PTGX US Equity

Protagonist Therapeutics, Inc

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Health Care · Pharmaceutical Preparations · CIK 1377121 · FYE 1231

$136.84

+1.28 (+0.94%)

USD · as of 2026-07-28 · marketstack

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Institutional ownership· 13F filers holding PTGX · 2026-Q1 methodology → sources →

320 holders

% of shares outstanding held

—

Shares held (13F)

79,332,570

Reporting holders

320

% of shares outstanding suppressed: the summed institutional 13F holdings (79,332,570) exceed the latest reported shares-outstanding count (64,311,373) by more than securities-lending double counting can explain (FINRA short interest 7,540,996 shares at 2026-04-30), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.

Top holders

largest 100 of 320 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	BlackRock, Inc.	9,779,3699.8M	$1.0B	—	—
2	FARALLON CAPITAL MANAGEMENT LLC	6,348,9066.3M	$669M	—	ADD 3%
3	UBS Group AG	5,177,7965.2M	$546M	—	ADD 87%
4	RTW INVESTMENTS, LP	5,059,0535.1M	$533M	—	—
5	WELLINGTON MANAGEMENT GROUP LLP	3,599,6443.6M	$379M	—	ADD 14%
6	VANGUARD PORTFOLIO MANAGEMENT LLC	3,481,2113.5M	$367M	—	NEW†
7	STATE STREET CORP	3,116,7493.1M	$329M	—	TRIM -3%
8	JANUS HENDERSON GROUP PLC	2,891,5272.9M	$305M	—	ADD 9%
9	VANGUARD CAPITAL MANAGEMENT LLC	2,805,8962.8M	$296M	—	NEW†
10	JOHNSON & JOHNSON	2,449,1832.4M	$258M	—	—
11	Invesco Ltd.	2,164,6702.2M	$228M	—	ADD 38%
12	GEODE CAPITAL MANAGEMENT, LLC	1,669,3711.7M	$176M	—	ADD 15%
13	PRICE T ROWE ASSOCIATES INC /MD/	1,665,4971.7M	$176M	—	ADD 19%
14	CITADEL ADVISORS LLC	1,551,9001.6M	$164M	—	ADD 38%
15	Woodline Partners LP	1,414,1731.4M	$149M	—	—
16	BANK OF AMERICA CORP /DE/	1,295,4341.3M	$137M	—	ADD 49%
17	PERCEPTIVE ADVISORS LLC	1,230,8791.2M	$130M	—	TRIM -9%
18	JENNISON ASSOCIATES LLC	1,072,0111.1M	$113M	—	ADD 224%
19	MORGAN STANLEY	1,018,2221.0M	$107M	—	ADD 16%
20	ADAR1 Capital Management, LLC	994,119994,119	$105M	—	TRIM -5%
21	Hood River Capital Management LLC	829,285829,285	$87M	—	NEW
22	GOLDMAN SACHS GROUP INC	778,945778,945	$82M	—	TRIM -19%
23	Driehaus Capital Management LLC	720,928720,928	$76M	—	TRIM -34%
24	FMR LLC	661,997661,997	$70M	—	ADD 23%
25	MARSHALL WACE, LLP	628,075628,075	$66M	—	TRIM -39%
26	Clearbridge Investments, LLC	621,820621,820	$66M	—	ADD 27%
27	Alyeska Investment Group, L.P.	593,197593,197	$63M	—	ADD 197%
28	NORTHERN TRUST CORP	587,968587,968	$62M	—	ADD 2%
29	Pictet Asset Management Holding SA	581,083581,083	$61M	—	ADD 10%
30	Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.	571,825571,825	$60M	—	—
31	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	552,956552,956	$58M	—	—
32	AMERICAN CENTURY COMPANIES INC	537,320537,320	$57M	—	—
33	DIMENSIONAL FUND ADVISORS LP	508,103508,103	$54M	—	ADD 23%
34	VOYA INVESTMENT MANAGEMENT LLC	454,383454,383	$48M	—	ADD 24%
35	Rubric Capital Management LP	427,998427,998	$45M	—	NEW
36	VANGUARD FIDUCIARY TRUST CO	412,730412,730	$44M	—	NEW
37	PRINCIPAL FINANCIAL GROUP INC	367,822367,822	$39M	—	ADD 6%
38	683 Capital Management, LLC	355,000355,000	$37M	—	TRIM -7%
39	Bank of New York Mellon Corp	341,465341,465	$36M	—	TRIM -3%
40	Vestal Point Capital, LP	326,159326,159	$34M	—	NEW
41	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	306,037306,037	$32M	—	TRIM -7%
42	ADAGE CAPITAL PARTNERS GP, L.L.C.	282,436282,436	$30M	—	ADD 21%
43	SEB Asset Management AB	232,416232,416	$24M	—	NEW
