| 1 | 1FMR LLC | 16,969,95417.0M | $371M | 14.98% | ADD 3% |
| 2 | 2T. Rowe Price Investment Management, Inc. | 16,364,01116.4M | $358M | 14.45% | ADD 12% |
| 3 | 3BlackRock, Inc. | 8,168,6748.2M | $179M | 7.21% | ADD 8% |
| 4 | 4Redmile Group, LLC | 5,558,8855.6M | $122M | 4.91% | TRIM -3% |
| 5 | 5STATE STREET CORP | 5,399,9015.4M | $118M | 4.77% | ADD 40% |
| 6 | 6PRIMECAP MANAGEMENT CO/CA/ | 4,788,2314.8M | $105M | 4.23% | ADD 2% |
| 7 | 7WELLINGTON MANAGEMENT GROUP LLP | 4,731,9774.7M | $103M | 4.18% | ADD 406% |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 4,429,6974.4M | $97M | 3.91% | NEW† |
| 9 | 9Driehaus Capital Management LLC | 4,099,9014.1M | $90M | 3.62% | ADD 11% |
| 10 | 10ENAVATE SCIENCES GP, LLC | 3,613,7993.6M | $79M | 3.19% | TRIM -24% |
| 11 | 11PRICE T ROWE ASSOCIATES INC /MD/ | 2,858,8632.9M | $63M | 2.52% | TRIM -15% |
| 12 | 12MORGAN STANLEY | 2,841,5892.8M | $62M | 2.51% | ADD 66% |
| 13 | 13GEODE CAPITAL MANAGEMENT, LLC | 2,560,6642.6M | $56M | 2.26% | ADD 8% |
| 14 | 14JPMORGAN CHASE & CO | 2,777,8362.8M | $54M | 2.45% | TRIM -3% |
| 15 | 15SILVERARC CAPITAL MANAGEMENT, LLC | 1,850,2781.9M | $40M | 1.63% | ADD 64% |
| 16 | 16Sofinnova Investments, Inc. | 1,701,9041.7M | $37M | 1.50% | ADD 5% |
| 17 | 17Woodline Partners LP | 1,575,3981.6M | $34M | 1.39% | — |
| 18 | 18MARSHALL WACE, LLP | 1,480,7881.5M | $32M | 1.31% | ADD 101% |
| 19 | 19PRINCIPAL FINANCIAL GROUP INC | 1,376,8671.4M | $30M | 1.22% | — |
| 20 | 20READYSTATE ASSET MANAGEMENT LP | 1,301,8621.3M | $28M | 1.15% | TRIM -29% |
| 21 | 21Jefferies Financial Group Inc. | 1,160,7151.2M | $25M | 1.02% | TRIM -42% |
| 22 | 22GOLDMAN SACHS GROUP INC | 1,101,4761.1M | $24M | 0.97% | ADD 46% |
| 23 | 23BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,097,8361.1M | $24M | 0.97% | ADD 502% |
| 24 | 24VANGUARD PORTFOLIO MANAGEMENT LLC | 1,006,9751.0M | $22M | 0.89% | NEW |
| 25 | 25NORTHERN TRUST CORP | 899,146899,146 | $20M | 0.79% | ADD 9% |
| 26 | 26CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 851,789851,789 | $19M | 0.75% | — |
| 27 | 27Polar Capital Holdings Plc | 849,479849,479 | $19M | 0.75% | ADD 7% |
| 28 | 28JANUS HENDERSON GROUP PLC | 808,019808,019 | $18M | 0.71% | TRIM -3% |
| 29 | 29BANK OF AMERICA CORP /DE/ | 781,607781,607 | $17M | 0.69% | ADD 286% |
| 30 | 30Pivotal bioVenture Partners Investment Advisor LLC | 732,512732,512 | $16M | 0.65% | — |
| 31 | 31VANGUARD FIDUCIARY TRUST CO | 716,395716,395 | $16M | 0.63% | NEW |
| 32 | 32NAN FUNG TRINITY (HK) LTD | 714,553714,553 | $16M | 0.63% | — |
| 33 | 33TD Asset Management Inc | 694,934694,934 | $15M | 0.61% | TRIM -8% |
