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Clinical trials
catalyst calendar across sponsors →Studies where RMD is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
79 interventional · 25 observational · 36 with posted results
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| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|
| PAP Systems External Clinical Studies (ECS)NCT06562205(usability) Comparison of the usability of an investigational component/s of the PAP system to a comparison component/s of the PAP system and/or Criterion Score of 6Randomized · Single-masked · Treatment | Not applicable | Not yet recruiting | Device: PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi) | Obstructive Sleep Apnea | 30 | 2028-10-01 | in 774 d | 2026-04-24 |
| Post Market Clinical Follow up of ResMed Mask SystemsNCT05262439Apnea Hypopnea Index (event/hour)Open-label · Treatment | Not applicable | Recruiting | Device: New generation CPAP mask | Obstructive Sleep Apnea | 500 | Jun 2027 | ≤ 315 d | 2026-04-29 |
| ASV Therapy for InsomniaNCT07011966Insomnia Severity Index (ISI) scoreOpen-label · Treatment | Not applicable | Recruiting | Device: ASV therapy | Insomnia, Insomnia (Moderate) | 25 | Dec 2026 | ≤ 134 d | 2026-05-19 |
| Data Collection Study to Review Novel Methods for Diagnosing Obstructive Sleep ApneaNCT06930404observationalCorrelation of measurement and obstructive sleep apnea status | — | Recruiting | Other: facial scans, videos and heart rate variability measurements | Obstructive Sleep Apnea (OSA) | 800 | 2026-12-30 | in 133 d | 2026-05-19 |
| Study of Min-Max APAP Recommender ToolNCT07400861Mean residual AHIRandomized · Single-masked · Treatment | Not applicable | Not yet recruiting | Device: CPAP with min-max recommender tool, CPAP with default settings | Obstructive Sleep Apnea (OSA) | 90 | 2026-12-01 | in 104 d | 2026-02-12 |
| INFORMing Patients With Oximetry Data to Improve MAD EngagementNCT07564310Mean overall patient reported experience measure (PREM) questionnaire scoreRandomized · Open-label · Treatment | Phase 4 | Not yet recruiting | Device: Narval MRD device, MyNarval intervention (Narval CC MAD + O2 ring + MyNarval smartphone application), | Obstructive Sleep Apnea (OSA) | 120 | 2026-12-01 | in 104 d | 2026-05-04 |
| Registry Study on Prescription, Patient Pathways, Therapy Efficacy and Usage of Mandibular Advancement Devices in Obstructive Sleep Apnea - PATT-OSA RegistryNCT03924817observationalChanges of the Apnoea-Hypopnea-Index (AHI) at baseline compared to a follow-up after 3 months | — | Active, not recruiting | — | Obstructive Sleep Apnea | 500 | 2026-10-31 | in 73 d | 2026-08-13 |
| Circadian Rhythm Monitoring StudyNCT07336654Feasibility of estimating circadian phase with the myCircadian wearable device. CorrelationOpen-label · Device feasibility | Not applicable | Not yet recruiting | Device: Circadian monitoring device | Circadian Rhythm | 30 | Oct 2026 | ≤ 73 d | 2026-05-19 |
| Exploration of Current and New Technologies for Accuracy of Diagnosing OSANCT07485582observationalSensitivity | — | Not yet recruiting | Device: Device A, Device B, Device C, Device D, Device E · Diagnostic test: Screener A | Obstructive Sleep Apnea | 90 | Oct 2026 | ≤ 73 d | 2026-08-19 |
| Evaluation of a Wearable PAP Device in a Tethered Configuration for the Treatment of Obstructive Sleep Apnoea.NCT07420140Subjective usability and overnight acceptabilityOpen-label · Treatment | Not applicable | Not yet recruiting | Device: Positive Airway Pressure | OSA - Obstructive Sleep Apnea | 15 | Jun 2026 | — | 2026-02-19 |
| Evaluation of a Novel Auto-Adjusting Positive Airway Pressure Algorithm for the Treatment of Obstructive Sleep Apnea Clinical StudyNCT06769607Comparison of the algorithm efficacy (AHI) to a clinically relevant dataRandomized · Single-masked · Treatment | Not applicable | Recruiting | Device: Investigational algorithm, Control algorithm | Obstructive Sleep Apnea | 80 | Dec 2025 | — | 2025-12-02 |
| Nyx3 Data Collection StudyNCT07099183observationalsleep-related EEG and accelerometry data | — | Not yet recruiting | — | Sleep Staging | 60 | 2025-10-01 | — | 2025-08-01 |
| Long-term Benefits of CPAP or MAD Treatment on the Sleep of OSAS PatientsNCT05435794observationalTo determine the evolution of deep slow-wave sleep at one year in OSA patients according to the treatment initiated by continuous positive pressure or mandibular advancement device (MAD). | — | Recruiting | Device: CPAP, MAD | OSA | 400 | 2022-10-15actual | — | 2024-05-21 |
