| 1 | 1FMR LLC | 10,386,84510.4M | $155M | 11.89% | ADD 107% |
| 2 | 2Paradigm Biocapital Advisors LP | 8,020,5768.0M | $120M | 9.18% | ADD 6% |
| 3 | 3Bain Capital Life Sciences Investors, LLC | 7,473,2387.5M | $111M | 8.56% | TRIM -12% |
| 4 | 4JANUS HENDERSON GROUP PLC | 7,108,4887.1M | $106M | 8.14% | ADD 6% |
| 5 | 5BlackRock, Inc. | 5,652,1355.7M | $84M | 6.47% | — |
| 6 | 6BVF INC/IL | 5,295,8935.3M | $79M | 6.06% | — |
| 7 | 7Siren, L.L.C. | 4,756,9494.8M | $71M | 5.45% | ADD 44% |
| 8 | 8STATE STREET CORP | 3,937,8313.9M | $59M | 4.51% | ADD 109% |
| 9 | 9Cormorant Asset Management, LP | 3,900,0003.9M | $58M | 4.46% | ADD 42% |
| 10 | 10Logos Global Management LP | 3,208,8753.2M | $48M | 3.67% | — |
| 11 | 11VANGUARD CAPITAL MANAGEMENT LLC | 3,083,5173.1M | $46M | 3.53% | NEW† |
| 12 | 12RA CAPITAL MANAGEMENT, L.P. | 2,600,0002.6M | $39M | 2.98% | — |
| 13 | 13JENNISON ASSOCIATES LLC | 1,822,1231.8M | $27M | 2.09% | ADD 89% |
| 14 | 14Polar Capital Holdings Plc | 1,602,9701.6M | $24M | 1.84% | ADD 16% |
| 15 | 15GEODE CAPITAL MANAGEMENT, LLC | 1,544,4171.5M | $23M | 1.77% | ADD 23% |
| 16 | 16Defilade Capital Management, L.P. | 1,504,5361.5M | $22M | 1.72% | ADD 22% |
| 17 | 17Woodline Partners LP | 1,482,0301.5M | $22M | 1.70% | — |
| 18 | 18LIGHTSPEED MANAGEMENT COMPANY, L.L.C. | 1,355,2991.4M | $20M | 1.55% | TRIM -30% |
| 19 | 19FRANKLIN RESOURCES INC | 1,218,9571.2M | $18M | 1.40% | TRIM -51% |
| 20 | 20MORGAN STANLEY | 1,215,6901.2M | $18M | 1.39% | ADD 83% |
| 21 | 21PRICE T ROWE ASSOCIATES INC /MD/ | 1,182,8361.2M | $18M | 1.35% | ADD 8% |
| 22 | 22TWO SIGMA INVESTMENTS, LP | 1,169,4211.2M | $17M | 1.34% | ADD 197% |
| 23 | 23DIMENSIONAL FUND ADVISORS LP | 1,082,4341.1M | $16M | 1.24% | ADD 13% |
| 24 | 24GOLDMAN SACHS GROUP INC | 1,045,5891.0M | $16M | 1.20% | ADD 28% |
| 25 | 25Duquesne Family Office LLC | 986,827986,827 | $15M | 1.13% | NEW |
| 26 | 26CITADEL ADVISORS LLC | 905,332905,332 | $13M | 1.04% | TRIM -25% |
| 27 | 27KINGDON CAPITAL MANAGEMENT, L.L.C. | 855,000855,000 | $13M | 0.98% | TRIM -10% |
| 28 | 28First Turn Management, LLC | 768,662768,662 | $11M | 0.88% | ADD 24% |
| 29 | 29Candriam S.C.A. | 759,513759,513 | $11M | 0.87% | ADD 12% |
| 30 | 30Squarepoint Ops LLC | 738,552738,552 | $11M | 0.85% | ADD 125% |
| 31 | 31Vivo Capital, LLC | 671,843671,843 | $10M | 0.77% | — |
| 32 | 32WELLINGTON MANAGEMENT GROUP LLP | 664,679664,679 | $10M | 0.76% | ADD 201% |
| 33 | 33Ikarian Capital, LLC | 598,281598,281 | $9M | 0.68% | TRIM -21% |
| 34 | 34VANGUARD PORTFOLIO MANAGEMENT LLC | 593,031593,031 | $9M | 0.68% | NEW |
