Institutional 13F holdings sum to 118.9% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 22,009,149 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Nextech Invest, Ltd. | 7,162,6377.2M | $91M | 7.14% | — |
| 2 | EcoR1 Capital, LLC | 6,728,1166.7M | $85M | 6.70% | — |
| 3 | BlackRock, Inc. | 5,984,5526.0M | $76M | 5.96% | — |
| 4 | VIKING GLOBAL INVESTORS LPtracked | 5,824,5335.8M | $74M | 5.80% | TRIM -11% |
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 5,387,7835.4M | $68M | 5.37% | ADD 64% |
| 6 | SR One Capital Management, LP | 4,514,9294.5M | $58M | 4.50% | — |
| 7 | Pfizer Inc | 4,780,4014.8M | $58M | 4.76% | TRIM -11% |
| 8 | ALKEON CAPITAL MANAGEMENT LLC | 4,504,0964.5M | $57M | 4.49% | — |
| 9 | Venrock Adviser, LLC | 4,319,7654.3M | $55M | 4.30% | TRIM -24% |
| 10 | NEA Management Company, LLC | 4,118,6214.1M | $52M | 4.10% | — |
| 11 | STATE STREET CORP | 3,702,1963.7M | $47M | 3.69% | TRIM -13% |
| 12 | VANGUARD CAPITAL MANAGEMENT LLC | 3,687,0073.7M | $47M | 3.67% | NEW† |
| 13 | Column Group LLC | 3,540,7773.5M | $45M | 3.53% | — |
| 14 | Siren, L.L.C. | 2,998,1923.0M | $38M | 2.99% | ADD 198% |
| 15 | ORBIMED ADVISORS LLC | 2,693,9292.7M | $34M | 2.68% | TRIM -26% |
| 16 | AIHC Capital Management Ltd | 2,459,5512.5M | $31M | 2.45% | NEW† |
| 17 | FMR LLC | 2,434,0802.4M | $31M | 2.43% | — |
| 18 | CITADEL ADVISORS LLC | 2,422,7412.4M | $31M | 2.41% | — |
| 19 | First Turn Management, LLC | 2,017,2842.0M | $26M | 2.01% | — |
| 20 | Vivo Capital, LLC | 1,848,7861.8M | $23M | 1.84% | TRIM -13% |
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 1,838,8011.8M | $23M | 1.83% | ADD 5% |
| 22 | MPM BIOIMPACT LLC | 1,803,9451.8M | $23M | 1.80% | — |
| 23 | Paradigm Biocapital Advisors LP | 1,701,2171.7M | $22M | 1.70% | TRIM -29% |
| 24 | MORGAN STANLEY | 1,682,5231.7M | $21M | 1.68% | ADD 41% |
| 25 | GOLDMAN SACHS GROUP INC | 1,475,7121.5M | $19M | 1.47% | TRIM -24% |
| 26 | DIMENSIONAL FUND ADVISORS LP | 1,471,2901.5M | $19M | 1.47% | ADD 20% |
| 27 | FRANKLIN RESOURCES INC | 1,452,8351.5M | $18M | 1.45% | ADD 20% |
| 28 | Integral Health Asset Management, LLC | 1,400,0001.4M | $18M | 1.40% | ADD 17% |
| 29 | Woodline Partners LP | 1,247,5151.2M | $16M | 1.24% | ADD 406% |
| 30 | ROYCE & ASSOCIATES LP | 1,207,2231.2M | $15M | 1.20% | TRIM -20% |
| 31 | BRAIDWELL LP | 1,128,0401.1M | $14M | 1.12% | NEW |
| 32 | SILVERARC CAPITAL MANAGEMENT, LLC | 1,100,0101.1M | $14M | 1.10% | — |
| 33 | BANK OF AMERICA CORP /DE/ | 1,043,1591.0M | $13M | 1.04% | ADD 106% |
| 34 | Euclidean Capital LLC | 989,410989,410 | $13M | 0.99% | — |
| 35 | ArrowMark Colorado Holdings LLC | 960,517960,517 | $12M | 0.96% | TRIM -10% |
| 36 | EVENTIDE ASSET MANAGEMENT, LLC | 953,451953,451 | $12M | 0.95% | — |
