| 1 | 1BAKER BROS. ADVISORS LP | 19,919,18619.9M | $759M | 31.83% | — |
| 2 | 2BlackRock, Inc. | 3,935,3023.9M | $150M | 6.29% | — |
| 3 | 3STATE STREET CORP | 2,250,9202.3M | $86M | 3.60% | ADD 30% |
| 4 | 4PRICE T ROWE ASSOCIATES INC /MD/ | 2,039,3502.0M | $78M | 3.26% | ADD 74% |
| 5 | 5BRAIDWELL LP | 1,818,6651.8M | $69M | 2.91% | TRIM -12% |
| 6 | 6VANGUARD CAPITAL MANAGEMENT LLC | 1,717,0761.7M | $65M | 2.74% | NEW† |
| 7 | 7GOLDMAN SACHS GROUP INC | 1,689,0031.7M | $64M | 2.70% | ADD 30% |
| 8 | 8RTW INVESTMENTS, LP | 1,487,9341.5M | $57M | 2.38% | — |
| 9 | 9TCG Crossover Management, LLC | 1,445,5381.4M | $55M | 2.31% | — |
| 10 | 10Boxer Capital Management, LLC | 1,361,0001.4M | $52M | 2.17% | ADD 20% |
| 11 | 11JANUS HENDERSON GROUP PLC | 1,325,4571.3M | $51M | 2.12% | ADD 33% |
| 12 | 12ICONIQ Capital, LLC | 1,266,5631.3M | $48M | 2.02% | — |
| 13 | 13Ikarian Capital, LLC | 1,265,7951.3M | $48M | 2.02% | ADD 76% |
| 14 | 14GEODE CAPITAL MANAGEMENT, LLC | 1,000,4111.0M | $38M | 1.60% | ADD 11% |
| 15 | 15SILVERARC CAPITAL MANAGEMENT, LLC | 991,930991,930 | $38M | 1.59% | TRIM -3% |
| 16 | 16CITADEL ADVISORS LLC | 870,788870,788 | $33M | 1.39% | ADD 200% |
| 17 | 17T. Rowe Price Investment Management, Inc. | 836,944836,944 | $32M | 1.34% | ADD 98% |
| 18 | 18Balyasny Asset Management L.P. | 726,547726,547 | $28M | 1.16% | ADD 176% |
| 19 | 19Board of Trustees of The Leland Stanford Junior University | 691,767691,767 | $26M | 1.11% | — |
| 20 | 20Artisan Partners Limited Partnership | 690,322690,322 | $26M | 1.10% | TRIM -17% |
| 21 | 21ADAGE CAPITAL PARTNERS GP, L.L.C. | 575,000575,000 | $22M | 0.92% | TRIM -27% |
| 22 | 22MORGAN STANLEY | 515,864515,864 | $20M | 0.82% | TRIM -26% |
| 23 | 23Point72 Asset Management, L.P. | 459,723459,723 | $18M | 0.73% | TRIM -79% |
| 24 | 24WELLINGTON MANAGEMENT GROUP LLP | 436,329436,329 | $17M | 0.70% | TRIM -8% |
| 25 | 25NORTHERN TRUST CORP | 391,349391,349 | $15M | 0.63% | ADD 17% |
| 26 | 26Squadron Capital Management LLC | 380,000380,000 | $14M | 0.61% | ADD 30% |
| 27 | 27VANGUARD PORTFOLIO MANAGEMENT LLC | 365,051365,051 | $14M | 0.58% | NEW |
| 28 | 28CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 349,803349,803 | $13M | 0.56% | ADD 3% |
| 29 | 29BOOTHBAY FUND MANAGEMENT, LLC | 328,670328,670 | $13M | 0.53% | ADD 90% |
| 30 | 30DIMENSIONAL FUND ADVISORS LP | 315,400315,400 | $12M | 0.50% | TRIM -4% |
| 31 | 31Invesco Ltd. | 305,074305,074 | $12M | 0.49% | TRIM -45% |
| 32 | 32BANK OF AMERICA CORP /DE/ | 300,356300,356 | $11M | 0.48% | ADD 53% |
| 33 | 33RENAISSANCE TECHNOLOGIES LLC | 294,300294,300 | $11M | 0.47% | TRIM -18% |
