| 1 | 1RTW INVESTMENTS, LP | 4,869,7984.9M | $147M | 9.61% | — |
| 2 | 2FMR LLC | 4,829,1544.8M | $146M | 9.53% | ADD 6% |
| 3 | 3WELLINGTON MANAGEMENT GROUP LLP | 4,706,1684.7M | $142M | 9.28% | — |
| 4 | 4PRIMECAP MANAGEMENT CO/CA/ | 3,693,2413.7M | $111M | 7.29% | TRIM -7% |
| 5 | 5Bellevue Group AG | 2,796,8032.8M | $84M | 5.52% | — |
| 6 | 6Vestal Point Capital, LP | 2,766,8682.8M | $83M | 5.46% | ADD 373% |
| 7 | 7TANG CAPITAL MANAGEMENT LLC | 2,649,3682.6M | $80M | 5.23% | — |
| 8 | 8Deep Track Capital, LP | 1,931,8841.9M | $58M | 3.81% | TRIM -4% |
| 9 | 9T. Rowe Price Investment Management, Inc. | 1,891,6001.9M | $57M | 3.73% | TRIM -72% |
| 10 | 10Logos Global Management LP | 1,500,0001.5M | $45M | 2.96% | ADD 76% |
| 11 | 11BVF INC/IL | 1,294,4631.3M | $39M | 2.55% | TRIM -13% |
| 12 | 12MILLENNIUM MANAGEMENT LLC | 1,237,4031.2M | $37M | 2.44% | ADD 36% |
| 13 | 13ARMISTICE CAPITAL, LLC | 1,188,0001.2M | $36M | 2.34% | ADD 8% |
| 14 | 14Point72 Asset Management, L.P. | 1,102,2711.1M | $33M | 2.17% | ADD 119% |
| 15 | 15Fiera Capital Corp | 1,080,0991.1M | $33M | 2.13% | ADD 3% |
| 16 | 16TWO SIGMA INVESTMENTS, LP | 1,021,2651.0M | $31M | 2.01% | ADD 184% |
| 17 | 17PRICE T ROWE ASSOCIATES INC /MD/ | 919,332919,332 | $28M | 1.81% | TRIM -5% |
| 18 | 18Kynam Capital Management, LP | 884,937884,937 | $27M | 1.75% | ADD 3% |
| 19 | 19BAKER BROS. ADVISORS LP | 734,397734,397 | $22M | 1.45% | TRIM -68% |
| 20 | 20Trails Edge Capital Partners, LP | 682,597682,597 | $21M | 1.35% | — |
| 21 | 21Caption Management, LLC | 661,786661,786 | $20M | 1.31% | ADD 601% |
| 22 | 22BlackRock, Inc. | 656,309656,309 | $20M | 1.29% | ADD 99% |
| 23 | 23Hudson Bay Capital Management LP | 633,174633,174 | $19M | 1.25% | ADD 65% |
| 24 | 24JANUS HENDERSON GROUP PLC | 594,712594,712 | $18M | 1.17% | ADD 31% |
| 25 | 25PRINCIPAL FINANCIAL GROUP INC | 519,130519,130 | $16M | 1.02% | TRIM -21% |
| 26 | 26ACADIAN ASSET MANAGEMENT LLC | 501,091501,091 | $15M | 0.99% | ADD 9% |
| 27 | 27Frazier Life Sciences Management, L.P. | 484,782484,782 | $15M | 0.96% | ADD 26% |
| 28 | 28MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 407,373407,373 | $12M | 0.80% | — |
| 29 | 29D. E. Shaw & Co., Inc. | 335,191335,191 | $10M | 0.66% | ADD 82% |
| 30 | 30MORGAN STANLEY | 323,606323,606 | $10M | 0.64% | ADD 13% |
| 31 | 31Woodline Partners LP | 316,762316,762 | $10M | 0.62% | — |
| 32 | 32Candriam S.C.A. | 269,729269,729 | $8M | 0.53% | — |
| 33 | 33CANTOR FITZGERALD, L. P. | 250,211250,211 | $8M | 0.49% | NEW |
| 34 | 34CITADEL ADVISORS LLC | 230,399230,399 | $7M | 0.45% | — |
