Only open-market buys / sells (codes P/S) are a conviction signal; grants, option exercises, tax-withholding, and gifts are compensation mechanics, shown but greyed. The trailing 12-month tallies run to today but the store covers filings through 2026-06-30 only (SEC bulk data sets publish quarterly), so recent activity may be absent.
| Date | Insider | Role | Transaction | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 2026-04-27 | Shah Rajeev M. | TenPercentOwner | −Other | 1,407,000 | — | — |
| 2026-04-21 | OrbiMed Genesis GP LLC | Director,TenPercentOwner | +Buy | 1,126,126 | $4.44 | $5M |
| 2026-04-21 | OrbiMed Genesis GP LLC | Director,TenPercentOwner | +Buy | 1,689,189 | $4.44 | $7M |
| 2026-04-21 | Bonita David P | Director,TenPercentOwner | +Buy | 1,126,126 | $4.44 | $5M |
| 2026-04-21 | Bonita David P | Director,TenPercentOwner | +Buy | 1,689,189 | $4.44 | $7M |
| 2025-10-04 | Huang Jane | Officer | −Tax w/h | 3,355 | $1.47 | $4,932 |
| 2025-10-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2025-07-04 | Huang Jane | Officer | −Tax w/h | 3,355 | $0.79 | $2,650 |
| 2025-07-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2025-04-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2025-04-04 | Huang Jane | Officer | −Tax w/h | 3,355 | $0.68 | $2,281 |
| 2025-03-25 | Vaddi Krishna | Director,Officer | +Buy | 675,000 | $0.69 | $465,750 |
| 2025-03-25 | Combs Andrew | Officer | +Buy | 100,000 | $0.69 | $69,000 |
| 2025-03-21 | Vaddi Krishna | Director,Officer | +Buy | 15,000 | $0.73 | $10,950 |
| 2025-03-20 | Vaddi Krishna | Director,Officer | +Buy | 5,416 | $0.73 | $3,954 |
| 2025-03-17 | Vaddi Krishna | Director,Officer | +Buy | 9,106 | $0.75 | $6,830 |
| 2025-03-14 | Vaddi Krishna | Director,Officer | +Buy | 29,999 | $0.75 | $22,499 |
| 2025-03-13 | Vaddi Krishna | Director,Officer | +Buy | 50,000 | $0.72 | $36,000 |
| 2025-03-12 | Vaddi Krishna | Director,Officer | +Buy | 47,500 | $0.71 | $33,725 |
| 2025-01-04 | Huang Jane | Officer | −Tax w/h | 3,859 | $1.39 | $5,364 |
| 2025-01-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2024-12-31 | Vaddi Krishna | Director,Officer | +Buy | 5,000 | $1.21 | $6,050 |
| 2024-12-30 | Vaddi Krishna | Director,Officer | +Buy | 10,000 | $1.20 | $12,000 |
| 2024-12-23 | Combs Andrew | Officer | +Buy | 60,000 | $1.37 | $82,200 |
| 2024-12-20 | Combs Andrew | Officer | +Buy | 3,075 | $1.15 | $3,536 |
| 2024-12-19 | Vaddi Krishna | Director,Officer | +Buy | 6,888 | $0.89 | $6,130 |
| 2024-12-19 | Lim Bryant David | Officer | +Buy | 25,000 | $0.91 | $22,750 |
| 2024-12-18 | Vaddi Krishna | Director,Officer | +Buy | 100,000 | $0.93 | $93,000 |
| 2024-10-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2024-10-04 | Huang Jane | Officer | −Tax w/h | 3,349 | $2.00 | $6,698 |
| 2024-07-04 | Huang Jane | Officer | −Tax w/h | 3,347 | $3.60 | $12,049 |
| 2024-07-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2024-04-04 | Huang Jane | Officer | −Tax w/h | 3,347 | $4.74 | $15,865 |
| 2024-04-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2024-01-04 | Huang Jane | Officer | −Tax w/h | 3,844 | $3.77 | $14,492 |
| 2024-01-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2023-10-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2023-07-04 | Huang Jane | Officer | −Tax w/h | 3,242 | $4.65 | $15,075 |
| 2023-07-04 | Huang Jane | Officer | +Exercise | 9,375 | — | — |
