Puma Biotechnology, Inc. (Nasdaq: PBYI), an SEC filer in Pharmaceutical Preparations, closed at $9.06, -1.9%, on 2026-08-28, with a market cap of $468M, a trailing P/E of 14.9, a return on equity of 28.0%, a net margin of 13.6% and 3-year sales growth of 0.0%. Institutional ownership, earnings history, filed financials and clinical trials are on the tabs below.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | ACORN CAPITAL ADVISORS, LLC | 4,131,2994.1M | $26M | 8.12% | — |
| 2 | BlackRock, Inc. | 3,598,9523.6M | $23M | 7.07% | — |
| 3 | ACADIAN ASSET MANAGEMENT LLC | 2,041,7592.0M | $13M | 4.01% | — |
| 4 | RENAISSANCE TECHNOLOGIES LLC | 1,942,4131.9M | $12M | 3.82% | TRIM -9% |
| 5 | AMERICAN CENTURY COMPANIES INC | 1,916,3461.9M | $12M | 3.77% | ADD 16% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 1,817,6811.8M | $12M | 3.57% | NEW† |
| 7 | VANGUARD PORTFOLIO MANAGEMENT LLC | 1,734,6491.7M | $11M | 3.41% | NEW† |
| 8 | MILLENNIUM MANAGEMENT LLC | 1,477,5191.5M | $9M | 2.90% | ADD 8793% |
| 9 | DIMENSIONAL FUND ADVISORS LP | 1,436,1061.4M | $9M | 2.82% | ADD 7% |
| 10 | LSV ASSET MANAGEMENT | 1,182,8681.2M | $8M | 2.32% | ADD 192% |
† NEW this big is usually a rename.
Ranked by each filer’s own reported value, not shares.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +1,817,681 | $12M | OPEN |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +1,734,649 | $11M | OPEN |
| MILLENNIUM MANAGEMENT LLC | +1,460,905 | $9M | ADD |
| LSV ASSET MANAGEMENT | +778,066 | $5M | ADD |
| UBS Group AG | +406,915 | $3M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −3,797,748 | $24M | CLOSE |
| RENAISSANCE TECHNOLOGIES LLC | −181,400 | $1M | TRIM |
| MACKENZIE FINANCIAL CORP | −160,973 | $1M | CLOSE |
| TWO SIGMA INVESTMENTS, LP | −149,351 | $954,353 | TRIM |
| LOS ANGELES CAPITAL MANAGEMENT LLC | −148,132 | $946,563 | CLOSE |
Prior quarter split-rebased · 13Fs are long, US-listed only.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| ACORN CAPITAL ADVISORS, LLC | 3.9M | 3.9M | 4.1M | 4.1M | 4.1M | 4.1M | $26M |
| BlackRock, Inc. | 3.8M | 3.8M | 3.8M | 3.6M | 3.6M | 3.6M | $23M |
| ACADIAN ASSET MANAGEMENT LLC | 2.0M | 2.0M | 2.0M | 2.1M | 2.0M | 2.0M | $13M |
| RENAISSANCE TECHNOLOGIES LLC | 1.8M | 1.8M | 1.9M | 2.2M | 2.1M | 1.9M | $12M |
| AMERICAN CENTURY COMPANIES INC | 948K | 1.1M | 1.3M | 1.5M | 1.7M | 1.9M | $12M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.8M | $12M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | — | — | — | — | — | 1.7M | $11M |
| MILLENNIUM MANAGEMENT LLC | 1.9M | 1.4M | 335K | 106K | 17K | 1.5M | $9M |
| DIMENSIONAL FUND ADVISORS LP | 864K | 889K | 1.2M | 1.3M | 1.3M | 1.4M | $9M |
| LSV ASSET MANAGEMENT | 53K | 53K | 536K | 560K | 405K | 1.2M | $8M |
Green = added, red = trimmed, grey = held; a dash is a quarter with no 13F on file — a gap, not an exit.
Breaks = no 13F that quarter.
Short interest has its own tab now — open SI →
SEC Form 13F · ~10,250 filers, 10y · long-only, US-listed, filed ≤45d after quarter-end.
