| 1 | 1RA CAPITAL MANAGEMENT, L.P. | 17,754,43017.8M | $40M | 9.84% | NEW† |
| 2 | 2TCG Crossover Management, LLC | 17,754,43017.8M | $39M | 9.84% | NEW† |
| 3 | 3Versant Venture Management, LLC | 12,166,10912.2M | $27M | 6.75% | NEW† |
| 4 | 4Deep Track Capital, LP | 9,487,7459.5M | $21M | 5.26% | NEW† |
| 5 | 5RTW INVESTMENTS, LP | 8,695,6528.7M | $20M | 4.82% | NEW† |
| 6 | 6Venrock Adviser, LLC | 8,695,6528.7M | $20M | 4.82% | NEW† |
| 7 | 7Commodore Capital LP | 8,695,6528.7M | $20M | 4.82% | NEW† |
| 8 | 8Point72 Asset Management, L.P. | 5,964,6786.0M | $13M | 3.31% | — |
| 9 | 9VANGUARD CAPITAL MANAGEMENT LLC | 5,686,2045.7M | $13M | 3.15% | NEW† |
| 10 | 10Balyasny Asset Management L.P. | 5,017,7335.0M | $11M | 2.78% | NEW† |
| 11 | 11MILLENNIUM MANAGEMENT LLC | 4,667,0634.7M | $11M | 2.59% | ADD 665% |
| 12 | 12Spruce Street Capital LP | 4,059,0544.1M | $9M | 2.25% | ADD 186% |
| 13 | 13ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,789,5383.8M | $9M | 2.10% | ADD 106% |
| 14 | 14Woodline Partners LP | 3,043,4783.0M | $7M | 1.69% | NEW |
| 15 | 15Seven Fleet Capital Management LP | 2,947,8262.9M | $7M | 1.63% | NEW |
| 16 | 16Trails Edge Capital Partners, LP | 2,449,9932.4M | $6M | 1.36% | NEW |
| 17 | 17DAFNA Capital Management LLC | 2,434,3532.4M | $6M | 1.35% | TRIM -13% |
| 18 | 18TWO SIGMA INVESTMENTS, LP | 2,371,4302.4M | $5M | 1.31% | ADD 59% |
| 19 | 19BlackRock, Inc. | 1,524,4221.5M | $3M | 0.85% | ADD 153% |
| 20 | 20Rock Springs Capital Management LP | 1,304,3471.3M | $3M | 0.72% | NEW |
| 21 | 21GEODE CAPITAL MANAGEMENT, LLC | 1,301,6641.3M | $3M | 0.72% | ADD 185% |
| 22 | 22Casdin Capital, LLC | 1,228,1901.2M | $3M | 0.68% | — |
| 23 | 23Syncona Portfolio Ltd | 1,213,0561.2M | $3M | 0.67% | — |
| 24 | 24RENAISSANCE TECHNOLOGIES LLC | 906,827906,827 | $2M | 0.50% | TRIM -33% |
| 25 | 25VANGUARD FIDUCIARY TRUST CO | 692,963692,963 | $2M | 0.38% | NEW |
| 26 | 26MARSHALL WACE, LLP | 673,584673,584 | $2M | 0.37% | NEW |
| 27 | 27STATE STREET CORP | 386,723386,723 | $873,994 | 0.21% | ADD 203% |
| 28 | 28ACADIAN ASSET MANAGEMENT LLC | 278,075278,075 | $627,000 | 0.15% | TRIM -77% |
| 29 | 29NORTHERN TRUST CORP | 230,820230,820 | $521,653 | 0.13% | ADD 120% |
| 30 | 30SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226,687226,687 | $512,313 | 0.13% | ADD 352% |
| 31 | 31GOLDMAN SACHS GROUP INC | 210,482210,482 | $475,689 | 0.12% | NEW |
| 32 | 32BANK OF AMERICA CORP /DE/ | 145,099145,099 | $327,924 | 0.08% | ADD 27538% |
| 33 | 33BARCLAYS PLC | 120,232120,232 | $271,724 | 0.07% | ADD 12023100% |
| 34 | 34Squarepoint Ops LLC | 119,504119,504 | $270,079 | 0.07% | NEW |
| 35 | 35SUPERSTRING CAPITAL MANAGEMENT LP | 119,308119,308 | $269,636 | 0.07% | TRIM -74% |