| 2023-05-25 | Vaddi Krishna | Director,Officer | +Buy | 900 | $5.31 | $4,779 |
| 2023-05-24 | Lim Bryant David | Officer | +Buy | 2,400 | $5.39 | $12,936 |
| 2023-05-24 | Vaddi Krishna | Director,Officer | +Buy | 1,000 | $5.01 | $5,010 |
| 2023-05-23 | Vaddi Krishna | Director,Officer | +Buy | 11,856 | $5.63 | $66,749 |
| 2023-05-23 | Chardonnet Laurent | Officer | +Buy | 5,000 | $5.50 | $27,500 |
| 2023-05-22 | Bonita David P | Director,TenPercentOwner | +Buy | 869,565 | $5.75 | $5M |
| 2023-05-22 | ORBIMED CAPITAL LLC | Director,TenPercentOwner | +Buy | 869,565 | $5.75 | $5M |
| 2023-04-06 | Huang Jane | Officer | −Sell | 13,280 | $6.12 | $81,274 |
| 2023-04-04 | Huang Jane | Officer | +Exercise | 37,500 | — | — |
| 2022-12-20 | Vaddi Krishna | Director,Officer | +Buy | 19,188 | $5.13 | $98,434 |
| 2022-12-08 | Chardonnet Laurent | Officer | +Buy | 10,000 | $4.76 | $47,600 |
| 2022-06-01 | Chardonnet Laurent | Officer | +Buy | 10,000 | $4.23 | $42,300 |
| 2022-03-31 | Combs Andrew | Officer | +Exercise | 36,062 | $1.89 | $68,157 |
| 2022-03-21 | Chardonnet Laurent | Officer | +Grant | 6,500 | $7.51 | $48,815 |
| 2021-12-15 | Morosini Deborah | Officer | +Exercise | 3,016 | $1.89 | $5,700 |
| 2021-12-15 | Morosini Deborah | Officer | −Sell | 28,751 | $13.00 | $373,763 |
| 2021-12-15 | Morosini Deborah | Officer | +Exercise | 25,735 | $12.85 | $330,695 |
| 2021-12-14 | Combs Andrew | Officer | +Buy | 4,000 | $11.60 | $46,400 |
| 2021-12-13 | Vaddi Krishna | Director,Officer | +Grant | 8,000 | $12.13 | $97,040 |
| 2021-12-13 | Chardonnet Laurent | Officer | +Grant | 5,000 | $12.28 | $61,400 |
| 2021-12-13 | Combs Andrew | Officer | +Buy | 4,000 | $12.12 | $48,480 |
| 2021-11-16 | Morosini Deborah | Officer | −Sell | 28,351 | $15.87 | $449,930 |
| 2021-11-16 | Morosini Deborah | Officer | +Exercise | 28,751 | $12.85 | $369,450 |
| 2021-11-16 | Morosini Deborah | Officer | −Sell | 400 | $16.43 | $6,572 |
| 2021-10-05 | Mauro David J | Officer | +Exercise | 15,000 | $1.89 | $28,350 |
| 2021-10-05 | Mauro David J | Officer | −Sell | 5,908 | $30.26 | $178,776 |
| 2021-10-05 | Mauro David J | Officer | −Sell | 7,803 | $31.30 | $244,234 |
| 2021-10-05 | Mauro David J | Officer | −Sell | 1,289 | $32.06 | $41,325 |
| 2021-09-07 | Mauro David J | Officer | −Sell | 4,640 | $37.79 | $175,346 |
| 2021-09-07 | Mauro David J | Officer | +Exercise | 15,000 | $1.89 | $28,350 |
| 2021-09-07 | Mauro David J | Officer | −Sell | 7,487 | $35.91 | $268,858 |
| 2021-09-07 | Mauro David J | Officer | −Sell | 2,873 | $36.92 | $106,071 |
| 2021-09-02 | Pierce Christopher | Officer | −Sell | 6,930 | $42.50 | $294,525 |
| 2021-09-02 | Pierce Christopher | Officer | +Exercise | 17,000 | $12.85 | $218,450 |
| 2021-09-02 | Pierce Christopher | Officer | −Sell | 3,343 | $40.29 | $134,689 |
| 2021-09-02 | Pierce Christopher | Officer | −Sell | 6,727 | $41.52 | $279,305 |
| 2021-08-27 | Scherle Peggy | Officer | −Sell | 2,707 | $36.23 | $98,075 |
| 2021-08-27 | Scherle Peggy | Officer | −Sell | 2,700 | $35.32 | $95,364 |
| 2021-08-27 | Scherle Peggy | Officer | +Exercise | 6,014 | $1.43 | $8,600 |
| 2021-08-27 | Scherle Peggy | Officer | −Sell | 607 | $37.08 | $22,508 |
| 2021-08-26 | Scherle Peggy | Officer | +Exercise | 1,700 | $1.43 | $2,431 |
| 2021-08-26 | Scherle Peggy | Officer | −Sell | 1,700 | $35.19 | $59,823 |
| 2021-08-25 | Piper Brian | Officer | −Sell | 3,889 | $33.23 | $129,231 |
