| 1 | 1FMR LLC | 13,172,10313.2M | $439M | 14.99% | — |
| 2 | 2BlackRock, Inc. | 8,442,1338.4M | $281M | 9.61% | ADD 3% |
| 3 | 3JANUS HENDERSON GROUP PLC | 7,265,2537.3M | $242M | 8.27% | — |
| 4 | 4Capital Research Global Investors | 5,163,5435.2M | $172M | 5.88% | TRIM -2% |
| 5 | 5BAKER BROS. ADVISORS LP | 3,946,5153.9M | $131M | 4.49% | ADD 9% |
| 6 | 6STATE STREET CORP | 3,781,1673.8M | $126M | 4.30% | TRIM -9% |
| 7 | 7VANGUARD CAPITAL MANAGEMENT LLC | 3,732,4223.7M | $124M | 4.25% | NEW† |
| 8 | 8Logos Global Management LP | 3,450,0003.5M | $115M | 3.93% | ADD 10% |
| 9 | 9FEDERATED HERMES, INC. | 2,987,1073.0M | $100M | 3.40% | TRIM -12% |
| 10 | 10ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,823,5002.8M | $94M | 3.21% | — |
| 11 | 11Fiera Capital Corp | 2,527,0762.5M | $84M | 2.88% | ADD 4% |
| 12 | 12GEODE CAPITAL MANAGEMENT, LLC | 2,500,7242.5M | $83M | 2.85% | ADD 21% |
| 13 | 13MORGAN STANLEY | 1,860,4531.9M | $62M | 2.12% | ADD 49% |
| 14 | 14GOLDMAN SACHS GROUP INC | 1,655,6171.7M | $55M | 1.88% | TRIM -7% |
| 15 | 15DEERFIELD MANAGEMENT COMPANY, L.P. | 1,530,0081.5M | $51M | 1.74% | TRIM -29% |
| 16 | 16GSK plc | 1,333,3331.3M | $44M | 1.52% | — |
| 17 | 17DIMENSIONAL FUND ADVISORS LP | 1,333,4781.3M | $44M | 1.52% | ADD 42% |
| 18 | 18PRICE T ROWE ASSOCIATES INC /MD/ | 1,315,8691.3M | $44M | 1.50% | TRIM -9% |
| 19 | 19Sofinnova Investments, Inc. | 1,131,7861.1M | $38M | 1.29% | ADD 28% |
| 20 | 20Candriam S.C.A. | 1,107,7081.1M | $37M | 1.26% | ADD 7% |
| 21 | 21BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,101,1451.1M | $37M | 1.25% | ADD 58% |
| 22 | 22BANK OF AMERICA CORP /DE/ | 942,091942,091 | $31M | 1.07% | ADD 4% |
| 23 | 23Ensign Peak Advisors, Inc | 899,504899,504 | $30M | 1.02% | TRIM -8% |
| 24 | 24Fisher Asset Management, LLC | 882,699882,699 | $29M | 1.00% | — |
| 25 | 25First Turn Management, LLC | 873,838873,838 | $29M | 0.99% | ADD 21% |
| 26 | 26UBS Group AG | 762,548762,548 | $25M | 0.87% | TRIM -30% |
| 27 | 27VANGUARD PORTFOLIO MANAGEMENT LLC | 745,593745,593 | $25M | 0.85% | NEW |
| 28 | 28NORTHERN TRUST CORP | 734,121734,121 | $24M | 0.84% | ADD 9% |
| 29 | 29Pictet Asset Management Holding SA | 715,906715,906 | $24M | 0.81% | TRIM -3% |
| 30 | 30CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 715,527715,527 | $24M | 0.81% | — |
| 31 | 31CITADEL ADVISORS LLC | 679,400679,400 | $23M | 0.77% | TRIM -29% |
| 32 | 32Qube Research & Technologies Ltd | 584,033584,033 | $19M | 0.66% | ADD 25% |
| 33 | 33VANGUARD FIDUCIARY TRUST CO | 561,563561,563 | $19M | 0.64% | NEW |