| 37 | Logos Global Management LP | 950,000950,000 | $12M | 0.95% | ADD 111% |
| 38 | Qube Research & Technologies Ltd | 859,491859,491 | $11M | 0.86% | TRIM -29% |
| 39 | Defilade Capital Management, L.P. | 842,928842,928 | $11M | 0.84% | NEW |
| 40 | NORTHERN TRUST CORP | 710,861710,861 | $9M | 0.71% | TRIM -20% |
| 41 | Sofinnova Investments, Inc. | 679,578679,578 | $9M | 0.68% | NEW |
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 605,037605,037 | $8M | 0.60% | TRIM -3% |
| 43 | Candriam S.C.A. | 574,085574,085 | $7M | 0.57% | NEW |
| 44 | VANGUARD PORTFOLIO MANAGEMENT LLC | 570,691570,691 | $7M | 0.57% | NEW |
| 45 | LORD, ABBETT & CO. LLC | 542,598542,598 | $7M | 0.54% | TRIM -4% |
| 46 | Polar Capital Holdings Plc | 539,377539,377 | $7M | 0.54% | ADD 7% |
| 47 | SPHERA FUNDS MANAGEMENT LTD. | 537,628537,628 | $7M | 0.54% | TRIM -46% |
| 48 | Balyasny Asset Management L.P. | 523,790523,790 | $7M | 0.52% | TRIM -45% |
| 49 | NEXTBio Capital Management LP | 523,619523,619 | $7M | 0.52% | TRIM -15% |
| 50 | Connor, Clark & Lunn Investment Management Ltd. | 522,061522,061 | $7M | 0.52% | ADD 49% |
| 51 | VANGUARD FIDUCIARY TRUST CO | 507,294507,294 | $6M | 0.51% | NEW |
| 52 | Redmile Group, LLC | 415,710415,710 | $5M | 0.41% | TRIM -7% |
| 53 | VICTORY CAPITAL MANAGEMENT INC | 405,280405,280 | $5M | 0.40% | ADD 22% |
| 54 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 344,315344,315 | $4M | 0.34% | TRIM -37% |
| 55 | JPMORGAN CHASE & CO | 323,584323,584 | $4M | 0.32% | TRIM -22% |
| 56 | Russell Investments Group, Ltd. | 263,059263,059 | $3M | 0.26% | ADD 27% |
| 57 | TD Asset Management Inc | 258,602258,602 | $3M | 0.26% | ADD 52% |
| 58 | Atom Investors LP | 226,804226,804 | $3M | 0.23% | TRIM -22% |
| 59 | UBS Group AG | 194,689194,689 | $2M | 0.19% | TRIM -74% |
| 60 | Bank of New York Mellon Corp | 190,470190,470 | $2M | 0.19% | — |
| 61 | ExodusPoint Capital Management, LP | 186,145186,145 | $2M | 0.19% | ADD 71% |
| 62 | WELLINGTON MANAGEMENT GROUP LLP | 186,099186,099 | $2M | 0.19% | TRIM -3% |
| 63 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 182,139182,139 | $2M | 0.18% | ADD 42% |
| 64 | Boxer Capital Management, LLC | 176,500176,500 | $2M | 0.18% | NEW |
| 65 | AQR CAPITAL MANAGEMENT LLC | 170,087170,087 | $2M | 0.17% | TRIM -2% |
| 66 | Hennion & Walsh Asset Management, Inc. | 160,054160,054 | $2M | 0.16% | TRIM -6% |
| 67 | Nuveen, LLC | 153,022153,022 | $2M | 0.15% | ADD 6% |
| 68 | Blue Owl Capital Holdings LP | 150,000150,000 | $2M | 0.15% | TRIM -71% |
| 69 | AMERICAN CENTURY COMPANIES INC | 146,804146,804 | $2M | 0.15% | ADD 9% |
| 70 | Alyeska Investment Group, L.P. | 137,489137,489 | $2M | 0.14% | NEW |
