| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Pfizer Inc | 7,032,7707.0M | $9M | 11.19% | — |
| 2 | Laurion Capital Management LP | 4,997,3335.0M | $7M | 7.95% | ADD 4% |
| 3 | GordonMD Global Investments LP | 4,121,8704.1M | $6M | 6.56% | — |
| 4 | VANGUARD CAPITAL MANAGEMENT LLC | 2,033,5102.0M | $3M | 3.24% | NEW† |
| 5 | Atle Fund Management AB | 197,036197,036 | $2M | 0.31% | TRIM -68% |
| 6 | Palo Alto Investors LP | 1,010,5101.0M | $1M | 1.61% | TRIM -3% |
| 7 | 683 Capital Management, LLC | 896,263896,263 | $1M | 1.43% | — |
| 8 | RENAISSANCE TECHNOLOGIES LLC | 888,680888,680 | $1M | 1.41% | ADD 22% |
| 9 | BlackRock, Inc. | 788,839788,839 | $1M | 1.26% | — |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 598,121598,121 | $873,815 | 0.95% | ADD 4% |
| 11 | Longaeva Partners L.P. | 503,214503,214 | $734,692 | 0.80% | — |
| 12 | JACOBS LEVY EQUITY MANAGEMENT, INC | 460,997460,997 | $673,056 | 0.73% | NEW |
| 13 | MILLENNIUM MANAGEMENT LLC | 397,625397,625 | $580,533 | 0.63% | TRIM -46% |
| 14 | MARSHALL WACE, LLP | 354,417354,417 | $517,448 | 0.56% | TRIM -9% |
| 15 | Decheng Capital LLC | 326,810326,810 | $477,143 | 0.52% | — |
| 16 | JANE STREET GROUP, LLC | 304,459304,459 | $444,510 | 0.48% | TRIM -61% |
| 17 | VANGUARD FIDUCIARY TRUST CO | 300,897300,897 | $439,310 | 0.48% | NEW |
| 18 | UBS Group AG | 254,124254,124 | $371,021 | 0.40% | TRIM -35% |
| 19 | STATE STREET CORP | 248,837248,837 | $363,302 | 0.40% | ADD 3% |
| 20 | XTX Topco Ltd | 200,096200,096 | $292,140 | 0.32% | TRIM -31% |
| 21 | ACADIAN ASSET MANAGEMENT LLC | 144,256144,256 | $209,000 | 0.23% | NEW |
| 22 | Bank of New York Mellon Corp | 133,996133,996 | $195,634 | 0.21% | TRIM -19% |
| 23 | NewEdge Wealth, LLC | 116,006116,006 | $169,369 | 0.18% | — |
| 24 | NORTHERN TRUST CORP | 101,948101,948 | $148,844 | 0.16% | — |
| 25 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 81,26081,260 | $118,640 | 0.13% | ADD 12% |
| 26 | TWO SIGMA INVESTMENTS, LP | 73,30073,300 | $107,018 | 0.12% | TRIM -31% |
| 27 | MORGAN STANLEY | 69,68869,688 | $101,744 | 0.11% | TRIM -22% |
| 28 | PANAGORA ASSET MANAGEMENT INC | 69,42469,424 | $101,359 | 0.11% | NEW |
| 29 | Cable Car Capital, LP | 61,60661,606 | $89,945 | 0.10% | — |
| 30 | CITADEL ADVISORS LLC | 61,24961,249 | $89,424 | 0.10% | TRIM -75% |
| 31 | STIFEL FINANCIAL CORP | 50,53750,537 | $73,784 | 0.08% | NEW |
| 32 | TORONTO DOMINION BANK | 50,00050,000 | $73,000 | 0.08% | TRIM -33% |
| 33 | BARCLAYS PLC | 49,82549,825 | $72,745 | 0.08% | TRIM -17% |
| 34 | UNIVERSITY OF CHICAGO | 48,73148,731 | $71,147 | 0.08% | — |
| 35 | GOLDMAN SACHS GROUP INC | 46,92046,920 | $68,503 | 0.07% | TRIM -46% |
| 36 | J. Derek Lewis & Associates Inc. | 43,00043,000 | $62,780 | 0.07% | TRIM -19% |
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,20141,201 | $60,153 | 0.07% | TRIM -62% |
| 38 | COMMONWEALTH EQUITY SERVICES, LLC | 34,75534,755 | $50,740 | 0.06% | TRIM -13% |