| 35 | 35NEW YORK STATE COMMON RETIREMENT FUND | 211,140211,140 | $6M | 0.42% | — |
| 36 | 36BANK OF AMERICA CORP /DE/ | 206,866206,866 | $6M | 0.41% | TRIM -12% |
| 37 | 37JANE STREET GROUP, LLC | 204,368204,368 | $6M | 0.40% | ADD 102% |
| 38 | 38MOORE CAPITAL MANAGEMENT, LP | 197,308197,308 | $6M | 0.39% | NEW |
| 39 | 39DIADEMA PARTNERS LP | 193,189193,189 | $6M | 0.38% | ADD 175% |
| 40 | 40MARSHALL WACE, LLP | 180,340180,340 | $5M | 0.36% | ADD 195% |
| 41 | 41RENAISSANCE TECHNOLOGIES LLC | 164,000164,000 | $5M | 0.32% | ADD 16% |
| 42 | 42Legal & General Group Plc | 156,143156,143 | $5M | 0.31% | ADD 5% |
| 43 | 43TD Asset Management Inc | 135,828135,828 | $4M | 0.27% | TRIM -54% |
| 44 | 44STEMPOINT CAPITAL LP | 127,086127,086 | $4M | 0.25% | NEW |
| 45 | 45GOLDMAN SACHS GROUP INC | 119,497119,497 | $4M | 0.24% | ADD 269% |
| 46 | 46Aberdeen Group plc | 116,857116,857 | $4M | 0.23% | NEW |
| 47 | 47J. Goldman & Co LP | 114,749114,749 | $3M | 0.23% | NEW |
| 48 | 48Balyasny Asset Management L.P. | 113,844113,844 | $3M | 0.22% | NEW |
| 49 | 49LORD, ABBETT & CO. LLC | 100,784100,784 | $3M | 0.20% | NEW |
| 50 | 50Integral Health Asset Management, LLC | 100,000100,000 | $3M | 0.20% | NEW |
| 51 | 51STATE STREET CORP | 97,94097,940 | $3M | 0.19% | ADD 5% |
| 52 | 52XTX Topco Ltd | 96,10696,106 | $3M | 0.19% | ADD 337% |
| 53 | 53BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 94,93694,936 | $3M | 0.19% | — |
| 54 | 54Rhenman & Partners Asset Management AB | 85,72485,724 | $3M | 0.17% | TRIM -44% |
| 55 | 55Catalio Capital Management, LP | 84,35284,352 | $3M | 0.17% | NEW |
| 56 | 56Eschler Asset Management LLP | 80,00080,000 | $2M | 0.16% | — |
| 57 | 57MANUFACTURERS LIFE INSURANCE COMPANY, THE | 76,51976,519 | $2M | 0.15% | TRIM -10% |
| 58 | 58WELLS FARGO & COMPANY/MN | 75,47375,473 | $2M | 0.15% | TRIM -2% |
| 59 | 59HUSSMAN STRATEGIC ADVISORS, INC. | 63,00063,000 | $2M | 0.12% | ADD 50% |
| 60 | 60SEI INVESTMENTS CO | 61,26061,260 | $2M | 0.12% | ADD 22% |
| 61 | 61HighVista Strategies LLC | 58,69758,697 | $2M | 0.12% | ADD 78% |
| 62 | 62Elmind Capital, LP | 58,24858,248 | $2M | 0.11% | — |
| 63 | 63ENVESTNET ASSET MANAGEMENT INC | 56,82556,825 | $2M | 0.11% | ADD 3% |
| 64 | 64Persistent Asset Partners Ltd | 48,96248,962 | $1M | 0.10% | ADD 75% |
| 65 | 65Hennion & Walsh Asset Management, Inc. | 47,12747,127 | $1M | 0.09% | TRIM -3% |
| 66 | 66Eagle Health Investments LP | 46,30046,300 | $1M | 0.09% | — |
| 67 | 67ROYAL BANK OF CANADA | 44,71444,714 | $1M | 0.09% | ADD 5% |
| 68 | 68GEODE CAPITAL MANAGEMENT, LLC | 42,88242,882 | $1M | 0.08% | — |