44	NEXTBio Capital Management LP	229,619229,619	$24M	—	—
45	SEGALL BRYANT & HAMILL, LLC	212,714212,714	$22M	—	ADD 65%
46	Public Sector Pension Investment Board	210,280210,280	$22M	—	ADD 3%
47	Holocene Advisors, LP	209,916209,916	$22M	—	—
48	BNP PARIBAS FINANCIAL MARKETS	194,530194,530	$21M	—	ADD 99%
49	TD Asset Management Inc	183,700183,700	$19M	—	ADD 16%
50	Eagle Health Investments LP	179,322179,322	$19M	—	ADD 213%
51	Fisher Asset Management, LLC	173,971173,971	$18M	—	ADD 167%
52	Affinity Asset Advisors, LLC	172,125172,125	$18M	—	—
53	Boxer Capital Management, LLC	170,000170,000	$18M	—	—
54	RAYMOND JAMES FINANCIAL INC	177,361177,361	$18M	—	TRIM -2%
55	SUSQUEHANNA INTERNATIONAL GROUP, LLP	167,576167,576	$18M	—	ADD 1325%
56	JPMORGAN CHASE & CO	172,990172,990	$17M	—	ADD 11%
57	LORD, ABBETT & CO. LLC	163,459163,459	$17M	—	NEW
58	NAN FUNG TRINITY (HK) LTD	160,670160,670	$17M	—	TRIM -11%
59	Duquesne Family Office LLC	159,700159,700	$17M	—	—
60	CITIGROUP INC	158,711158,711	$17M	—	ADD 67%
61	RHUMBLINE ADVISERS	157,413157,413	$17M	—	—
62	AMERIPRISE FINANCIAL INC	145,690145,690	$15M	—	TRIM -14%
63	STEMPOINT CAPITAL LP	145,154145,154	$15M	—	ADD 144%
64	NEUBERGER BERMAN GROUP LLC	141,441141,441	$15M	—	ADD 44%
65	FRANKLIN RESOURCES INC	137,871137,871	$15M	—	ADD 80%
66	KENNEDY CAPITAL MANAGEMENT LLC	137,099137,099	$14M	—	TRIM -38%
67	Legal & General Group Plc	135,367135,367	$14M	—	TRIM -9%
68	Nuveen, LLC	127,914127,914	$13M	—	—
69	MANUFACTURERS LIFE INSURANCE COMPANY, THE	127,818127,818	$13M	—	ADD 13%
70	DEUTSCHE BANK AG\	125,451125,451	$13M	—	ADD 19%
71	PANAGORA ASSET MANAGEMENT INC	116,609116,609	$12M	—	TRIM -7%
72	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	107,437107,437	$11M	—	ADD 3%
73	Universal- Beteiligungs- und Servicegesellschaft mbH	105,514105,514	$11M	—	TRIM -7%
74	Balyasny Asset Management L.P.	101,299101,299	$11M	—	NEW
75	Opaleye Management Inc.	100,000100,000	$11M	—	TRIM -5%
76	Swiss National Bank	98,90098,900	$10M	—	—
77	PRUDENTIAL FINANCIAL INC	95,23595,235	$10M	—	TRIM -14%
78	SCHRODER INVESTMENT MANAGEMENT GROUP	100,166100,166	$10M	—	NEW
79	FIRST TRUST ADVISORS LP	87,85887,858	$9M	—	ADD 89%
80	AXIOM INVESTORS LLC /DE	85,47585,475	$9M	—	TRIM -4%
81	VICTORY CAPITAL MANAGEMENT INC	83,54483,544	$9M	—	ADD 4%
82	SEI INVESTMENTS CO	83,19783,197	$9M	—	ADD 123%
83	ALGERT GLOBAL LLC	78,47078,470	$8M	—	ADD 1442%
84	GREAT LAKES ADVISORS, LLC	71,04371,043	$7M	—	TRIM -4%
85	Knott David M Jr	63,00063,000	$7M	—	TRIM -14%
86	Atika Capital Management LLC	62,10062,100	$7M	—	TRIM -28%
87	ALLIANCEBERNSTEIN L.P.	73,79073,790	$6M	—	—
88	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	58,67758,677	$6M	—	ADD 22%
89	Twin Lakes Capital Management, LLC	58,18758,187	$6M	—	TRIM -4%
90	BESSEMER GROUP INC	54,17854,178	$6M	—	—
91	Moody Aldrich Partners LLC	53,89353,893	$6M	—	TRIM -33%
92	KVP Capital Advisors, LP	53,00053,000	$6M	—	—
93	NORDEA INVESTMENT MANAGEMENT AB	51,82151,821	$5M	—	NEW
94	EFG International AG	50,08650,086	$5M	—	TRIM -31%
95	Integral Health Asset Management, LLC	50,00050,000	$5M	—	NEW
96	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	49,02049,020	$5M	—	—
97	Creative Planning	47,97147,971	$5M	—	ADD 16%
98	SILVERCREST ASSET MANAGEMENT GROUP LLC	47,93147,931	$5M	—	TRIM -10%
99	CANADA LIFE ASSURANCE Co	47,44047,440	$5M	—	TRIM -4%
100	NEW YORK STATE TEACHERS RETIREMENT SYSTEM	47,42447,424	$5M	—	TRIM -4%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