| 39 | LPL Financial LLC | 33,55433,554 | $48,989 | 0.05% | TRIM -4% |
| 40 | Point72 Asset Management, L.P. | 32,00632,006 | $46,729 | 0.05% | TRIM -83% |
| 41 | Cetera Investment Advisers | 27,26027,260 | $39,800 | 0.04% | — |
| 42 | DIMENSIONAL FUND ADVISORS LP | 25,91225,912 | $37,832 | 0.04% | TRIM -48% |
| 43 | Graham Capital Management, L.P. | 22,74822,748 | $33,212 | 0.04% | TRIM -88% |
| 44 | Maia Wealth LLC | 21,27721,277 | $31,064 | 0.03% | TRIM -3% |
| 45 | Vanguard Global Advisers, LLC | 21,24221,242 | $31,013 | 0.03% | NEW |
| 46 | Catalyst Funds Management Pty Ltd | 20,40020,400 | $29,784 | 0.03% | NEW |
| 47 | Squarepoint Ops LLC | 17,53717,537 | $25,604 | 0.03% | NEW |
| 48 | BANK OF AMERICA CORP /DE/ | 16,80716,807 | $24,538 | 0.03% | TRIM -97% |
| 49 | OSAIC HOLDINGS, INC. | 13,72113,721 | $20,032 | 0.02% | TRIM -20% |
| 50 | TWO SIGMA SECURITIES, LLC | 13,47413,474 | $19,672 | 0.02% | NEW |
| 51 | FMR LLC | 11,91211,912 | $17,392 | 0.02% | TRIM -7% |
| 52 | PACES FERRY WEALTH ADVISORS, LLC | 11,44011,440 | $16,702 | 0.02% | — |
| 53 | Qube Research & Technologies Ltd | 11,28611,286 | $16,478 | 0.02% | TRIM -92% |
| 54 | China Universal Asset Management Co., Ltd. | 11,04911,049 | $16,132 | 0.02% | ADD 9% |
| 55 | Tower Research Capital LLC (TRC) | 10,33210,332 | $15,085 | 0.02% | TRIM -4% |
| 56 | PNC FINANCIAL SERVICES GROUP, INC. | 6,5006,500 | $9,490 | 0.01% | NEW |
| 57 | ROYAL BANK OF CANADA | 5,8395,839 | $9,000 | 0.01% | TRIM -89% |
| 58 | Winthrop Capital Management, LLC | 6,0006,000 | $9,000 | 0.01% | — |
| 59 | HAGER INVESTMENT MANAGEMENT SERVICES, LLC | 5,0005,000 | $7,300 | 0.01% | NEW |
| 60 | JPMORGAN CHASE & CO | 5,1735,173 | $6,570 | 0.01% | TRIM -6% |
| 61 | Mirae Asset Global Investments Co., Ltd. | 3,2483,248 | $4,742 | 0.01% | ADD 7% |
| 62 | FEDERATED HERMES, INC. | 3,1813,181 | $4,644 | 0.01% | ADD 68% |
| 63 | CITIGROUP INC | 1,7401,740 | $2,540 | 0.00% | TRIM -40% |
| 64 | BNP PARIBAS FINANCIAL MARKETS | 1,6541,654 | $2,415 | 0.00% | TRIM -93% |
| 65 | GF FUND MANAGEMENT CO. LTD. | 1,3161,316 | $1,921 | 0.00% | ADD 3% |
| 66 | NISA INVESTMENT ADVISORS, LLC | 961961 | $1,403 | 0.00% | — |
| 67 | Physician Wealth Advisors, Inc. | 943943 | $1,377 | 0.00% | — |
| 68 | Balyasny Asset Management L.P. | 743743 | $1,085 | 0.00% | TRIM -91% |
| 69 | JONES FINANCIAL COMPANIES LLLP | 500500 | $655 | 0.00% | — |
| 70 | WELLS FARGO & COMPANY/MN | 285285 | $416 | 0.00% | TRIM -88% |
| 71 | SIMPLEX TRADING, LLC | 253253 | $369 | 0.00% | TRIM -97% |
| 72 | Cornerstone Financial Management LLC | 172172 | $251 | 0.00% | — |
| 73 | CWM, LLC | 3434 | $50 | 0.00% | TRIM -51% |
| 74 | Arax Advisory Partners | 11 | $20 | 0.00% | TRIM -93% |
| 75 | Ascentis Independent Advisors | 1010 | $14 | 0.00% | NEW |
| 76 | Caitong International Asset Management Co., Ltd | 44 | $6 | 0.00% | NEW |
