Institutional 13F holdings sum to 107.4% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 3,720,441 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | SAMSARA BIOCAPITAL, LLC | 1,717,1271.7M | $35M | 10.87% | — |
| 2 | Redmile Group, LLC | 1,459,5991.5M | $29M | 9.24% | — |
| 3 | Casdin Capital, LLC | 1,420,3611.4M | $29M | 8.99% | ADD 10% |
| 4 | RTW INVESTMENTS, LP | 1,362,4561.4M | $27M | 8.62% | — |
| 5 | EcoR1 Capital, LLC | 1,271,3421.3M | $26M | 8.05% | — |
| 6 | BlackRock, Inc. | 1,005,0701.0M | $20M | 6.36% | ADD 6% |
| 7 | BAKER BROS. ADVISORS LP | 991,691991,691 | $20M | 6.28% | — |
| 8 | Trails Edge Capital Partners, LP | 782,787782,787 | $16M | 4.95% | — |
| 9 | Balyasny Asset Management L.P. | 718,389718,389 | $14M | 4.55% | ADD 18% |
| 10 | TORONTO DOMINION BANK | 681,337681,337 | $14M | 4.31% | — |
| 11 | JENNISON ASSOCIATES LLC | 527,685527,685 | $11M | 3.34% | — |
| 12 | ArrowMark Colorado Holdings LLC | 524,796524,796 | $11M | 3.32% | TRIM -9% |
| 13 | VANGUARD CAPITAL MANAGEMENT LLC | 514,727514,727 | $10M | 3.26% | NEW† |
| 14 | GREAT POINT PARTNERS LLC | 500,000500,000 | $10M | 3.16% | ADD 43% |
| 15 | CITADEL ADVISORS LLC | 387,031387,031 | $8M | 2.45% | ADD 6% |
| 16 | FMR LLC | 382,647382,647 | $8M | 2.42% | ADD 194% |
| 17 | STATE STREET CORP | 313,005313,005 | $6M | 1.98% | — |
| 18 | MORGAN STANLEY | 285,239285,239 | $6M | 1.81% | TRIM -23% |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 279,003279,003 | $6M | 1.77% | ADD 12% |
| 20 | MILLENNIUM MANAGEMENT LLC | 204,809204,809 | $4M | 1.30% | ADD 187% |
| 21 | UBS Group AG | 185,679185,679 | $4M | 1.18% | ADD 20% |
| 22 | BLAIR WILLIAM & CO/IL | 168,218168,218 | $3M | 1.06% | ADD 3% |
| 23 | GOLDMAN SACHS GROUP INC | 107,714107,714 | $2M | 0.68% | TRIM -34% |
| 24 | DEUTSCHE BANK AG\ | 106,255106,255 | $2M | 0.67% | ADD 24% |
| 25 | Rock Springs Capital Management LP | 104,339104,339 | $2M | 0.66% | — |
| 26 | NORTHERN TRUST CORP | 97,62197,621 | $2M | 0.62% | ADD 14% |
| 27 | Woodline Partners LP | 83,83583,835 | $2M | 0.53% | — |
| 28 | VANGUARD FIDUCIARY TRUST CO | 69,71269,712 | $1M | 0.44% | NEW |
| 29 | VANGUARD PORTFOLIO MANAGEMENT LLC | 65,08065,080 | $1M | 0.41% | NEW |
| 30 | JPMORGAN CHASE & CO | 64,92264,922 | $1M | 0.41% | ADD 1111% |
| 31 | DAFNA Capital Management LLC | 56,63556,635 | $1M | 0.36% | ADD 102% |
| 32 | SCHRODER INVESTMENT MANAGEMENT GROUP | 52,30052,300 | $1M | 0.33% | — |
| 33 | RENAISSANCE TECHNOLOGIES LLC | 43,40043,400 | $874,944 | 0.27% | ADD 210% |
| 34 | Raiffeisen Bank International AG | 43,00043,000 | $829,900 | 0.27% | ADD 2% |
| 35 | Driehaus Capital Management LLC | 32,76532,765 | $660,542 | 0.21% | — |
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 30,05830,058 | $605,969 | 0.19% | — |
| 37 | XTX Topco Ltd | 27,43127,431 | $553,009 | 0.17% | NEW |
| 38 | Bank of New York Mellon Corp | 26,04326,043 | $525,032 | 0.16% | ADD 13% |
| 39 | Nuveen, LLC | 25,21025,210 | $508,234 | 0.16% | ADD 20% |