| 2021-08-25 | Piper Brian | Officer | −Sell | 2,100 | $32.44 | $68,124 |
| 2021-08-25 | Piper Brian | Officer | +Exercise | 8,333 | $1.89 | $15,749 |
| 2021-08-25 | Piper Brian | Officer | −Sell | 2,344 | $34.33 | $80,470 |
| 2021-08-13 | Scherle Peggy | Officer | −Sell | 2,286 | $35.07 | $80,170 |
| 2021-08-13 | Scherle Peggy | Officer | +Exercise | 558 | $1.89 | $1,055 |
| 2021-08-13 | Scherle Peggy | Officer | +Exercise | 1,728 | $1.43 | $2,471 |
| 2021-08-05 | Mauro David J | Officer | −Sell | 2,063 | $31.03 | $64,015 |
| 2021-08-05 | Mauro David J | Officer | −Sell | 6,721 | $32.15 | $216,080 |
| 2021-08-05 | Mauro David J | Officer | −Sell | 100 | $32.63 | $3,263 |
| 2021-08-05 | Mauro David J | Officer | −Sell | 6,116 | $29.93 | $183,052 |
| 2021-08-05 | Mauro David J | Officer | +Exercise | 15,000 | $1.89 | $28,350 |
| 2021-07-27 | Scherle Peggy | Officer | +Exercise | 20,000 | $1.43 | $28,600 |
| 2021-07-27 | Scherle Peggy | Officer | −Sell | 680 | $36.09 | $24,541 |
| 2021-07-27 | Scherle Peggy | Officer | −Sell | 19,320 | $35.45 | $684,894 |
| 2021-07-06 | Mauro David J | Officer | −Sell | 10,445 | $27.17 | $283,791 |
| 2021-07-06 | Mauro David J | Officer | +Exercise | 15,000 | $1.89 | $28,350 |
| 2021-07-06 | Mauro David J | Officer | −Sell | 4,255 | $28.13 | $119,693 |
| 2021-07-06 | Mauro David J | Officer | −Sell | 300 | $28.84 | $8,652 |
| 2021-06-07 | Mauro David J | Officer | −Sell | 12,700 | $32.73 | $415,671 |
| 2021-06-07 | Mauro David J | Officer | −Sell | 1,400 | $30.35 | $42,490 |
| 2021-06-07 | Mauro David J | Officer | +Exercise | 15,000 | $1.89 | $28,350 |
| 2021-06-07 | Mauro David J | Officer | −Sell | 900 | $31.62 | $28,458 |
| 2021-05-25 | Piper Brian | Officer | −Sell | 1,736 | $35.45 | $61,541 |
| 2021-05-25 | Piper Brian | Officer | +Exercise | 8,333 | $1.89 | $15,749 |
| 2021-05-25 | Piper Brian | Officer | −Sell | 3,088 | $34.11 | $105,332 |
| 2021-05-25 | Piper Brian | Officer | −Sell | 399 | $36.09 | $14,400 |
| 2021-05-25 | Piper Brian | Officer | −Sell | 3,110 | $33.53 | $104,278 |
| 2021-05-07 | Scherle Peggy | Officer | −Sell | 3,964 | $40.30 | $159,749 |
| 2021-05-07 | Scherle Peggy | Officer | −Sell | 5,836 | $41.14 | $240,093 |
| 2021-05-07 | Scherle Peggy | Officer | −Sell | 200 | $41.85 | $8,370 |
| 2021-05-07 | Scherle Peggy | Officer | +Exercise | 10,000 | $1.43 | $14,300 |
| 2021-05-05 | Mauro David J | Officer | −Sell | 3,415 | $39.36 | $134,414 |
| 2021-05-05 | Mauro David J | Officer | +Exercise | 15,000 | $1.89 | $28,350 |
| 2021-05-05 | Mauro David J | Officer | −Sell | 1,109 | $41.07 | $45,547 |
| 2021-05-05 | Mauro David J | Officer | −Sell | 10,476 | $40.30 | $422,183 |
| 2021-04-29 | Morosini Deborah | Officer | +Exercise | 3,223 | $1.89 | $6,091 |
| 2021-04-29 | Morosini Deborah | Officer | −Sell | 3,223 | $40.29 | $129,855 |
| 2021-04-29 | Pierce Christopher | Officer | −Sell | 3,295 | $40.29 | $132,756 |
Source: the SEC bulk insider (Form 3/4/5) data sets — non-derivative transactions in the issuer's common stock, most recent first, covering filings through 2026-06-30. Insiders file within 2 business days of a transaction, but the bulk sets publish quarterly, so this store lags live filings; option/derivative lines are excluded. Codes: P buy · S sell · A grant · M/X/C exercise · F tax · G gift.
Model-derived estimate for research. See the Disclaimer.
