KRYS US Equity

Krystal Biotech, Inc.

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Health Care · Biological Products, (No Diagnostic Substances) · CIK 1711279 · FYE 1231

$364.23

+12.41 (+3.53%)

USD · as of 2026-07-28 · marketstack

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Institutional ownership· 13F filers holding KRYS · 2026-Q1 methodology → sources →

366 holders

% of shares outstanding held

96.2%

Shares held (13F)

28,367,320

Reporting holders

366

Top holders

largest 100 of 366 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	FMR LLC	4,373,9874.4M	$1.1B	14.84%	—
2	BlackRock, Inc.	3,940,4563.9M	$1.0B	13.37%	—
3	Avoro Capital Advisors LLC	2,888,8882.9M	$746M	9.80%	—
4	VANGUARD PORTFOLIO MANAGEMENT LLC	1,456,7271.5M	$376M	4.94%	NEW†
5	STATE STREET CORP	1,314,4341.3M	$340M	4.46%	TRIM -2%
6	VANGUARD CAPITAL MANAGEMENT LLC	1,165,3241.2M	$301M	3.95%	NEW†
7	Soleus Capital Management, L.P.	1,153,0871.2M	$298M	3.91%	ADD 23%
8	Capital World Investors	824,720824,720	$213M	2.80%	—
9	Redmile Group, LLC	673,505673,505	$174M	2.28%	—
10	GEODE CAPITAL MANAGEMENT, LLC	643,975643,975	$166M	2.18%	ADD 5%
11	Hood River Capital Management LLC	619,586619,586	$160M	2.10%	—
12	PRICE T ROWE ASSOCIATES INC /MD/	485,074485,074	$125M	1.65%	TRIM -8%
13	Bellevue Group AG	481,785481,785	$124M	1.63%	ADD 17%
14	Frazier Life Sciences Management, L.P.	481,307481,307	$124M	1.63%	—
15	DIMENSIONAL FUND ADVISORS LP	468,990468,990	$121M	1.59%	TRIM -5%
16	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	407,178407,178	$105M	1.38%	ADD 8%
17	FIRST TRUST ADVISORS LP	350,521350,521	$91M	1.19%	ADD 43%
18	JANUS HENDERSON GROUP PLC	266,659266,659	$69M	0.90%	ADD 22%
19	BANK OF AMERICA CORP /DE/	260,647260,647	$67M	0.88%	ADD 37%
20	NORTHERN TRUST CORP	252,463252,463	$65M	0.86%	ADD 2%
21	Invesco Ltd.	251,373251,373	$65M	0.85%	ADD 319%
22	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	241,986241,986	$63M	0.82%	—
23	GOLDMAN SACHS GROUP INC	214,949214,949	$56M	0.73%	TRIM -27%
24	MORGAN STANLEY	209,082209,082	$54M	0.71%	TRIM -6%
25	BRAIDWELL LP	182,425182,425	$47M	0.62%	TRIM -10%
26	FRANKLIN RESOURCES INC	179,265179,265	$46M	0.61%	ADD 43%
27	VANGUARD FIDUCIARY TRUST CO	179,161179,161	$46M	0.61%	NEW
28	PRINCIPAL FINANCIAL GROUP INC	162,070162,070	$42M	0.55%	—
29	RAYMOND JAMES FINANCIAL INC	156,064156,064	$40M	0.53%	ADD 104%
30	Woodline Partners LP	150,616150,616	$39M	0.51%	—
31	Bank of New York Mellon Corp	149,307149,307	$39M	0.51%	—
32	UBS Group AG	143,525143,525	$37M	0.49%	TRIM -10%
33	Nuveen, LLC	143,368143,368	$37M	0.49%	TRIM -24%
34	TimesSquare Capital Management, LLC	112,342112,342	$29M	0.38%	ADD 15%
35	Pictet Asset Management Holding SA	110,665110,665	$29M	0.38%	TRIM -29%
36	VOYA INVESTMENT MANAGEMENT LLC	108,397108,397	$28M	0.37%	ADD 5%
37	JPMORGAN CHASE & CO	99,10599,105	$24M	0.34%	TRIM -26%
38	BNP PARIBAS FINANCIAL MARKETS	93,03193,031	$24M	0.32%	ADD 73%
39	Public Sector Pension Investment Board	92,28692,286	$24M	0.31%	ADD 3%
40	Handelsbanken Fonder AB	91,40091,400	$24M	0.31%	TRIM -14%
41	S SQUARED TECHNOLOGY, LLC	86,21586,215	$22M	0.29%	TRIM -10%
42	SEGALL BRYANT & HAMILL, LLC	79,49779,497	$21M	0.27%	TRIM -5%
43	Biondo Investment Advisors, LLC	72,04572,045	$19M	0.24%	ADD 6%
44	ORBIMED ADVISORS LLC	69,10069,100	$18M	0.23%	TRIM -42%
45	MARSHALL WACE, LLP	68,34368,343	$18M	0.23%	TRIM -63%
46	RHUMBLINE ADVISERS	68,09968,099	$18M	0.23%	ADD 3%