| 36 | 36Brevan Howard Capital Management LP | 96,64196,641 | $218,409 | 0.05% | NEW |
| 37 | 37RAYMOND JAMES FINANCIAL INC | 91,32391,323 | $206,390 | 0.05% | — |
| 38 | 38CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,41579,415 | $179,478 | 0.04% | NEW |
| 39 | 39GSA CAPITAL PARTNERS LLP | 76,83676,836 | $174,000 | 0.04% | TRIM -77% |
| 40 | 40WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 77,79777,797 | $165,708 | 0.04% | — |
| 41 | 41Invesco Ltd. | 62,10962,109 | $140,366 | 0.03% | NEW |
| 42 | 42AMERICAN CENTURY COMPANIES INC | 58,74258,742 | $132,757 | 0.03% | NEW |
| 43 | 43DIMENSIONAL FUND ADVISORS LP | 55,18355,183 | $122,209 | 0.03% | NEW |
| 44 | 44Cannon Global Investment Management, LLC | 49,00049,000 | $110,740 | 0.03% | NEW |
| 45 | 45OMERS ADMINISTRATION Corp | 47,80047,800 | $108,028 | 0.03% | NEW |
| 46 | 46Vanguard Global Advisers, LLC | 44,61644,616 | $100,832 | 0.02% | NEW |
| 47 | 47Tower Research Capital LLC (TRC) | 32,98732,987 | $74,551 | 0.02% | NEW |
| 48 | 48HarbourVest Partners LLC | 29,01829,018 | $65,581 | 0.02% | — |
| 49 | 49Parametrica Management Ltd | 27,84027,840 | $62,918 | 0.02% | — |
| 50 | 50MORGAN STANLEY | 26,24926,249 | $59,323 | 0.01% | NEW |
| 51 | 51PRUDENTIAL FINANCIAL INC | 25,30025,300 | $57,178 | 0.01% | TRIM -58% |
| 52 | 52XTX Topco Ltd | 22,51822,518 | $50,891 | 0.01% | ADD 47% |
| 53 | 53Quadrant Private Wealth Management, LLC | 20,02220,022 | $45,249 | 0.01% | ADD 31% |
| 54 | 54UBS Group AG | 14,21514,215 | $32,126 | 0.01% | TRIM -93% |
| 55 | 55Bank of New York Mellon Corp | 12,89712,897 | $29,147 | 0.01% | NEW |
| 56 | 56SIMPLEX TRADING, LLC | 9,0289,028 | $20,403 | 0.01% | ADD 277% |
| 57 | 57FMR LLC | 8,7798,779 | $19,839 | 0.00% | TRIM -88% |
| 58 | 58Advisors Asset Management, Inc. | 8,3138,313 | $18,787 | 0.00% | — |
| 59 | 59ROYAL BANK OF CANADA | 4,3944,394 | $9,000 | 0.00% | ADD 6268% |
| 60 | 60Farther Finance Advisors, LLC | 2,5002,500 | $5,475 | 0.00% | NEW |
| 61 | 61BNP PARIBAS FINANCIAL MARKETS | 1,4181,418 | $3,205 | 0.00% | TRIM -2% |
| 62 | 62SBI Securities Co., Ltd. | 1,2601,260 | $2,848 | 0.00% | TRIM -18% |
| 63 | 63NISA INVESTMENT ADVISORS, LLC | 883883 | $1,996 | 0.00% | — |
| 64 | 64MARK SHEPTOFF FINANCIAL PLANNING, LLC | 500500 | $1,145 | 0.00% | — |
| 65 | 65Advisory Services Network, LLC | 407407 | $920 | 0.00% | NEW |
| 66 | 66Fortitude Family Office, LLC | 294294 | $664 | 0.00% | NEW |
| 67 | 67JPMORGAN CHASE & CO | 115115 | $233 | 0.00% | TRIM -96% |
| 68 | 68Arax Advisory Partners | 9999 | $224 | 0.00% | — |
| 69 | 69WELLS FARGO & COMPANY/MN | 4040 | $90 | 0.00% | — |
| 70 | 70Optiver Holding B.V. | 3232 | $72 | 0.00% | — |
| 71 | 71Smartleaf Asset Management LLC | 11 | $2 | 0.00% | — |
