| 1 | 1JANUS HENDERSON GROUP PLC | 16,575,87516.6M | $960M | 11.48% | ADD 24% |
| 2 | 2FMR LLC | 16,492,86116.5M | $958M | 11.42% | ADD 19% |
| 3 | 3T. Rowe Price Investment Management, Inc. | 12,126,01712.1M | $705M | 8.40% | TRIM -33% |
| 4 | 4RA CAPITAL MANAGEMENT, L.P. | 11,474,59911.5M | $667M | 7.95% | ADD 7% |
| 5 | 5BlackRock, Inc. | 10,971,81611.0M | $638M | 7.60% | ADD 7% |
| 6 | 6VANGUARD PORTFOLIO MANAGEMENT LLC | 6,279,5456.3M | $365M | 4.35% | NEW† |
| 7 | 7VANGUARD CAPITAL MANAGEMENT LLC | 6,266,7016.3M | $364M | 4.34% | NEW† |
| 8 | 8WELLINGTON MANAGEMENT GROUP LLP | 5,614,5975.6M | $326M | 3.89% | TRIM -6% |
| 9 | 9Paradigm Biocapital Advisors LP | 4,793,0204.8M | $279M | 3.32% | ADD 18% |
| 10 | 10STATE STREET CORP | 4,440,5194.4M | $258M | 3.08% | TRIM -11% |
| 11 | 11Deep Track Capital, LP | 4,300,0004.3M | $250M | 2.98% | ADD 7% |
| 12 | 12WESTFIELD CAPITAL MANAGEMENT CO LP | 3,646,1383.6M | $212M | 2.53% | ADD 3% |
| 13 | 13GEODE CAPITAL MANAGEMENT, LLC | 3,201,2833.2M | $186M | 2.22% | ADD 12% |
| 14 | 14Kynam Capital Management, LP | 2,922,3352.9M | $170M | 2.02% | — |
| 15 | 15D. E. Shaw & Co., Inc. | 2,865,3182.9M | $167M | 1.98% | TRIM -21% |
| 16 | 16Caligan Partners LP | 2,060,7192.1M | $120M | 1.43% | ADD 21% |
| 17 | 17JENNISON ASSOCIATES LLC | 1,698,0111.7M | $99M | 1.18% | ADD 151% |
| 18 | 18Polar Capital Holdings Plc | 1,425,7881.4M | $83M | 0.99% | TRIM -15% |
| 19 | 19CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,403,9481.4M | $82M | 0.97% | ADD 9% |
| 20 | 20MAVERICK CAPITAL LTD | 1,377,7381.4M | $80M | 0.95% | — |
| 21 | 21EVENTIDE ASSET MANAGEMENT, LLC | 1,374,2921.4M | $80M | 0.95% | ADD 50% |
| 22 | 22Pivotal bioVenture Partners Investment Advisor LLC | 1,372,4251.4M | $80M | 0.95% | — |
| 23 | 23UBS Group AG | 1,337,3901.3M | $78M | 0.93% | ADD 22% |
| 24 | 24GOLDMAN SACHS GROUP INC | 1,275,0361.3M | $74M | 0.88% | ADD 18% |
| 25 | 25FARALLON CAPITAL MANAGEMENT LLC | 1,261,0001.3M | $73M | 0.87% | ADD 25120% |
| 26 | 26BANK OF AMERICA CORP /DE/ | 1,216,8431.2M | $71M | 0.84% | ADD 73% |
| 27 | 27Bellevue Group AG | 1,190,6971.2M | $69M | 0.82% | NEW |
| 28 | 28Assenagon Asset Management S.A. | 1,164,8131.2M | $68M | 0.81% | ADD 114% |
| 29 | 29NORTHERN TRUST CORP | 1,144,4691.1M | $67M | 0.79% | ADD 11% |
| 30 | 30Aberdeen Group plc | 978,969978,969 | $57M | 0.68% | — |
| 31 | 31PRICE T ROWE ASSOCIATES INC /MD/ | 976,429976,429 | $57M | 0.68% | TRIM -17% |
| 32 | 32JPMORGAN CHASE & CO | 1,008,3141.0M | $55M | 0.70% | TRIM -7% |
| 33 | 33Eversept Partners, LP | 924,193924,193 | $54M | 0.64% | TRIM -23% |
| 34 | 34Capital Research Global Investors | 912,688912,688 | $53M | 0.63% | ADD 8% |
