| 1 | 1FMR LLC | 37,430,28437.4M | $108M | 13.45% | — |
| 2 | 2Flagship Pioneering, LLC | 25,001,85625.0M | $72M | 8.98% | — |
| 3 | 3BlackRock, Inc. | 14,240,17514.2M | $41M | 5.12% | — |
| 4 | 4STATE STREET CORP | 10,538,08610.5M | $30M | 3.79% | ADD 31% |
| 5 | 5CANADA PENSION PLAN INVESTMENT BOARD | 10,221,90010.2M | $29M | 3.67% | — |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 7,434,7247.4M | $21M | 2.67% | NEW† |
| 7 | 7BAILLIE GIFFORD & CO | 6,609,0656.6M | $19M | 2.37% | — |
| 8 | 8GEODE CAPITAL MANAGEMENT, LLC | 4,181,9734.2M | $12M | 1.50% | — |
| 9 | 9Marex Group plc | 3,999,1004.0M | $12M | 1.44% | ADD 7% |
| 10 | 10Integral Health Asset Management, LLC | 3,200,0003.2M | $9M | 1.15% | ADD 7% |
| 11 | 11GOLDMAN SACHS GROUP INC | 3,181,1153.2M | $9M | 1.14% | ADD 114% |
| 12 | 12BANK OF AMERICA CORP /DE/ | 2,946,8612.9M | $8M | 1.06% | ADD 148% |
| 13 | 13Alphabet Inc. | 2,812,5002.8M | $8M | 1.01% | — |
| 14 | 14VANGUARD PORTFOLIO MANAGEMENT LLC | 1,707,5211.7M | $5M | 0.61% | NEW |
| 15 | 15MILLENNIUM MANAGEMENT LLC | 1,591,0301.6M | $5M | 0.57% | ADD 155% |
| 16 | 16NORTHERN TRUST CORP | 1,478,8511.5M | $4M | 0.53% | ADD 5% |
| 17 | 17MORGAN STANLEY | 1,460,0151.5M | $4M | 0.52% | ADD 14% |
| 18 | 18RENAISSANCE TECHNOLOGIES LLC | 1,451,2001.5M | $4M | 0.52% | TRIM -14% |
| 19 | 19CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,366,1481.4M | $4M | 0.49% | TRIM -2% |
| 20 | 20UBS Group AG | 1,355,2891.4M | $4M | 0.49% | ADD 15% |
| 21 | 21Woodline Partners LP | 1,317,9321.3M | $4M | 0.47% | — |
| 22 | 22TWO SIGMA INVESTMENTS, LP | 1,198,5791.2M | $3M | 0.43% | TRIM -24% |
| 23 | 23AQR CAPITAL MANAGEMENT LLC | 1,124,2791.1M | $3M | 0.40% | — |
| 24 | 24VANGUARD FIDUCIARY TRUST CO | 1,063,6491.1M | $3M | 0.38% | NEW |
| 25 | 25Balyasny Asset Management L.P. | 1,033,8041.0M | $3M | 0.37% | TRIM -38% |
| 26 | 26Omega Fund Management, LLC | 843,750843,750 | $2M | 0.30% | — |
| 27 | 27Crestline Management, L.P. | 755,736755,736 | $2M | 0.27% | TRIM -38% |
| 28 | 28JPMORGAN CHASE & CO | 785,834785,834 | $2M | 0.28% | TRIM -4% |
| 29 | 29ArrowMark Colorado Holdings LLC | 685,125685,125 | $2M | 0.25% | — |
| 30 | 30MARSHALL WACE, LLP | 664,457664,457 | $2M | 0.24% | ADD 648% |
| 31 | 31Corient Private Wealth LLC | 642,100642,100 | $2M | 0.23% | TRIM -50% |
| 32 | 32DEUTSCHE BANK AG\ | 591,911591,911 | $2M | 0.21% | ADD 5% |
| 33 | 33Invesco Ltd. | 569,186569,186 | $2M | 0.20% | — |
| 34 | 34CITADEL ADVISORS LLC | 569,090569,090 | $2M | 0.20% | ADD 4103% |
| 35 | 35Bank of New York Mellon Corp | 442,604442,604 | $1M | 0.16% | TRIM -3% |
| 36 | 36SUSQUEHANNA INTERNATIONAL GROUP, LLP | 421,555421,555 | $1M | 0.15% | TRIM -25% |
