MDGL US Equity

MADRIGAL PHARMACEUTICALS, INC.

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Health Care · Pharmaceutical Preparations · CIK 1157601 · FYE 1231

$538.80

-12.45 (-2.26%)

USD · as of 2026-07-28 · marketstack

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Institutional ownership· 13F filers holding MDGL · 2026-Q1 methodology → sources →

376 holders

% of shares outstanding held

103.1%

Shares held (13F)

23,773,155

Reporting holders

376

Institutional 13F holdings sum to 103.1% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 3,854,441 shares (settlement 2026-04-30) accounts for the excess.

Top holders

largest 100 of 376 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	BAKER BROS. ADVISORS LP	2,141,7012.1M	$1.1B	9.29%	—
2	JANUS HENDERSON GROUP PLC	2,018,6472.0M	$1.1B	8.76%	ADD 27%
3	RTW INVESTMENTS, LP	1,993,6872.0M	$1.0B	8.65%	—
4	Avoro Capital Advisors LLC	1,818,1811.8M	$952M	7.89%	—
5	BlackRock, Inc.	1,559,9651.6M	$817M	6.77%	TRIM -5%
6	PAULSON & CO. INC.	1,392,1881.4M	$729M	6.04%	TRIM -18%
7	VANGUARD PORTFOLIO MANAGEMENT LLC	841,145841,145	$440M	3.65%	NEW†
8	VANGUARD CAPITAL MANAGEMENT LLC	827,144827,144	$433M	3.59%	NEW†
9	WELLINGTON MANAGEMENT GROUP LLP	694,958694,958	$364M	3.01%	ADD 51%
10	STATE STREET CORP	609,525609,525	$319M	2.64%	ADD 5%
11	FMR LLC	511,728511,728	$268M	2.22%	ADD 16%
12	GEODE CAPITAL MANAGEMENT, LLC	455,870455,870	$239M	1.98%	—
13	CITADEL ADVISORS LLC	453,843453,843	$238M	1.97%	ADD 1156%
14	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	340,519340,519	$178M	1.48%	TRIM -4%
15	Invesco Ltd.	329,519329,519	$172M	1.43%	TRIM -10%
16	PRICE T ROWE ASSOCIATES INC /MD/	328,110328,110	$172M	1.42%	ADD 5%
17	Polar Capital Holdings Plc	289,310289,310	$151M	1.25%	ADD 7%
18	GOLDMAN SACHS GROUP INC	277,371277,371	$145M	1.20%	TRIM -9%
19	ARMISTICE CAPITAL, LLC	264,583264,583	$139M	1.15%	—
20	Hood River Capital Management LLC	249,511249,511	$131M	1.08%	—
21	LORD, ABBETT & CO. LLC	242,726242,726	$127M	1.05%	—
22	Point72 Asset Management, L.P.	225,510225,510	$118M	0.98%	ADD 78%
23	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	216,720216,720	$113M	0.94%	—
24	MORGAN STANLEY	191,294191,294	$100M	0.83%	ADD 27%
25	BANK OF AMERICA CORP /DE/	189,527189,527	$99M	0.82%	TRIM -54%
26	Pictet Asset Management Holding SA	187,240187,240	$98M	0.81%	ADD 3%
27	ADAGE CAPITAL PARTNERS GP, L.L.C.	185,331185,331	$97M	0.80%	ADD 698%
28	Artisan Partners Limited Partnership	183,540183,540	$96M	0.80%	TRIM -8%
29	Fiera Capital Corp	174,011174,011	$91M	0.75%	ADD 3%
30	Rock Springs Capital Management LP	170,999170,999	$90M	0.74%	ADD 22%
31	AMERICAN CENTURY COMPANIES INC	163,933163,933	$86M	0.71%	TRIM -11%
32	Erste Asset Management GmbH	160,210160,210	$81M	0.69%	ADD 14%
33	NORTHERN TRUST CORP	149,214149,214	$78M	0.65%	—
34	ALLIANCEBERNSTEIN L.P.	125,447125,447	$73M	0.54%	ADD 473%
35	Bank of New York Mellon Corp	135,908135,908	$71M	0.59%	—
36	TORONTO DOMINION BANK	130,460130,460	$68M	0.57%	NEW
37	VANGUARD FIDUCIARY TRUST CO	128,079128,079	$67M	0.56%	NEW
38	Woodline Partners LP	125,899125,899	$66M	0.55%	—
39	UBS Group AG	117,779117,779	$62M	0.51%	ADD 15%
40	Driehaus Capital Management LLC	110,960110,960	$58M	0.48%	—
41	Tri Locum Partners LP	103,288103,288	$54M	0.45%	ADD 20%
42	AMERIPRISE FINANCIAL INC	98,18198,181	$51M	0.43%	ADD 235%
43	DEUTSCHE BANK AG\	98,06798,067	$51M	0.43%	TRIM -49%
44	WESTFIELD CAPITAL MANAGEMENT CO LP	94,81394,813	$50M	0.41%	NEW
45	Logos Global Management LP	85,00085,000	$44M	0.37%	NEW
46	Candriam S.C.A.	84,94884,948	$44M	0.37%	ADD 33%