| 40 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,78118,781 | $378,625 | 0.12% | ADD 74% |
| 41 | AMERICAN CENTURY COMPANIES INC | 18,54018,540 | $373,766 | 0.12% | ADD 6% |
| 42 | Mariner, LLC | 16,68716,687 | $336,410 | 0.11% | NEW |
| 43 | RHUMBLINE ADVISERS | 13,89213,892 | $280,054 | 0.09% | ADD 4% |
| 44 | TWO SIGMA INVESTMENTS, LP | 13,89113,891 | $280,043 | 0.09% | ADD 16% |
| 45 | LOS ANGELES CAPITAL MANAGEMENT LLC | 13,79313,793 | $278,067 | 0.09% | TRIM -5% |
| 46 | Virtus Investment Advisers, LLC | 13,03313,033 | $262,745 | 0.08% | ADD 2% |
| 47 | Brevan Howard Capital Management LP | 12,75412,754 | $257,121 | 0.08% | NEW |
| 48 | NOMURA HOLDINGS INC | 12,72412,724 | $256,516 | 0.08% | NEW |
| 49 | ALPS ADVISORS INC | 12,60612,606 | $254,137 | 0.08% | — |
| 50 | DIMENSIONAL FUND ADVISORS LP | 11,41511,415 | $230,126 | 0.07% | — |
| 51 | BANK OF AMERICA CORP /DE/ | 10,86410,864 | $219,018 | 0.07% | TRIM -74% |
| 52 | ALLIANCEBERNSTEIN L.P. | 10,57010,570 | $217,742 | 0.07% | — |
| 53 | AQR CAPITAL MANAGEMENT LLC | 10,31110,311 | $207,870 | 0.07% | NEW |
| 54 | Mitsubishi UFJ Asset Management Co., Ltd. | 7,9947,994 | $161,159 | 0.05% | TRIM -2% |
| 55 | MetLife Investment Management, LLC | 5,9325,932 | $119,589 | 0.04% | — |
| 56 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,3075,307 | $106,989 | 0.03% | ADD 16% |
| 57 | PNC FINANCIAL SERVICES GROUP, INC. | 5,0475,047 | $101,748 | 0.03% | — |
| 58 | Vanguard Global Advisers, LLC | 4,8544,854 | $97,857 | 0.03% | NEW |
| 59 | WELLS FARGO & COMPANY/MN | 4,2684,268 | $86,043 | 0.03% | TRIM -61% |
| 60 | NEW YORK STATE COMMON RETIREMENT FUND | 4,2004,200 | $84,672 | 0.03% | — |
| 61 | Police & Firemen's Retirement System of New Jersey | 3,8463,846 | $77,535 | 0.02% | ADD 91% |
| 62 | BARCLAYS PLC | 2,7512,751 | $55,461 | 0.02% | TRIM -82% |
| 63 | China Universal Asset Management Co., Ltd. | 2,7492,749 | $55,420 | 0.02% | ADD 9% |
| 64 | BNP PARIBAS FINANCIAL MARKETS | 2,6942,694 | $54,311 | 0.02% | ADD 11% |
| 65 | Russell Investments Group, Ltd. | 1,6071,607 | $32,397 | 0.01% | ADD 88% |
| 66 | Tower Research Capital LLC (TRC) | 1,2791,279 | $25,785 | 0.01% | ADD 4% |
| 67 | CWM, LLC | 1,0301,030 | $20,765 | 0.01% | ADD 569% |
| 68 | Ameritas Investment Partners, Inc. | 1,0091,009 | $20,341 | 0.01% | — |
| 69 | CITIGROUP INC | 930930 | $18,749 | 0.01% | ADD 23% |
| 70 | Legal & General Group Plc | 898898 | $18,104 | 0.01% | — |
| 71 | Mirae Asset Global Investments Co., Ltd. | 808808 | $16,289 | 0.01% | ADD 7% |
| 72 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 604604 | $12,177 | 0.00% | — |
| 73 | GAMMA Investing LLC | 535535 | $10,786 | 0.00% | ADD 31% |
| 74 | Sterling Capital Management LLC | 374374 | $7,540 | 0.00% | TRIM -34% |
| 75 | GF FUND MANAGEMENT CO. LTD. | 340340 | $6,854 | 0.00% | ADD 13% |
| 76 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 292292 | $5,887 | 0.00% | NEW |
| 77 | Farther Finance Advisors, LLC | 170170 | $3,682 | 0.00% | NEW |
