| 1 | 1Sanofi | 12,197,73712.2M | $106M | 13.17% | — |
| 2 | 2PERCEPTIVE ADVISORS LLC | 10,326,10310.3M | $89M | 11.15% | — |
| 3 | 3Rubric Capital Management LP | 7,000,0007.0M | $61M | 7.56% | ADD 13% |
| 4 | 4JOHNSON & JOHNSON | 6,641,0646.6M | $58M | 7.17% | — |
| 5 | 5ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,000,0004.0M | $35M | 4.32% | — |
| 6 | 6MILLENNIUM MANAGEMENT LLC | 3,465,6993.5M | $30M | 3.74% | ADD 9% |
| 7 | 7BlackRock, Inc. | 3,168,1483.2M | $27M | 3.42% | ADD 3% |
| 8 | 8Prosight Management, LP | 2,629,9712.6M | $23M | 2.84% | TRIM -18% |
| 9 | 9683 Capital Management, LLC | 2,450,0002.5M | $21M | 2.65% | TRIM -4% |
| 10 | 10Opaleye Management Inc. | 2,123,2592.1M | $18M | 2.29% | ADD 443% |
| 11 | 11MORGAN STANLEY | 1,589,9401.6M | $14M | 1.72% | TRIM -13% |
| 12 | 12Knoll Capital Management, LLC | 1,250,0001.3M | $11M | 1.35% | — |
| 13 | 13KENNEDY CAPITAL MANAGEMENT LLC | 858,379858,379 | $7M | 0.93% | ADD 1113% |
| 14 | 14STATE STREET CORP | 753,378753,378 | $7M | 0.81% | ADD 3% |
| 15 | 15Logos Global Management LP | 700,000700,000 | $6M | 0.76% | NEW |
| 16 | 16Erste Asset Management GmbH | 719,702719,702 | $6M | 0.78% | TRIM -9% |
| 17 | 17GEODE CAPITAL MANAGEMENT, LLC | 584,899584,899 | $5M | 0.63% | — |
| 18 | 18Long Focus Capital Management, LLC | 524,745524,745 | $5M | 0.57% | — |
| 19 | 19GOLDMAN SACHS GROUP INC | 441,414441,414 | $4M | 0.48% | TRIM -3% |
| 20 | 20D. E. Shaw & Co., Inc. | 425,281425,281 | $4M | 0.46% | ADD 11% |
| 21 | 21VANGUARD PORTFOLIO MANAGEMENT LLC | 397,281397,281 | $3M | 0.43% | NEW |
| 22 | 22Hennion & Walsh Asset Management, Inc. | 354,755354,755 | $3M | 0.38% | ADD 15% |
| 23 | 23UBS Group AG | 303,198303,198 | $3M | 0.33% | ADD 37% |
| 24 | 24Woodline Partners LP | 300,323300,323 | $3M | 0.32% | — |
| 25 | 25NORTHERN TRUST CORP | 271,879271,879 | $2M | 0.29% | ADD 5% |
| 26 | 26BANK OF AMERICA CORP /DE/ | 244,944244,944 | $2M | 0.26% | ADD 18% |
| 27 | 27Privium Fund Management B.V. | 212,112212,112 | $2M | 0.23% | ADD 6% |
| 28 | 28J. Goldman & Co LP | 206,210206,210 | $2M | 0.22% | TRIM -35% |
| 29 | 29Jefferies Financial Group Inc. | 167,452167,452 | $1M | 0.18% | TRIM -44% |
| 30 | 30Nuveen, LLC | 132,454132,454 | $1M | 0.14% | — |
| 31 | 31WELLINGTON MANAGEMENT GROUP LLP | 126,331126,331 | $1M | 0.14% | TRIM -3% |
| 32 | 32BLAIR WILLIAM & CO/IL | 125,422125,422 | $1M | 0.14% | — |
| 33 | 33CITADEL ADVISORS LLC | 115,995115,995 | $1M | 0.13% | TRIM -19% |
| 34 | 34BNP PARIBAS FINANCIAL MARKETS | 111,719111,719 | $967,487 | 0.12% | TRIM -13% |
| 35 | 35AQR CAPITAL MANAGEMENT LLC | 110,993110,993 | $961,199 | 0.12% | ADD 3% |
