| 1 | 1NEA Management Company, LLC | 7,692,2987.7M | $127M | 9.11% | — |
| 2 | 2PRICE T ROWE ASSOCIATES INC /MD/ | 6,720,1886.7M | $111M | 7.95% | ADD 31% |
| 3 | 3BlackRock, Inc. | 5,637,6845.6M | $93M | 6.67% | ADD 35% |
| 4 | 4TCG Crossover Management, LLC | 4,622,1514.6M | $76M | 5.47% | — |
| 5 | 5BVF INC/IL | 4,460,8864.5M | $73M | 5.28% | ADD 16% |
| 6 | 6BAKER BROS. ADVISORS LP | 4,345,7364.3M | $71M | 5.14% | — |
| 7 | 7SUVRETTA CAPITAL MANAGEMENT, LLC | 4,226,8094.2M | $70M | 5.00% | ADD 26% |
| 8 | 8Vestal Point Capital, LP | 3,603,4653.6M | $59M | 4.27% | ADD 365% |
| 9 | 9STATE STREET CORP | 3,353,9803.4M | $55M | 3.97% | ADD 59% |
| 10 | 10BRAIDWELL LP | 3,206,5743.2M | $53M | 3.80% | ADD 238% |
| 11 | 11Versant Venture Management, LLC | 3,180,7803.2M | $52M | 3.77% | TRIM -27% |
| 12 | 12VANGUARD CAPITAL MANAGEMENT LLC | 3,100,2453.1M | $51M | 3.67% | NEW† |
| 13 | 13AMERICAN CENTURY COMPANIES INC | 2,809,6472.8M | $46M | 3.33% | ADD 111% |
| 14 | 14SILVERARC CAPITAL MANAGEMENT, LLC | 2,002,0402.0M | $33M | 2.37% | ADD 95% |
| 15 | 15Aisling Capital Management LP | 1,555,6641.6M | $26M | 1.84% | ADD 6% |
| 16 | 16GEODE CAPITAL MANAGEMENT, LLC | 1,540,8121.5M | $25M | 1.82% | ADD 28% |
| 17 | 17MARSHALL WACE, LLP | 1,433,1521.4M | $24M | 1.70% | ADD 259% |
| 18 | 18Bellevue Group AG | 1,250,0001.3M | $21M | 1.48% | NEW |
| 19 | 19MPM BIOIMPACT LLC | 1,176,9281.2M | $19M | 1.39% | — |
| 20 | 20DIMENSIONAL FUND ADVISORS LP | 1,041,3721.0M | $17M | 1.23% | ADD 83% |
| 21 | 21FMR LLC | 1,024,3041.0M | $17M | 1.21% | TRIM -21% |
| 22 | 22GOLDMAN SACHS GROUP INC | 1,001,5271.0M | $16M | 1.19% | ADD 238% |
| 23 | 23Frazier Life Sciences Management, L.P. | 1,000,0001.0M | $16M | 1.18% | NEW |
| 24 | 24NORTHERN TRUST CORP | 826,624826,624 | $14M | 0.98% | ADD 19% |
| 25 | 25JANUS HENDERSON GROUP PLC | 685,926685,926 | $11M | 0.81% | NEW |
| 26 | 26Alphabet Inc. | 684,275684,275 | $11M | 0.81% | TRIM -8% |
| 27 | 27MORGAN STANLEY | 684,063684,063 | $11M | 0.81% | TRIM -15% |
| 28 | 28AQR CAPITAL MANAGEMENT LLC | 658,483658,483 | $11M | 0.78% | TRIM -16% |
| 29 | 29Nantahala Capital Management, LLC | 651,993651,993 | $11M | 0.77% | ADD 1024% |
| 30 | 30ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 647,739647,739 | $11M | 0.77% | ADD 111% |
| 31 | 31CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 546,689546,689 | $9M | 0.65% | ADD 22% |
| 32 | 32BRIDGEWAY CAPITAL MANAGEMENT, LLC | 528,698528,698 | $9M | 0.63% | — |
| 33 | 33VANGUARD PORTFOLIO MANAGEMENT LLC | 515,966515,966 | $8M | 0.61% | NEW |
| 34 | 34Parkwood LLC | 505,000505,000 | $8M | 0.60% | TRIM -29% |