BlackRock, Inc.

9.9M

9.7M

9.6M

9.4M

9.7M

9.8M

$1.0B

FARALLON CAPITAL MANAGEMENT LLC

5.9M

6.1M

6.2M

6.1M

6.3M

$669M

UBS Group AG

133K

353K

2.5M

1.9M

2.8M

5.2M

$546M

RTW INVESTMENTS, LP

5.5M

5.7M

5.8M

5.1M

$533M

WELLINGTON MANAGEMENT GROUP LLP

940K

987K

1.0M

1.9M

3.2M

3.6M

$379M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

3.5M

$367M

STATE STREET CORP

3.3M

2.7M

3.2M

3.1M

$329M

JANUS HENDERSON GROUP PLC

21K

447K

1.1M

2.6M

2.9M

$305M

VANGUARD CAPITAL MANAGEMENT LLC

—

2.8M

$296M

JOHNSON & JOHNSON

2.4M

$258M

Invesco Ltd.

739K

860K

722K

1.0M

1.6M

2.2M

$228M

GEODE CAPITAL MANAGEMENT, LLC

1.4M

1.5M

1.7M

$176M

PRICE T ROWE ASSOCIATES INC /MD/

1.4M

1.3M

937K

1.2M

1.4M

1.7M

$176M

CITADEL ADVISORS LLC

164K

154K

27K

238K

1.1M

1.6M

$164M

Woodline Partners LP

582K

898K

947K

1.4M

$149M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	320	79,332,570	—	$8.3B
2025-Q4	318	71,064,393	—	$6.2B
2025-Q3	275	70,997,478	—	$4.7B
2025-Q2	274	71,104,007	—	$3.9B
2025-Q1	276	65,503,254	101.9%	$3.2B
2024-Q4

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · PTGX

Large holders — 13G, passive (top 5 of 10 by % of class)

Holder

% of class

Type

As of

BlackRock, Inc.

13.8%

QII

2025-09-30

SEC →

Farallon Capital Partners, L.P.