| 77 | SBI Securities Co., Ltd. | 11 | $1 | 0.00% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Pfizer Inc | 7.0M | 7.0M | 7.0M | 7.0M | 7.0M | 7.0M | $9M |
| Laurion Capital Management LP | 3.6M | 3.6M | 3.6M | 3.6M | 4.8M | 5.0M | $7M |
| GordonMD Global Investments LP | — | — | — | — | 4.1M | 4.1M | $6M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 2.0M | $3M |
| Atle Fund Management AB | — | — | — | — | 617K | 197K | $2M |
| Palo Alto Investors LP | 1.0M | 1.0M | 1.0M | 1.0M | 1.0M | 1.0M | $1M |
| 683 Capital Management, LLC | 415K | 550K | 545K | 525K | 892K | 896K | $1M |
| RENAISSANCE TECHNOLOGIES LLC | 293K | 582K | 418K | 576K | 728K | 889K | $1M |
| BlackRock, Inc. | 3.3M | 3.3M | 927K | 684K | 784K | 789K | $1M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.1M | 1.1M | 511K | 545K | 577K | 598K | $873,815 |
| Longaeva Partners L.P. | — | — | — | 503K | 503K | 503K | $734,692 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 602K | — | — | 60K | — | 461K | $673,056 |
| MILLENNIUM MANAGEMENT LLC | 3.0M | 2.5M | 3.5M | 815K | 743K | 398K | $580,533 |
| MARSHALL WACE, LLP | 158K | — | 148K | — | 390K | 354K | $517,448 |
| Decheng Capital LLC | 327K | 327K | 327K | 327K | 327K | 327K | $477,143 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 77 | 27,559,625 | 43.9% | $41M |
| 2025-Q4 | 79 | 30,196,015 | 48.5% | $35M |
| 2025-Q3 | 73 | 26,834,145 | 43.3% | $60M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Holder | % of class | Type | As of | |
|---|---|---|---|---|
| BIOTECHNOLOGY VALUE FUND L P | 9.99% | Passive | 2026-07-02 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +2,033,510 | $3M | OPEN |
| JACOBS LEVY EQUITY MANAGEMENT, INC | +460,997 | $673,056 | OPEN |
| VANGUARD FIDUCIARY TRUST CO | +300,897 | $439,310 | OPEN |
| Laurion Capital Management LP | +200,854 | $293,247 | ADD |
| RENAISSANCE TECHNOLOGIES LLC | +160,300 | $234,038 | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −2,335,768 | $3M | CLOSE |
| BANK OF AMERICA CORP /DE/ | −571,044 | $833,724 | TRIM |
| JANE STREET GROUP, LLC | −481,551 | $703,064 | TRIM |
| Atle Fund Management AB | −420,209 | $613,505 | TRIM |
| MILLENNIUM MANAGEMENT LLC | −345,482 | $504,404 | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| 2025-Q2 | 74 | 27,544,166 | 44.5% | $30M |
| 2025-Q1 | 88 | 30,265,636 | 49.1% | $30M |
| 2024-Q4 | 99 | 31,554,785 | 53.1% | $49M |
| 2024-Q3 | 92 | 27,907,915 | 47.3% | $103M |
| 2024-Q2 | 80 | 28,154,661 | 47.8% | $93M |
| 2024-Q1 | 71 | 23,016,375 | 39.6% | $98M |
| 2023-Q4 | 51 | 8,799,625 | 19.9% | $16M |
| 2023-Q3 | 54 | 7,812,292 | 19.8% | $15M |
| 2023-Q2 | 48 | 9,605,406 | 25.1% | $25M |
| 2023-Q1 | 47 | 10,354,999 | 28.0% | $42M |
| 2022-Q4 | 31 | 19,762,209 | 56.3% | $26M |
| 2022-Q3 | 38 | 19,444,443 | 59.2% | $38M |
| 2022-Q2 | 39 | 20,034,642 | 61.0% | $48M |
| 2022-Q1 | 45 | 18,946,339 | 57.7% | $76M |
| 2021-Q4 | 51 | 20,282,742 | 61.9% | $221M |