47	ALKEON CAPITAL MANAGEMENT LLC	80,00080,000	$42M	0.35%	TRIM -67%
48	NEW YORK STATE COMMON RETIREMENT FUND	75,12975,129	$39M	0.33%	—
49	FRANKLIN RESOURCES INC	74,04174,041	$39M	0.32%	TRIM -14%
50	RENAISSANCE TECHNOLOGIES LLC	71,87071,870	$38M	0.31%	TRIM -14%
51	RAYMOND JAMES FINANCIAL INC	66,52966,529	$34M	0.29%	—
52	ArrowMark Colorado Holdings LLC	62,44162,441	$33M	0.27%	TRIM -24%
53	Nuveen, LLC	62,06062,060	$32M	0.27%	TRIM -48%
54	VOYA INVESTMENT MANAGEMENT LLC	59,97159,971	$31M	0.26%	TRIM -7%
55	BNP PARIBAS FINANCIAL MARKETS	57,17757,177	$30M	0.25%	TRIM -22%
56	Affinity Asset Advisors, LLC	55,00055,000	$29M	0.24%	ADD 77%
57	Squarepoint Ops LLC	52,88452,884	$28M	0.23%	TRIM -29%
58	EULAV Asset Management	49,00049,000	$26M	0.21%	—
59	Russell Investments Group, Ltd.	44,50444,504	$23M	0.19%	TRIM -8%
60	Mirae Asset Global Investments Co., Ltd.	40,92640,926	$21M	0.18%	TRIM -19%
61	MILLENNIUM MANAGEMENT LLC	40,85340,853	$21M	0.18%	ADD 485%
62	SCHRODER INVESTMENT MANAGEMENT GROUP	39,85239,852	$20M	0.17%	ADD 37%
63	EMERALD ADVISERS, LLC	37,65437,654	$20M	0.16%	TRIM -3%
64	JANE STREET GROUP, LLC	35,83835,838	$19M	0.16%	TRIM -62%
65	GROUPAMA ASSET MANAGMENT	35,23835,238	$18M	0.15%	ADD 15%
66	JPMORGAN CHASE & CO	36,31536,315	$18M	0.16%	TRIM -9%
67	PFM Health Sciences, LP	34,14634,146	$18M	0.15%	ADD 370%
68	Rockefeller Capital Management L.P.	33,84933,849	$18M	0.15%	ADD 72%
69	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	32,87932,879	$17M	0.14%	ADD 114%
70	WELLS FARGO & COMPANY/MN	32,21232,212	$17M	0.14%	TRIM -26%
71	SEGALL BRYANT & HAMILL, LLC	31,87031,870	$17M	0.14%	TRIM -5%
72	Vestal Point Capital, LP	31,46831,468	$16M	0.14%	NEW
73	D. E. Shaw & Co., Inc.	30,13930,139	$16M	0.13%	TRIM -66%
74	GILDER GAGNON HOWE & CO LLC	29,39129,391	$15M	0.13%	TRIM -12%
75	Swiss National Bank	29,22029,220	$15M	0.13%	ADD 2%
76	Connor, Clark & Lunn Investment Management Ltd.	27,93727,937	$15M	0.12%	TRIM -52%
77	CITIGROUP INC	25,58925,589	$13M	0.11%	ADD 10%
78	Integral Health Asset Management, LLC	25,00025,000	$13M	0.11%	NEW
79	Clearbridge Investments, LLC	24,44724,447	$13M	0.11%	NEW
80	SEI INVESTMENTS CO	24,19824,198	$13M	0.10%	ADD 5%
81	Rhenman & Partners Asset Management AB	24,05024,050	$13M	0.10%	ADD 23%
82	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	23,79623,796	$12M	0.10%	—
83	California Public Employees Retirement System	23,19823,198	$12M	0.10%	TRIM -26%
84	WCM INVESTMENT MANAGEMENT, LLC	23,56023,560	$12M	0.10%	ADD 37%
85	FIRST TRUST ADVISORS LP	22,23322,233	$12M	0.10%	TRIM -10%
86	SUSQUEHANNA INTERNATIONAL GROUP, LLP	22,21622,216	$12M	0.10%	TRIM -66%
87	MARSHALL WACE, LLP	21,90221,902	$11M	0.09%	TRIM -45%
88	RHUMBLINE ADVISERS	21,76421,764	$11M	0.09%	TRIM -8%
89	Tao Capital Management LP	21,00021,000	$11M	0.09%	—
90	Universal- Beteiligungs- und Servicegesellschaft mbH	18,45218,452	$10M	0.08%	TRIM -3%
91	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	17,04717,047	$9M	0.07%	ADD 22%
92	FEDERATED HERMES, INC.	16,90316,903	$9M	0.07%	ADD 4%
93	EMERALD MUTUAL FUND ADVISERS TRUST	16,50016,500	$9M	0.07%	TRIM -34%
94	MANUFACTURERS LIFE INSURANCE COMPANY, THE	16,30016,300	$9M	0.07%	—
95	Assenagon Asset Management S.A.	16,03316,033	$8M	0.07%	ADD 197%
96	SILVERCREST ASSET MANAGEMENT GROUP LLC	15,96315,963	$8M	0.07%	NEW
97	AQR CAPITAL MANAGEMENT LLC	15,95315,953	$8M	0.07%	ADD 59%
98	ENVESTNET ASSET MANAGEMENT INC	15,46115,461	$8M	0.07%	—
99	Cinctive Capital Management LP	15,32615,326	$8M	0.07%	ADD 316%
100	VANGUARD ASSET MANAGEMENT, Ltd	14,09014,090	$7M	0.06%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