| 35 | 35NORTHERN TRUST CORP | 569,956569,956 | $8M | 0.65% | ADD 28% |
| 36 | 36BANK OF AMERICA CORP /DE/ | 508,706508,706 | $8M | 0.58% | ADD 113% |
| 37 | 37Hennion & Walsh Asset Management, Inc. | 481,485481,485 | $7M | 0.55% | ADD 8% |
| 38 | 38CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 466,546466,546 | $7M | 0.53% | ADD 15% |
| 39 | 39Jump Financial, LLC | 452,966452,966 | $7M | 0.52% | ADD 352% |
| 40 | 40Vestal Point Capital, LP | 428,551428,551 | $6M | 0.49% | TRIM -74% |
| 41 | 41UBS Group AG | 385,061385,061 | $6M | 0.44% | ADD 31% |
| 42 | 42VANGUARD FIDUCIARY TRUST CO | 358,310358,310 | $5M | 0.41% | NEW |
| 43 | 43SEB Asset Management AB | 339,461339,461 | $5M | 0.39% | NEW |
| 44 | 44Trexquant Investment LP | 325,173325,173 | $5M | 0.37% | ADD 554% |
| 45 | 45Qube Research & Technologies Ltd | 312,812312,812 | $5M | 0.36% | NEW |
| 46 | 46Fisher Asset Management, LLC | 299,756299,756 | $4M | 0.34% | NEW |
| 47 | 47SUSQUEHANNA INTERNATIONAL GROUP, LLP | 285,882285,882 | $4M | 0.33% | ADD 2447% |
| 48 | 48Nuveen, LLC | 278,990278,990 | $4M | 0.32% | ADD 22% |
| 49 | 49ADAGE CAPITAL PARTNERS GP, L.L.C. | 275,000275,000 | $4M | 0.31% | ADD 31% |
| 50 | 50Birchview Capital, LP | 219,000219,000 | $3M | 0.25% | TRIM -19% |
| 51 | 51Pictet Asset Management Holding SA | 217,023217,023 | $3M | 0.25% | TRIM -57% |
| 52 | 52VICTORY CAPITAL MANAGEMENT INC | 203,959203,959 | $3M | 0.23% | ADD 137% |
| 53 | 53Bank of New York Mellon Corp | 193,483193,483 | $3M | 0.22% | ADD 10% |
| 54 | 54MILLENNIUM MANAGEMENT LLC | 182,935182,935 | $3M | 0.21% | TRIM -63% |
| 55 | 55BOOTHBAY FUND MANAGEMENT, LLC | 174,603174,603 | $3M | 0.20% | TRIM -20% |
| 56 | 56Rock Springs Capital Management LP | 170,378170,378 | $3M | 0.20% | ADD 73% |
| 57 | 57DEUTSCHE BANK AG\ | 161,396161,396 | $2M | 0.18% | ADD 156% |
| 58 | 58Hudson Bay Capital Management LP | 154,770154,770 | $2M | 0.18% | NEW |
| 59 | 59Integral Health Asset Management, LLC | 150,000150,000 | $2M | 0.17% | NEW |
| 60 | 60Pier Capital, LLC | 136,108136,108 | $2M | 0.16% | TRIM -3% |
| 61 | 61Rafferty Asset Management, LLC | 131,520131,520 | $2M | 0.15% | ADD 192% |
| 62 | 62Invesco Ltd. | 130,933130,933 | $2M | 0.15% | TRIM -16% |
| 63 | 63JPMORGAN CHASE & CO | 142,762142,762 | $2M | 0.16% | TRIM -47% |
| 64 | 64Burkehill Global Management, LP | 125,000125,000 | $2M | 0.14% | — |
| 65 | 65XTX Topco Ltd | 123,218123,218 | $2M | 0.14% | NEW |
| 66 | 66VOYA INVESTMENT MANAGEMENT LLC | 121,494121,494 | $2M | 0.14% | ADD 367% |
| 67 | 67HighVista Strategies LLC | 117,601117,601 | $2M | 0.13% | TRIM -51% |
