| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 2,252,9872.3M | $14M | 15.40% | — |
| 2 | Atlas Venture Life Science Advisors, LLC | 2,092,1062.1M | $13M | 14.30% | — |
| 3 | Opaleye Management Inc. | 1,256,2281.3M | $8M | 8.59% | ADD 489% |
| 4 | Carlyle Group Inc. | 1,102,7411.1M | $7M | 7.54% | — |
| 5 | ARCH Venture Management, LLC | 320,482320,482 | $2M | 2.19% | — |
| 6 | ACORN CAPITAL ADVISORS, LLC | 315,052315,052 | $2M | 2.15% | TRIM -36% |
| 7 | VANGUARD CAPITAL MANAGEMENT LLC | 306,401306,401 | $2M | 2.09% | NEW |
| 8 | MACKENZIE FINANCIAL CORP | 246,304246,304 | $2M | 1.68% | NEW |
| 9 | Sanofi | 244,083244,083 | $2M | 1.67% | — |
| 10 | RENAISSANCE TECHNOLOGIES LLC | 206,915206,915 | $1M | 1.41% | ADD 108% |
| 11 | ACADIAN ASSET MANAGEMENT LLC | 172,586172,586 | $1M | 1.18% | ADD 257% |
| 12 | MONIMUS CAPITAL MANAGEMENT, LP | 134,310134,310 | $862,270 | 0.92% | NEW |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 118,152118,152 | $758,740 | 0.81% | ADD 11% |
| 14 | Pfizer Inc | 101,618101,618 | $736,731 | 0.69% | TRIM -63% |
| 15 | BlackRock, Inc. | 86,14786,147 | $553,063 | 0.59% | ADD 44% |
| 16 | JANE STREET GROUP, LLC | 65,59965,599 | $421,145 | 0.45% | ADD 159% |
| 17 | MARSHALL WACE, LLP | 52,44052,440 | $336,664 | 0.36% | NEW |
| 18 | VANGUARD FIDUCIARY TRUST CO | 49,99549,995 | $320,968 | 0.34% | NEW |
| 19 | TWO SIGMA INVESTMENTS, LP | 42,34642,346 | $271,861 | 0.29% | TRIM -10% |
| 20 | STATE STREET CORP | 41,51441,514 | $266,520 | 0.28% | ADD 95% |
| 21 | Cambridge Investment Research Advisors, Inc. | 35,02535,025 | $225,000 | 0.24% | NEW |
| 22 | ADAR1 Capital Management, LLC | 35,00035,000 | $224,700 | 0.24% | ADD 75% |
| 23 | Affinity Asset Advisors, LLC | 27,77727,777 | $178,328 | 0.19% | — |
| 24 | NORTHERN TRUST CORP | 25,03325,033 | $160,712 | 0.17% | — |
| 25 | Cetera Investment Advisers | 20,69520,695 | $132,862 | 0.14% | NEW |
| 26 | AMERICAN CENTURY COMPANIES INC | 18,77018,770 | $120,503 | 0.13% | NEW |
| 27 | CITADEL ADVISORS LLC | 15,48115,481 | $99,388 | 0.11% | TRIM -66% |
| 28 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 12,61312,613 | $80,975 | 0.09% | NEW |
| 29 | MORGAN STANLEY | 9,5609,560 | $61,375 | 0.07% | ADD 75% |
| 30 | EverSource Wealth Advisors, LLC | 4,6404,640 | $29,789 | 0.03% | — |
| 31 | FMR LLC | 3,4003,400 | $21,828 | 0.02% | — |
| 32 | ROYAL BANK OF CANADA | 2,7442,744 | $18,000 | 0.02% | ADD 1068% |
| 33 | FEDERATED HERMES, INC. | 2,2732,273 | $14,593 | 0.02% | — |
| 34 | Vanguard Global Advisers, LLC | 1,9151,915 | $12,294 | 0.01% | NEW |
| 35 | Tower Research Capital LLC (TRC) | 1,8711,871 | $12,012 | 0.01% | ADD 92% |
| 36 | Arax Advisory Partners | 1,1481,148 | $7,370 | 0.01% | ADD 3% |
| 37 | Rockefeller Capital Management L.P. | 577577 | $3,704 | 0.00% | — |
| 38 | JONES FINANCIAL COMPANIES LLLP | 500500 | $3,625 | 0.00% | — |
| 39 | Russell Investments Group, Ltd. | 454454 | $2,915 | 0.00% | — |
| 40 | BNP PARIBAS FINANCIAL MARKETS | 303303 | $1,945 | 0.00% | — |
| 41 | UBS Group AG | 270270 | $1,733 | 0.00% | TRIM -98% |