BAKER BROS. ADVISORS LP

2.0M

2.1M

$1.1B

JANUS HENDERSON GROUP PLC

2.2M

1.8M

1.6M

2.0M

$1.1B

RTW INVESTMENTS, LP

2.0M

$1.0B

Avoro Capital Advisors LLC

2.0M

1.9M

1.8M

$952M

BlackRock, Inc.

1.5M

1.4M

1.6M

$817M

PAULSON & CO. INC.

2.0M

2.1M

1.9M

1.7M

1.4M

$729M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

841K

$440M

VANGUARD CAPITAL MANAGEMENT LLC

—

827K

$433M

WELLINGTON MANAGEMENT GROUP LLP

404K

461K

695K

$364M

STATE STREET CORP

781K

759K

691K

658K

583K

610K

$319M

FMR LLC

868K

652K

445K

401K

439K

512K

$268M

GEODE CAPITAL MANAGEMENT, LLC

411K

421K

414K

446K

452K

456K

$239M

CITADEL ADVISORS LLC

15K

801

207K

48K

36K

454K

$238M

WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC

372K

353K

350K

412K

354K

341K

$178M

Invesco Ltd.

129K

133K

200K

300K

365K

330K

$172M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	376	23,773,155	103.1%	$12.4B
2025-Q4	386	23,570,166	102.2%	$13.7B
2025-Q3	352	23,438,416	101.7%	$10.7B
2025-Q2	305	23,581,776	102.3%	$7.1B
2025-Q1	321	23,727,503	102.9%

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · MDGL

Activists — 13D, active intent

Taub Rebecca7.8%NEWSCHEDULE 13D/A · Amd 2 · event 2025-12-10SEC →

1,814,831 shares

“No changes, except that the Reporting Person no longer serves as Chief Medical Officer of the Issuer; the Reporting Person serves as Senior Scientific and Medical Advisor of the Issuer and continues to serve as a member of the Board of Directors of the Issuer.”

FRIEDMAN PAUL A7.8%NEWSCHEDULE 13D/A · Amd 2 · event 2025-12-10SEC →

1,814,831 shares

“No changes, except that the Reporting Person no longer serves as Chairman of the Board and Chief Executive Officer of the Issuer; the Reporting Person continues to serve as a member of the Board of Directors of the Issuer.”

