Gyre Therapeutics, Inc. (Nasdaq: GYRE), an SEC filer in Pharmaceutical Preparations, closed at $6.59, -1.3%, on 2026-08-28, with a market cap of $745M as of 2026-08-27, a trailing P/E of 334.0, a return on equity of 11.7%, a net margin of 8.5% and 3-year sales growth of 4.5%. Institutional ownership, earnings history and filed financials are on the tabs below.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | VANGUARD CAPITAL MANAGEMENT LLC | 984,204984,204 | $7M | 1.02% | NEW |
| 2 | BlackRock, Inc. | 758,630758,630 | $5M | 0.78% | ADD 5% |
| 3 | GEODE CAPITAL MANAGEMENT, LLC | 431,414431,414 | $3M | 0.44% | — |
| 4 | STATE STREET CORP | 216,326216,326 | $2M | 0.22% | ADD 7% |
| 5 | SBI Securities Co., Ltd. | 170,837170,837 | $1M | 0.18% | ADD 5% |
| 6 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 165,238165,238 | $1M | 0.17% | TRIM -2% |
| 7 | VANGUARD FIDUCIARY TRUST CO | 137,682137,682 | $959,644 | 0.14% | NEW |
| 8 | NORTHERN TRUST CORP | 133,841133,841 | $932,872 | 0.14% | ADD 4% |
| 9 | GOLDMAN SACHS GROUP INC | 73,12273,122 | $509,660 | 0.08% | ADD 135% |
| 10 | VANGUARD PORTFOLIO MANAGEMENT LLC | 69,81469,814 | $486,604 | 0.07% | NEW |
Ranked by each filer’s own reported value, not shares.
1 holder — The filer reported no value for this line, so it carries no dollar figure and is left out of the percentage and value columns.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | +984,204 | $7M | OPEN |
| VANGUARD FIDUCIARY TRUST CO | +137,682 | $959,644 | OPEN |
| VANGUARD PORTFOLIO MANAGEMENT LLC | +69,814 | $486,604 | OPEN |
| GOLDMAN SACHS GROUP INC | +42,014 | $292,838 | ADD |
| BlackRock, Inc. | +38,339 | $267,223 | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −1,201,589 | $8M | CLOSE |
| MORGAN STANLEY | −45,857 | $319,623 | TRIM |
| STATE OF WISCONSIN INVESTMENT BOARD | −24,800 | $172,856 | CLOSE |
| BARCLAYS PLC | −16,231 | $113,130 | TRIM |
| WELLS FARGO & COMPANY/MN | −8,629 | $60,144 | TRIM |
Prior quarter split-rebased · 13Fs are long, US-listed only.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 984K | $7M |
| BlackRock, Inc. | 532K | 547K | 843K | 659K | 720K | 759K | $5M |
| GEODE CAPITAL MANAGEMENT, LLC | 304K | 312K | 402K | 375K | 423K | 431K | $3M |
| STATE STREET CORP | 127K | 129K | 178K | 183K | 202K | 216K | $2M |
| SBI Securities Co., Ltd. | 101K | 124K | 232K | 168K | 163K | 171K | $1M |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 115K | 111K | 129K | 123K | 169K | 165K | $1M |
| VANGUARD FIDUCIARY TRUST CO | — | — | — | — | — | 138K | $959,644 |
| NORTHERN TRUST CORP | 103K | 108K | 143K | 116K | 129K | 134K | $932,872 |
| GOLDMAN SACHS GROUP INC | 26K | 16K | — | 18K | 31K | 73K | $509,660 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | — | — | — | — | — | 70K | $486,604 |
Green = added, red = trimmed, grey = held; a dash is a quarter with no 13F on file — a gap, not an exit.
Breaks = no 13F that quarter.
Short interest has its own tab now — open SI →
SEC Form 13F · ~10,250 filers, 10y · long-only, US-listed, filed ≤45d after quarter-end.