| Long-term Observation of PAP-therapy With Telemonitoring: Telemedicine Registry TelePAPNCT03043716observationalUsage Patterns of PAP therapy with telemonitoring, assessed by data continuously recorded by the device and transferred via telemonitoring | — | Completed | Other: PAP therapy with telemonitoring | Obstructive Sleep Apnea, Central Sleep Apnea, Mixed Sleep Apnea | 14,147 | 2026-07-31actual | — | 2026-08-17 |
| Whitsundays (Nasal) Singapore External Clinical Study 1 ProtocolNCT05255744Subjective usabilityRandomized · Single-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: The study was discontinued prior to initiation because startup activities could not be completed within the planned timelines. | Device: Positive Airway Pressure (PAP) Therapy | Obstructive Sleep Apnea | 30 | 2025-05-06actual | — | 2026-04-27 |
| HomeVent ( Connect) Registry: EU COPD Home NIV RegistryNCT02811588observationalPhase 1: Prevalence of hypercapnia in patients with GOLD stage 3 and 4 COPD.Study Protocol ↗ | — | Completed | Device: Non-invasive ventilation | Chronic Obstructive Pulmonary Disease | 169 | Dec 2024actual | — | 2026-08-14 |
| PAP Systems Internal Clinical Studies (ICS)NCT06173050Subjective outcomes parameters scoresRandomized · Single-masked · Treatment | Not applicable | Completed | Device: PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi) | Obstructive Sleep Apnea | 30 | 2024-07-22actual | — | 2026-04-24 |
| Oran Park Mask External Clinical Study (3) Marketing Claims StudyNCT0607986611 point Likert Scale QuestionnaireRandomized · Open-label · Treatment | Not applicable | Completed | Device: Mask A (Oran Park Mask) then Mask B (Evora Mask), Mask B (Evora Mask) then Mask A (Oran Park Mask) | Obstructive Sleep Apnea | 58 | 2023-11-20actual | — | 2024-02-29 |
| Whitsundays (Nasal) Mask Take Home Study (90 Days)NCT0603632911 point Likert Scale QuestionnaireRandomized · Open-label · Other | Not applicable | Completed | Device: Group A : provided with 1 Whitsundays Nasal mask without a spare mask cushion, Group B : provided with 1 Whitsundays Nasal mask with 2 spare mask cushions | Obstructive Sleep Apnea | 120 | 2023-11-06actual | — | 2024-02-29 |
| The Effects of a Personalized Sleep Improvement App From SleepScore LabsNCT05195359results2025-11-26Change in SF B Sleep Quality From Baseline to 6 WeeksRandomized · Double-masked · PreventionStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Behavioral: Dein Schlaf. Dein Tag. sleep improvement application powered by SleepScore | Health Behavior | 637 | 2023-08-15actual | — | 2025-11-26 |
| Personal Therapy Comfort Settings Pilot Clinical StudyNCT05376137Comparison of treatment continuance between the control group and active treatment group.Randomized · Double-masked · Treatment | Not applicable | Completed | Device: continuous positive airway pressure (CPAP) | Obstructive Sleep Apnea | 66 | 2023-06-30actual | — | 2023-11-18 |
| Leo Study Unstable AsthmaNCT05308277Airway resistance through oscillometry testOpen-label · Other | Not applicable | Unknown status | Device: Leo device monitoring | Asthma in Children | 30 | Apr 2023 | — | 2022-09-26 |
| A Preference Study of Two Pneumatic Compression Devices for Patients With Lower Limb LymphedemaNCT05485454Satisfaction and PreferenceRandomized · Open-label · Other | Not applicable | Completed | Device: Aria Health Aria Free, A Traditional PCD | Lymphedema of Leg, Lymphedema, Lymphedema, Secondary, Lymphedema Primary, Lymphedema, Lower Limb | 20 | 2022-07-30actual | — | 2022-09-15 |
| Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-VentilationNCT03032029observationalQuality of Life, assessed with the Functional Outcomes of Sleep Questionnaire (FOSQ) by comparing the score at baseline with the 12 months follow-up. | — | Completed | Device: Adaptive Servo-Ventilation | Central Sleep Apnea, Complex Sleep Apnea, Obstructive Sleep Apnea, Mixed Sleep Apnea | 847 | 2022-06-30actual | — | 2024-10-16 |
| Safety and Feasibility of a Novel Device for Assessing Respiratory Function in ChildrenNCT04873193Slow vital capacity from Leo deviceOpen-label · Device feasibility | Not applicable | Completed | Device: Leo device | Asthma in Children | 30 | 2022-01-21actual | — | 2022-09-26 |
| An Exploratory Investigation of the Use of Drive App to Measure Sleep Parameters in Users of CPAP TherapyNCT04500327Identify any failures when using the Drive app for users of CPAP therapyOpen-label · Device feasibility | Not applicable | Unknown status | Other: Drive app · Device: Non contact motion sensor | Obstructive Sleep Apnea | 12 | Jun 2021 | — | 2020-08-05 |
