Institutional 13F holdings sum to 111.4% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 4,033,554 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Frazier Life Sciences Management, L.P. | 6,652,0136.7M | $199M | 13.98% | — |
| 2 | ORBIMED ADVISORS LLC | 3,637,8873.6M | $109M | 7.64% | TRIM -8% |
| 3 | NEA Management Company, LLC | 3,614,4863.6M | $108M | 7.59% | — |
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,191,8243.2M | $95M | 6.71% | TRIM -5% |
| 5 | BlackRock, Inc. | 2,941,4062.9M | $88M | 6.18% | — |
| 6 | FMR LLC | 2,936,6842.9M | $88M | 6.17% | ADD 18550% |
| 7 | Deep Track Capital, LP | 2,757,5692.8M | $82M | 5.79% | TRIM -15% |
| 8 | NVP ASSOCIATES, LLC | 2,136,3352.1M | $64M | 4.49% | — |
| 9 | Polar Capital Holdings Plc | 1,622,1861.6M | $48M | 3.41% | NEW† |
| 10 | BRAIDWELL LP | 1,492,4671.5M | $45M | 3.14% | ADD 47% |
| 11 | VANGUARD CAPITAL MANAGEMENT LLC | 1,477,5921.5M | $44M | 3.10% | NEW† |
| 12 | Aaron Wealth Advisors LLC | 1,168,1761.2M | $35M | 2.45% | ADD 1569% |
| 13 | Cormorant Asset Management, LP | 1,120,0001.1M | $33M | 2.35% | — |
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,029,0071.0M | $31M | 2.16% | ADD 22% |
| 15 | Driehaus Capital Management LLC | 1,018,2121.0M | $30M | 2.14% | TRIM -28% |
| 16 | STEMPOINT CAPITAL LP | 998,938998,938 | $30M | 2.10% | ADD 1172% |
| 17 | Kynam Capital Management, LP | 934,799934,799 | $28M | 1.96% | — |
| 18 | CITADEL ADVISORS LLC | 932,833932,833 | $28M | 1.96% | ADD 15% |
| 19 | Woodline Partners LP | 900,063900,063 | $27M | 1.89% | TRIM -10% |
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 890,000890,000 | $27M | 1.87% | — |
| 21 | Caligan Partners LP | 848,590848,590 | $25M | 1.78% | NEW |
| 22 | Parkman Healthcare Partners LLC | 800,037800,037 | $24M | 1.68% | TRIM -10% |
| 23 | STATE STREET CORP | 787,208787,208 | $23M | 1.65% | ADD 17% |
| 24 | EcoR1 Capital, LLC | 777,000777,000 | $23M | 1.63% | TRIM -63% |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 670,385670,385 | $20M | 1.41% | ADD 3% |
| 26 | TCG Crossover Management, LLC | 650,000650,000 | $19M | 1.37% | — |
| 27 | MILLENNIUM MANAGEMENT LLC | 564,415564,415 | $17M | 1.19% | ADD 22% |
| 28 | GOLDMAN SACHS GROUP INC | 457,945457,945 | $14M | 0.96% | ADD 38% |
| 29 | UBS Group AG | 346,914346,914 | $10M | 0.73% | ADD 23% |
| 30 | Candriam S.C.A. | 294,374294,374 | $9M | 0.62% | NEW |
| 31 | VANGUARD PORTFOLIO MANAGEMENT LLC | 293,295293,295 | $9M | 0.62% | NEW |
| 32 | D. E. Shaw & Co., Inc. | 288,889288,889 | $9M | 0.61% | TRIM -57% |
| 33 | Rock Springs Capital Management LP | 287,967287,967 | $9M | 0.61% | — |
| 34 | Opaleye Management Inc. | 260,000260,000 | $8M | 0.55% | — |
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 214,908214,908 | $6M | 0.45% | TRIM -3% |
| 36 | Elmind Capital, LP | 211,000211,000 | $6M | 0.44% | — |
| 37 | NORTHERN TRUST CORP | 210,575210,575 | $6M | 0.44% | ADD 10% |
| 38 | BOOTHBAY FUND MANAGEMENT, LLC | 208,049208,049 | $6M | 0.44% | NEW |
| 39 | Soleus Capital Management, L.P. | 178,897178,897 | $5M | 0.38% | TRIM -56% |
| 40 | DAFNA Capital Management LLC | 175,465175,465 | $5M | 0.37% | ADD 6% |