9.99%

Passive

2025-12-31

SEC →

RTW INVESTMENTS, LP

8.1%

QII

2025-12-31

SEC →

VANGUARD PORTFOLIO MANAGEMENT LLC

5.53%

QII

2026-03-31

SEC →

WELLINGTON MANAGEMENT GROUP LLP

5.1%

QII

Institutional ownership· 13F filers holding PTGX · 2026-Q1 methodology → sources →

320 holders

% of shares outstanding held

—

Shares held (13F)

79,332,570

Reporting holders

320

Top holders

largest 100 of 320 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	BlackRock, Inc.	9,779,3699.8M	$1.0B	—	—
2	FARALLON CAPITAL MANAGEMENT LLC	6,348,9066.3M	$669M	—	ADD 3%
3	UBS Group AG	5,177,7965.2M	$546M	—	ADD 87%
4	RTW INVESTMENTS, LP	5,059,0535.1M	$533M	—	—
5	WELLINGTON MANAGEMENT GROUP LLP	3,599,6443.6M	$379M	—	ADD 14%
6	VANGUARD PORTFOLIO MANAGEMENT LLC	3,481,2113.5M	$367M	—	NEW†
7	STATE STREET CORP	3,116,7493.1M	$329M	—	TRIM -3%
8	JANUS HENDERSON GROUP PLC	2,891,5272.9M	$305M	—	ADD 9%
9	VANGUARD CAPITAL MANAGEMENT LLC	2,805,8962.8M	$296M	—	NEW†
10	JOHNSON & JOHNSON	2,449,1832.4M	$258M	—	—
11	Invesco Ltd.	2,164,6702.2M	$228M	—	ADD 38%
12	GEODE CAPITAL MANAGEMENT, LLC	1,669,3711.7M	$176M	—	ADD 15%
13	PRICE T ROWE ASSOCIATES INC /MD/	1,665,4971.7M	$176M	—	ADD 19%
14	CITADEL ADVISORS LLC	1,551,9001.6M	$164M	—	ADD 38%
15	Woodline Partners LP	1,414,1731.4M	$149M	—	—
16	BANK OF AMERICA CORP /DE/	1,295,4341.3M	$137M	—	ADD 49%
17	PERCEPTIVE ADVISORS LLC	1,230,8791.2M	$130M	—	TRIM -9%
18	JENNISON ASSOCIATES LLC	1,072,0111.1M	$113M	—	ADD 224%
19	MORGAN STANLEY	1,018,2221.0M	$107M	—	ADD 16%
20	ADAR1 Capital Management, LLC	994,119994,119	$105M	—	TRIM -5%
21	Hood River Capital Management LLC	829,285829,285	$87M	—	NEW
22	GOLDMAN SACHS GROUP INC	778,945778,945	$82M	—	TRIM -19%
23	Driehaus Capital Management LLC	720,928720,928	$76M	—	TRIM -34%
24	FMR LLC	661,997661,997	$70M	—	ADD 23%
25	MARSHALL WACE, LLP	628,075628,075	$66M	—	TRIM -39%
26	Clearbridge Investments, LLC	621,820621,820	$66M	—	ADD 27%
27	Alyeska Investment Group, L.P.	593,197593,197	$63M	—	ADD 197%
28	NORTHERN TRUST CORP	587,968587,968	$62M	—	ADD 2%
29	Pictet Asset Management Holding SA	581,083581,083	$61M	—	ADD 10%
30	Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.	571,825571,825	$60M	—	—
31	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	552,956552,956	$58M	—	—
32	AMERICAN CENTURY COMPANIES INC	537,320537,320	$57M	—	—
33	DIMENSIONAL FUND ADVISORS LP	508,103508,103	$54M	—	ADD 23%
34	VOYA INVESTMENT MANAGEMENT LLC	454,383454,383	$48M	—	ADD 24%
35	Rubric Capital Management LP	427,998427,998	$45M	—	NEW
36	VANGUARD FIDUCIARY TRUST CO	412,730412,730	$44M	—	NEW
37	PRINCIPAL FINANCIAL GROUP INC	367,822367,822	$39M	—	ADD 6%
38	683 Capital Management, LLC	355,000355,000	$37M	—	TRIM -7%
39	Bank of New York Mellon Corp	341,465341,465	$36M	—	TRIM -3%
40	Vestal Point Capital, LP	326,159326,159	$34M	—	NEW
41	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	306,037306,037	$32M	—	TRIM -7%
42	ADAGE CAPITAL PARTNERS GP, L.L.C.	282,436282,436	$30M	—	ADD 21%
43	SEB Asset Management AB	232,416232,416	$24M	—	NEW
44	NEXTBio Capital Management LP	229,619229,619	$24M	—	—
45	SEGALL BRYANT & HAMILL, LLC	212,714212,714	$22M	—	ADD 65%
46	Public Sector Pension Investment Board	210,280210,280	$22M	—	ADD 3%