| 35 | 35VANGUARD FIDUCIARY TRUST CO | 407,078407,078 | $7M | 0.48% | NEW |
| 36 | 36Cormorant Asset Management, LP | 400,000400,000 | $7M | 0.47% | NEW |
| 37 | 37Allspring Global Investments Holdings, LLC | 392,227392,227 | $6M | 0.46% | ADD 1355% |
| 38 | 38BANK OF AMERICA CORP /DE/ | 387,542387,542 | $6M | 0.46% | ADD 73% |
| 39 | 39RENAISSANCE TECHNOLOGIES LLC | 379,100379,100 | $6M | 0.45% | NEW |
| 40 | 40Fisher Asset Management, LLC | 314,862314,862 | $5M | 0.37% | NEW |
| 41 | 41Empowered Funds, LLC | 305,398305,398 | $5M | 0.36% | ADD 10% |
| 42 | 42Nextech Invest, Ltd. | 304,237304,237 | $5M | 0.36% | ADD 9% |
| 43 | 43TD Asset Management Inc | 286,978286,978 | $5M | 0.34% | ADD 34% |
| 44 | 44Balyasny Asset Management L.P. | 256,731256,731 | $4M | 0.30% | NEW |
| 45 | 45CITADEL ADVISORS LLC | 254,518254,518 | $4M | 0.30% | ADD 450% |
| 46 | 46ADAGE CAPITAL PARTNERS GP, L.L.C. | 250,000250,000 | $4M | 0.30% | NEW |
| 47 | 47ADAR1 Capital Management, LLC | 215,752215,752 | $4M | 0.26% | — |
| 48 | 48MANUFACTURERS LIFE INSURANCE COMPANY, THE | 209,801209,801 | $3M | 0.25% | ADD 56% |
| 49 | 49Bank of New York Mellon Corp | 204,687204,687 | $3M | 0.24% | ADD 18% |
| 50 | 50NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 200,000200,000 | $3M | 0.24% | — |
| 51 | 51FRANKLIN RESOURCES INC | 199,722199,722 | $3M | 0.24% | ADD 134% |
| 52 | 52Atom Investors LP | 194,476194,476 | $3M | 0.23% | ADD 42% |
| 53 | 53MILLENNIUM MANAGEMENT LLC | 191,382191,382 | $3M | 0.23% | ADD 84% |
| 54 | 54DIADEMA PARTNERS LP | 187,307187,307 | $3M | 0.22% | ADD 201% |
| 55 | 55Casdin Capital, LLC | 186,014186,014 | $3M | 0.22% | ADD 116% |
| 56 | 56Jump Financial, LLC | 184,522184,522 | $3M | 0.22% | NEW |
| 57 | 57Exome Asset Management LLC | 179,484179,484 | $3M | 0.21% | NEW |
| 58 | 58J. Goldman & Co LP | 171,771171,771 | $3M | 0.20% | ADD 432% |
| 59 | 59VICTORY CAPITAL MANAGEMENT INC | 154,658154,658 | $3M | 0.18% | NEW |
| 60 | 60UBS Group AG | 152,620152,620 | $3M | 0.18% | ADD 24% |
| 61 | 61Informed Momentum Co LLC | 130,246130,246 | $2M | 0.15% | ADD 86% |
| 62 | 62WELLINGTON MANAGEMENT GROUP LLP | 128,792128,792 | $2M | 0.15% | TRIM -13% |
| 63 | 63Nuveen, LLC | 120,872120,872 | $2M | 0.14% | TRIM -58% |
| 64 | 64Rafferty Asset Management, LLC | 104,621104,621 | $2M | 0.12% | ADD 55% |
| 65 | 65Invesco Ltd. | 102,197102,197 | $2M | 0.12% | TRIM -72% |
| 66 | 66OpenArc Corporate Advisory, LLC | 100,227100,227 | $2M | 0.12% | NEW |
| 67 | 67VOYA INVESTMENT MANAGEMENT LLC | 82,33982,339 | $1M | 0.10% | ADD 212% |