| 34 | 34Candriam S.C.A. | 539,882539,882 | $12M | 0.48% | — |
| 35 | 35UBS Group AG | 432,912432,912 | $9M | 0.38% | ADD 41% |
| 36 | 36Parkman Healthcare Partners LLC | 403,487403,487 | $9M | 0.36% | ADD 45% |
| 37 | 37BNP PARIBAS FINANCIAL MARKETS | 362,621362,621 | $8M | 0.32% | ADD 3158% |
| 38 | 38Rock Springs Capital Management LP | 347,666347,666 | $8M | 0.31% | — |
| 39 | 39Granahan Investment Management, LLC | 307,021307,021 | $7M | 0.27% | TRIM -29% |
| 40 | 40Atom Investors LP | 306,880306,880 | $7M | 0.27% | ADD 75% |
| 41 | 41Nuveen, LLC | 305,254305,254 | $7M | 0.27% | ADD 80% |
| 42 | 42KENNEDY CAPITAL MANAGEMENT LLC | 287,030287,030 | $6M | 0.25% | — |
| 43 | 43Bank of New York Mellon Corp | 276,066276,066 | $6M | 0.24% | ADD 5% |
| 44 | 44Tidal Investments LLC | 275,896275,896 | $6M | 0.24% | NEW |
| 45 | 45Tema ETFs LLC | 275,896275,896 | $6M | 0.24% | ADD 170% |
| 46 | 46Atika Capital Management LLC | 262,900262,900 | $6M | 0.23% | TRIM -21% |
| 47 | 47Balyasny Asset Management L.P. | 251,396251,396 | $5M | 0.22% | TRIM -82% |
| 48 | 48Universal- Beteiligungs- und Servicegesellschaft mbH | 230,738230,738 | $5M | 0.20% | ADD 36% |
| 49 | 49MANUFACTURERS LIFE INSURANCE COMPANY, THE | 206,799206,799 | $5M | 0.18% | TRIM -13% |
| 50 | 50Burkehill Global Management, LP | 200,000200,000 | $4M | 0.18% | — |
| 51 | 51Qube Research & Technologies Ltd | 188,229188,229 | $4M | 0.17% | NEW |
| 52 | 52UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 187,011187,011 | $4M | 0.17% | ADD 51% |
| 53 | 53Swiss National Bank | 185,000185,000 | $4M | 0.16% | — |
| 54 | 54GILDER GAGNON HOWE & CO LLC | 169,267169,267 | $4M | 0.15% | TRIM -3% |
| 55 | 55Trexquant Investment LP | 166,812166,812 | $4M | 0.15% | ADD 27% |
| 56 | 56Sio Capital Management, LLC | 165,110165,110 | $4M | 0.15% | NEW |
| 57 | 57ALLIANCEBERNSTEIN L.P. | 163,450163,450 | $4M | 0.14% | ADD 76% |
| 58 | 58Rafferty Asset Management, LLC | 156,220156,220 | $3M | 0.14% | ADD 38% |
| 59 | 59MILLENNIUM MANAGEMENT LLC | 130,367130,367 | $3M | 0.12% | ADD 594% |
| 60 | 60AMERIPRISE FINANCIAL INC | 129,515129,515 | $3M | 0.11% | TRIM -32% |
| 61 | 61Aristotle Atlantic Partners, LLC | 125,018125,018 | $3M | 0.11% | NEW |
| 62 | 62RHUMBLINE ADVISERS | 120,900120,900 | $3M | 0.11% | ADD 6% |
| 63 | 63ExodusPoint Capital Management, LP | 115,370115,370 | $3M | 0.10% | TRIM -85% |
| 64 | 64CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 111,444111,444 | $2M | 0.10% | ADD 66% |
| 65 | 65Walleye Capital LLC | 111,183111,183 | $2M | 0.10% | NEW |
| 66 | 66LMR Partners LLP | 101,401101,401 | $2M | 0.09% | — |