47	Holocene Advisors, LP	209,916209,916	$22M	—	—
48	BNP PARIBAS FINANCIAL MARKETS	194,530194,530	$21M	—	ADD 99%
49	TD Asset Management Inc	183,700183,700	$19M	—	ADD 16%
50	Eagle Health Investments LP	179,322179,322	$19M	—	ADD 213%
51	Fisher Asset Management, LLC	173,971173,971	$18M	—	ADD 167%
52	Affinity Asset Advisors, LLC	172,125172,125	$18M	—	—
53	Boxer Capital Management, LLC	170,000170,000	$18M	—	—
54	RAYMOND JAMES FINANCIAL INC	177,361177,361	$18M	—	TRIM -2%
55	SUSQUEHANNA INTERNATIONAL GROUP, LLP	167,576167,576	$18M	—	ADD 1325%
56	JPMORGAN CHASE & CO	172,990172,990	$17M	—	ADD 11%
57	LORD, ABBETT & CO. LLC	163,459163,459	$17M	—	NEW
58	NAN FUNG TRINITY (HK) LTD	160,670160,670	$17M	—	TRIM -11%
59	Duquesne Family Office LLC	159,700159,700	$17M	—	—
60	CITIGROUP INC	158,711158,711	$17M	—	ADD 67%
61	RHUMBLINE ADVISERS	157,413157,413	$17M	—	—
62	AMERIPRISE FINANCIAL INC	145,690145,690	$15M	—	TRIM -14%
63	STEMPOINT CAPITAL LP	145,154145,154	$15M	—	ADD 144%
64	NEUBERGER BERMAN GROUP LLC	141,441141,441	$15M	—	ADD 44%
65	FRANKLIN RESOURCES INC	137,871137,871	$15M	—	ADD 80%
66	KENNEDY CAPITAL MANAGEMENT LLC	137,099137,099	$14M	—	TRIM -38%
67	Legal & General Group Plc	135,367135,367	$14M	—	TRIM -9%
68	Nuveen, LLC	127,914127,914	$13M	—	—
69	MANUFACTURERS LIFE INSURANCE COMPANY, THE	127,818127,818	$13M	—	ADD 13%
70	DEUTSCHE BANK AG\	125,451125,451	$13M	—	ADD 19%
71	PANAGORA ASSET MANAGEMENT INC	116,609116,609	$12M	—	TRIM -7%
72	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	107,437107,437	$11M	—	ADD 3%
73	Universal- Beteiligungs- und Servicegesellschaft mbH	105,514105,514	$11M	—	TRIM -7%
74	Balyasny Asset Management L.P.	101,299101,299	$11M	—	NEW
75	Opaleye Management Inc.	100,000100,000	$11M	—	TRIM -5%
76	Swiss National Bank	98,90098,900	$10M	—	—
77	PRUDENTIAL FINANCIAL INC	95,23595,235	$10M	—	TRIM -14%
78	SCHRODER INVESTMENT MANAGEMENT GROUP	100,166100,166	$10M	—	NEW
79	FIRST TRUST ADVISORS LP	87,85887,858	$9M	—	ADD 89%
80	AXIOM INVESTORS LLC /DE	85,47585,475	$9M	—	TRIM -4%
81	VICTORY CAPITAL MANAGEMENT INC	83,54483,544	$9M	—	ADD 4%
82	SEI INVESTMENTS CO	83,19783,197	$9M	—	ADD 123%
83	ALGERT GLOBAL LLC	78,47078,470	$8M	—	ADD 1442%
84	GREAT LAKES ADVISORS, LLC	71,04371,043	$7M	—	TRIM -4%
85	Knott David M Jr	63,00063,000	$7M	—	TRIM -14%
86	Atika Capital Management LLC	62,10062,100	$7M	—	TRIM -28%
87	ALLIANCEBERNSTEIN L.P.	73,79073,790	$6M	—	—
88	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	58,67758,677	$6M	—	ADD 22%
89	Twin Lakes Capital Management, LLC	58,18758,187	$6M	—	TRIM -4%
90	BESSEMER GROUP INC	54,17854,178	$6M	—	—
91	Moody Aldrich Partners LLC	53,89353,893	$6M	—	TRIM -33%
92	KVP Capital Advisors, LP	53,00053,000	$6M	—	—
93	NORDEA INVESTMENT MANAGEMENT AB	51,82151,821	$5M	—	NEW
94	EFG International AG	50,08650,086	$5M	—	TRIM -31%
95	Integral Health Asset Management, LLC	50,00050,000	$5M	—	NEW
96	NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO	49,02049,020	$5M	—	—
97	Creative Planning	47,97147,971	$5M	—	ADD 16%
98	SILVERCREST ASSET MANAGEMENT GROUP LLC	47,93147,931	$5M	—	TRIM -10%
99	CANADA LIFE ASSURANCE Co	47,44047,440	$5M	—	TRIM -4%
100	NEW YORK STATE TEACHERS RETIREMENT SYSTEM	47,42447,424	$5M	—	TRIM -4%