47	C WorldWide Group Holding A/S	67,80967,809	$18M	0.23%	TRIM -21%
48	ACT CAPITAL MANAGEMENT, LLC	60,47760,477	$16M	0.21%	—
49	Legal & General Group Plc	59,05059,050	$15M	0.20%	TRIM -7%
50	AMERIPRISE FINANCIAL INC	49,83749,837	$13M	0.17%	TRIM -5%
51	SEI INVESTMENTS CO	46,57046,570	$12M	0.16%	ADD 44%
52	Bridgewater Associates, LP	46,36746,367	$12M	0.16%	ADD 363%
53	SEB Asset Management AB	46,34346,343	$12M	0.16%	NEW
54	Palisades Investment Partners, LLC	45,40545,405	$12M	0.15%	ADD 6%
55	TD Asset Management Inc	43,31843,318	$11M	0.15%	TRIM -20%
56	Swiss National Bank	43,00043,000	$11M	0.15%	—
57	1832 Asset Management L.P.	42,60042,600	$11M	0.14%	ADD 142%
58	VICTORY CAPITAL MANAGEMENT INC	40,71540,715	$11M	0.14%	ADD 54%
59	GILDER GAGNON HOWE & CO LLC	40,12840,128	$10M	0.14%	NEW
60	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	36,93736,937	$10M	0.13%	ADD 10%
61	MANUFACTURERS LIFE INSURANCE COMPANY, THE	36,06936,069	$9M	0.12%	TRIM -11%
62	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	35,85935,859	$9M	0.12%	TRIM -4%
63	FEDERATED HERMES, INC.	35,49535,495	$9M	0.12%	ADD 3%
64	NEUBERGER BERMAN GROUP LLC	33,08433,084	$9M	0.11%	ADD 3103%
65	CASTLEARK MANAGEMENT LLC	31,63031,630	$8M	0.11%	ADD 8%
66	NEW YORK STATE COMMON RETIREMENT FUND	31,34231,342	$8M	0.11%	—
67	CITIGROUP INC	31,17231,172	$8M	0.11%	ADD 4%
68	ALLIANCEBERNSTEIN L.P.	31,92931,929	$8M	0.11%	—
69	Aberdeen Group plc	30,15530,155	$8M	0.10%	TRIM -23%
70	PRUDENTIAL FINANCIAL INC	29,63829,638	$8M	0.10%	ADD 10%
71	Fisher Asset Management, LLC	27,78427,784	$7M	0.09%	ADD 634%
72	Atle Fund Management AB	37,57937,579	$7M	0.13%	ADD 11%
73	Russell Investments Group, Ltd.	26,21026,210	$7M	0.09%	TRIM -9%
74	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	26,18626,186	$7M	0.09%	ADD 27%
75	DEUTSCHE BANK AG\	24,83124,831	$6M	0.08%	ADD 11%
76	Granite Investment Partners, LLC	24,28424,284	$6M	0.08%	TRIM -6%
77	Fiera Capital Corp	24,14624,146	$6M	0.08%	ADD 28%
78	Elmind Capital, LP	22,00022,000	$6M	0.07%	—
79	CANADA LIFE ASSURANCE Co	21,41321,413	$6M	0.07%	TRIM -3%
80	STATE OF WISCONSIN INVESTMENT BOARD	20,69120,691	$5M	0.07%	ADD 43%
81	VANGUARD ASSET MANAGEMENT, Ltd	20,60620,606	$5M	0.07%	NEW
82	BESSEMER GROUP INC	20,28520,285	$5M	0.07%	—
83	Pinnacle Financial Partners, Inc.	20,18020,180	$5M	0.07%	ADD 19%
84	EFG International AG	20,04920,049	$5M	0.07%	TRIM -15%
85	ADAR1 Capital Management, LLC	20,01420,014	$5M	0.07%	—
86	Tetragon Partners GP Ltd	19,66819,668	$5M	0.07%	ADD 66%
87	GW&K Investment Management, LLC	19,24519,245	$5M	0.07%	—
88	Lisanti Capital Growth, LLC	18,51518,515	$5M	0.06%	NEW
89	ZACKS INVESTMENT MANAGEMENT	17,91917,919	$5M	0.06%	NEW
90	Campbell & CO Investment Adviser LLC	17,79517,795	$5M	0.06%	NEW
91	Rafferty Asset Management, LLC	17,68717,687	$5M	0.06%	TRIM -27%
92	State of Alaska, Department of Revenue	17,48417,484	$5M	0.06%	TRIM -2%
93	Thrivent Financial for Lutherans	17,22617,226	$4M	0.06%	TRIM -3%
94	Rhenman & Partners Asset Management AB	16,67516,675	$4M	0.06%	TRIM -33%
95	Informed Momentum Co LLC	16,48316,483	$4M	0.06%	TRIM -33%
96	Creative Planning	15,93715,937	$4M	0.05%	ADD 15%
97	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	15,75615,756	$4M	0.05%	—
98	NEW YORK STATE TEACHERS RETIREMENT SYSTEM	15,63715,637	$4M	0.05%	—
99	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	15,12115,121	$4M	0.05%	ADD 17%
100	CIM, LLC	14,99014,990	$4M	0.05%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