Large holders — 13G, passive (top 3 by % of class)

Holder

% of class

Type

As of

JANUS HENDERSON GROUP PLC

8.8%

QII

2026-03-31

Institutional ownership· 13F filers holding MDGL · 2026-Q1 methodology → sources →

376 holders

% of shares outstanding held

103.1%

Shares held (13F)

23,773,155

Reporting holders

376

Top holders

largest 100 of 376 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	BAKER BROS. ADVISORS LP	2,141,7012.1M	$1.1B	9.29%	—
2	JANUS HENDERSON GROUP PLC	2,018,6472.0M	$1.1B	8.76%	ADD 27%
3	RTW INVESTMENTS, LP	1,993,6872.0M	$1.0B	8.65%	—
4	Avoro Capital Advisors LLC	1,818,1811.8M	$952M	7.89%	—
5	BlackRock, Inc.	1,559,9651.6M	$817M	6.77%	TRIM -5%
6	PAULSON & CO. INC.	1,392,1881.4M	$729M	6.04%	TRIM -18%
7	VANGUARD PORTFOLIO MANAGEMENT LLC	841,145841,145	$440M	3.65%	NEW†
8	VANGUARD CAPITAL MANAGEMENT LLC	827,144827,144	$433M	3.59%	NEW†
9	WELLINGTON MANAGEMENT GROUP LLP	694,958694,958	$364M	3.01%	ADD 51%
10	STATE STREET CORP	609,525609,525	$319M	2.64%	ADD 5%
11	FMR LLC	511,728511,728	$268M	2.22%	ADD 16%
12	GEODE CAPITAL MANAGEMENT, LLC	455,870455,870	$239M	1.98%	—
13	CITADEL ADVISORS LLC	453,843453,843	$238M	1.97%	ADD 1156%
14	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	340,519340,519	$178M	1.48%	TRIM -4%
15	Invesco Ltd.	329,519329,519	$172M	1.43%	TRIM -10%
16	PRICE T ROWE ASSOCIATES INC /MD/	328,110328,110	$172M	1.42%	ADD 5%
17	Polar Capital Holdings Plc	289,310289,310	$151M	1.25%	ADD 7%
18	GOLDMAN SACHS GROUP INC	277,371277,371	$145M	1.20%	TRIM -9%
19	ARMISTICE CAPITAL, LLC	264,583264,583	$139M	1.15%	—
20	Hood River Capital Management LLC	249,511249,511	$131M	1.08%	—
21	LORD, ABBETT & CO. LLC	242,726242,726	$127M	1.05%	—
22	Point72 Asset Management, L.P.	225,510225,510	$118M	0.98%	ADD 78%
23	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	216,720216,720	$113M	0.94%	—
24	MORGAN STANLEY	191,294191,294	$100M	0.83%	ADD 27%
25	BANK OF AMERICA CORP /DE/	189,527189,527	$99M	0.82%	TRIM -54%
26	Pictet Asset Management Holding SA	187,240187,240	$98M	0.81%	ADD 3%
27	ADAGE CAPITAL PARTNERS GP, L.L.C.	185,331185,331	$97M	0.80%	ADD 698%
28	Artisan Partners Limited Partnership	183,540183,540	$96M	0.80%	TRIM -8%
29	Fiera Capital Corp	174,011174,011	$91M	0.75%	ADD 3%
30	Rock Springs Capital Management LP	170,999170,999	$90M	0.74%	ADD 22%
31	AMERICAN CENTURY COMPANIES INC	163,933163,933	$86M	0.71%	TRIM -11%
32	Erste Asset Management GmbH	160,210160,210	$81M	0.69%	ADD 14%
33	NORTHERN TRUST CORP	149,214149,214	$78M	0.65%	—
34	ALLIANCEBERNSTEIN L.P.	125,447125,447	$73M	0.54%	ADD 473%
35	Bank of New York Mellon Corp	135,908135,908	$71M	0.59%	—
36	TORONTO DOMINION BANK	130,460130,460	$68M	0.57%	NEW
37	VANGUARD FIDUCIARY TRUST CO	128,079128,079	$67M	0.56%	NEW
38	Woodline Partners LP	125,899125,899	$66M	0.55%	—
39	UBS Group AG	117,779117,779	$62M	0.51%	ADD 15%
40	Driehaus Capital Management LLC	110,960110,960	$58M	0.48%	—
41	Tri Locum Partners LP	103,288103,288	$54M	0.45%	ADD 20%
42	AMERIPRISE FINANCIAL INC	98,18198,181	$51M	0.43%	ADD 235%
43	DEUTSCHE BANK AG\	98,06798,067	$51M	0.43%	TRIM -49%
44	WESTFIELD CAPITAL MANAGEMENT CO LP	94,81394,813	$50M	0.41%	NEW
45	Logos Global Management LP	85,00085,000	$44M	0.37%	NEW
46	Candriam S.C.A.	84,94884,948	$44M	0.37%	ADD 33%
47	ALKEON CAPITAL MANAGEMENT LLC	80,00080,000	$42M	0.35%	TRIM -67%
48	NEW YORK STATE COMMON RETIREMENT FUND	75,12975,129	$39M	0.33%	—