| 36 | 36JANE STREET GROUP, LLC | 105,944105,944 | $917,475 | 0.11% | ADD 8% |
| 37 | 37CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 100,194100,194 | $867,680 | 0.11% | TRIM -10% |
| 38 | 38Bank of New York Mellon Corp | 100,097100,097 | $866,837 | 0.11% | — |
| 39 | 39SEI INVESTMENTS CO | 99,62799,627 | $862,770 | 0.11% | NEW |
| 40 | 40Trexquant Investment LP | 97,62097,620 | $845,389 | 0.11% | ADD 45% |
| 41 | 41Russell Investments Group, Ltd. | 97,16897,168 | $841,474 | 0.10% | — |
| 42 | 42Invesco Ltd. | 94,43594,435 | $817,807 | 0.10% | ADD 4% |
| 43 | 43PLATINUM INVESTMENT MANAGEMENT LTD | 93,92293,922 | $813,365 | 0.10% | — |
| 44 | 44Point72 Asset Management, L.P. | 70,95370,953 | $614,453 | 0.08% | NEW |
| 45 | 45DAVENPORT & Co LLC | 69,20069,200 | $599,272 | 0.07% | — |
| 46 | 46TOCQUEVILLE ASSET MANAGEMENT L.P. | 68,20068,200 | $590,612 | 0.07% | ADD 3% |
| 47 | 47Fort Sheridan Advisors LLC | 66,86066,860 | $579,012 | 0.07% | — |
| 48 | 48Quantinno Capital Management LP | 56,40256,402 | $488,441 | 0.06% | TRIM -7% |
| 49 | 49Jump Financial, LLC | 56,25356,253 | $487,151 | 0.06% | ADD 52% |
| 50 | 50RHUMBLINE ADVISERS | 55,76155,761 | $482,879 | 0.06% | — |
| 51 | 51RAYMOND JAMES FINANCIAL INC | 53,85653,856 | $466,393 | 0.06% | TRIM -6% |
| 52 | 52AlphaCentric Advisors LLC | 53,69453,694 | $464,990 | 0.06% | ADD 88% |
| 53 | 53ALLIANCEBERNSTEIN L.P. | 54,59054,590 | $433,991 | 0.06% | — |
| 54 | 54BROWN ADVISORY INC | 50,00050,000 | $433,000 | 0.05% | — |
| 55 | 55XTX Topco Ltd | 43,35643,356 | $375,463 | 0.05% | ADD 14% |
| 56 | 56HSBC HOLDINGS PLC | 39,78739,787 | $337,792 | 0.04% | TRIM -16% |
| 57 | 57BARCLAYS PLC | 38,13838,138 | $330,275 | 0.04% | TRIM -60% |
| 58 | 58SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,91436,914 | $319,675 | 0.04% | TRIM -52% |
| 59 | 59VANGUARD FIDUCIARY TRUST CO | 33,66533,665 | $291,539 | 0.04% | NEW |
| 60 | 60LETKO, BROSSEAU & ASSOCIATES INC | 32,00032,000 | $277,120 | 0.03% | — |
| 61 | 61EntryPoint Capital, LLC | 31,93231,932 | $276,531 | 0.03% | NEW |
| 62 | 62PRICE T ROWE ASSOCIATES INC /MD/ | 31,43031,430 | $273,000 | 0.03% | ADD 38% |
| 63 | 63Virtus Investment Advisers, LLC | 30,57030,570 | $264,736 | 0.03% | ADD 3% |
| 64 | 64DEUTSCHE BANK AG\ | 30,21630,216 | $261,671 | 0.03% | TRIM -26% |
| 65 | 65Engineers Gate Manager LP | 26,80026,800 | $232,088 | 0.03% | — |
| 66 | 66Beacon Pointe Advisors, LLC | 26,76326,763 | $231,768 | 0.03% | ADD 29% |
| 67 | 67CreativeOne Wealth, LLC | 26,42426,424 | $228,832 | 0.03% | — |
| 68 | 68HRT FINANCIAL LP | 24,44424,444 | $211,000 | 0.03% | NEW |