| 41 | VANGUARD FIDUCIARY TRUST CO | 170,154170,154 | $5M | 0.36% | NEW |
| 42 | Goelzer Investment Management, Inc. | 164,172164,172 | $5M | 0.34% | TRIM -26% |
| 43 | Affinity Asset Advisors, LLC | 150,000150,000 | $4M | 0.32% | TRIM -40% |
| 44 | Tetragon Partners GP Ltd | 145,480145,480 | $4M | 0.31% | — |
| 45 | JPMORGAN CHASE & CO | 147,057147,057 | $4M | 0.31% | ADD 904% |
| 46 | Schonfeld Strategic Advisors LLC | 123,814123,814 | $4M | 0.26% | TRIM -26% |
| 47 | KVP Capital Advisors, LP | 121,524121,524 | $4M | 0.26% | — |
| 48 | TD Asset Management Inc | 115,998115,998 | $3M | 0.24% | ADD 14% |
| 49 | TWO SIGMA INVESTMENTS, LP | 115,075115,075 | $3M | 0.24% | TRIM -17% |
| 50 | Burkehill Global Management, LP | 100,000100,000 | $3M | 0.21% | — |
| 51 | Squarepoint Ops LLC | 97,21597,215 | $3M | 0.20% | ADD 108% |
| 52 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 90,63490,634 | $3M | 0.19% | ADD 30% |
| 53 | Nuveen, LLC | 81,79281,792 | $2M | 0.17% | ADD 8% |
| 54 | Bank of New York Mellon Corp | 80,22280,222 | $2M | 0.17% | ADD 7% |
| 55 | PFM Health Sciences, LP | 71,89471,894 | $2M | 0.15% | TRIM -9% |
| 56 | VICTORY CAPITAL MANAGEMENT INC | 71,02871,028 | $2M | 0.15% | NEW |
| 57 | MARSHALL WACE, LLP | 62,70362,703 | $2M | 0.13% | NEW |
| 58 | XTX Topco Ltd | 53,21053,210 | $2M | 0.11% | ADD 164% |
| 59 | SCHRODER INVESTMENT MANAGEMENT GROUP | 57,32257,322 | $2M | 0.12% | TRIM -22% |
| 60 | DIMENSIONAL FUND ADVISORS LP | 46,75346,753 | $1M | 0.10% | NEW |
| 61 | Swiss National Bank | 44,40044,400 | $1M | 0.09% | NEW |
| 62 | PLATINUM INVESTMENT MANAGEMENT LTD | 43,59743,597 | $1M | 0.09% | — |
| 63 | ALPS ADVISORS INC | 36,55036,550 | $1M | 0.08% | — |
| 64 | ALGERT GLOBAL LLC | 36,02036,020 | $1M | 0.08% | NEW |
| 65 | Creative Planning | 35,97035,970 | $1M | 0.08% | ADD 7% |
| 66 | EXCHANGE TRADED CONCEPTS, LLC | 34,26434,264 | $1M | 0.07% | NEW |
| 67 | RHUMBLINE ADVISERS | 33,87133,871 | $1M | 0.07% | — |
| 68 | ALLIANCEBERNSTEIN L.P. | 30,50030,500 | $961,970 | 0.06% | ADD 9% |
| 69 | MORGAN STANLEY | 31,56231,562 | $942,126 | 0.07% | TRIM -47% |
| 70 | BANK OF AMERICA CORP /DE/ | 28,75028,750 | $858,188 | 0.06% | TRIM -24% |
| 71 | ExodusPoint Capital Management, LP | 28,08728,087 | $838,397 | 0.06% | TRIM -51% |
| 72 | Invesco Ltd. | 27,52527,525 | $821,621 | 0.06% | ADD 30% |
| 73 | AQR CAPITAL MANAGEMENT LLC | 27,38727,387 | $817,501 | 0.06% | TRIM -13% |
| 74 | DEUTSCHE BANK AG\ | 22,95022,950 | $685,058 | 0.05% | ADD 15% |
| 75 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,76522,765 | $679,535 | 0.05% | ADD 1198% |
| 76 | Swiss Life Asset Management Ltd | 12,13012,130 | $657,200 | 0.03% | NEW |
| 77 | Cerity Partners LLC | 21,16321,163 | $631,715 | 0.04% | — |
| 78 | Legal & General Group Plc | 19,35819,358 | $577,837 | 0.04% | ADD 662% |
| 79 | STATE OF WISCONSIN INVESTMENT BOARD | 19,26219,262 | $574,971 | 0.04% | NEW |
| 80 | Koa Wealth Management, LLC | 17,91317,913 | $534,703 | 0.04% | TRIM -3% |
| 81 | Engineers Gate Manager LP | 17,38017,380 | $518,793 | 0.04% | NEW |
| 82 | Qube Research & Technologies Ltd | 17,18717,187 | $513,032 | 0.04% | TRIM -26% |
| 83 | Vanguard Global Advisers, LLC | 16,02816,028 | $478,436 | 0.03% | NEW |
