| 1 | 1Venrock Adviser, LLC | 3,851,6543.9M | $18M | 17.83% | — |
| 2 | 2ORBIMED ADVISORS LLC | 3,832,8433.8M | $18M | 17.74% | — |
| 3 | 3MILLENNIUM MANAGEMENT LLC | 2,415,8412.4M | $12M | 11.18% | ADD 135% |
| 4 | 4ACORN CAPITAL ADVISORS, LLC | 1,540,2661.5M | $7M | 7.13% | TRIM -2% |
| 5 | 5Rosalind Advisors, Inc. | 1,531,8141.5M | $7M | 7.09% | TRIM -8% |
| 6 | 6EVENTIDE ASSET MANAGEMENT, LLC | 1,410,8151.4M | $7M | 6.53% | ADD 12% |
| 7 | 7Deep Track Capital, LP | 1,313,1371.3M | $6M | 6.08% | TRIM -29% |
| 8 | 8MORGAN STANLEY | 1,025,3181.0M | $5M | 4.75% | TRIM -21% |
| 9 | 9SPHERA FUNDS MANAGEMENT LTD. | 987,090987,090 | $5M | 4.57% | ADD 20% |
| 10 | 10CITADEL ADVISORS LLC | 877,347877,347 | $4M | 4.06% | ADD 9% |
| 11 | 11ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000700,000 | $3M | 3.24% | — |
| 12 | 12DCF Advisers, LLC | 691,988691,988 | $3M | 3.20% | TRIM -11% |
| 13 | 13Boxer Capital Management, LLC | 640,000640,000 | $3M | 2.96% | TRIM -10% |
| 14 | 14DAFNA Capital Management LLC | 498,361498,361 | $2M | 2.31% | ADD 10% |
| 15 | 15Nan Fung Group Holdings Ltd | 460,000460,000 | $2M | 2.13% | — |
| 16 | 16Knott David M Jr | 350,000350,000 | $2M | 1.62% | ADD 23% |
| 17 | 17UBS Group AG | 238,302238,302 | $1M | 1.10% | — |
| 18 | 18AdvisorShares Investments LLC | 195,604195,604 | $938,899 | 0.91% | ADD 99% |
| 19 | 19HRT FINANCIAL LP | 187,052187,052 | $897,000 | 0.87% | NEW |
| 20 | 20ROYCE & ASSOCIATES LP | 155,050155,050 | $744,240 | 0.72% | NEW |
| 21 | 21Pale Fire Capital SE | 153,505153,505 | $736,824 | 0.71% | — |
| 22 | 22SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,925147,925 | $710,040 | 0.68% | TRIM -51% |
| 23 | 23Stonepine Capital Management, LLC | 134,060134,060 | $643,488 | 0.62% | TRIM -61% |
| 24 | 24Ikarian Capital, LLC | 132,153132,153 | $634,334 | 0.61% | — |
| 25 | 25JANE STREET GROUP, LLC | 106,349106,349 | $510,475 | 0.49% | ADD 7% |
| 26 | 26PEAK6 LLC | 62,59762,597 | $300,466 | 0.29% | TRIM -89% |
| 27 | 27GOLDMAN SACHS GROUP INC | 51,58851,588 | $247,622 | 0.24% | ADD 8% |
| 28 | 28Fore Capital, LLC | 36,42136,421 | $174,821 | 0.17% | TRIM -45% |
| 29 | 29ROYAL BANK OF CANADA | 31,59231,592 | $151,000 | 0.15% | TRIM -38% |
| 30 | 30ADAR1 Capital Management, LLC | 31,27831,278 | $150,134 | 0.14% | TRIM -87% |
| 31 | 31PDS Planning, Inc | 30,34430,344 | $145,499 | 0.14% | — |
| 32 | 32BOOTHBAY FUND MANAGEMENT, LLC | 29,40429,404 | $141,139 | 0.14% | — |
| 33 | 33BlackRock, Inc. | 29,12629,126 | $139,805 | 0.13% | ADD 15% |
| 34 | 34AXQ CAPITAL, LP | 29,11429,114 | $139,747 | 0.13% | NEW |
| 35 | 35OXFORD ASSET MANAGEMENT LLP | 22,27722,277 | $106,930 | 0.10% | NEW |
| 36 | 36Point72 Asset Management, L.P. | 19,68419,684 | $94,483 | 0.09% | TRIM -100% |
| 37 | 37Graham Capital Management, L.P. | 18,26318,263 | $87,662 | 0.08% | TRIM -49% |
| 38 | 38Formidable Asset Management, LLC | 10,64910,649 | $87,109 | 0.05% | NEW |