| 35 | 35NOVO HOLDINGS A/S | 860,000860,000 | $50M | 0.60% | TRIM -6% |
| 36 | 36VANGUARD FIDUCIARY TRUST CO | 842,273842,273 | $49M | 0.58% | NEW |
| 37 | 37Saturn V Capital Management LP | 824,532824,532 | $48M | 0.57% | ADD 3% |
| 38 | 38BAUPOST GROUP LLC/MAtracked | 800,000800,000 | $46M | 0.55% | NEW |
| 39 | 39MORGAN STANLEY | 735,907735,907 | $43M | 0.51% | TRIM -12% |
| 40 | 40Pictet Asset Management Holding SA | 700,311700,311 | $41M | 0.48% | TRIM -21% |
| 41 | 41Trails Edge Capital Partners, LP | 662,470662,470 | $38M | 0.46% | TRIM -10% |
| 42 | 42Jones Hill Capital LP | 644,831644,831 | $37M | 0.45% | NEW |
| 43 | 43Point72 Asset Management, L.P. | 620,401620,401 | $36M | 0.43% | ADD 284% |
| 44 | 44FEDERATED HERMES, INC. | 566,828566,828 | $33M | 0.39% | ADD 8% |
| 45 | 45BOOTHBAY FUND MANAGEMENT, LLC | 522,019522,019 | $30M | 0.36% | ADD 5% |
| 46 | 46Balyasny Asset Management L.P. | 514,577514,577 | $30M | 0.36% | ADD 1815% |
| 47 | 47BROWN ADVISORY INC | 511,701511,701 | $30M | 0.35% | TRIM -10% |
| 48 | 48VICTORY CAPITAL MANAGEMENT INC | 501,857501,857 | $29M | 0.35% | TRIM -9% |
| 49 | 49Bank of New York Mellon Corp | 474,526474,526 | $28M | 0.33% | ADD 6% |
| 50 | 50FRANKLIN RESOURCES INC | 473,363473,363 | $28M | 0.33% | ADD 41% |
| 51 | 51Ensign Peak Advisors, Inc | 445,903445,903 | $26M | 0.31% | TRIM -15% |
| 52 | 52Alyeska Investment Group, L.P. | 435,581435,581 | $25M | 0.30% | ADD 78% |
| 53 | 53Ikarian Capital, LLC | 428,682428,682 | $25M | 0.30% | ADD 13% |
| 54 | 54UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 410,605410,605 | $24M | 0.28% | ADD 6% |
| 55 | 55Soleus Capital Management, L.P. | 385,472385,472 | $22M | 0.27% | TRIM -37% |
| 56 | 56DIMENSIONAL FUND ADVISORS LP | 375,772375,772 | $22M | 0.26% | ADD 96% |
| 57 | 57ALGERT GLOBAL LLC | 363,984363,984 | $21M | 0.25% | ADD 440% |
| 58 | 58AMERICAN CENTURY COMPANIES INC | 355,854355,854 | $21M | 0.25% | — |
| 59 | 59ADAGE CAPITAL PARTNERS GP, L.L.C. | 350,000350,000 | $20M | 0.24% | TRIM -80% |
| 60 | 60Boxer Capital Management, LLC | 325,000325,000 | $19M | 0.23% | NEW |
| 61 | 61Nuveen, LLC | 320,789320,789 | $19M | 0.22% | ADD 4% |
| 62 | 62Elmind Capital, LP | 316,500316,500 | $18M | 0.22% | ADD 9% |
| 63 | 63Candriam S.C.A. | 315,022315,022 | $18M | 0.22% | NEW |
| 64 | 64TD Asset Management Inc | 312,762312,762 | $18M | 0.22% | TRIM -14% |
| 65 | 65Logos Global Management LP | 300,000300,000 | $17M | 0.21% | TRIM -54% |
| 66 | 66DEUTSCHE BANK AG\ | 299,693299,693 | $17M | 0.21% | TRIM -13% |
| 67 | 67Artisan Partners Limited Partnership | 297,432297,432 | $17M | 0.21% | TRIM -2% |
