| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 8,021,1178.0M | $208M | 23.99% | NEW† |
| 2 | NEA Management Company, LLC | 7,392,3017.4M | $192M | 22.11% | NEW† |
| 3 | Sands Capital Alternatives, LLC | 2,500,0122.5M | $65M | 7.48% | NEW† |
| 4 | SAMSARA BIOCAPITAL, LLC | 2,109,9532.1M | $55M | 6.31% | NEW† |
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 704,440704,440 | $18M | 2.11% | NEW† |
| 6 | Vestal Point Capital, LP | 666,760666,760 | $17M | 1.99% | NEW |
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 550,000550,000 | $14M | 1.65% | NEW |
| 8 | JPMORGAN CHASE & CO | 577,109577,109 | $13M | 1.73% | NEW |
| 9 | MILLENNIUM MANAGEMENT LLC | 468,794468,794 | $12M | 1.40% | NEW |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 434,813434,813 | $11M | 1.30% | NEW |
| 11 | First Light Asset Management, LLC | 375,000375,000 | $10M | 1.12% | NEW |
| 12 | FRANKLIN RESOURCES INC | 300,000300,000 | $8M | 0.90% | NEW |
| 13 | Affinity Asset Advisors, LLC | 250,000250,000 | $6M | 0.75% | NEW |
| 14 | Aberdeen Group plc | 220,454220,454 | $6M | 0.66% | NEW |
| 15 | BlackRock, Inc. | 144,739144,739 | $4M | 0.43% | NEW |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 126,540126,540 | $3M | 0.38% | NEW |
| 17 | Monashee Investment Management LLC | 95,00095,000 | $2M | 0.28% | NEW |
| 18 | VANGUARD FIDUCIARY TRUST CO | 59,78259,782 | $2M | 0.18% | NEW |
| 19 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 59,61059,610 | $2M | 0.18% | NEW |
| 20 | Alyeska Investment Group, L.P. | 57,00057,000 | $1M | 0.17% | NEW |
| 21 | TD Asset Management Inc | 47,58047,580 | $1M | 0.14% | NEW |
| 22 | AMERIPRISE FINANCIAL INC | 44,47744,477 | $1M | 0.13% | NEW |
| 23 | MARSHALL WACE, LLP | 29,34829,348 | $760,406 | 0.09% | NEW |
| 24 | BANK OF AMERICA CORP /DE/ | 28,02028,020 | $725,998 | 0.08% | NEW |
| 25 | NORTHERN TRUST CORP | 20,86220,862 | $540,534 | 0.06% | NEW |
| 26 | GOLDMAN SACHS GROUP INC | 19,28319,283 | $499,623 | 0.06% | NEW |
| 27 | STATE STREET CORP | 17,25017,250 | $446,948 | 0.05% | NEW |
| 28 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,87011,870 | $307,552 | 0.04% | NEW |
| 29 | Squarepoint Ops LLC | 7,8117,811 | $202,383 | 0.02% | NEW |
| 30 | Vanguard Global Advisers, LLC | 4,9274,927 | $127,659 | 0.01% | NEW |
| 31 | MORGAN STANLEY | 4,1794,179 | $108,278 | 0.01% | NEW |
| 32 | VANGUARD PORTFOLIO MANAGEMENT LLC | 3,6803,680 | $95,349 | 0.01% | NEW |
| 33 | UBS Group AG | 455455 | $11,789 | 0.00% | NEW |
| 34 | BARCLAYS PLC | 140140 | $3,627 | 0.00% | NEW |
| 35 | ROYAL BANK OF CANADA | 8585 | $2,000 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | — | — | — | — | — | 8.0M | $208M |
| NEA Management Company, LLC | — | — | — | — | — | 7.4M | $192M |
| Sands Capital Alternatives, LLC | — | — | — | — | — | 2.5M | $65M |
| SAMSARA BIOCAPITAL, LLC | — | — | — | — | — | 2.1M | $55M |
| PRICE T ROWE ASSOCIATES INC /MD/ | — | — | — | — | — | 704K | $18M |
| Vestal Point Capital, LP | — | — | — | — | — | 667K | $17M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | — | — | — | — | — | 550K | $14M |
| JPMORGAN CHASE & CO | — | — | — | — | — | 577K | $13M |
| MILLENNIUM MANAGEMENT LLC | — | — | — | — | — | 469K | $12M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 435K | $11M |
| First Light Asset Management, LLC | — | — | — | — | — | 375K | $10M |
| FRANKLIN RESOURCES INC | — | — | — | — | — | 300K | $8M |
| Affinity Asset Advisors, LLC | — | — | — | — | — | 250K | $6M |
| Aberdeen Group plc | — | — | — | — | — | 220K | $6M |
| BlackRock, Inc. | — | — | — | — | — | 145K | $4M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