| Development of Advanced Leak Detection Technologies for Positive Airway Pressure Devices TherapiesNCT04741854Acoustic signalsOpen-label · Treatment | Not applicable | Completed | Device: Positive Airway Pressure (PAP) Therapy | Obstructive Sleep Apnea (OSA) | 27 | 2021-03-12actual | — | 2024-10-16 |
| Evaluating the Efficacy of PAP Therapy for Treating OSA in the Home EnvironmentNCT04744038UsabilityOpen-label · Treatment | Not applicable | Completed | Device: Positive Airway Pressure (PAP) Therapy | Obstructive Sleep Apnea (OSA) | 108 | 2021-03-05actual | — | 2021-07-13 |
| Nebula Study - Screener Apps and HSAT vs. PSG ComparisonNCT04597749AHI value. Clinical decision for treatment output (Y to CPAP or N to CPAP) of Screener apps and HSAT compared to PSG.Open-label · Screening | Not applicable | Completed | Diagnostic test: PSG, Home Sleep Apnea Test with FDA cleared devices · Other: Non-Contact Screening App | Sleep Apnea, Obstructive | 50 | 2020-12-31actual | — | 2021-02-04 |
| Evaluation of a Health Dashboard Intervention to Improve Engagement With CPAP Therapy in PAP-Naïve Patients: Project NeoNCT04912635Mean CPAP use hoursRandomized · Open-label · Other | Not applicable | Completed | Other: Neo App | Sleep Apnea, Obstructive | 300 | 2020-12-19actual | — | 2021-06-03 |
| French Cohort Study of Chronic Heart Failure Patients With Central Sleep Apnoea Eligible for Adaptive Servo-Ventilation (PaceWave, AutoSet CS)NCT01831128observationalTime to first event of all cause mortality or unplanned hospitalization for worsening heart failure | — | Completed | Device: ASV Treatment | Chronic Heart Failure, Central Sleep Apnea | 509 | Sep 2020actual | — | 2021-02-02 |
| Portable Oxygen Concentrator Improvements to Physical Activity, Oxygen Usage, and Quality of Life in Chronic Obstructive Pulmonary Disease Patients Using Long-term Oxygen Therapy (POC-STEP)NCT03513068results2022-02-16Physical Activity LevelRandomized · Open-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: COVID-19 | Device: Portable Oxygen Concentrator (POC) | COPD | 108 | 2020-09-02actual | — | 2022-02-16 |
| Compact Pneumatic Compression Device for Patients With LymphedemaNCT04226287Usability of the Monterey Investigational System in a monitored clinic environmentNon-randomized · Open-label · Other | Not applicable | Completed | Device: Monterey Pneumatic Compression Device | Lymphedema of Limb | 12 | 2020-08-31actual | — | 2020-10-22 |
| Evaluation of an Incentive-based Intervention to Improve 90-day Adherence in PAP-Naive PatientsNCT03851094results2021-06-15Mean PAP Usage at 90 DaysRandomized · Open-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ · Informed Consent Form ↗ | Not applicable | Completed | Behavioral: Wellth app | Obstructive Sleep Apnea | 166 | 2020-05-18actual | — | 2021-06-15 |
| AirSense 10 AHI Validation StudyNCT03043703To evaluate the diagnostic accuracy of the AirSense 10 Apnea-Hypopnea-Index (AHI) algorithm compared to polysomnography (PSG) scored AHI.Open-label · Diagnostic | Not applicable | Withdrawnsponsor's stated reason: Study has no principal investigator at the moment. | Device: AirSense 10 AutoSet for Her | Sleep Apnea | 0 | Mar 2020 | — | 2019-03-28 |
| Evaluation of a Portable Oxygen Concentrator During Ambulation for Patients Who Require Supplemental Oxygen (POC-LEAN)NCT04107493results2021-05-26Mean SpO2 (Oxygen Saturation) During Six Minute Walk Tests (6MWTs)Randomized · Open-label · Supportive careStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Portable Oxygen Cylinder, Mobi | Chronic Obstructive Pulmonary Disease | 33 | 2020-03-09actual | — | 2021-05-26 |
| Validation of ApneaLink Air Home Sleep Testing in the Diagnosis of Obstructive Sleep Apnea in Adolescent ChildrenNCT03748771results2021-11-15Accuracy of HST Compared to ALT (ApneaLink Lab Testing) and PSG (Polysomnography)Open-label · DiagnosticStudy Protocol and Statistical Analysis Plan ↗ | — | Completed | Device: ApneaLink Air | Sleep Apnea, Obstructive | 20 | 2020-02-28actual | — | 2021-11-15 |
| Assessment of the Effect of PAP on Energy and Vitality in Mild OSA Patients: The Merge StudyNCT02699463results2021-01-26Change in Quality of Life Using the Energy and Vitality Subscale of the Short Form 36 (SF-36) QuestionnaireRandomized · Open-label · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Not applicable | Completed | Device: Continous Positive Airway Pressure · Other: Control Group | Obstructive Sleep Apnea | 301 | May 2019actual | — | 2021-01-26 |