| 34 | 34BOONE CAPITAL MANAGEMENT LLC | 281,332281,332 | $11M | 0.45% | TRIM -44% |
| 35 | 35VANGUARD FIDUCIARY TRUST CO | 258,128258,128 | $10M | 0.41% | NEW |
| 36 | 36D. E. Shaw & Co., Inc. | 229,955229,955 | $9M | 0.37% | TRIM -28% |
| 37 | 37FEDERATED HERMES, INC. | 210,210210,210 | $8M | 0.34% | TRIM -14% |
| 38 | 38DIADEMA PARTNERS LP | 192,962192,962 | $7M | 0.31% | NEW |
| 39 | 39Atom Investors LP | 190,773190,773 | $7M | 0.30% | TRIM -8% |
| 40 | 40FMR LLC | 183,919183,919 | $7M | 0.29% | TRIM -8% |
| 41 | 41TD Asset Management Inc | 162,298162,298 | $6M | 0.26% | ADD 21% |
| 42 | 42UBS Group AG | 153,166153,166 | $6M | 0.24% | TRIM -9% |
| 43 | 43ALGERT GLOBAL LLC | 147,930147,930 | $6M | 0.24% | ADD 1475% |
| 44 | 44Bruce & Co., Inc. | 145,000145,000 | $6M | 0.23% | TRIM -12% |
| 45 | 45Trexquant Investment LP | 123,402123,402 | $5M | 0.20% | TRIM -35% |
| 46 | 46MANUFACTURERS LIFE INSURANCE COMPANY, THE | 120,629120,629 | $5M | 0.19% | ADD 32% |
| 47 | 47SPHERA FUNDS MANAGEMENT LTD. | 114,796114,796 | $4M | 0.18% | TRIM -35% |
| 48 | 48PFM Health Sciences, LP | 114,719114,719 | $4M | 0.18% | NEW |
| 49 | 49Bank of New York Mellon Corp | 111,341111,341 | $4M | 0.18% | ADD 8% |
| 50 | 50Resolute Capital Asset Partners LLC | 100,000100,000 | $4M | 0.16% | NEW |
| 51 | 51TWO SIGMA INVESTMENTS, LP | 99,46899,468 | $4M | 0.16% | ADD 93% |
| 52 | 52Nuveen, LLC | 95,29295,292 | $4M | 0.15% | ADD 30% |
| 53 | 53Informed Momentum Co LLC | 88,36988,369 | $3M | 0.14% | NEW |
| 54 | 54AQR CAPITAL MANAGEMENT LLC | 85,81885,818 | $3M | 0.14% | ADD 49% |
| 55 | 55RIA Advisory Group LLC | 84,67284,672 | $3M | 0.14% | TRIM -25% |
| 56 | 56PRUDENTIAL FINANCIAL INC | 80,21580,215 | $3M | 0.13% | ADD 2% |
| 57 | 57WELLS FARGO & COMPANY/MN | 77,13777,137 | $3M | 0.12% | TRIM -16% |
| 58 | 58Rafferty Asset Management, LLC | 71,50471,504 | $3M | 0.11% | ADD 20% |
| 59 | 59Harvest Investment Services, LLC | 71,34971,349 | $3M | 0.11% | ADD 15% |
| 60 | 60Squarepoint Ops LLC | 71,05671,056 | $3M | 0.11% | NEW |
| 61 | 61JPMORGAN CHASE & CO | 79,70879,708 | $3M | 0.13% | ADD 345% |
| 62 | 62NEW YORK STATE COMMON RETIREMENT FUND | 69,86069,860 | $3M | 0.11% | ADD 4% |
| 63 | 63National Philanthropic Trust | 66,39866,398 | $3M | 0.11% | — |
| 64 | 64Jefferies Financial Group Inc. | 66,26966,269 | $3M | 0.11% | ADD 405% |
| 65 | 65AMERIPRISE FINANCIAL INC | 65,49265,492 | $2M | 0.10% | ADD 229% |
| 66 | 66Maven Securities LTD | 58,95358,953 | $2M | 0.09% | NEW |
| 67 | 67Swiss National Bank | 57,40057,400 | $2M | 0.09% | NEW |
| 68 | 68Jain Global LLC | 52,56952,569 | $2M | 0.08% | TRIM -82% |