FMR LLC

4.3M

4.4M

$1.1B

BlackRock, Inc.

4.0M

3.9M

3.8M

3.9M

$1.0B

Avoro Capital Advisors LLC

2.6M

2.7M

2.8M

2.9M

$746M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

1.5M

$376M

STATE STREET CORP

1.3M

1.2M

1.4M

1.3M

$340M

VANGUARD CAPITAL MANAGEMENT LLC

—

1.2M

$301M

Soleus Capital Management, L.P.

358K

442K

923K

1.0M

941K

1.2M

$298M

Capital World Investors

879K

954K

942K

809K

810K

825K

$213M

Redmile Group, LLC

753K

738K

663K

661K

678K

674K

$174M

GEODE CAPITAL MANAGEMENT, LLC

592K

612K

620K

611K

612K

644K

$166M

Hood River Capital Management LLC

513K

525K

533K

607K

613K

620K

$160M

PRICE T ROWE ASSOCIATES INC /MD/

509K

411K

261K

467K

530K

485K

$125M

Bellevue Group AG

410K

482K

$124M

Frazier Life Sciences Management, L.P.

788K

688K

488K

481K

$124M

DIMENSIONAL FUND ADVISORS LP

589K

534K

506K

534K

493K

469K

$121M

Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	366	28,367,320	96.2%	$7.3B
2025-Q4	333	28,463,728	96.6%	$7.0B
2025-Q3	284	28,160,483	95.5%	$5.0B
2025-Q2	275	27,653,611	93.8%	$3.8B
2025-Q1	299	27,672,062	93.9%	$5.0B
2024-Q4	264	27,775,564	94.2%	$4.4B
2024-Q3

Short interest has its own tab now — open SI →

Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.

Activists & large holders· Schedule 13D/G beneficial owners · KRYS

Large holders — 13G, passive (top 4 by % of class)

Holder	% of class	Type	As of
Krishnan Krish S	11.5%	Exempt	2026-03-31	SEC →
VANGUARD PORTFOLIO MANAGEMENT LLC	5.05%	QII	2026-03-31	SEC →
STATE STREET CORP	4.4%	QII	2024-12-31	SEC →
VANGUARD GROUP INC	0%	QII	2026-03-13	SEC →

Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).