| Evaluation of Prophylactic Heated Humidification on Obstructive Sleep Apnea (OSA) Patient Short Term Compliance to CPAP TherapyNCT04391699CPAP mean usage (hours/night) at the 3 month follow upRandomized · Open-label · Treatment | Not applicable | Withdrawnsponsor's stated reason: cancelled before initiation | Device: heated humidification | Osa Syndrome | 0 | Apr 2019 | — | 2020-05-18 |
| ApneaLink Air Home Sleep Testing (HST) Device Validation StudyNCT03470493results2021-05-20Diagnostic Sensitivity of Apnealink (AL) Compared With Polysomnography (PSG)Open-label · DiagnosticStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Diagnostic test: ApneaLink Air | Sleep-disordered Breathing | 130 | 2019-03-06actual | — | 2021-05-20 |
| Narval CC Mandibular Repositioning Device in the Second-line Treatment of Severe Obstructive Sleep Apnea Hypopnea (OSAH)NCT01326143observationalPercentage of patients with Apnea/Hypopnea Index (AHI) reduced by at least 50% compared to baseline measured by Polygraphy/Polysomnography (PG/PSG) | — | Completed | Device: ORM Narval MRD | Obstructive Sleep Apnea Syndrome | 360 | Feb 2019actual | — | 2020-04-02 |
| European Home Mechanical Ventilation RegistryNCT02315339observationalDetermine the mortality rate and the number of hospital readmissions | — | Terminated | — | Pulmonary Disease, Chronic Obstructive, Amyotrophic Lateral Sclerosis, Spinal Cord Injury, Muscular Dystrophies, Obesity Hypoventilation Syndrome, Kyphoscoliosis, Congenital Central Hypoventilation Syndrome, Duchenne Muscular Dystrophy, Myopathies, Myotonic Dystrophy | 37 | Jan 2019actual | — | 2020-04-09 |
| Prospective Cohort Study of Patients Intolerant to High Pressure Under Continuous Positive Airway Pressure Treated With Bilevel Positive Airway Pressure as Second-line Therapy.NCT02930460observationalCompliance | — | Terminated | — | Obstructive Sleep Apnea | 30 | Nov 2018actual | — | 2020-02-28 |
| Snore Positive Airway Pressure TrialNCT03201055Subjectively assess the participant and bed partner acceptability and usability of Snore PAP systemOpen-label · Treatment | Not applicable | Completed | Device: Snore PAP System | Non-Apnoeic Snorers | 24 | 2018-07-31actual | — | 2021-02-18 |
| Usability of a Breathing-CBT Platform (CBT = Cognitive Behavioural Therapy)NCT04776122Ease of useRandomized · Open-label · Treatment | Not applicable | Completed | Device: Therapy · Other: No device | Breathing, Mouth | 10 | 2018-06-30actual | — | 2021-03-01 |
| Pilot Study Evaluating Feasibility and Benefits of Telemonitored NIV Treatment on COPD PatientsNCT02258191Blood Gaz and nocturnal transcutaneous carbon dioxyde partial pressure (PtCO2) evolutionRandomized · Open-label · Other | Not applicable | Completed | Device: telemonitoring, sham telemonitoring | COPD | 20 | Jan 2018actual | — | 2018-01-23 |
| SchlaHF-XT-Register. Sleep Disordered Breathing in Heart Failure RegisterNCT02301689observationalNumber of heart failure patients with sleep disordered breathing (apnea hypopnoea index >5) | — | Completed | — | Heart Failure (HF) | 4,749 | Dec 2017actual | — | 2020-04-09 |
| Vent Flow Study of Prototype Nasal CPAP MaskNCT02805777Changes in vent flow of the mask system, which will be recorded on a flow testing rig (units= LPM). Baseline flow in LPM will be compared to that at the conclusion of the trial.Randomized · Open-label · Treatment | Not applicable | Withdrawnsponsor's stated reason: Study not required due to change in device | Device: CPAP mask | Obstructive Sleep Apnea (OSA) | 0 | Dec 2017 | — | 2021-02-04 |
| Adherence to ASV Therapy in Heart Failure With Preserved Ejection Fraction Feasibility StudyNCT03195660results2021-05-14ASV AdherenceOpen-label · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Terminatedsponsor's stated reason: Funding for study was withdrawn | Device: ASV Therapy | Heart Failure With Normal Ejection Fraction, Sleep Apnea | 6 | 2017-11-15actual | — | 2021-05-14 |
| A Study of Expiratory Pressure Modulation in Moderate to Severe COPD Patients - Phase 1bNCT02585752Visual Analogue ScaleOpen-label · Other | Not applicable | Terminatedsponsor's stated reason: Low recruitment | Device: Noninvasive ventilation | Chronic Obstructive Pulmonary Disease | 20 | 2017-09-30actual | — | 2018-04-23 |