49	FRANKLIN RESOURCES INC	74,04174,041	$39M	0.32%	TRIM -14%
50	RENAISSANCE TECHNOLOGIES LLC	71,87071,870	$38M	0.31%	TRIM -14%
51	RAYMOND JAMES FINANCIAL INC	66,52966,529	$34M	0.29%	—
52	ArrowMark Colorado Holdings LLC	62,44162,441	$33M	0.27%	TRIM -24%
53	Nuveen, LLC	62,06062,060	$32M	0.27%	TRIM -48%
54	VOYA INVESTMENT MANAGEMENT LLC	59,97159,971	$31M	0.26%	TRIM -7%
55	BNP PARIBAS FINANCIAL MARKETS	57,17757,177	$30M	0.25%	TRIM -22%
56	Affinity Asset Advisors, LLC	55,00055,000	$29M	0.24%	ADD 77%
57	Squarepoint Ops LLC	52,88452,884	$28M	0.23%	TRIM -29%
58	EULAV Asset Management	49,00049,000	$26M	0.21%	—
59	Russell Investments Group, Ltd.	44,50444,504	$23M	0.19%	TRIM -8%
60	Mirae Asset Global Investments Co., Ltd.	40,92640,926	$21M	0.18%	TRIM -19%
61	MILLENNIUM MANAGEMENT LLC	40,85340,853	$21M	0.18%	ADD 485%
62	SCHRODER INVESTMENT MANAGEMENT GROUP	39,85239,852	$20M	0.17%	ADD 37%
63	EMERALD ADVISERS, LLC	37,65437,654	$20M	0.16%	TRIM -3%
64	JANE STREET GROUP, LLC	35,83835,838	$19M	0.16%	TRIM -62%
65	GROUPAMA ASSET MANAGMENT	35,23835,238	$18M	0.15%	ADD 15%
66	JPMORGAN CHASE & CO	36,31536,315	$18M	0.16%	TRIM -9%
67	PFM Health Sciences, LP	34,14634,146	$18M	0.15%	ADD 370%
68	Rockefeller Capital Management L.P.	33,84933,849	$18M	0.15%	ADD 72%
69	BNP PARIBAS ASSET MANAGEMENT Holding S.A.	32,87932,879	$17M	0.14%	ADD 114%
70	WELLS FARGO & COMPANY/MN	32,21232,212	$17M	0.14%	TRIM -26%
71	SEGALL BRYANT & HAMILL, LLC	31,87031,870	$17M	0.14%	TRIM -5%
72	Vestal Point Capital, LP	31,46831,468	$16M	0.14%	NEW
73	D. E. Shaw & Co., Inc.	30,13930,139	$16M	0.13%	TRIM -66%
74	GILDER GAGNON HOWE & CO LLC	29,39129,391	$15M	0.13%	TRIM -12%
75	Swiss National Bank	29,22029,220	$15M	0.13%	ADD 2%
76	Connor, Clark & Lunn Investment Management Ltd.	27,93727,937	$15M	0.12%	TRIM -52%
77	CITIGROUP INC	25,58925,589	$13M	0.11%	ADD 10%
78	Integral Health Asset Management, LLC	25,00025,000	$13M	0.11%	NEW
79	Clearbridge Investments, LLC	24,44724,447	$13M	0.11%	NEW
80	SEI INVESTMENTS CO	24,19824,198	$13M	0.10%	ADD 5%
81	Rhenman & Partners Asset Management AB	24,05024,050	$13M	0.10%	ADD 23%
82	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	23,79623,796	$12M	0.10%	—
83	California Public Employees Retirement System	23,19823,198	$12M	0.10%	TRIM -26%
84	WCM INVESTMENT MANAGEMENT, LLC	23,56023,560	$12M	0.10%	ADD 37%
85	FIRST TRUST ADVISORS LP	22,23322,233	$12M	0.10%	TRIM -10%
86	SUSQUEHANNA INTERNATIONAL GROUP, LLP	22,21622,216	$12M	0.10%	TRIM -66%
87	MARSHALL WACE, LLP	21,90221,902	$11M	0.09%	TRIM -45%
88	RHUMBLINE ADVISERS	21,76421,764	$11M	0.09%	TRIM -8%
89	Tao Capital Management LP	21,00021,000	$11M	0.09%	—
90	Universal- Beteiligungs- und Servicegesellschaft mbH	18,45218,452	$10M	0.08%	TRIM -3%
91	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	17,04717,047	$9M	0.07%	ADD 22%
92	FEDERATED HERMES, INC.	16,90316,903	$9M	0.07%	ADD 4%
93	EMERALD MUTUAL FUND ADVISERS TRUST	16,50016,500	$9M	0.07%	TRIM -34%
94	MANUFACTURERS LIFE INSURANCE COMPANY, THE	16,30016,300	$9M	0.07%	—
95	Assenagon Asset Management S.A.	16,03316,033	$8M	0.07%	ADD 197%
96	SILVERCREST ASSET MANAGEMENT GROUP LLC	15,96315,963	$8M	0.07%	NEW
97	AQR CAPITAL MANAGEMENT LLC	15,95315,953	$8M	0.07%	ADD 59%
98	ENVESTNET ASSET MANAGEMENT INC	15,46115,461	$8M	0.07%	—
99	Cinctive Capital Management LP	15,32615,326	$8M	0.07%	ADD 316%
100	VANGUARD ASSET MANAGEMENT, Ltd	14,09014,090	$7M	0.06%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