| 34 | 34Aberdeen Group plc | 545,631545,631 | $18M | 0.62% | TRIM -3% |
| 35 | 35Redmile Group, LLC | 521,117521,117 | $17M | 0.59% | TRIM -30% |
| 36 | 36NEW YORK STATE COMMON RETIREMENT FUND | 515,445515,445 | $17M | 0.59% | — |
| 37 | 37DAFNA Capital Management LLC | 476,740476,740 | $16M | 0.54% | TRIM -6% |
| 38 | 38TANG CAPITAL MANAGEMENT LLC | 450,000450,000 | $15M | 0.51% | — |
| 39 | 39Nuveen, LLC | 448,273448,273 | $15M | 0.51% | ADD 20% |
| 40 | 40DEUTSCHE BANK AG\ | 378,442378,442 | $13M | 0.43% | ADD 3% |
| 41 | 41Point72 Asset Management, L.P. | 327,901327,901 | $11M | 0.37% | TRIM -82% |
| 42 | 42GENERAL AMERICAN INVESTORS CO INC | 280,261280,261 | $9M | 0.32% | — |
| 43 | 43JPMORGAN CHASE & CO | 292,106292,106 | $9M | 0.33% | TRIM -3% |
| 44 | 44ENVESTNET ASSET MANAGEMENT INC | 256,318256,318 | $9M | 0.29% | TRIM -8% |
| 45 | 45JENNISON ASSOCIATES LLC | 255,764255,764 | $9M | 0.29% | NEW |
| 46 | 46Rhenman & Partners Asset Management AB | 255,500255,500 | $9M | 0.29% | ADD 2% |
| 47 | 47Bank of New York Mellon Corp | 250,325250,325 | $8M | 0.28% | ADD 3% |
| 48 | 48Nicholas Investment Partners, LP | 248,202248,202 | $8M | 0.28% | ADD 29% |
| 49 | 49WELLS FARGO & COMPANY/MN | 243,328243,328 | $8M | 0.28% | TRIM -5% |
| 50 | 50AMERICAN CENTURY COMPANIES INC | 241,508241,508 | $8M | 0.27% | ADD 18% |
| 51 | 51FRANKLIN RESOURCES INC | 230,268230,268 | $8M | 0.26% | TRIM -4% |
| 52 | 52MILLENNIUM MANAGEMENT LLC | 228,980228,980 | $8M | 0.26% | ADD 10% |
| 53 | 53Balyasny Asset Management L.P. | 208,345208,345 | $7M | 0.24% | TRIM -65% |
| 54 | 54Susquehanna Portfolio Strategies, LLC | 202,434202,434 | $7M | 0.23% | — |
| 55 | 55Woodline Partners LP | 201,667201,667 | $7M | 0.23% | — |
| 56 | 56Alyeska Investment Group, L.P. | 192,308192,308 | $6M | 0.22% | — |
| 57 | 57Connor, Clark & Lunn Investment Management Ltd. | 177,272177,272 | $6M | 0.20% | ADD 262% |
| 58 | 58UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 175,151175,151 | $6M | 0.20% | — |
| 59 | 59Man Group plc | 171,846171,846 | $6M | 0.20% | ADD 621% |
| 60 | 60WCM INVESTMENT MANAGEMENT, LLC | 181,593181,593 | $6M | 0.21% | TRIM -17% |
| 61 | 61SummitTX Capital, L.P. | 162,733162,733 | $5M | 0.19% | NEW |
| 62 | 62ROYAL BANK OF CANADA | 161,837161,837 | $5M | 0.18% | TRIM -2% |
| 63 | 63VICTORY CAPITAL MANAGEMENT INC | 157,270157,270 | $5M | 0.18% | TRIM -4% |
| 64 | 64Swiss National Bank | 155,600155,600 | $5M | 0.18% | — |
| 65 | 65Creative Planning | 145,028145,028 | $5M | 0.17% | ADD 7% |
| 66 | 66GREAT LAKES ADVISORS, LLC | 141,048141,048 | $5M | 0.16% | TRIM -6% |