Institutional ownership· 13F filers holding KRYS · 2026-Q1 methodology → sources →

366 holders

% of shares outstanding held

96.2%

Shares held (13F)

28,367,320

Reporting holders

366

Top holders

largest 100 of 366 · Δ vs 2025-Q4

#	Holder	Shares	Value	% of shares out	Δ QoQ
1	FMR LLC	4,373,9874.4M	$1.1B	14.84%	—
2	BlackRock, Inc.	3,940,4563.9M	$1.0B	13.37%	—
3	Avoro Capital Advisors LLC	2,888,8882.9M	$746M	9.80%	—
4	VANGUARD PORTFOLIO MANAGEMENT LLC	1,456,7271.5M	$376M	4.94%	NEW†
5	STATE STREET CORP	1,314,4341.3M	$340M	4.46%	TRIM -2%
6	VANGUARD CAPITAL MANAGEMENT LLC	1,165,3241.2M	$301M	3.95%	NEW†
7	Soleus Capital Management, L.P.	1,153,0871.2M	$298M	3.91%	ADD 23%
8	Capital World Investors	824,720824,720	$213M	2.80%	—
9	Redmile Group, LLC	673,505673,505	$174M	2.28%	—
10	GEODE CAPITAL MANAGEMENT, LLC	643,975643,975	$166M	2.18%	ADD 5%
11	Hood River Capital Management LLC	619,586619,586	$160M	2.10%	—
12	PRICE T ROWE ASSOCIATES INC /MD/	485,074485,074	$125M	1.65%	TRIM -8%
13	Bellevue Group AG	481,785481,785	$124M	1.63%	ADD 17%
14	Frazier Life Sciences Management, L.P.	481,307481,307	$124M	1.63%	—
15	DIMENSIONAL FUND ADVISORS LP	468,990468,990	$121M	1.59%	TRIM -5%
16	WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC	407,178407,178	$105M	1.38%	ADD 8%
17	FIRST TRUST ADVISORS LP	350,521350,521	$91M	1.19%	ADD 43%
18	JANUS HENDERSON GROUP PLC	266,659266,659	$69M	0.90%	ADD 22%
19	BANK OF AMERICA CORP /DE/	260,647260,647	$67M	0.88%	ADD 37%
20	NORTHERN TRUST CORP	252,463252,463	$65M	0.86%	ADD 2%
21	Invesco Ltd.	251,373251,373	$65M	0.85%	ADD 319%
22	CHARLES SCHWAB INVESTMENT MANAGEMENT INC	241,986241,986	$63M	0.82%	—
23	GOLDMAN SACHS GROUP INC	214,949214,949	$56M	0.73%	TRIM -27%
24	MORGAN STANLEY	209,082209,082	$54M	0.71%	TRIM -6%
25	BRAIDWELL LP	182,425182,425	$47M	0.62%	TRIM -10%
26	FRANKLIN RESOURCES INC	179,265179,265	$46M	0.61%	ADD 43%
27	VANGUARD FIDUCIARY TRUST CO	179,161179,161	$46M	0.61%	NEW
28	PRINCIPAL FINANCIAL GROUP INC	162,070162,070	$42M	0.55%	—
29	RAYMOND JAMES FINANCIAL INC	156,064156,064	$40M	0.53%	ADD 104%
30	Woodline Partners LP	150,616150,616	$39M	0.51%	—
31	Bank of New York Mellon Corp	149,307149,307	$39M	0.51%	—
32	UBS Group AG	143,525143,525	$37M	0.49%	TRIM -10%
33	Nuveen, LLC	143,368143,368	$37M	0.49%	TRIM -24%
34	TimesSquare Capital Management, LLC	112,342112,342	$29M	0.38%	ADD 15%
35	Pictet Asset Management Holding SA	110,665110,665	$29M	0.38%	TRIM -29%
36	VOYA INVESTMENT MANAGEMENT LLC	108,397108,397	$28M	0.37%	ADD 5%
37	JPMORGAN CHASE & CO	99,10599,105	$24M	0.34%	TRIM -26%
38	BNP PARIBAS FINANCIAL MARKETS	93,03193,031	$24M	0.32%	ADD 73%
39	Public Sector Pension Investment Board	92,28692,286	$24M	0.31%	ADD 3%
40	Handelsbanken Fonder AB	91,40091,400	$24M	0.31%	TRIM -14%
41	S SQUARED TECHNOLOGY, LLC	86,21586,215	$22M	0.29%	TRIM -10%
42	SEGALL BRYANT & HAMILL, LLC	79,49779,497	$21M	0.27%	TRIM -5%
43	Biondo Investment Advisors, LLC	72,04572,045	$19M	0.24%	ADD 6%
44	ORBIMED ADVISORS LLC	69,10069,100	$18M	0.23%	TRIM -42%
45	MARSHALL WACE, LLP	68,34368,343	$18M	0.23%	TRIM -63%
46	RHUMBLINE ADVISERS	68,09968,099	$18M	0.23%	ADD 3%
47	C WorldWide Group Holding A/S	67,80967,809	$18M	0.23%	TRIM -21%
48	ACT CAPITAL MANAGEMENT, LLC	60,47760,477	$16M	0.21%	—