| 69 | 69UBS Group AG | 42,13442,134 | $1M | 0.08% | ADD 484% |
| 70 | 70SCHRODER INVESTMENT MANAGEMENT GROUP | 42,92042,920 | $1M | 0.08% | TRIM -61% |
| 71 | 71ALPS ADVISORS INC | 41,26141,261 | $1M | 0.08% | — |
| 72 | 72ExodusPoint Capital Management, LP | 40,27940,279 | $1M | 0.08% | NEW |
| 73 | 73Eversept Partners, LP | 39,23839,238 | $1M | 0.08% | NEW |
| 74 | 74Jump Financial, LLC | 38,49838,498 | $1M | 0.08% | TRIM -37% |
| 75 | 75Crossmark Global Holdings, Inc. | 36,45736,457 | $1M | 0.07% | — |
| 76 | 76Y-Intercept (Hong Kong) Ltd | 34,92734,927 | $1M | 0.07% | TRIM -28% |
| 77 | 77COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 31,67431,674 | $954,971 | 0.06% | ADD 287% |
| 78 | 78PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 31,25331,253 | $942,278 | 0.06% | ADD 24% |
| 79 | 79BARCLAYS PLC | 30,90930,909 | $931,906 | 0.06% | TRIM -70% |
| 80 | 80Tidal Investments LLC | 30,65130,651 | $924,128 | 0.06% | NEW |
| 81 | 81ASSETMARK, INC | 28,38728,387 | $855,868 | 0.06% | TRIM -10% |
| 82 | 82State of New Jersey Common Pension Fund D | 27,66327,663 | $834,039 | 0.05% | — |
| 83 | 83Virtus Investment Advisers, LLC | 22,94022,940 | $691,641 | 0.05% | ADD 24% |
| 84 | 84HRT FINANCIAL LP | 22,86122,861 | $689,000 | 0.05% | TRIM -30% |
| 85 | 85Trexquant Investment LP | 20,68520,685 | $623,653 | 0.04% | NEW |
| 86 | 86Orion Porfolio Solutions, LLC | 20,52420,524 | $618,811 | 0.04% | TRIM -7% |
| 87 | 87VOLORIDGE INVESTMENT MANAGEMENT, LLC | 19,49219,492 | $587,684 | 0.04% | TRIM -31% |
| 88 | 88Quadrature Capital Ltd | 19,25419,254 | $580,508 | 0.04% | TRIM -50% |
| 89 | 89Bridgewater Associates, LP | 18,93018,930 | $570,740 | 0.04% | ADD 90% |
| 90 | 90BNP PARIBAS FINANCIAL MARKETS | 16,93616,936 | $510,620 | 0.03% | TRIM -16% |
| 91 | 91Brevan Howard Capital Management LP | 16,42016,420 | $481,763 | 0.03% | NEW |
| 92 | 92Squarepoint Ops LLC | 15,43415,434 | $465,335 | 0.03% | — |
| 93 | 93PSP Research LLC | 15,14115,141 | $456,501 | 0.03% | ADD 5% |
| 94 | 94Engineers Gate Manager LP | 13,89213,892 | $418,844 | 0.03% | NEW |
| 95 | 95STIFEL FINANCIAL CORP | 11,22211,222 | $338,349 | 0.02% | TRIM -4% |
| 96 | 96China Universal Asset Management Co., Ltd. | 10,78310,783 | $325,107 | 0.02% | TRIM -29% |
| 97 | 97TrinityBridge Ltd | 10,10010,100 | $304,000 | 0.02% | NEW |
| 98 | 98Entropy Technologies, LP | 10,02010,020 | $302,103 | 0.02% | NEW |
| 99 | 99SUSQUEHANNA INTERNATIONAL GROUP, LLP | 8,6228,622 | $259,953 | 0.02% | TRIM -75% |
| 100 | 100Federation des caisses Desjardins du Quebec | 8,3128,312 | $251,243 | 0.02% | ADD 52% |