| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Affinity Asset Advisors, LLC | 3,107,2003.1M | $6M | 6.25% | ADD 51% |
| 2 | Frazier Life Sciences Management, L.P. | 1,953,4672.0M | $4M | 3.93% | — |
| 3 | EcoR1 Capital, LLC | 1,583,0001.6M | $3M | 3.19% | TRIM -29% |
| 4 | MILLENNIUM MANAGEMENT LLC | 1,549,8501.5M | $3M | 3.12% | NEW† |
| 5 | Logos Global Management LP | 1,300,0001.3M | $2M | 2.62% | TRIM -35% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 1,088,2991.1M | $2M | 2.19% | NEW† |
| 7 | Balyasny Asset Management L.P. | 1,010,9551.0M | $2M | 2.03% | TRIM -8% |
| 8 | Ikarian Capital, LLC | 957,062957,062 | $2M | 1.93% | — |
| 9 | CITADEL ADVISORS LLC | 956,429956,429 | $2M | 1.93% | NEW |
| 10 | Sio Capital Management, LLC | 904,268904,268 | $2M | 1.82% | ADD 22% |
| 11 | MARSHALL WACE, LLP | 620,602620,602 | $1M | 1.25% | ADD 412% |
| 12 | ADAR1 Capital Management, LLC | 469,878469,878 | $892,768 | 0.95% | ADD 16% |
| 13 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 412,725412,725 | $784,178 | 0.83% | NEW |
| 14 | TWO SIGMA INVESTMENTS, LP | 408,858408,858 | $776,830 | 0.82% | TRIM -10% |
| 15 | Walleye Capital LLC | 388,554388,554 | $738,253 | 0.78% | ADD 96% |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 387,567387,567 | $736,602 | 0.78% | ADD 74% |
| 17 | NOESIS CAPITAL MANGEMENT CORP | 311,500311,500 | $591,850 | 0.63% | ADD 39% |
| 18 | BANK OF AMERICA CORP /DE/ | 290,413290,413 | $551,785 | 0.58% | ADD 151% |
| 19 | BOOTHBAY FUND MANAGEMENT, LLC | 254,412254,412 | $483,383 | 0.51% | — |
| 20 | SILVERARC CAPITAL MANAGEMENT, LLC | 226,000226,000 | $429,400 | 0.45% | ADD 113% |
| 21 | VANGUARD FIDUCIARY TRUST CO | 205,015205,015 | $389,529 | 0.41% | NEW |
| 22 | GOLDMAN SACHS GROUP INC | 200,212200,212 | $380,403 | 0.40% | NEW |
| 23 | DAFNA Capital Management LLC | 193,638193,638 | $367,912 | 0.39% | NEW |
| 24 | STATE STREET CORP | 141,199141,199 | $268,278 | 0.28% | ADD 94% |
| 25 | BlackRock, Inc. | 131,215131,215 | $249,309 | 0.26% | ADD 207% |
| 26 | NORTHERN TRUST CORP | 77,32477,324 | $146,916 | 0.16% | ADD 92% |
| 27 | Lynx1 Capital Management LP | 68,07668,076 | $129,344 | 0.14% | NEW |
| 28 | XTX Topco Ltd | 62,45162,451 | $118,657 | 0.13% | ADD 69% |
| 29 | Verdad Advisers, LP | 56,31856,318 | $107,004 | 0.11% | NEW |
| 30 | MORGAN STANLEY | 30,93730,937 | $58,780 | 0.06% | ADD 12% |
| 31 | PFG Investments, LLC | 20,00020,000 | $38,000 | 0.04% | TRIM -7% |
| 32 | Vanguard Personalized Indexing Management, LLC | 12,18012,180 | $23,142 | 0.02% | TRIM -2% |
| 33 | Scientech Research LLC | 11,40211,402 | $21,664 | 0.02% | NEW |
| 34 | Virtu Financial LLC | 10,82210,822 | $21,000 | 0.02% | NEW |
| 35 | Headlands Technologies LLC | 10,95010,950 | $20,805 | 0.02% | NEW |
| 36 | Vanguard Global Advisers, LLC | 5,4605,460 | $10,374 | 0.01% | NEW |
| 37 | ROYAL BANK OF CANADA | 3,8913,891 | $7,000 | 0.01% | NEW |
| 38 | UBS Group AG | 2,1732,173 | $4,129 | 0.00% | TRIM -98% |
| 39 | CITIGROUP INC | 1,3731,373 | $2,609 | 0.00% | TRIM -73% |
| 40 | Fortitude Family Office, LLC | 638638 | $1,212 | 0.00% | ADD 48% |
| 41 | OSAIC HOLDINGS, INC. | 584584 | $1,110 | 0.00% | ADD 52% |
| 42 | SHP Wealth Management | 6060 | $114 | 0.00% | — |
| 43 | Hillsdale Investment Management Inc. | 3232 | $61 | 0.00% | NEW |
| 44 | SBI Securities Co., Ltd. | 2222 | $42 | 0.00% | — |
| 45 | SOA Wealth Advisors, LLC. | 1313 | $25 | 0.00% | — |
| 46 | BNP PARIBAS FINANCIAL MARKETS | 55 | $10 | 0.00% | — |
| 47 | Activest Wealth Management | 44 | $8 | 0.00% | — |
| 48 | Financial Gravity Asset Management, Inc. | 22 | $4 | 0.00% | — |
| 49 | Caitong International Asset Management Co., Ltd | 22 | $4 | 0.00% | NEW |