49	Legal & General Group Plc	59,05059,050	$15M	0.20%	TRIM -7%
50	AMERIPRISE FINANCIAL INC	49,83749,837	$13M	0.17%	TRIM -5%
51	SEI INVESTMENTS CO	46,57046,570	$12M	0.16%	ADD 44%
52	Bridgewater Associates, LP	46,36746,367	$12M	0.16%	ADD 363%
53	SEB Asset Management AB	46,34346,343	$12M	0.16%	NEW
54	Palisades Investment Partners, LLC	45,40545,405	$12M	0.15%	ADD 6%
55	TD Asset Management Inc	43,31843,318	$11M	0.15%	TRIM -20%
56	Swiss National Bank	43,00043,000	$11M	0.15%	—
57	1832 Asset Management L.P.	42,60042,600	$11M	0.14%	ADD 142%
58	VICTORY CAPITAL MANAGEMENT INC	40,71540,715	$11M	0.14%	ADD 54%
59	GILDER GAGNON HOWE & CO LLC	40,12840,128	$10M	0.14%	NEW
60	UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	36,93736,937	$10M	0.13%	ADD 10%
61	MANUFACTURERS LIFE INSURANCE COMPANY, THE	36,06936,069	$9M	0.12%	TRIM -11%
62	MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC	35,85935,859	$9M	0.12%	TRIM -4%
63	FEDERATED HERMES, INC.	35,49535,495	$9M	0.12%	ADD 3%
64	NEUBERGER BERMAN GROUP LLC	33,08433,084	$9M	0.11%	ADD 3103%
65	CASTLEARK MANAGEMENT LLC	31,63031,630	$8M	0.11%	ADD 8%
66	NEW YORK STATE COMMON RETIREMENT FUND	31,34231,342	$8M	0.11%	—
67	CITIGROUP INC	31,17231,172	$8M	0.11%	ADD 4%
68	ALLIANCEBERNSTEIN L.P.	31,92931,929	$8M	0.11%	—
69	Aberdeen Group plc	30,15530,155	$8M	0.10%	TRIM -23%
70	PRUDENTIAL FINANCIAL INC	29,63829,638	$8M	0.10%	ADD 10%
71	Fisher Asset Management, LLC	27,78427,784	$7M	0.09%	ADD 634%
72	Atle Fund Management AB	37,57937,579	$7M	0.13%	ADD 11%
73	Russell Investments Group, Ltd.	26,21026,210	$7M	0.09%	TRIM -9%
74	CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	26,18626,186	$7M	0.09%	ADD 27%
75	DEUTSCHE BANK AG\	24,83124,831	$6M	0.08%	ADD 11%
76	Granite Investment Partners, LLC	24,28424,284	$6M	0.08%	TRIM -6%
77	Fiera Capital Corp	24,14624,146	$6M	0.08%	ADD 28%
78	Elmind Capital, LP	22,00022,000	$6M	0.07%	—
79	CANADA LIFE ASSURANCE Co	21,41321,413	$6M	0.07%	TRIM -3%
80	STATE OF WISCONSIN INVESTMENT BOARD	20,69120,691	$5M	0.07%	ADD 43%
81	VANGUARD ASSET MANAGEMENT, Ltd	20,60620,606	$5M	0.07%	NEW
82	BESSEMER GROUP INC	20,28520,285	$5M	0.07%	—
83	Pinnacle Financial Partners, Inc.	20,18020,180	$5M	0.07%	ADD 19%
84	EFG International AG	20,04920,049	$5M	0.07%	TRIM -15%
85	ADAR1 Capital Management, LLC	20,01420,014	$5M	0.07%	—
86	Tetragon Partners GP Ltd	19,66819,668	$5M	0.07%	ADD 66%
87	GW&K Investment Management, LLC	19,24519,245	$5M	0.07%	—
88	Lisanti Capital Growth, LLC	18,51518,515	$5M	0.06%	NEW
89	ZACKS INVESTMENT MANAGEMENT	17,91917,919	$5M	0.06%	NEW
90	Campbell & CO Investment Adviser LLC	17,79517,795	$5M	0.06%	NEW
91	Rafferty Asset Management, LLC	17,68717,687	$5M	0.06%	TRIM -27%
92	State of Alaska, Department of Revenue	17,48417,484	$5M	0.06%	TRIM -2%
93	Thrivent Financial for Lutherans	17,22617,226	$4M	0.06%	TRIM -3%
94	Rhenman & Partners Asset Management AB	16,67516,675	$4M	0.06%	TRIM -33%
95	Informed Momentum Co LLC	16,48316,483	$4M	0.06%	TRIM -33%
96	Creative Planning	15,93715,937	$4M	0.05%	ADD 15%
97	STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM	15,75615,756	$4M	0.05%	—
98	NEW YORK STATE TEACHERS RETIREMENT SYSTEM	15,63715,637	$4M	0.05%	—
99	MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.	15,12115,121	$4M	0.05%	ADD 17%
100	CIM, LLC	14,99014,990	$4M	0.05%	NEW

† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.

Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.

Holder trends· top 15 holders · shares held over 6 quarters

green added · red trimmed

Holder

2024-Q4

2025-Q1

2025-Q2

2025-Q3

2025-Q4

2026-Q1

Latest value

FMR LLC

4.3M

4.4M

$1.1B

BlackRock, Inc.

4.0M

3.9M

3.8M

3.9M

$1.0B

Avoro Capital Advisors LLC

2.6M

2.7M

2.8M

2.9M

$746M

VANGUARD PORTFOLIO MANAGEMENT LLC

—

1.5M

$376M

STATE STREET CORP

1.3M

1.2M

1.4M

1.3M

$340M

VANGUARD CAPITAL MANAGEMENT LLC

—

1.2M

$301M

Soleus Capital Management, L.P.

358K

442K

923K

1.0M

941K

1.2M

$298M

Capital World Investors

879K

954K

942K

809K

810K

825K

$213M

Redmile Group, LLC

753K

738K

663K

661K

678K

674K

$174M

GEODE CAPITAL MANAGEMENT, LLC

592K

612K

620K

611K

612K

644K

$166M

Hood River Capital Management LLC

513K

525K

533K

607K

613K

620K

$160M

PRICE T ROWE ASSOCIATES INC /MD/

509K

411K

261K

467K

530K

485K

$125M

Bellevue Group AG

410K

482K

$124M

Frazier Life Sciences Management, L.P.

788K

688K

488K

481K

$124M

DIMENSIONAL FUND ADVISORS LP

589K

534K

506K

534K

493K

469K

$121M

Institutional footprint by quarter

Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).

Quarter	Holders	Shares held	% shares out	Value held
2026-Q1	366	28,367,320	96.2%	$7.3B
2025-Q4	333	28,463,728	96.6%	$7.0B
2025-Q3	284	28,160,483	95.5%	$5.0B
2025-Q2	275	27,653,611	93.8%	$3.8B
2025-Q1	299	27,672,062	93.9%	$5.0B
2024-Q4	264	27,775,564	94.2%	$4.4B
2024-Q3

Short interest has its own tab now — open SI →

Activists & large holders· Schedule 13D/G beneficial owners · KRYS

Large holders — 13G, passive (top 4 by % of class)

Holder	% of class	Type	As of
Krishnan Krish S	11.5%	Exempt	2026-03-31	SEC →
VANGUARD PORTFOLIO MANAGEMENT LLC	5.05%	QII	2026-03-31	SEC →
STATE STREET CORP	4.4%	QII	2024-12-31	SEC →
VANGUARD GROUP INC	0%	QII	2026-03-13	SEC →

KRYS US Equity☆

Institutional ownership· 13F filers holding KRYS · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · KRYS

Institutional ownership· 13F filers holding KRYS · 2026-Q1 methodology → sources →

Top holders

Holder trends· top 15 holders · shares held over 6 quarters

Institutional footprint by quarter

Activists & large holders· Schedule 13D/G beneficial owners · KRYS

KRYS US Equity