| 37 | 37Rafferty Asset Management, LLC | 353,582353,582 | $1M | 0.13% | ADD 29% |
| 38 | 38Swiss National Bank | 342,600342,600 | $986,688 | 0.12% | ADD 2% |
| 39 | 39Clearstead Advisors, LLC | 336,781336,781 | $969,929 | 0.12% | ADD 7141% |
| 40 | 40Nuveen, LLC | 326,972326,972 | $941,680 | 0.12% | — |
| 41 | 41BAKER BROS. ADVISORS LP | 310,483310,483 | $894,191 | 0.11% | — |
| 42 | 42DIMENSIONAL FUND ADVISORS LP | 291,268291,268 | $838,852 | 0.10% | ADD 119% |
| 43 | 43ALLIANCEBERNSTEIN L.P. | 186,945186,945 | $760,866 | 0.07% | — |
| 44 | 44UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 231,706231,706 | $667,313 | 0.08% | TRIM -4% |
| 45 | 45ALGERT GLOBAL LLC | 220,869220,869 | $636,000 | 0.08% | ADD 268% |
| 46 | 46PRICE T ROWE ASSOCIATES INC /MD/ | 207,492207,492 | $598,000 | 0.07% | TRIM -73% |
| 47 | 47RHUMBLINE ADVISERS | 198,696198,696 | $572,232 | 0.07% | ADD 5% |
| 48 | 48IEQ CAPITAL, LLC | 187,727187,727 | $540,654 | 0.07% | TRIM -21% |
| 49 | 49VOYA INVESTMENT MANAGEMENT LLC | 181,594181,594 | $522,991 | 0.07% | ADD 11% |
| 50 | 50Susquehanna Portfolio Strategies, LLC | 167,503167,503 | $482,409 | 0.06% | — |
| 51 | 51CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 163,559163,559 | $471,050 | 0.06% | — |
| 52 | 52PROFUND ADVISORS LLC | 157,122157,122 | $452,511 | 0.06% | ADD 54% |
| 53 | 53MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 143,510143,510 | $408,298 | 0.05% | ADD 10% |
| 54 | 54Optimize Financial Inc | 140,705140,705 | $405,230 | 0.05% | NEW |
| 55 | 55TUDOR INVESTMENT CORP ET AL | 133,183133,183 | $383,567 | 0.05% | NEW |
| 56 | 56JANE STREET GROUP, LLC | 132,715132,715 | $382,219 | 0.05% | TRIM -80% |
| 57 | 57SG Americas Securities, LLC | 130,083130,083 | $375,000 | 0.05% | ADD 32% |
| 58 | 58Legal & General Group Plc | 126,417126,417 | $364,081 | 0.05% | TRIM -16% |
| 59 | 59Squarepoint Ops LLC | 118,475118,475 | $341,208 | 0.04% | TRIM -64% |
| 60 | 60GROUP ONE TRADING LLC | 111,917111,917 | $322,321 | 0.04% | ADD 199% |
| 61 | 61XTX Topco Ltd | 110,310110,310 | $317,693 | 0.04% | TRIM -6% |
| 62 | 62Virtu Financial LLC | 109,865109,865 | $316,000 | 0.04% | TRIM -8% |
| 63 | 63Jump Financial, LLC | 108,475108,475 | $312,408 | 0.04% | NEW |
| 64 | 64VANGUARD ASSET MANAGEMENT, Ltd | 101,668101,668 | $292,804 | 0.04% | NEW |
| 65 | 65Qube Research & Technologies Ltd | 100,082100,082 | $288,236 | 0.04% | ADD 282% |
| 66 | 66STATE OF WISCONSIN INVESTMENT BOARD | 99,25899,258 | $285,863 | 0.04% | TRIM -23% |
| 67 | 67GILDER GAGNON HOWE & CO LLC | 95,79695,796 | $275,892 | 0.03% | — |
| 68 | 68Banque Cantonale Vaudoise | 90,69890,698 | $261,000 | 0.03% | NEW |