| 69 | 69SkyView Investment Advisors, LLC | 24,00024,000 | $208,000 | 0.03% | — |
| 70 | 70JPMORGAN CHASE & CO | 24,33824,338 | $196,894 | 0.03% | — |
| 71 | 71MetLife Investment Management, LLC | 22,70122,701 | $196,591 | 0.02% | ADD 13% |
| 72 | 72Voleon Capital Management LP | 22,35922,359 | $193,629 | 0.02% | ADD 35% |
| 73 | 73Mitsubishi UFJ Asset Management Co., Ltd. | 22,03322,033 | $190,806 | 0.02% | TRIM -2% |
| 74 | 74ExodusPoint Capital Management, LP | 21,84721,847 | $189,195 | 0.02% | TRIM -75% |
| 75 | 75MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,51621,516 | $186,329 | 0.02% | ADD 2% |
| 76 | 76Squarepoint Ops LLC | 18,58418,584 | $160,937 | 0.02% | NEW |
| 77 | 77CIBC Bancorp USA Inc. | 17,27717,277 | $149,619 | 0.02% | NEW |
| 78 | 78WELLS FARGO & COMPANY/MN | 16,59416,594 | $143,704 | 0.02% | TRIM -67% |
| 79 | 79Creative Planning | 15,45915,459 | $133,875 | 0.02% | — |
| 80 | 80Perigon Wealth Management, LLC | 15,14015,140 | $131,112 | 0.02% | — |
| 81 | 81China Universal Asset Management Co., Ltd. | 14,28414,284 | $123,699 | 0.02% | ADD 9% |
| 82 | 82JACOBS LEVY EQUITY MANAGEMENT, INC | 13,67313,673 | $118,408 | 0.01% | TRIM -76% |
| 83 | 83MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,19013,190 | $114,225 | 0.01% | TRIM -11% |
| 84 | 84GSA CAPITAL PARTNERS LLP | 12,52612,526 | $108,000 | 0.01% | NEW |
| 85 | 85STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,23712,237 | $105,972 | 0.01% | — |
| 86 | 86BANK OF NOVA SCOTIA | 12,10612,106 | $104,838 | 0.01% | NEW |
| 87 | 87Police & Firemen's Retirement System of New Jersey | 11,66111,661 | $100,984 | 0.01% | — |
| 88 | 88INTECH INVESTMENT MANAGEMENT LLC | 10,41310,413 | $90,177 | 0.01% | TRIM -35% |
| 89 | 89STATE OF WISCONSIN INVESTMENT BOARD | 10,34510,345 | $89,588 | 0.01% | TRIM -76% |
| 90 | 90ALGERT GLOBAL LLC | 10,27010,270 | $89,000 | 0.01% | NEW |
| 91 | 91Hudson Bay Capital Management LP | 10,19010,190 | $88,245 | 0.01% | NEW |
| 92 | 92ProShare Advisors LLC | 10,15610,156 | $87,951 | 0.01% | TRIM -14% |
| 93 | 93ROYAL BANK OF CANADA | 9,6439,643 | $84,000 | 0.01% | TRIM -11% |
| 94 | 94CWM, LLC | 7,7687,768 | $67,271 | 0.01% | — |
| 95 | 95NEW YORK STATE COMMON RETIREMENT FUND | 7,2637,263 | $62,898 | 0.01% | — |
| 96 | 96Rockefeller Capital Management L.P. | 6,6506,650 | $57,589 | 0.01% | ADD 8% |
| 97 | 97FMR LLC | 5,8215,821 | $50,410 | 0.01% | TRIM -58% |
| 98 | 98CITIGROUP INC | 5,3725,372 | $46,521 | 0.01% | TRIM -65% |
| 99 | 99Mirae Asset Global Investments Co., Ltd. | 4,1984,198 | $36,355 | 0.00% | ADD 7% |
| 100 | 100State of Alaska, Department of Revenue | 4,0304,030 | $34,000 | 0.00% | — |