| 84 | MetLife Investment Management, LLC | 16,01816,018 | $478,137 | 0.03% | — |
| 85 | VANGUARD ASSET MANAGEMENT, Ltd | 14,75214,752 | $440,347 | 0.03% | NEW |
| 86 | Optimize Financial Inc | 14,50814,508 | $433,064 | 0.03% | NEW |
| 87 | CITIGROUP INC | 13,49913,499 | $402,945 | 0.03% | TRIM -18% |
| 88 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,32513,325 | $397,751 | 0.03% | — |
| 89 | Jump Financial, LLC | 12,70012,700 | $379,095 | 0.03% | NEW |
| 90 | BARCLAYS PLC | 11,83811,838 | $353,365 | 0.02% | TRIM -78% |
| 91 | HighVista Strategies LLC | 11,47211,472 | $342,439 | 0.02% | NEW |
| 92 | CANADA PENSION PLAN INVESTMENT BOARD | 10,90010,900 | $325,365 | 0.02% | TRIM -6% |
| 93 | WELLS FARGO & COMPANY/MN | 10,76210,762 | $321,246 | 0.02% | TRIM -66% |
| 94 | BNP PARIBAS FINANCIAL MARKETS | 10,38410,384 | $309,962 | 0.02% | ADD 53% |
| 95 | JANUS HENDERSON GROUP PLC | 10,30010,300 | $308,176 | 0.02% | NEW |
| 96 | Verition Fund Management LLC | 10,22210,222 | $305,127 | 0.02% | TRIM -82% |
| 97 | Aquatic Capital Management LLC | 10,15510,155 | $303,127 | 0.02% | NEW |
| 98 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 9,4879,487 | $283,187 | 0.02% | TRIM -88% |
| 99 | Virtus Investment Advisers, LLC | 9,1319,131 | $272,560 | 0.02% | ADD 2% |
| 100 | NEW YORK STATE COMMON RETIREMENT FUND | 9,0009,000 | $268,650 | 0.02% | ADD 109% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 6.0M | 6.0M | 6.0M | 6.7M | 6.7M | 6.7M | $199M |
| ORBIMED ADVISORS LLC | 3.8M | 4.0M | 4.0M | 4.0M | 3.9M | 3.6M | $109M |
| NEA Management Company, LLC | 3.6M | 3.6M | 3.6M | 3.6M | 3.6M | 3.6M | $108M |
| WELLINGTON MANAGEMENT GROUP LLP | 2.9M | 2.6M | 2.3M | 4.8M | 3.3M | 3.2M | $95M |
| BlackRock, Inc. | 728K | 783K | 1.0M | 2.0M | 2.9M | 2.9M | $88M |
| FMR LLC | 25K | 44K | 61K | 69K | 16K | 2.9M | $88M |
| Deep Track Capital, LP | 3.0M | 3.0M | 2.2M | 3.1M | 3.2M | 2.8M | $82M |
| NVP ASSOCIATES, LLC | 2.1M | 2.1M | 2.1M | 2.1M | 2.1M | 2.1M | $64M |
| Polar Capital Holdings Plc | — | — | — | — | — | 1.6M | $48M |
| BRAIDWELL LP | — | — | — | — | 1.0M | 1.5M | $45M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.5M | $44M |
| Aaron Wealth Advisors LLC | — | 50K | 50K | 50K | 70K | 1.2M | $35M |
| Cormorant Asset Management, LP | 700K | 700K | 700K | 1.2M | 1.1M | 1.1M | $33M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1.2M | 1.1M | 1.3M | 955K | 841K | 1.0M | $31M |
| Driehaus Capital Management LLC | 1.6M | 1.6M | 1.6M | 1.5M | 1.4M | 1.0M | $30M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 157 | 53,035,292 | 111.4% | $1.6B |
| 2025-Q4 | 138 | 48,428,720 | 101.7% | $1.5B |
| 2025-Q3 | 118 | 47,796,242 | 100.4% | $836M |
| 2025-Q2 | 88 | 36,874,800 | 77.5% | $421M |
| 2025-Q1 | 79 | 35,666,449 | 74.9% | $263M |
| 2024-Q4 | 63 | 32,941,714 | 69.2% | $606M |
| 2024-Q3 | 45 | 30,305,441 | 63.7% | $784M |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“NEA 17 acquired the NEA 17 Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, NEA 17 and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities ”
“The Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporti”
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