| 71 | ALGERT GLOBAL LLC | 136,350136,350 | $2M | 0.14% | ADD 237% |
| 72 | Rafferty Asset Management, LLC | 115,480115,480 | $1M | 0.12% | TRIM -35% |
| 73 | SUPERSTRING CAPITAL MANAGEMENT LP | 115,234115,234 | $1M | 0.11% | TRIM -55% |
| 74 | Y-Intercept (Hong Kong) Ltd | 111,992111,992 | $1M | 0.11% | TRIM -67% |
| 75 | Invesco Ltd. | 108,954108,954 | $1M | 0.11% | — |
| 76 | Ishara Investments LP | 102,500102,500 | $1M | 0.10% | TRIM -36% |
| 77 | PRUDENTIAL FINANCIAL INC | 96,14596,145 | $1M | 0.10% | NEW |
| 78 | Abu Dhabi Investment Council Co P.J.S.C | 89,44189,441 | $1M | 0.09% | NEW |
| 79 | Swiss National Bank | 86,20086,200 | $1M | 0.09% | — |
| 80 | RHUMBLINE ADVISERS | 79,06379,063 | $1M | 0.08% | — |
| 81 | DAFNA Capital Management LLC | 98,72498,724 | $945,460 | 0.10% | TRIM -30% |
| 82 | BOOTHBAY FUND MANAGEMENT, LLC | 61,95761,957 | $784,995 | 0.06% | TRIM -72% |
| 83 | MOORE CAPITAL MANAGEMENT, LP | 59,56359,563 | $754,663 | 0.06% | NEW |
| 84 | Tidal Investments LLC | 57,60257,602 | $729,817 | 0.06% | NEW |
| 85 | Tema ETFs LLC | 57,22757,227 | $725,066 | 0.06% | ADD 105% |
| 86 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 54,23954,239 | $687,208 | 0.05% | ADD 7% |
| 87 | JANE STREET GROUP, LLC | 53,03753,037 | $671,978 | 0.05% | TRIM -78% |
| 88 | PROFUND ADVISORS LLC | 51,51951,519 | $652,746 | 0.05% | TRIM -21% |
| 89 | DEUTSCHE BANK AG\ | 51,33351,333 | $650,389 | 0.05% | ADD 14% |
| 90 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 48,36948,369 | $612,835 | 0.05% | ADD 42% |
| 91 | PRELUDE CAPITAL MANAGEMENT, LLC | 46,07046,070 | $583,707 | 0.05% | NEW |
| 92 | D. E. Shaw & Co., Inc. | 44,39044,390 | $562,421 | 0.04% | ADD 177% |
| 93 | XTX Topco Ltd | 43,29143,291 | $548,497 | 0.04% | TRIM -61% |
| 94 | LOS ANGELES CAPITAL MANAGEMENT LLC | 43,13743,137 | $546,546 | 0.04% | NEW |
| 95 | SummitTX Capital, L.P. | 42,44642,446 | $537,791 | 0.04% | NEW |
| 96 | ALLIANCEBERNSTEIN L.P. | 63,81063,810 | $521,966 | 0.06% | — |
| 97 | Vanguard Global Advisers, LLC | 39,85539,855 | $504,963 | 0.04% | NEW |
| 98 | WELLS FARGO & COMPANY/MN | 39,10839,108 | $495,498 | 0.04% | TRIM -53% |
| 99 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,18839,188 | $492,584 | 0.04% | TRIM -5% |
| 100 | STATE OF WISCONSIN INVESTMENT BOARD | 38,29538,295 | $485,198 | 0.04% | TRIM -69% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Nextech Invest, Ltd. | — | 5.3M | 7.2M | 7.2M | 7.2M | 7.2M | $91M |
| EcoR1 Capital, LLC | 3.4M | 3.4M | 1.6M | 6.7M | 6.7M | 6.7M | $85M |
| BlackRock, Inc. | 5.1M | 5.4M | 4.1M | 5.3M | 5.9M | 6.0M | $76M |
| VIKING GLOBAL INVESTORS LPtracked | 4.4M | 6.6M | 6.6M | 6.6M | 6.6M | 5.8M | $74M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.3M | 1.3M | 2.8M | 2.9M | 3.3M | 5.4M | $68M |