BAKER BROS. ADVISORS LP

2.0M

2.1M

$1.1B

JANUS HENDERSON GROUP PLC

2.2M

1.8M

1.6M

2.0M

$1.1B

RTW INVESTMENTS, LP

2.0M

$1.0B

Avoro Capital Advisors LLC

2.0M

1.9M

1.8M

$952M

BlackRock, Inc.

1.5M

1.4M

1.6M

$817M

PAULSON & CO. INC.

2.0M

2.1M

1.9M

1.7M

1.4M

$729M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

841K

$440M

VANGUARD CAPITAL MANAGEMENT LLC

—

827K

$433M

WELLINGTON MANAGEMENT GROUP LLP

404K

461K

695K

$364M

STATE STREET CORP

781K

759K

691K

658K

583K

610K

$319M

FMR LLC

868K

652K

445K

401K

439K

512K

$268M

GEODE CAPITAL MANAGEMENT, LLC

411K

421K

414K

446K

452K

456K

$239M

CITADEL ADVISORS LLC

15K

801

207K

48K

36K

454K

$238M

WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC

372K

353K

350K

412K

354K

341K

$178M

Invesco Ltd.

129K

133K

200K

300K

365K

330K

$172M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	376	23,773,155	103.1%	$12.4B
2025-Q4	386	23,570,166	102.2%	$13.7B
2025-Q3	352	23,438,416	101.7%	$10.7B
2025-Q2	305	23,581,776	102.3%	$7.1B
2025-Q1	321	23,727,503	102.9%

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · MDGL

Activists — 13D, active intent

Taub Rebecca7.8%NEWSCHEDULE 13D/A · Amd 2 · event 2025-12-10SEC →

1,814,831 shares

FRIEDMAN PAUL A7.8%NEWSCHEDULE 13D/A · Amd 2 · event 2025-12-10SEC →

1,814,831 shares

Large holders — 13G, passive (top 3 by % of class)

Holder

% of class

Type

As of

JANUS HENDERSON GROUP PLC

8.8%

QII

2026-03-31

MDGL US Equity☆

Institutional ownership· 13F filers holding MDGL · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · MDGL

Institutional ownership· 13F filers holding MDGL · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · MDGL

MDGL US Equity