| 69 | 69Engineers Gate Manager LP | 90,17190,171 | $259,692 | 0.03% | ADD 219% |
| 70 | 70CWM, LLC | 84,44584,445 | $243,202 | 0.03% | — |
| 71 | 71GSA CAPITAL PARTNERS LLP | 84,02084,020 | $242,000 | 0.03% | ADD 161% |
| 72 | 72Zurcher Kantonalbank (Zurich Cantonalbank) | 82,39382,393 | $237,292 | 0.03% | — |
| 73 | 73SCS Capital Management LLC | 81,25081,250 | $234,000 | 0.03% | — |
| 74 | 74MANUFACTURERS LIFE INSURANCE COMPANY, THE | 79,53779,537 | $229,067 | 0.03% | TRIM -14% |
| 75 | 75WELLS FARGO & COMPANY/MN | 75,68275,682 | $217,965 | 0.03% | TRIM -60% |
| 76 | 76LOS ANGELES CAPITAL MANAGEMENT LLC | 74,82774,827 | $215,502 | 0.03% | ADD 4909% |
| 77 | 77HSBC HOLDINGS PLC | 72,19472,194 | $205,031 | 0.03% | TRIM -62% |
| 78 | 78WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 62,03662,036 | $198,515 | 0.02% | ADD 17% |
| 79 | 79MetLife Investment Management, LLC | 66,55166,551 | $191,667 | 0.02% | TRIM -29% |
| 80 | 80Headlands Technologies LLC | 62,05562,055 | $178,718 | 0.02% | NEW |
| 81 | 81Creative Planning | 61,73661,736 | $177,799 | 0.02% | — |
| 82 | 82ExodusPoint Capital Management, LP | 61,65961,659 | $177,578 | 0.02% | NEW |
| 83 | 83CITIGROUP INC | 60,39160,391 | $173,926 | 0.02% | TRIM -61% |
| 84 | 84Vanguard Global Advisers, LLC | 60,32560,325 | $173,736 | 0.02% | NEW |
| 85 | 85Quinn Opportunity Partners LLC | 60,10060,100 | $173,088 | 0.02% | — |
| 86 | 86State of New Jersey Common Pension Fund D | 59,17159,171 | $170,412 | 0.02% | NEW |
| 87 | 87Palumbo Wealth Management LLC | 58,45958,459 | $168,362 | 0.02% | TRIM -52% |
| 88 | 88JANUS HENDERSON GROUP PLC | 58,18958,189 | $167,293 | 0.02% | — |
| 89 | 89FRANKLIN RESOURCES INC | 57,90957,909 | $166,778 | 0.02% | TRIM -17% |
| 90 | 90BNP PARIBAS FINANCIAL MARKETS | 57,11857,118 | $164,500 | 0.02% | ADD 230% |
| 91 | 91AXQ CAPITAL, LP | 56,91156,911 | $163,904 | 0.02% | ADD 3% |
| 92 | 92Modus Advisors, LLC | 55,00055,000 | $158,400 | 0.02% | — |
| 93 | 93Virtus Investment Advisers, LLC | 53,05253,052 | $152,790 | 0.02% | ADD 3% |
| 94 | 94Brevan Howard Capital Management LP | 52,81052,810 | $152,093 | 0.02% | TRIM -25% |
| 95 | 95BFSG, LLC | 51,00051,000 | $146,880 | 0.02% | NEW |
| 96 | 96ARIZONA STATE RETIREMENT SYSTEM | 47,55747,557 | $136,964 | 0.02% | — |
| 97 | 97China Universal Asset Management Co., Ltd. | 47,26947,269 | $136,135 | 0.02% | ADD 9% |
| 98 | 98COLDSTREAM CAPITAL MANAGEMENT INC | 45,00145,001 | $129,603 | 0.02% | NEW |
| 99 | 99E Fund Management Co., Ltd. | 44,44644,446 | $128,004 | 0.02% | NEW |
| 100 | 100Police & Firemen's Retirement System of New Jersey | 44,24544,245 | $127,426 | 0.02% | — |