| 69 | 69Persistent Asset Partners Ltd | 51,33651,336 | $2M | 0.08% | NEW |
| 70 | 70STATE OF WISCONSIN INVESTMENT BOARD | 49,25949,259 | $2M | 0.08% | ADD 34% |
| 71 | 71FRED ALGER MANAGEMENT, LLC | 48,37948,379 | $2M | 0.08% | NEW |
| 72 | 72RHUMBLINE ADVISERS | 47,95847,958 | $2M | 0.08% | ADD 11% |
| 73 | 73UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 43,75143,751 | $2M | 0.07% | ADD 22569% |
| 74 | 74HighVista Strategies LLC | 43,56943,569 | $2M | 0.07% | NEW |
| 75 | 75POLEN CAPITAL MANAGEMENT LLCtracked | 41,35441,354 | $2M | 0.07% | — |
| 76 | 76DEUTSCHE BANK AG\ | 41,26441,264 | $2M | 0.07% | ADD 17% |
| 77 | 77JACOBS LEVY EQUITY MANAGEMENT, INC | 40,93940,939 | $2M | 0.07% | TRIM -68% |
| 78 | 78VICTORY CAPITAL MANAGEMENT INC | 37,63837,638 | $1M | 0.06% | TRIM -15% |
| 79 | 79SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,22734,227 | $1M | 0.05% | TRIM -7% |
| 80 | 80PROFUND ADVISORS LLC | 31,84431,844 | $1M | 0.05% | ADD 44% |
| 81 | 81Vanguard Global Advisers, LLC | 30,59730,597 | $1M | 0.05% | NEW |
| 82 | 82PANAGORA ASSET MANAGEMENT INC | 29,71729,717 | $1M | 0.05% | TRIM -84% |
| 83 | 83CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,39629,396 | $1M | 0.05% | ADD 1359% |
| 84 | 84FRANKLIN RESOURCES INC | 29,34829,348 | $1M | 0.05% | ADD 50% |
| 85 | 85BNP PARIBAS FINANCIAL MARKETS | 29,12629,126 | $1M | 0.05% | ADD 246% |
| 86 | 86ALLIANCEBERNSTEIN L.P. | 38,48038,480 | $1M | 0.06% | ADD 9% |
| 87 | 87Aries Wealth Management | 25,00025,000 | $953,000 | 0.04% | — |
| 88 | 88Walleye Capital LLC | 23,57223,572 | $898,565 | 0.04% | NEW |
| 89 | 89MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 22,83322,833 | $847,795 | 0.04% | ADD 22% |
| 90 | 90Schonfeld Strategic Advisors LLC | 22,15222,152 | $844,433 | 0.04% | NEW |
| 91 | 91Headlands Technologies LLC | 20,59320,593 | $785,005 | 0.03% | ADD 27% |
| 92 | 92MetLife Investment Management, LLC | 20,36320,363 | $776,238 | 0.03% | ADD 5% |
| 93 | 93Legal & General Group Plc | 20,17320,173 | $768,996 | 0.03% | ADD 591% |
| 94 | 94SIMPLEX TRADING, LLC | 19,75519,755 | $753,060 | 0.03% | ADD 222% |
| 95 | 95VANGUARD ASSET MANAGEMENT, Ltd | 19,17419,174 | $730,913 | 0.03% | NEW |
| 96 | 96Russell Investments Group, Ltd. | 18,62918,629 | $710,166 | 0.03% | TRIM -41% |
| 97 | 97BRIDGEWAY CAPITAL MANAGEMENT, LLC | 18,20018,200 | $693,784 | 0.03% | TRIM -58% |
| 98 | 98XTX Topco Ltd | 17,97717,977 | $685,283 | 0.03% | NEW |
| 99 | 99Optimize Financial Inc | 17,82817,828 | $679,603 | 0.03% | NEW |
| 100 | 100SG Americas Securities, LLC | 17,12417,124 | $653,000 | 0.03% | TRIM -29% |