| 50 | JPMORGAN CHASE & CO | 22 | $3 | 0.00% | — |
| 51 | WELLS FARGO & COMPANY/MN | 11 | $2 | 0.00% | — |
| 52 | Steward Partners Investment Advisory, LLC | 11 | $2 | 0.00% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Affinity Asset Advisors, LLC | — | — | — | — | 2.1M | 3.1M | $6M |
| Frazier Life Sciences Management, L.P. | — | — | — | — | 2.0M | 2.0M | $4M |
| EcoR1 Capital, LLC | — | — | — | — | 2.2M | 1.6M | $3M |
| MILLENNIUM MANAGEMENT LLC | — | — | — | — | — | 1.5M | $3M |
| Logos Global Management LP | — | — | — | — | 2.0M | 1.3M | $2M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 1.1M | $2M |
| Balyasny Asset Management L.P. | — | — | — | 10K | 1.1M | 1.0M | $2M |
| Ikarian Capital, LLC | 600K | 600K | 600K | 617K | 957K | 957K | $2M |
| CITADEL ADVISORS LLC | — | — | — | 132K | — | 956K | $2M |
| Sio Capital Management, LLC | — | — | — | — | 740K | 904K | $2M |
| MARSHALL WACE, LLP | — | — | — | — | 121K | 621K | $1M |
| ADAR1 Capital Management, LLC | 416K | — | 55K | 27K | 406K | 470K | $892,768 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | — | 32K | — | 44K | — | 413K | $784,178 |
| TWO SIGMA INVESTMENTS, LP | — | 13K | — | — | 456K | 409K | $776,830 |
| Walleye Capital LLC | — | — | — | — | 198K | 389K | $738,253 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 52 | 19,427,041 | 39.1% | $37M |
| 2025-Q4 | 50 | 16,339,468 |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| 32.9% |
| $32M |
| 2025-Q3 | 32 | 3,569,990 | 7.2% | $3M |
| 2025-Q2 | 30 | 3,204,109 | 6.4% | $2M |
| 2025-Q1 | 34 | 2,587,200 | 5.2% | $10M |
| 2024-Q4 | 30 | 2,612,410 | 5.3% | $6M |
| 2024-Q3 | 32 | 2,607,522 | 5.2% | $6M |
| 2024-Q2 | 28 | 2,691,920 | 5.4% | $6M |
| 2024-Q1 | 28 | 2,885,904 | 5.8% | $11M |
| 2023-Q4 | 21 | 251,805 | 0.5% | $345,056 |
| 2023-Q3 | 29 | 891,327 | 1.8% | $269,875 |
| 2023-Q2 | 29 | 1,140,342 | 2.3% | $695,661 |
| 2023-Q1 | 30 | 1,658,899 | 3.3% | $3M |
| 2022-Q4 | 38 | 2,304,231 | 4.6% | $990,467 |
| 2022-Q3 | 46 | 29,240,341 | 58.9% | $5M |
| 2022-Q2 | 57 | 28,918,644 | 58.2% | $8M |
| 2022-Q1 | 77 | 40,917,578 | 82.4% | $17M |
| 2021-Q4 | 83 | 46,873,379 | 94.4% | $26M |
| 2021-Q3 | 90 | 44,713,392 | 90.0% | $48M |
| 2021-Q2 | 87 | 43,387,579 | 87.3% | $66M |
| 2021-Q1 | 94 | 44,518,437 | 89.6% | $69M |
| 2020-Q4 | 92 | 31,430,425 | 63.3% | $33M |
| 2020-Q3 | 81 | 16,000,307 | 32.2% | $32M |
| 2020-Q2 | 61 | 10,210,904 | 20.6% | $23M |
| 2020-Q1 | 33 | 3,087,867 | 6.2% | $3M |
| 2019-Q4 | 16 | 1,350,565 | 2.7% | $337,000 |
| 2019-Q3 | 14 | 364,850 | 0.7% | $197,000 |
| 2019-Q2 | 15 | 332,088 | 0.7% | $234,000 |
| 2019-Q1 | 14 | 305,427 | 0.6% | $267,000 |
| 2018-Q4 | 17 | 278,804 | 0.6% | $209,000 |
| 2018-Q3 | 16 | 322,760 | 0.6% | $275,000 |
| 2018-Q2 | 12 | 436,739 | 0.9% | $393,000 |
| 2018-Q1 | 23 | 3,387,580 | 6.8% | $731,000 |
| 2017-Q4 | 17 | 2,873,534 | 5.8% | $510,000 |
| 2017-Q3 | 18 | 3,165,397 | 6.4% | $1M |
| 2017-Q2 | 20 | 3,004,767 | 6.0% | $1M |
| 2017-Q1 | 19 | 6,209,645 | 12.5% | $3M |
| 2016-Q4 | 20 | 6,039,374 | 12.2% | $2M |
| 2016-Q3 | 20 | 6,085,474 | 12.2% | $3M |
| 2016-Q2 | 19 | 2,913,199 | 5.9% | $2M |
| 2016-Q1 | 22 | 3,961,265 | 8.0% | $2M |
| 2015-Q4 | 21 | 3,859,504 | 7.8% | $2M |
| 2015-Q3 | 18 | 2,867,538 | 5.8% | $2M |
| 2015-Q2 | 19 | 2,714,599 | 5.5% | $3M |
| 2015-Q1 | 19 | 2,686,655 | 5.4% | $2M |
| 2014-Q4 | 24 | 2,910,240 | 5.9% | $2M |
| 2014-Q3 | 12 | 1,524,008 | 3.1% | $937,000 |
| 2014-Q2 | 14 | 1,382,155 | 2.8% | $580,502 |
| 2014-Q1 | 13 | 1,429,291 | 2.9% | $766,538 |
| 2013-Q4 | 15 | 1,051,808 | 2.1% | $349,407 |
| 2013-Q3 | 13 | 1,179,793 | 2.4% | $512,000 |
| 2013-Q2 | 13 | 1,336,239 | 2.7% | $563,000 |