| CPAP vs ASV for InsomniaNCT02365064results2021-09-09Insomnia Severity IndexRandomized · Single-masked · TreatmentStudy Protocol and Statistical Analysis Plan ↗ | Not applicable | Completed | Device: AirCurve 10 ASV | Insomnia, Sleep-Disordered Breathing | 78 | Aug 2017actual | — | 2021-09-09 |
| Portable Oxygen Concentrator Signal Capture StudyNCT03182036OxygenationOpen-label · Treatment | Not applicable | Completed | Device: Portable pulsed oxygen | Hypoxia | 20 | 2017-08-03actual | — | 2021-04-19 |
| Clinical Impact of 2 Types of Mandibular Retention Devices - Narval O.R.M CadCam Design vs Narval O.R.M Traditional Design - on Obstructive Sleep Apnea (OSA) Therapy: ESTAMPS StudyNCT02755662upper airway volumeRandomized · Open-label · Treatment | Not applicable | Completed | Device: Mandibular Retention Device | Obstructive Sleep Apnea Syndrome | 12 | Jul 2017actual | — | 2017-09-28 |
| Respiration Rate Monitoring in COPD PatientsNCT03030313Correlation of Respiration Rate to Indicators of Healthcare UtilizationOpen-label · Prevention | Not applicable | Completed | Device: Reassure Non-Contact Respiration Monitor | Pulmonary Disease, Chronic Obstructive | 50 | 2017-07-26actual | — | 2017-11-17 |
| French Cohort Study of Chronic Heart Failure Patients With Central Sleep Apnoea Eligible for Adaptive Servo-Ventilation (PaceWave, AutoSet CS, AirCurve 10CS): Predictive Factors of Poor Compliance (FACE)NCT02356367observationalto define the phenotype of compliant or not compliant patients to sleep disordered breathing therapy using microneurography | — | Withdrawn | Other: telemonitoring | Central Sleep Apnea, Heart Failure | 0 | May 2017 | — | 2017-04-12 |
| Positive Airway Pressure Therapy Study in Sleep Apnea and Diastolic Heart FailureNCT02254382Change in Apnea-Hypopnea-Index (AHI)Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Recruitment rates too low | Device: Adaptive servo ventilation (ASV) | Diastolic Heart Failure | 2 | Mar 2017actual | — | 2017-04-17 |
| Astral VAPS AutoEPAP Clinical TrialNCT02683772results2019-07-26Oxygen Desaturation Index 4% (ODI4%)Randomized · Single-masked · TreatmentStudy Protocol ↗ · Statistical Analysis Plan ↗ | Phase 3 | Completed | Device: Astral | Upper Airway Obstruction, Respiratory Insufficiency, Respiratory Failure | 42 | 2017-03-01actual | — | 2019-07-26 |
| AutoSet for Her Quality of Life Clinical TrialNCT02400073results2019-10-02Assessment of Quality of Life Using the Functional Outcomes of Sleep Questionnaire (FOSQ)Open-label · Treatment | Not applicable | Completed | Device: AutoSet for Her | Obstructive Sleep Apnea | 122 | 2017-01-05actual | — | 2019-10-02 |
| The Effect of NIV on QoL and Exercise Capacity in a COPD Exercise Rehabilitation ProgramNCT02100709Daily Physical ActivityRandomized · Open-label · Treatment | Not applicable | Terminatedsponsor's stated reason: Sample size calculation would have been overinflated; re-think study design | Device: BiLevel Noninvasive Ventilation | Chronic Obstructive Pulmonary Disease | 14 | Oct 2016actual | — | 2017-05-02 |
| Comparison of Two Continuous Positive Airway Pressure SystemsNCT02535234Subjective usability ratings of the prototype system using a visual analogue scale, compared to a reference level and the second full system.Randomized · Open-label · Treatment | Not applicable | Completed | Device: Novel System, Traditional System | Obstructive Sleep Apnoea | 30 | Jun 2016actual | — | 2021-02-04 |
| Reassure Remote Respiration Monitoring in Heart Failure PatientsNCT02624739results2021-05-13Percent Successful Data TransmissionsRandomized · Open-label · Supportive care | Not applicable | Terminatedsponsor's stated reason: Funding for study was withdrawn. | Device: Reassure Non-Contact Respiration Monitor | Heart Failure | 17 | 2016-06-02actual | — | 2021-05-13 |
| Cardiovascular Improvements With MV ASV Therapy in Heart FailureNCT01953874results2018-02-28Global Rank EndpointRandomized · Open-label · Supportive care | Not applicable | Terminatedsponsor's stated reason: SERVE-HF results showed ASV increased CV mortality in patients with reduced LVEF | Device: MV ASV · Drug: Optimized Medical Treatment | Acute Decompensated Heart Failure, Sleep Disordered Breathing | 126 | Dec 2015actual | — | 2018-02-28 |
| Juno Perth Clinical TrialNCT02317042results2021-06-08Apnoea-Hypopnoea Index (AHI)Randomized · Triple-masked · Treatment | Not applicable | Terminatedsponsor's stated reason: Phase II not initiated for commercial reasons (no safety related issues) | Device: Juno, Juno, Juno | Respiratory Insufficiency, Obesity Hypoventilation Syndrome, Chronic Obstructive Pulmonary Disease (COPD), Neuromuscular Disease, Upper Airway Obstruction | 25 | Nov 2015actual | — | 2021-06-08 |
