionRandomized · Open-label · Treatment | Not applicable | Completed | Device: RENASYS TOUCH Negative Pressure Wound Therapy System | Wound and Injuries, Surgical Wound Dehiscence | 80 | Aug 2016actual | — | 2018-02-19 |
| Five and Ten Year Results of the CMK21 Hip SystemNCT03908151observationalImplant revision rate | — | Terminatedsponsor's stated reason: Business Decision | Device: CMK21 Hip system | Osteoarthritis | 100 | Aug 2016actual | — | 2019-04-09 |
| Treatment of Wounds With a New Adhesive Foam DressingNCT02807584Wound progression, (percentage change in area) using a wound imaging measurement and wound documentation systemOpen-label · Treatment | Not applicable | Completed | Device: ELECT | Wounds and Injuries, Burns | 25 | Jul 2016actual | — | 2018-02-19 |
| Mini Stem Radiostereometric Analysis StudyNCT01064531results2020-04-09observationalMigration of the MIS Femoral Neck Stem Compared to the Synergy Hip System Using RSA (Translational Movement) | — | Completed | Device: MIS Femoral Neck Stem implant | Osteoarthritis, Hip | 41 | 2016-04-22actual | — | 2020-04-09 |
| Mini Stem DEXA (Dual Energy X-ray Absorptiometry)NCT01066936results2020-03-06observationalDEXA Analysis of BMD at Preoperative Visit | — | Completed | — | Osteoarthritis, Hip | 20 | 2016-04-18actual | — | 2020-03-06 |
| A RCT to Compare the Effects of Two Wound Products on Biofilm Disruption in DFUsNCT02181621results2024-02-29Within-patient Change From Baseline in Log^10 Biofilm-protected Bacteria Count (Colony Forming Units [Cfu]/Gram[g])Randomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Recruitment challenges | Device: Iodosorb, Solosite gel | Diabetic Foot Ulcer | 19 | Oct 2015actual | — | 2024-02-29 |
| A RCT to Compare Performance of Two Foam Dressings on Patient Well-being Related Endpoints.NCT02053337Subjective rating of the impact of the dressing performance and characteristics on patient wellbeing (referred to as patient wellbeing score)Randomized · Open-label · Other | Not applicable | Completed | Device: Self adhesive foam dressing | Chronic Wounds | 60 | Jul 2015actual | — | 2018-02-19 |
| Trial of PICO Versus Standard Care in Chronic and Sub-acute WoundsNCT02458859Time to closureRandomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Poor recruitment | Device: PICO (single use portable negative pressure wound therapy) | Wounds | 62 | Jun 2015actual | — | 2018-02-13 |
| Ascension PyroCarbon Radial Head StudyNCT02405234The proportion of patient successes with the Carbon Modular Radial Head vs patient successes with the Metal Radial Head as assessed by implant survivalRandomized · Double-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: Business Decision | Device: Carbon Modular Radial Head replacement, Metal Radial Head replacement | Degenerative Arthritis, Radial Head Fracture, Rheumatoid Arthritis | 78 | Mar 2015actual | — | 2022-08-11 |
| A Pilot Study of the WoundWand™ Debridement Device on Infection PreventionNCT01924806results2020-02-28Bacterial Diversity and Number of Bacteria Present in the WoundRandomized · Single-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: Lower than expected accrual rate and desire to reassess overall study strategy. | Device: WoundWand™ Debridement Device, Standard of Care sharp debridement | Lower Leg Wound | 11 | 2015-02-09actual | — | 2020-02-28 |
| Ascension® Post- Approval Study; PyroCarbon Metacarpophalangeal Total Joint ProsthesisNCT02408471results2023-10-10Number of Participants With RevisionsOpen-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Business Priorities | Device: Ascension® MCP Finger Implant | Rheumatoid Arthritis, Systemic Lupus Erythematosus, Osteoarthritis, Post-traumatic Arthritis | 97 | Jan 2015actual | — | 2023-10-10 |
| Safety and Effectiveness Study of the Reflection Ceramic Acetabular SystemNCT00663351results2022-10-13Survival of Hip Implant Based on Number of Hips Requiring RevisionNon-randomized · Open-label · Treatment | Not applicable | Completed | Device: Reflection Ceramic-Ceramic Total Hip Replacement, Reflection FSO V Total Hip Replacement | Osteoarthritis | 456 | Oct 2014actual | — | 2022-10-13 |
| PICO Breast Reduction Clinical Study Looking at Incision Healing ComplicationsNCT01640366results2020-02-28Number of Participants Experiencing Incision Healing Complications up to Day 21 PostoperativelyRandomized · Single-masked · Prevention | Not applicable | Completed | Device: PICO | Delayed Healing | 200 | Apr 2014actual | — | 2020-02-28 |
| Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)NCT01084772results2020-04-03Knee Society Clinical (KSS) Score at 2 Years Following Surgery - Total ScoreRandomized · Open-label · Basic science | Not applicable | Terminated | Other: VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty | Degenerative Arthritis of Knee | 134 | 2014-04-15actual | — | 2020-04-03 |
| INTUIT Hip Fracture Outcome StudyNCT00595634observationalMobility function as defined by the Timed Up & Go (TUG) frequency. | — | Terminatedsponsor's stated reason: Could not power primary endpoint due to lost to follow-up rate | — | Unstable Intertrochanteric Hip Fractures | 92 | Nov 2013actual | — | 2014-04-01 |
| TRIGEN SURESHOT™ Distal Targeting System StudyNCT01327508results2016-02-09Radiation Exposure MeasurementRandomized · Open-label · Supportive care | Not applicable | Terminatedsponsor's stated reason: Primary endpoint voided. Dosimeters did not capture radiation dose as expected. | Device: TRIGEN SURESHOT Distal Targeting Instrumentation. · Other: Free-hand technique | Femoral Shaft Fracture | 60 | Jan 2013actual | — | 2018-03-14 |
| Knee Articular Cartilage Debridement in Conjunction With Partial MeniscectomyNCT00613535In vivo magnetic resonance imaging (MRI) features of the femoral condyle chondral lesionRandomized · Single-masked · Treatment | Phase 4 | Terminatedsponsor's stated reason: The correlation coefficient at the interim analysis with results for all three groups pooled, did not reach the level of statistical significance of (p\<0.05). | Device: Mechanical debridement, Paragon T2, Mechanical Debridement, RF- based Debridement · Procedure: Lavage debridement | Torn Meniscus | 165 | Jun 2012actual | — | 2015-05-19 |
| A Study of Patients Treated With the Journey Deuce Bicompartmental Knee SystemNCT01704326observationalChange in Knee Society Score | — | Completed | — | Osteoarthritis | 59 | Feb 2012actual | — | 2012-10-11 |
| Smith & Nephew's European Trufit StudyNCT01246635Percent change in the Knee injury and Osteoarthritis Outcome Score (KOOS) from baselineRandomized · Single-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: The study was terminated early due to slow and insufficient total enrollment. | Device: Trufit CB (Cartilage Bone) Implant · Procedure: Microfracture if the knee | Defect of Articular Cartilage | 153 | Nov 2011actual | — | 2021-04-01 |
| Clinical Outcome of Birmingham Hip Resurfacing (BHR) Using VISIONAIRE Femoral Alignment GuideNCT01427361observationalInvestigate the accuracy of the femoral implant placement utilizing the VISIONAIRE Femoral Alignment Guide in BHR surgery postoperatively after total hip resurfacing using the BHR System | — | Completed | — | Osteoarthritis | 25 | Aug 2011actual | — | 2018-03-22 |
| Trial of Versajet Compared With Conventional Treatment in Acute and Chronic WoundsNCT01050673results2012-10-08Difference in Time to Closure Between Wounds Surgically Excised With VERSAJET™ Hydrosurgery System and Those Surgically Excised Using Conventional Operating Room Techniques.Randomized · Open-label · Treatment | Not applicable | Completed | Device: VERSAJET · Procedure: Scalpel or blade | Surgical Wound Dehiscence | 40 | Jun 2011actual | — | 2018-03-12 |
| VISIONAIRE™ Value StudyNCT01107769observationalHealth Economic Criteria | — | Completed | — | Osteoarthritis of the Knee | 38 | Feb 2011actual | — | 2011-11-21 |
| Evaluation of the Use of EZCare/V1STA in the Management of Acute and Chronic WoundsNCT00994162results2022-09-21Number of Wounds Stratified by Wound Area for the Performance of EZCare/V1STA in Terms of Wound Progress Towards Closure in Wounds Deemed Suitable for Treatment With Negative Pressure Wound Therapy (NPWT) - Wound Area (Baseline Measurements)Open-label · Treatment | Not applicable | Completed | Device: EZCare/V1STA Negative Pressure Wound Therapy System | Wounds | 153 | Jan 2009actual | — | 2022-09-21 |
| Study Comparing VERSAJET With Conventional Surgical Procedures in the Removal of Unhealthy Tissue From Lower Limb UlcersNCT00521027Reduction in the average skin-to-skin time of the first surgical debridement with VERSAJET™, compared to conventional debridement techniques.Randomized · Open-label · Treatment | Phase 4 | Completed | Device: Versajet Hydrosurgery System · Procedure: Conventional surgical debridement techniques | Diabetic Foot, Varicose Ulcer, Pressure Ulcer | 46 | — | — | 2018-02-19 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19