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

BlackRock, Inc.

9.9M

9.7M

9.6M

9.4M

9.7M

9.8M

$1.0B

FARALLON CAPITAL MANAGEMENT LLC

5.9M

6.1M

6.2M

6.1M

6.3M

$669M

UBS Group AG

133K

353K

2.5M

1.9M

2.8M

5.2M

$546M

RTW INVESTMENTS, LP

5.5M

5.7M

5.8M

5.1M

$533M

WELLINGTON MANAGEMENT GROUP LLP

940K

987K

1.0M

1.9M

3.2M

3.6M

$379M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

3.5M

$367M

STATE STREET CORP

3.3M

2.7M

3.2M

3.1M

$329M

JANUS HENDERSON GROUP PLC

21K

447K

1.1M

2.6M

2.9M

$305M

VANGUARD CAPITAL MANAGEMENT LLC

—

2.8M

$296M

JOHNSON & JOHNSON

2.4M

$258M

Invesco Ltd.

739K

860K

722K

1.0M

1.6M

2.2M

$228M

GEODE CAPITAL MANAGEMENT, LLC

1.4M

1.5M

1.7M

$176M

PRICE T ROWE ASSOCIATES INC /MD/

1.4M

1.3M

937K

1.2M

1.4M

1.7M

$176M

CITADEL ADVISORS LLC

164K

154K

27K

238K

1.1M

1.6M

$164M

Woodline Partners LP

582K

898K

947K

1.4M

$149M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	320	79,332,570	—	$8.3B
2025-Q4	318	71,064,393	—	$6.2B
2025-Q3	275	70,997,478	—	$4.7B
2025-Q2	274	71,104,007	—	$3.9B
2025-Q1	276	65,503,254	101.9%	$3.2B
2024-Q4

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · PTGX

Large holders — 13G, passive (top 5 of 10 by % of class)

Holder

% of class

Type

As of

BlackRock, Inc.

13.8%

QII

2025-09-30

SEC →

Farallon Capital Partners, L.P.

9.99%

Passive

2025-12-31

SEC →

RTW INVESTMENTS, LP

8.1%

QII

2025-12-31

SEC →

VANGUARD PORTFOLIO MANAGEMENT LLC

5.53%

QII

2026-03-31

SEC →

WELLINGTON MANAGEMENT GROUP LLP

5.1%

QII

PTGX US Equity☆

Institutional ownership· 13F filers holding PTGX · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · PTGX

Institutional ownership· 13F filers holding PTGX · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · PTGX

PTGX US Equity