| 39 | 39Jump Financial, LLC | 18,00018,000 | $86,400 | 0.08% | NEW |
| 40 | 40Mitsubishi UFJ Asset Management (UK) Ltd. | 15,00015,000 | $72,000 | 0.07% | NEW |
| 41 | 41Tower Research Capital LLC (TRC) | 11,87311,873 | $56,990 | 0.05% | ADD 365% |
| 42 | 42Millington Financial Advisors, LLC | 10,00010,000 | $54,000 | 0.05% | NEW |
| 43 | 43GEODE CAPITAL MANAGEMENT, LLC | 10,90010,900 | $52,320 | 0.05% | NEW |
| 44 | 44Mayflower Financial Advisors, LLC | 10,29010,290 | $49,392 | 0.05% | NEW |
| 45 | 45Centiva Capital, LP | 10,00010,000 | $48,000 | 0.05% | NEW |
| 46 | 46China Universal Asset Management Co., Ltd. | 6,4006,400 | $30,720 | 0.03% | NEW |
| 47 | 47CITIGROUP INC | 5,9525,952 | $28,661 | 0.03% | NEW |
| 48 | 48Quent Capital, LLC | 4,4534,453 | $21,372 | 0.02% | NEW |
| 49 | 49NATIONAL BANK OF CANADA /FI/ | 5,1325,132 | $17,450 | 0.02% | TRIM -5% |
| 50 | 50GROUP ONE TRADING LLC | 3,4623,462 | $16,618 | 0.02% | TRIM -68% |
| 51 | 51North Star Investment Management Corp. | 3,3803,380 | $16,224 | 0.02% | ADD 35% |
| 52 | 52Federation des caisses Desjardins du Quebec | 3,1213,121 | $14,879 | 0.01% | — |
| 53 | 53OSAIC HOLDINGS, INC. | 2,9782,978 | $14,294 | 0.01% | — |
| 54 | 54IAG Wealth Partners, LLC | 2,7502,750 | $13,200 | 0.01% | — |
| 55 | 55Advisory Services Network, LLC | 2,0602,060 | $9,888 | 0.01% | NEW |
| 56 | 56JPMORGAN CHASE & CO | 2,2442,244 | $9,694 | 0.01% | TRIM -90% |
| 57 | 57BARCLAYS PLC | 862862 | $4,138 | 0.00% | — |
| 58 | 58Ancora Advisors LLC | 653653 | $3,134 | 0.00% | NEW |
| 59 | 59HARBOUR INVESTMENTS, INC. | 250250 | $1,200 | 0.00% | — |
| 60 | 60Farther Finance Advisors, LLC | 221221 | $1,103 | 0.00% | TRIM -11% |
| 61 | 61IFP Advisors, Inc | 200200 | $960 | 0.00% | — |
| 62 | 62Avalon Trust Co | 197197 | $946 | 0.00% | — |
| 63 | 63Atlantic Edge Private Wealth Management, LLC | 137137 | $658 | 0.00% | — |
| 64 | 64Tidemark, LLC | 131131 | $629 | 0.00% | — |
| 65 | 65AMERIFLEX GROUP, INC. | 131131 | $629 | 0.00% | — |
| 66 | 66TD Waterhouse Canada Inc. | 117117 | $580 | 0.00% | TRIM -94% |
| 67 | 67Hilton Head Capital Partners, LLC | 117117 | $562 | 0.00% | — |
| 68 | 68NVWM, LLC | 5959 | $283 | 0.00% | — |
| 69 | 69CENTRAL TRUST Co | 2626 | $125 | 0.00% | — |
| 70 | 70Westside Investment Management, Inc. | 2626 | $125 | 0.00% | — |
| 71 | 71City State Bank | 2525 | $120 | 0.00% | — |
| 72 | 72Allworth Financial LP | 2020 | $96 | 0.00% | — |
| 73 | 73McIlrath & Eck, LLC | 1010 | $48 | 0.00% | — |
| 74 | 74NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 77 | $34 | 0.00% | — |
| 75 | 75CNB Bank | 44 | $19 | 0.00% | — |
| 76 | 76CoreCap Advisors, LLC | 33 | $14 | 0.00% | — |
| 77 | 77Caitong International Asset Management Co., Ltd | 11 | $5 | 0.00% | NEW |
| 78 | 78MCGUIRE CAPITAL ADVISORS INC | 11 | $5 | 0.00% | — |
| 79 | 79FNY Investment Advisers, LLC | 100100 | $0 | 0.00% | — |
| 80 | 80TSFG, LLC | 22 | $0 | 0.00% | — |