| 67 | 67NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 97,14097,140 | $2M | 0.09% | ADD 18% |
| 68 | 68RAYMOND JAMES FINANCIAL INC | 96,37496,374 | $2M | 0.09% | ADD 107% |
| 69 | 69SummitTX Capital, L.P. | 92,88092,880 | $2M | 0.08% | TRIM -27% |
| 70 | 70DEUTSCHE BANK AG\ | 89,13789,137 | $2M | 0.08% | ADD 17% |
| 71 | 71Cerity Partners LLC | 83,58183,581 | $2M | 0.07% | ADD 95% |
| 72 | 72Legal & General Group Plc | 81,58881,588 | $2M | 0.07% | TRIM -14% |
| 73 | 73CITADEL ADVISORS LLC | 80,19780,197 | $2M | 0.07% | TRIM -95% |
| 74 | 74Informed Momentum Co LLC | 71,75771,757 | $2M | 0.06% | NEW |
| 75 | 75PROFUND ADVISORS LLC | 69,91869,918 | $2M | 0.06% | ADD 64% |
| 76 | 76RENAISSANCE TECHNOLOGIES LLC | 68,90268,902 | $2M | 0.06% | NEW |
| 77 | 77Squarepoint Ops LLC | 67,77867,778 | $1M | 0.06% | ADD 131% |
| 78 | 78Invesco Ltd. | 66,56566,565 | $1M | 0.06% | TRIM -75% |
| 79 | 79Schonfeld Strategic Advisors LLC | 62,43662,436 | $1M | 0.06% | ADD 95% |
| 80 | 80Freestone Capital Holdings, LLC | 61,51461,514 | $1M | 0.05% | — |
| 81 | 81XTX Topco Ltd | 60,49860,498 | $1M | 0.05% | ADD 240% |
| 82 | 82Edgestream Partners, L.P. | 59,88859,888 | $1M | 0.05% | NEW |
| 83 | 83VANGUARD ASSET MANAGEMENT, Ltd | 59,40059,400 | $1M | 0.05% | NEW |
| 84 | 84SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,98558,985 | $1M | 0.05% | TRIM -65% |
| 85 | 85MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 58,96258,962 | $1M | 0.05% | ADD 18% |
| 86 | 86MetLife Investment Management, LLC | 55,85755,857 | $1M | 0.05% | ADD 7% |
| 87 | 87SEI INVESTMENTS CO | 52,77052,770 | $1M | 0.05% | ADD 90% |
| 88 | 88Vanguard Global Advisers, LLC | 50,18850,188 | $1M | 0.04% | NEW |
| 89 | 89Birchview Capital, LP | 50,00050,000 | $1M | 0.04% | TRIM -62% |
| 90 | 90STATE OF WISCONSIN INVESTMENT BOARD | 48,98348,983 | $1M | 0.04% | ADD 7% |
| 91 | 91Lido Advisors, LLC | 48,95048,950 | $1M | 0.04% | TRIM -17% |
| 92 | 92NISA INVESTMENT ADVISORS, LLC | 47,95147,951 | $1M | 0.04% | TRIM -40% |
| 93 | 93VICTORY CAPITAL MANAGEMENT INC | 47,36047,360 | $1M | 0.04% | ADD 361% |
| 94 | 94Erste Asset Management GmbH | 52,00052,000 | $1M | 0.05% | — |
| 95 | 95Magnus Financial Group LLC | 45,75945,759 | $1M | 0.04% | — |
| 96 | 96Zurcher Kantonalbank (Zurich Cantonalbank) | 44,48844,488 | $972,953 | 0.04% | ADD 26% |
| 97 | 97Scharf Investments, LLC | 44,38944,389 | $970,787 | 0.04% | — |
| 98 | 98Susquehanna Portfolio Strategies, LLC | 44,16444,164 | $965,867 | 0.04% | — |
| 99 | 99Corient Private Wealth LLC | 43,47743,477 | $950,843 | 0.04% | TRIM -50% |
| 100 | 100WELLS FARGO & COMPANY/MN | 41,75441,754 | $913,160 | 0.04% | TRIM -61% |