| SR One Capital Management, LP | — | — | 4.5M | 4.5M | 4.5M | 4.5M | $58M |
| Pfizer Inc | 5.4M | 5.4M | 5.4M | 5.4M | 5.4M | 4.8M | $58M |
| ALKEON CAPITAL MANAGEMENT LLC | 3.9M | 4.0M | 4.5M | 4.5M | 4.5M | 4.5M | $57M |
| Venrock Adviser, LLC | 4.4M | 3.2M | 6.6M | 6.6M | 5.7M | 4.3M | $55M |
| NEA Management Company, LLC | 1.6M | 2.2M | 4.1M | 4.1M | 4.1M | 4.1M | $52M |
| STATE STREET CORP | 1.8M | 2.2M | 1.6M | 2.4M | 4.3M | 3.7M | $47M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 3.7M | $47M |
| Column Group LLC | 3.5M | 3.5M | 3.5M | 3.5M | 3.5M | 3.5M | $45M |
| Siren, L.L.C. | 1.0M | 1.0M | 1.0M | 1.0M | 1.0M | 3.0M | $38M |
| ORBIMED ADVISORS LLC | — | 700K | 899K | 3.6M | 3.6M | 2.7M | $34M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“Not applicable.”
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +3,687,007 | $47M | OPEN |
| AIHC Capital Management Ltd | +2,459,551 | $31M | OPEN |
| PRICE T ROWE ASSOCIATES INC /MD/ | +2,092,661 | $27M | ADD |
| Siren, L.L.C. | +1,990,617 | $25M | ADD |
| BRAIDWELL LP | +1,128,040 | $14M | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −4,541,974 | $58M | CLOSE |
| Point72 Asset Management, L.P. | −2,923,077 | $37M | CLOSE |
| Venrock Adviser, LLC | −1,356,465 | $17M | TRIM |
| ORBIMED ADVISORS LLC | −947,827 | $12M | TRIM |
| VIKING GLOBAL INVESTORS LP | −748,158 | $9M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 182 | 119,358,492 | 118.9% | $1.5B |
| 2025-Q4 | 165 | 119,666,800 | — | $980M |
| 2025-Q3 | 152 | 107,721,185 | — | $1.3B |
| 2025-Q2 | 142 | 93,464,035 | — | $949M |
| 2025-Q1 | 143 | 79,226,368 | — | $442M |
| 2024-Q4 | 129 | 75,794,185 | 107.4% | $612M |
| 2024-Q3 | 122 | 69,858,494 | 99.0% | $715M |
| 2024-Q2 | 112 | 67,609,788 | 100.3% | $478M |
| 2024-Q1 | 112 | 64,588,191 | 95.9% | $888M |
| 2023-Q4 | 92 | 51,157,433 | 93.8% | $471M |
| 2023-Q3 | 90 | 49,042,634 | 89.9% | $297M |
| 2023-Q2 | 83 | 45,537,877 | 101.0% | $353M |
| 2023-Q1 | 70 | 37,049,453 | 82.2% | $211M |
| 2022-Q4 | 64 | 32,430,298 | 81.9% | $192M |
| 2022-Q3 | 76 | 32,703,381 | 82.6% | $105M |
| 2022-Q2 | 83 | 32,838,758 | 83.2% | $147M |
| 2022-Q1 | 101 | 34,017,592 | 86.3% | $182M |
| 2021-Q4 | 80 | 34,883,686 | 88.6% | $513M |
| 2021-Q3 | 82 | 36,421,728 | 92.6% | $762M |
| 2021-Q2 | 78 | 36,145,633 | 98.5% | $639M |
| 2021-Q1 | 82 | 35,685,719 | 97.2% | $874M |
| 2020-Q4 | 77 | 33,104,762 | 107.4% | $1.1B |
| 2020-Q3 | 55 | 22,648,883 | 75.6% | $565M |
| 2020-Q2 | 66 | 21,514,508 | 71.9% | $722M |
| SEC → |
| BlackRock, Inc. | 5.6% | QII | 2025-12-31 | SEC → |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5.4% | QII | 2026-03-31 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