| 78 | SBI Securities Co., Ltd. | 125125 | $2,520 | 0.00% | ADD 400% |
| 79 | ROYAL BANK OF CANADA | 112112 | $2,000 | 0.00% | TRIM -74% |
| 80 | Parallel Advisors, LLC | 9696 | $1,935 | 0.00% | NEW |
| 81 | SIMPLEX TRADING, LLC | 8989 | $1,794 | 0.00% | ADD 44% |
| 82 | Optiver Holding B.V. | 6767 | $1,351 | 0.00% | ADD 10% |
| 83 | NISA INVESTMENT ADVISORS, LLC | 6363 | $1,270 | 0.00% | ADD 40% |
| 84 | Truvestments Capital LLC | 4646 | $927 | 0.00% | — |
| 85 | ROTHSCHILD INVESTMENT LLC | 4545 | $907 | 0.00% | ADD 13% |
| 86 | EverSource Wealth Advisors, LLC | 4444 | $888 | 0.00% | — |
| 87 | US BANCORP \DE\ | 3030 | $605 | 0.00% | TRIM -82% |
| 88 | Allworth Financial LP | 3030 | $605 | 0.00% | NEW |
| 89 | Investors Portfolio Services LLC | 1515 | $477 | 0.00% | NEW |
| 90 | Essential Partners LLC | 2020 | $403 | 0.00% | NEW |
| 91 | Arax Advisory Partners | 1414 | $282 | 0.00% | ADD 600% |
| 92 | MAI Capital Management | 1111 | $222 | 0.00% | NEW |
| 93 | NATIONAL BANK OF CANADA /FI/ | 88 | $161 | 0.00% | — |
| 94 | Sunbelt Securities, Inc. | 22 | $40 | 0.00% | NEW |
| 95 | IFP Advisors, Inc | 11 | $20 | 0.00% | NEW |
| 96 | Larson Financial Group LLC | 11 | $20 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| SAMSARA BIOCAPITAL, LLC | 1.7M | 1.7M | 1.7M | 1.7M | 1.7M | 1.7M | $35M |
| Redmile Group, LLC | 1.3M | 1.3M | 1.3M | 1.3M | 1.5M | 1.5M | $29M |
| Casdin Capital, LLC | 1.3M | 1.3M | 1.3M | 1.3M | 1.3M | 1.4M | $29M |
| RTW INVESTMENTS, LP | 1.4M | 1.3M | 1.4M | 1.4M | 1.4M | 1.4M | $27M |
| EcoR1 Capital, LLC | 1.3M | 1.3M | 1.3M | 1.3M | 1.3M | 1.3M | $26M |
| BlackRock, Inc. | 1.5M | 1.4M | 978K | 951K | 946K | 1.0M | $20M |
| BAKER BROS. ADVISORS LP | 674K | 1.5M | 992K | 992K | 992K | 992K | $20M |
| Trails Edge Capital Partners, LP | — | — | — | — | 785K | 783K | $16M |
| Balyasny Asset Management L.P. | — | — | — | 699K | 609K | 718K | $14M |
| TORONTO DOMINION BANK | — | 239K | 681K | 681K | 681K | 681K | $14M |
| JENNISON ASSOCIATES LLC | 73K | 108K | 168K | 394K | 533K | 528K | $11M |
| ArrowMark Colorado Holdings LLC | 449K | 442K | 585K | 596K | 577K | 525K | $11M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 515K | $10M |
| GREAT POINT PARTNERS LLC | 443K | 471K | 486K | 447K | 350K | 500K | $10M |
| CITADEL ADVISORS LLC | — | 16K | — | — | 364K | 387K | $8M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 96 | 16,969,516 | 107.4% | $342M |
| 2025-Q4 | 93 | 16,506,555 | 104.5% | $340M |
| 2025-Q3 | 88 | 15,305,510 | 96.9% | $265M |
| 2025-Q2 | 83 | 15,390,490 | 97.4% | $230M |
| 2025-Q1 | 86 | 16,458,955 | 104.2% | $193M |
| 2024-Q4 | 89 | 16,091,359 | 101.8% | $368M |
| 2024-Q3 | 86 | 13,852,246 | 87.7% | $581M |
| 2024-Q2 | 66 | 13,342,205 | 84.4% | $486M |
| 2024-Q1 | 60 | 13,162,728 | 83.3% | $670M |
| 2023-Q4 | 35 | 9,646,133 | 61.0% | $187M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| 2025-06-30 |
| SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