| Usability Evaluation - Reassure Respiration Rate Device: Home User StudyNCT02740517results2021-05-07observationalPercentage of Nights' Data That Were Successfully Recorded | — | Completed | — | Ease of Use | 48 | Nov 2015actual | — | 2021-05-07 |
| Adaptive Servo-ventilation Monitoring StudyNCT02133859observationalCorrelation of hypoxemia, as measured by overnight pulse oximetery, with worsening heart failure | — | Completed | — | Chronic Heart Failure | 40 | Jul 2015actual | — | 2017-04-27 |
| Usability Evaluation of Menai CPAP MasksNCT02364375Usability Performance EvaluationRandomized · Open-label · Supportive care | Not applicable | Completed | Device: Menai mask (full face), Menai Standard mask (full face), Menai mask (nasal), Menai Standard mask (nasal), Menai mask (pillows), Menai Standard mask (pillows) | Obstructive Sleep Apnea | 30 | Jul 2015actual | — | 2021-02-04 |
| Reassure Device: Measurement Accuracy of Continuous Respiration RateNCT02740478results2021-04-02observationalRespiration Rate Comparability | — | Completed | — | Accuracy of Respiration Rate Measurement | 20 | Jul 2015actual | — | 2021-04-02 |
| Comparison of Auto-Adjusting Positive Airway Pressure DevicesNCT02357706results2020-04-20Mean Apnoea-Hypopnoea-Index (AHI)Randomized · Single-masked · Treatment | Not applicable | Completed | Device: APAP A (ResMed AirSense AutoSet), APAP B (Apex iCH Auto) | Obstructive Sleep Apnea | 20 | Jun 2015actual | — | 2020-04-20 |
| Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart FailureNCT00733343results2020-05-12All Cause Mortality or Unplanned Hospitalisation/Prolongation of Hospitalisation for Worsening Heart FailureRandomized · Open-label · Treatment | Not applicable | Completed | Device: Europe: AutoSet CS (USA: VPAP Adapt SV) | Heart Failure, Sleep Disordered Breathing | 1,325 | Apr 2015actual | — | 2020-05-12 |
| Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilationNCT01164592Change in Left Ventricular Ejection Fraction (LVEF) from baseline to 12 months of therapy as measured by echocardiography (Echo).Randomized · Open-label · Treatment | Phase 4 | Completed | Device: adaptive servoventilation (ASV) | Heart Failure, Sleep Disorder, Cheyne Stokes Respiration | 312 | Apr 2015actual | — | 2015-08-07 |
| Bioburden and Usability Evaluation of a Nasal Prototype CPAP MaskNCT02255539Changes from baseline in Bioburden and Impedance of the prototype mask components at 6 weeksOpen-label · Supportive care | Not applicable | Completed | Device: Geelong Prototype Mask | Obstructive Sleep Apnea | 42 | Mar 2015actual | — | 2021-02-01 |
| Reassure Spot Respiration Rate Accuracy Compared to SOMNOScreenNCT02740504results2021-04-02observationalRespiration Rate Accuracy | — | Completed | — | Accuracy of Measurement of Respiration Rate | 20 | Mar 2015actual | — | 2021-04-02 |
| Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated AlgorithmNCT01403584results2021-03-26Index of Apneoas Plus Hypopnoeas Per Hour of Sleep (AHI)Randomized · Single-masked · Treatment | Not applicable | Completed | Device: AutoVPAP with addition of AutoEPAP, AutoVPAP with EPAP manually selected | Respiratory Insufficiency, Sleep Disordered Breathing | 21 | Feb 2015actual | — | 2021-03-26 |
| Analysis of a New Mask for Positive Airway Pressure (PAP) Device UsersNCT01847846To measure and compare the prevalence of microorganisms within the new mask over a period of 8 weeksOpen-label · Supportive care | Not applicable | Completed | Device: CPAP mask - prototype | Obstructive Sleep Apnea | 23 | Oct 2014actual | — | 2021-02-04 |
| The Evaluation of a New Sleep AlgorithmNCT01925430observationalTotal sleep time | — | Completed | Device: Screening device, Comparative product | Healthy | 36 | Feb 2014actual | — | 2014-05-02 |
| Ventilator Monitoring in Early Exacerbation DetectionNCT01644162Change in ventilator pressure support from baselineOpen-label · Supportive care | Not applicable | Completed | Device: iVAPS ventilation | Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome | 30 | Jan 2014actual | — | 2014-10-17 |
| AutoSet for Her Clinical Trial ProtocolNCT01826513results2017-03-27Apnoea Hypopnoea Index (AHI)Randomized · Single-masked · Treatment | Not applicable | Completed | Device: Standard AutoSet algorithm, Modified AutoSet algorithm | Obstructive Sleep Apnea | 25 | Jun 2013actual | — | 2017-03-27 |