| 68 | 68MILLENNIUM MANAGEMENT LLC | 293,695293,695 | $17M | 0.20% | TRIM -31% |
| 69 | 69Rosalind Advisors, Inc. | 290,000290,000 | $17M | 0.20% | NEW |
| 70 | 70Woodline Partners LP | 274,740274,740 | $16M | 0.19% | — |
| 71 | 71FRED ALGER MANAGEMENT, LLC | 270,115270,115 | $16M | 0.19% | ADD 367% |
| 72 | 72ADAR1 Capital Management, LLC | 259,137259,137 | $15M | 0.18% | TRIM -18% |
| 73 | 73JANE STREET GROUP, LLC | 252,877252,877 | $15M | 0.18% | TRIM -10% |
| 74 | 74RAYMOND JAMES FINANCIAL INC | 260,395260,395 | $15M | 0.18% | ADD 40% |
| 75 | 75Spruce Street Capital LP | 245,709245,709 | $14M | 0.17% | TRIM -39% |
| 76 | 76University of Wisconsin Foundation | 239,749239,749 | $14M | 0.17% | TRIM -3% |
| 77 | 77Nantahala Capital Management, LLC | 238,746238,746 | $14M | 0.17% | NEW |
| 78 | 78Swiss National Bank | 233,100233,100 | $14M | 0.16% | — |
| 79 | 79Freestone Grove Partners LP | 224,731224,731 | $13M | 0.16% | NEW |
| 80 | 80BNP PARIBAS FINANCIAL MARKETS | 224,518224,518 | $13M | 0.16% | ADD 342% |
| 81 | 81C WorldWide Group Holding A/S | 195,000195,000 | $11M | 0.14% | — |
| 82 | 82Invesco Ltd. | 184,043184,043 | $11M | 0.13% | ADD 30% |
| 83 | 83SEGALL BRYANT & HAMILL, LLC | 183,935183,935 | $11M | 0.13% | TRIM -5% |
| 84 | 84RHUMBLINE ADVISERS | 158,841158,841 | $9M | 0.11% | ADD 5% |
| 85 | 85California Public Employees Retirement System | 151,555151,555 | $9M | 0.10% | ADD 5% |
| 86 | 86Qube Research & Technologies Ltd | 145,371145,371 | $8M | 0.10% | TRIM -30% |
| 87 | 87SILVERARC CAPITAL MANAGEMENT, LLC | 144,981144,981 | $8M | 0.10% | TRIM -3% |
| 88 | 88First Light Asset Management, LLC | 141,784141,784 | $8M | 0.10% | NEW |
| 89 | 89Creative Planning | 140,177140,177 | $8M | 0.10% | ADD 37% |
| 90 | 90CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,100136,100 | $8M | 0.09% | ADD 23% |
| 91 | 91CITIGROUP INC | 132,178132,178 | $8M | 0.09% | TRIM -45% |
| 92 | 92Seven Fleet Capital Management LP | 128,450128,450 | $7M | 0.09% | ADD 406% |
| 93 | 93Clearbridge Investments, LLC | 128,377128,377 | $7M | 0.09% | NEW |
| 94 | 94ExodusPoint Capital Management, LP | 125,827125,827 | $7M | 0.09% | NEW |
| 95 | 95HighVista Strategies LLC | 124,647124,647 | $7M | 0.09% | ADD 9% |
| 96 | 96NAN FUNG TRINITY (HK) LTD | 122,930122,930 | $7M | 0.09% | TRIM -14% |
| 97 | 97NEW YORK STATE COMMON RETIREMENT FUND | 121,320121,320 | $7M | 0.08% | ADD 4% |
| 98 | 98STEMPOINT CAPITAL LP | 118,122118,122 | $7M | 0.08% | NEW |
| 99 | 99TWO SIGMA INVESTMENTS, LP | 111,310111,310 | $6M | 0.08% | — |
| 100 | 100AMERIPRISE FINANCIAL INC | 110,986110,986 | $6M | 0.08% | TRIM -64% |