| 68 | 68ACADIAN ASSET MANAGEMENT LLC | 78,51378,513 | $1M | 0.09% | TRIM -68% |
| 69 | 69SEI INVESTMENTS CO | 77,68177,681 | $1M | 0.09% | ADD 30% |
| 70 | 70RHUMBLINE ADVISERS | 76,40876,408 | $1M | 0.09% | ADD 24% |
| 71 | 71Woodline Partners LP | 74,49674,496 | $1M | 0.09% | NEW |
| 72 | 72STATE OF WISCONSIN INVESTMENT BOARD | 74,19774,197 | $1M | 0.09% | ADD 278% |
| 73 | 73D. E. Shaw & Co., Inc. | 66,32766,327 | $1M | 0.08% | TRIM -22% |
| 74 | 74JPMORGAN CHASE & CO | 67,53667,536 | $1M | 0.08% | ADD 180% |
| 75 | 75HUSSMAN STRATEGIC ADVISORS, INC. | 63,00063,000 | $1M | 0.07% | NEW |
| 76 | 76IEQ CAPITAL, LLC | 62,70362,703 | $1M | 0.07% | TRIM -30% |
| 77 | 77Swiss National Bank | 61,10061,100 | $1M | 0.07% | NEW |
| 78 | 78XTX Topco Ltd | 57,75957,759 | $950,136 | 0.07% | ADD 86% |
| 79 | 79MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 56,49156,491 | $929,277 | 0.07% | ADD 14% |
| 80 | 80PRUDENTIAL FINANCIAL INC | 56,28056,280 | $925,806 | 0.07% | NEW |
| 81 | 81Quantinno Capital Management LP | 54,00354,003 | $888,349 | 0.06% | ADD 61% |
| 82 | 82ALLIANCEBERNSTEIN L.P. | 55,70055,700 | $873,376 | 0.07% | TRIM -12% |
| 83 | 83Trexquant Investment LP | 49,17949,179 | $808,995 | 0.06% | TRIM -67% |
| 84 | 84DEUTSCHE BANK AG\ | 47,86247,862 | $787,330 | 0.06% | ADD 45% |
| 85 | 85Persistent Asset Partners Ltd | 47,50047,500 | $781,375 | 0.06% | ADD 114% |
| 86 | 86PROFUND ADVISORS LLC | 46,68446,684 | $767,952 | 0.06% | ADD 85% |
| 87 | 87BNP PARIBAS FINANCIAL MARKETS | 45,06345,063 | $741,286 | 0.05% | ADD 691% |
| 88 | 88SEVEN GRAND MANAGERS, LLC | 45,00045,000 | $740,250 | 0.05% | NEW |
| 89 | 89Aquatic Capital Management LLC | 44,87544,875 | $738,194 | 0.05% | ADD 45% |
| 90 | 90PRELUDE CAPITAL MANAGEMENT, LLC | 43,47343,473 | $715,131 | 0.05% | NEW |
| 91 | 91STRS OHIO | 42,70042,700 | $702,415 | 0.05% | ADD 18% |
| 92 | 92PRINCIPAL FINANCIAL GROUP INC | 42,39142,391 | $697,332 | 0.05% | NEW |
| 93 | 93Round Rock Advisors LLC | 37,22937,229 | $612,417 | 0.04% | NEW |
| 94 | 94Squarepoint Ops LLC | 37,10737,107 | $610,410 | 0.04% | ADD 270% |
| 95 | 95Vanguard Global Advisers, LLC | 35,99835,998 | $592,167 | 0.04% | NEW |
| 96 | 96AMERIPRISE FINANCIAL INC | 35,99735,997 | $592,151 | 0.04% | TRIM -71% |
| 97 | 97MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,79535,795 | $582,008 | 0.04% | ADD 40% |
| 98 | 98MetLife Investment Management, LLC | 33,40933,409 | $549,578 | 0.04% | ADD 28% |
| 99 | 99KENNEDY CAPITAL MANAGEMENT LLC | 31,97731,977 | $526,022 | 0.04% | NEW |
| 100 | 100ADVISORY RESEARCH INC | 31,23631,236 | $513,832 | 0.04% | TRIM -51% |