| Sleep-Disordered Breathing in Heart Failure - The SchlaHF-RegistryNCT01500759results2020-07-09observationalPrevalence of SDB in Chronic HF Patients | — | Completed | — | Congestive Heart Failure, Left Ventricular Systolic Dysfunction | 6,876 | May 2013actual | — | 2020-07-09 |
| Nasal Pillows vs. Nasal Masks at High CPAP PressureNCT01690923results2014-10-08AHI on Nasal Mask and Pillows MaskRandomized · Open-label · Treatment | Not applicable | Completed | Device: Nasal mask, Pillows mask | OSA | 20 | Dec 2012actual | — | 2014-10-08 |
| Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid UseNCT01462084results2017-04-17Apnea Hypopnea Index (AHI)Randomized · Triple-masked · Treatment | Not applicable | Completed | Device: Adaptive servo-ventilation (ASV), Bi-Level PAP | Obstructive Sleep Apnea, Central Sleep Apnea (Diagnosis), Chronic Opioid Use | 21 | Nov 2012actual | — | 2017-04-17 |
| Performance of the Tasman Continuous Positive Airway Pressure (CPAP) SystemNCT01171066To determine if the efficacy of the treatment is clinically equivalent to or better than the predicate device (S8 Escape)Open-label · Treatment | Not applicable | Completed | Device: Tasman CPAP system | Obstructive Sleep Apnea | 57 | Oct 2012actual | — | 2021-02-04 |
| Assessment of the Performance of a New Reduced Noise Mask VentNCT01575210The apnoea/hypopnoea index (AHI) will be recorded and analysed.Randomized · Open-label · Treatment | Not applicable | Completed | Device: CPAP mask, CPAP mask | Obstructive Sleep Apnoea (OSA) | 31 | Oct 2012actual | — | 2021-03-01 |
| GLYCOSA Study:Effect of PAP Treatment on Glycemic Control in Patients With Type 2 DiabetesNCT00509223results2013-10-17HbA1c ChangeRandomized · Open-label · Treatment | Not applicable | Completed | Device: Positive Airway Pressure therapy · Behavioral: Lifestyle counseling | Diabetes Mellitus Type 2 | 416 | Feb 2012actual | — | 2013-12-30 |
| Evaluation of Acclimate Feature for Positive Airway Pressure (PAP) TherapyNCT01421654results2013-03-07Hours UsedRandomized · Single-masked · Treatment | Not applicable | Completed | Device: S9 Elite with Acclimate, S9 Elite | Obstructive Sleep Apnea | 20 | Dec 2011actual | — | 2013-03-12 |
| Complex Sleep Apnea Syndrome (CompSAS) Resolution StudyNCT00915499results2013-02-22Apnea-hypopnea Index (AHI) Per Polysomnography (PSG) at the End of Treatment PeriodRandomized · Double-masked · Treatment | Not applicable | Completed | Device: VPAP Adapt SV | Complex Sleep Apnea Syndrome | 66 | Oct 2011actual | — | 2013-02-28 |
| Mechanisms of Action of Adaptive ServoventilationNCT00976417observational | — | Completed | — | Heart Failure, Sleep Apnea Syndromes | 50 | Oct 2011actual | — | 2011-12-07 |
| Modified Adaptive Servoventilation (ASV) Compared to Conventional ASVNCT01405313results2017-03-20Apnea/Hypopnea Index (AHI)Randomized · Open-label · Treatment | Not applicable | Completed | Device: Modified Adaptive Servoventilation Device, Conventional Adaptive Servoventilation device | Periodic Breathing, Breathing-Related Sleep Disorder | 21 | Sep 2011actual | — | 2017-03-20 |
| Pediatric Nasal Mask Usability StudyNCT01154322results2013-01-16Apnea-hypopnea Index (AHI) Using the New Pediatric Mask (Pixi) Compared to the Child's Currently-used MaskNon-randomized · Open-label · Treatment | Not applicable | Completed | Device: Pixi pediatric mask | Obstructive Sleep Apnea | 16 | Jul 2011actual | — | 2013-01-24 |
| Performance of the Salt Lake Mask SystemNCT01395693Subjectively Assessed Levels of Seal, Comfort, Stability and Overall Performance.Open-label · Supportive care | Phase 2 | Completed | Device: Salt Lake mask system | Obstructive Sleep Apnea | 20 | Jul 2011actual | — | 2012-04-20 |
| Study of the Usability and Efficacy of a New Pediatric CPAP MaskNCT01312948results2012-03-19Usability Ratings of the Pixi Paediatric Mask Compared With the Child's Current MaskOpen-label · Treatment | Not applicable | Completed | Device: Prototype mask (known as Pixi) | Obstructive Sleep Apnea, Respiratory Insufficiency | 6 | Jun 2011actual | — | 2017-06-26 |
| Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed PatientsNCT00901485results2021-06-18Overnight Mean Oxygen SaturationRandomized · Single-masked · Treatment | Not applicable | Completed | Device: AutoVPAP, VPAPIIIST-A | Nocturnal Hypoventilation, Neuromuscular Disease, Chest Wall Disorder | 23 | Mar 2011actual | — | 2021-06-18 |
| Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Acute Exacerbation of Respiratory FailureNCT01174316pH at 1+ hourRandomized · Single-masked · Treatment | Not applicable | Withdrawnsponsor's stated reason: difficulty recruiting | Device: AutoVPAP™, VPAPIIIST-A™ | Respiratory Failure, Neuromuscular Disease, Chest Wall Disorder, Chronic Obstructive Pulmonary Disease, Obesity Hypoventilation Syndrome | 0 | 2011-03-01actual | — | 2021-04-19 |
| Performance Validation of a Non-contact Breathing Frequency Monitor (Model BM07)NCT01319396results2011-08-15observationalRespiration Rate Accuracy - Mean Difference in Breaths Per Minute Between the BM07 5GHz Sensor and SomnoScreen Devices | — | Completed | — | Unspecified Threat to Breathing | 24 | Dec 2010actual | — | 2021-04-01 |
| Investigation of Heart Failure Status Over Time Using Respiratory ParametersNCT00494117observational | — | Completed | Device: ApneaLink | Heart Failure, Congestive, Sleep Apnea Syndromes | 50 | Mar 2010actual | — | 2010-07-27 |
| Cardiovascular Responses in Congestive Heart Failure With Cheyne- Stokes RespirationNCT00495196Cardiovascular parameters such as continuous blood pressure and heart rate.Non-randomized · Open-label · Basic science | Not applicable | Completed | Procedure: Experimental lung function test | Heart Failure, Congestive, Cheyne-Stokes Respiration | 50 | Mar 2010actual | — | 2010-07-27 |
| Nexus Compliance StudyNCT01013207results2010-09-01Compliance on CPAPNon-randomized · Open-label · Treatment | Not applicable | Completed | Device: CPAP Pre Nexus (S9), Nexus (S9), CPAP Post Nexus (S9) | Obstructive Sleep Apnea | 50 | Mar 2010actual | — | 2010-09-08 |
| Comparison of Modified With Conventional Adaptive Servoventilation ProcessesNCT01037439Apnea/hypopnea index (AHI)Randomized · Single-masked · Treatment | Not applicable | Completed | Device: Adaptive Servo-controlled Ventilation (ASV) | Periodic Breathing, Cheyne-Stokes Respiration | 20 | Sep 2009actual | — | 2021-02-05 |
| Modified AutoSet Device vs Existing AutoSet Device, the Assessment of Efficacy and Subjective Comfort of the Treatment.NCT00906958results2021-03-22Apnoea-Hypopnoea Index (AHI)Randomized · Single-masked · Treatment | Not applicable | Completed | Device: Nexus Flow Generator, VPAP Flow Generator 25 | Sleep Apnea | 20 | 2009-06-15actual | — | 2021-03-22 |
| Evaluation of a Portable Device for Assessing Sleep Disordered Breathing in Congestive Heart FailureNCT00493948observationalApnea- Hypopnea Index | — | Completed | Device: ApneaLink | Heart Failure, Congestive, Sleep Apnea Syndromes | 35 | Apr 2009actual | — | 2009-11-11 |
| Evaluation of ApneaLink Plus Scoring CapabilitiesNCT00823134results2020-05-12Assessment of the Apnoea-Hypopnea-Index (Number of Apneas (All Apneas, Obstructive, Mixed, Central) and Number of Hypopneas) Between ApneaLink Plus and a PSG System Within the Same Evaluation PeriodOpen-label · Screening | Not applicable | Completed | Device: ApneaLink Plus | Sleep Apnea, Central, Sleep Apnea, Obstructive | 23 | Mar 2009actual | — | 2020-05-12 |
| Foam Mask - Assessment of Bioburden in a New Mask Seal MaterialNCT00773721Measurement of bacterial accumulation in the new material.Open-label · Treatment | Not applicable | Completed | Device: CPAP mask | Obstructive Sleep Apnea (OSA) | 20 | Dec 2008actual | — | 2021-02-04 |
| Improved Automatic CPAP Algorithm to Treat Obstructive Sleep Apnea (OSA)NCT00850434Physiological sleep signals including EEG, Sp02, respiratory effort and nasal flow, will be recorded, analysed and reported in the form of a series of indices, which are the outcome variables of the study.Randomized · Double-masked · Treatment | Not applicable | Completed | Device: Modified AutoSet Algorithm, Standard AutoSet Algorithm | Obstructive Sleep Apnea (OSA) | 20 | Sep 2008actual | — | 2021-02-04 |
| AutoVPAP Versus VPAP; Assessment of Sleep and VentilationNCT00252252Compare objective measures of sleep, sleep related ventilation and daytime respiratory function between the two treatment devices, VPAP and AutoVPAP.Randomized · Open-label · Treatment | Phase 1 | Completed | Device: VPAP non-invasive ventilator, AutoVPAP non-invasive ventilator | Chest Wall Disorder, Neuromuscular Disease | 20 | Jun 2007actual | — | 2008-06-24 |
| Validation of the ApneaLink Sleep Screener for Obstructive Sleep Apnea (OSA)NCT00354614results2017-06-28observationalSensitivity and Specificity | — | Completed | Device: ApneaLink Sleep Screener | Obstructive Sleep Apnea | 81 | Mar 2007actual | — | 2017-06-28 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19