| 67 | 67Russell Investments Group, Ltd. | 134,932134,932 | $4M | 0.15% | ADD 1293% |
| 68 | 68FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 122,064122,064 | $4M | 0.14% | ADD 8% |
| 69 | 69NEUBERGER BERMAN GROUP LLC | 120,603120,603 | $4M | 0.14% | ADD 8% |
| 70 | 70Atle Fund Management AB | 31,13331,133 | $4M | 0.04% | TRIM -68% |
| 71 | 71TWO SIGMA INVESTMENTS, LP | 119,116119,116 | $4M | 0.14% | ADD 5% |
| 72 | 72Tidal Investments LLC | 112,309112,309 | $4M | 0.13% | NEW |
| 73 | 73Tema ETFs LLC | 112,309112,309 | $4M | 0.13% | ADD 60% |
| 74 | 74Invesco Ltd. | 111,112111,112 | $4M | 0.13% | TRIM -53% |
| 75 | 75RHUMBLINE ADVISERS | 107,383107,383 | $4M | 0.12% | — |
| 76 | 76ALLIANCEBERNSTEIN L.P. | 100,786100,786 | $3M | 0.11% | ADD 3% |
| 77 | 77Squarepoint Ops LLC | 99,27899,278 | $3M | 0.11% | NEW |
| 78 | 78CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 96,65596,655 | $3M | 0.11% | ADD 27% |
| 79 | 79PLATINUM INVESTMENT MANAGEMENT LTD | 91,63791,637 | $3M | 0.10% | TRIM -24% |
| 80 | 80CITIGROUP INC | 88,88088,880 | $3M | 0.10% | TRIM -30% |
| 81 | 81JANE STREET GROUP, LLC | 88,13388,133 | $3M | 0.10% | NEW |
| 82 | 82Rafferty Asset Management, LLC | 86,68486,684 | $3M | 0.10% | TRIM -31% |
| 83 | 83Seven Fleet Capital Management LP | 86,28386,283 | $3M | 0.10% | NEW |
| 84 | 84SEI INVESTMENTS CO | 84,76084,760 | $3M | 0.10% | ADD 23% |
| 85 | 85KVP Capital Advisors, LP | 79,70079,700 | $3M | 0.09% | NEW |
| 86 | 86MANUFACTURERS LIFE INSURANCE COMPANY, THE | 72,90672,906 | $2M | 0.08% | ADD 4% |
| 87 | 87ALPS ADVISORS INC | 71,48771,487 | $2M | 0.08% | — |
| 88 | 88Legal & General Group Plc | 70,49270,492 | $2M | 0.08% | TRIM -16% |
| 89 | 89Mitsubishi UFJ Asset Management Co., Ltd. | 66,06666,066 | $2M | 0.08% | ADD 1173% |
| 90 | 90ASSETMARK, INC | 65,63265,632 | $2M | 0.07% | TRIM -9% |
| 91 | 91SCHRODER INVESTMENT MANAGEMENT GROUP | 65,94465,944 | $2M | 0.08% | TRIM -61% |
| 92 | 92MML INVESTORS SERVICES, LLC | 58,95058,950 | $2M | 0.07% | TRIM -30% |
| 93 | 93AlphaCore Capital LLC | 57,40657,406 | $2M | 0.07% | ADD 750% |
| 94 | 94XTX Topco Ltd | 56,62256,622 | $2M | 0.06% | TRIM -14% |
| 95 | 95Lido Advisors, LLC | 55,46355,463 | $2M | 0.06% | — |
| 96 | 96Y-Intercept (Hong Kong) Ltd | 54,61854,618 | $2M | 0.06% | TRIM -33% |
| 97 | 97VANGUARD ASSET MANAGEMENT, Ltd | 52,44052,440 | $2M | 0.06% | NEW |
| 98 | 98DekaBank Deutsche Girozentrale | 50,00050,000 | $2M | 0.06% | — |
| 99 | 99Orion Porfolio Solutions, LLC | 49,35749,357 | $2M | 0.06% | TRIM -15% |
| 100 | 100ACUTA CAPITAL PARTNERS, LLC | 48,23448,234 | $2M | 0.05% | NEW |