| 68 | 68FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 116,812116,812 | $2M | 0.13% | ADD 3237% |
| 69 | 69Susquehanna Portfolio Strategies, LLC | 113,842113,842 | $2M | 0.13% | TRIM -6% |
| 70 | 70Aquatic Capital Management LLC | 111,186111,186 | $2M | 0.13% | ADD 626% |
| 71 | 71PRUDENTIAL FINANCIAL INC | 110,150110,150 | $2M | 0.13% | NEW |
| 72 | 72MANUFACTURERS LIFE INSURANCE COMPANY, THE | 109,582109,582 | $2M | 0.13% | ADD 7% |
| 73 | 73TD Asset Management Inc | 106,214106,214 | $2M | 0.12% | TRIM -22% |
| 74 | 74ALLIANCEBERNSTEIN L.P. | 57,84057,840 | $1M | 0.07% | TRIM -8% |
| 75 | 75Ensign Peak Advisors, Inc | 96,78296,782 | $1M | 0.11% | NEW |
| 76 | 76Quantinno Capital Management LP | 95,33695,336 | $1M | 0.11% | ADD 56% |
| 77 | 77Y-Intercept (Hong Kong) Ltd | 90,37590,375 | $1M | 0.10% | ADD 143% |
| 78 | 78Balyasny Asset Management L.P. | 89,67189,671 | $1M | 0.10% | TRIM -46% |
| 79 | 79AQR CAPITAL MANAGEMENT LLC | 89,56289,562 | $1M | 0.10% | ADD 10% |
| 80 | 80Tidal Investments LLC | 85,15185,151 | $1M | 0.10% | NEW |
| 81 | 81RHUMBLINE ADVISERS | 84,35084,350 | $1M | 0.10% | ADD 13% |
| 82 | 82AMERICAN CENTURY COMPANIES INC | 81,73481,734 | $1M | 0.09% | TRIM -13% |
| 83 | 83Tema ETFs LLC | 79,24379,243 | $1M | 0.09% | ADD 78% |
| 84 | 84Swiss National Bank | 74,60074,600 | $1M | 0.09% | NEW |
| 85 | 85STATE OF WISCONSIN INVESTMENT BOARD | 72,70372,703 | $1M | 0.08% | ADD 108% |
| 86 | 86Creative Planning | 72,23472,234 | $1M | 0.08% | ADD 12% |
| 87 | 87Point72 Asset Management, L.P. | 71,10771,107 | $1M | 0.08% | TRIM -77% |
| 88 | 88Connor, Clark & Lunn Investment Management Ltd. | 70,71170,711 | $1M | 0.08% | NEW |
| 89 | 89Engineers Gate Manager LP | 70,47170,471 | $1M | 0.08% | ADD 169% |
| 90 | 90ALPS ADVISORS INC | 64,03564,035 | $954,762 | 0.07% | — |
| 91 | 91Headlands Technologies LLC | 59,37459,374 | $885,266 | 0.07% | NEW |
| 92 | 92PROFUND ADVISORS LLC | 58,57758,577 | $873,383 | 0.07% | ADD 237% |
| 93 | 93LPL Financial LLC | 57,40557,405 | $855,909 | 0.07% | ADD 2% |
| 94 | 94AMERIPRISE FINANCIAL INC | 57,36257,362 | $855,268 | 0.07% | TRIM -72% |
| 95 | 95Swedbank AB | 55,10055,100 | $821,541 | 0.06% | — |
| 96 | 96NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 50,00050,000 | $746,000 | 0.06% | — |
| 97 | 97PORTLAND INVESTMENT COUNSEL INC. | 50,00050,000 | $745,500 | 0.06% | — |
| 98 | 98MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 47,01247,012 | $700,948 | 0.05% | NEW |
| 99 | 99WELLS FARGO & COMPANY/MN | 46,43346,433 | $692,316 | 0.05% | TRIM -45% |
| 100 | 100NOMURA HOLDINGS INC | 41,96041,960 | $625,624 | 0.05% | NEW |