| 42 | NISA INVESTMENT ADVISORS, LLC | 166166 | $1,066 | 0.00% | — |
| 43 | OSAIC HOLDINGS, INC. | 124124 | $796 | 0.00% | TRIM -6% |
| 44 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111111 | $713 | 0.00% | ADD 270% |
| 45 | SBI Securities Co., Ltd. | 104104 | $668 | 0.00% | TRIM -34% |
| 46 | Allworth Financial LP | 9898 | $630 | 0.00% | — |
| 47 | WELLS FARGO & COMPANY/MN | 8484 | $539 | 0.00% | NEW |
| 48 | Federation des caisses Desjardins du Quebec | 7070 | $446 | 0.00% | — |
| 49 | CWM, LLC | 3939 | $250 | 0.00% | TRIM -28% |
| 50 | GROUP ONE TRADING LLC | 3434 | $218 | 0.00% | — |
| 51 | HARBOUR INVESTMENTS, INC. | 1111 | $71 | 0.00% | — |
| 52 | AdvisorNet Financial, Inc | 22 | $13 | 0.00% | — |
| 53 | DANSKE BANK A/S | 11 | $6 | 0.00% | — |
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 2.3M | 2.3M | 2.3M | 2.3M | 2.3M | 2.3M | $14M |
| Atlas Venture Life Science Advisors, LLC | 2.1M | 2.1M | 2.1M | 2.1M | 2.1M | 2.1M | $13M |
| Opaleye Management Inc. | — | — | — | — | 213K | 1.3M | $8M |
| Carlyle Group Inc. | 1.1M | 1.1M | 1.1M | 1.1M | 1.1M | 1.1M | $7M |
| ARCH Venture Management, LLC | 320K | 320K | 320K | 320K | 320K | 320K | $2M |
| ACORN CAPITAL ADVISORS, LLC | 803K | 803K | 803K | 803K | 493K | 315K | $2M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 306K | $2M |
| MACKENZIE FINANCIAL CORP | — | — | — | — | — | 246K | $2M |
| Sanofi | 244K | 244K | 244K | 244K | 244K | 244K | $2M |
| RENAISSANCE TECHNOLOGIES LLC | — | — | 77K | 47K | 100K | 207K | $1M |
| ACADIAN ASSET MANAGEMENT LLC | — | 31K | 30K | 30K | 48K | 173K | $1M |
| MONIMUS CAPITAL MANAGEMENT, LP | — | — | — | — | — | 134K | $862,270 |
| GEODE CAPITAL MANAGEMENT, LLC | 133K | 138K | 62K | 88K | 106K | 118K | $758,740 |
| Pfizer Inc | 278K | 278K | 278K | 278K | 278K | 102K | $736,731 |
| BlackRock, Inc. | 467K | 457K | 179K | 93K | 60K | 86K | $553,063 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 53 | 9,428,899 | 64.5% | $61M |
| 2025-Q4 | 52 | 8,043,910 | 65.4% | $27M |
| 2025-Q3 | 53 | 8,428,833 | 69.1% | $17M |
| 2025-Q2 | 61 | 8,985,000 | 73.7% | $13M |
| 2025-Q1 | 73 | 9,407,070 | 77.1% | $16M |
| 2024-Q4 | 92 | 10,995,395 | 90.3% | $38M |
| 2024-Q3 | 73 | 9,112,107 | 75.6% | $406M |
| 2024-Q2 | 54 | 8,067,948 | 67.6% | $144M |
| 2024-Q1 | 38 | 7,431,787 | — | $126M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporti”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| Opaleye Management Inc. | +1,042,865 | $7M | ADD |
| VANGUARD CAPITAL MANAGEMENT LLC | +306,401 | $2M | OPEN |
| MACKENZIE FINANCIAL CORP | +246,304 | $2M | OPEN |
| MONIMUS CAPITAL MANAGEMENT, LP | +134,310 | $862,270 | OPEN |
| ACADIAN ASSET MANAGEMENT LLC | +124,213 | $797,447 | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −321,051 | $2M | CLOSE |
| ACORN CAPITAL ADVISORS, LLC | −178,373 | $1M | TRIM |
| Pfizer Inc | −176,159 | $1M | TRIM |
| MILLENNIUM MANAGEMENT LLC | −51,268 | $329,141 | CLOSE |
| Monaco Asset Management SAM | −50,919 | $326,900 | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
