| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Flagship Pioneering, LLC | 62,673,11762.7M | $783M | 48.89% | NEW† |
| 2 | FMR LLC | 4,217,5244.2M | $53M | 3.29% | NEW† |
| 3 | Capital World Investors | 4,004,1494.0M | $50M | 3.12% | NEW† |
| 4 | BRAIDWELL LP | 3,592,9993.6M | $45M | 2.80% | NEW† |
| 5 | JPMORGAN CHASE & CO | 2,947,2592.9M | $34M | 2.30% | NEW† |
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,109,6332.1M | $26M | 1.65% | NEW |
| 7 | ARCH Venture Management, LLC | 1,944,4261.9M | $24M | 1.52% | NEW |
| 8 | HarbourVest Partners LLC | 1,722,2101.7M | $22M | 1.34% | NEW |
| 9 | BAKER BROS. ADVISORS LP | 1,423,6021.4M | $18M | 1.11% | NEW |
| 10 | HARVARD MANAGEMENT CO INC | 1,111,1001.1M | $14M | 0.87% | NEW |
| 11 | NVIDIA CORP | 833,325833,325 | $10M | 0.65% | NEW |
| 12 | Siren, L.L.C. | 736,104736,104 | $9M | 0.57% | NEW |
| 13 | Davern Capital Partners, LP | 591,800591,800 | $7M | 0.46% | NEW |
| 14 | Alyeska Investment Group, L.P. | 500,000500,000 | $6M | 0.39% | NEW |
| 15 | ARK Investment Management LLC | 498,408498,408 | $6M | 0.39% | NEW |
| 16 | MILLENNIUM MANAGEMENT LLC | 376,893376,893 | $5M | 0.29% | NEW |
| 17 | UBS Group AG | 356,704356,704 | $4M | 0.28% | NEW |
| 18 | Affinity Asset Advisors, LLC | 350,000350,000 | $4M | 0.27% | NEW |
| 19 | MORGAN STANLEY | 337,302337,302 | $4M | 0.26% | NEW |
| 20 | ExodusPoint Capital Management, LP | 311,986311,986 | $4M | 0.24% | NEW |
| 21 | CenterBook Partners LP | 266,813266,813 | $3M | 0.21% | NEW |
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 185,000185,000 | $2M | 0.14% | NEW |
| 23 | GOLDMAN SACHS GROUP INC | 170,695170,695 | $2M | 0.13% | NEW |
| 24 | VANGUARD CAPITAL MANAGEMENT LLC | 131,319131,319 | $2M | 0.10% | NEW |
| 25 | SEVEN GRAND MANAGERS, LLC | 125,000125,000 | $2M | 0.10% | NEW |
| 26 | JANE STREET GROUP, LLC | 123,371123,371 | $2M | 0.10% | NEW |
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 118,243118,243 | $1M | 0.09% | NEW |
| 28 | LMR Partners LLP | 100,000100,000 | $1M | 0.08% | NEW |
| 29 | SILVERARC CAPITAL MANAGEMENT, LLC | 100,000100,000 | $1M | 0.08% | NEW |
| 30 | D. E. Shaw & Co., Inc. | 95,00095,000 | $1M | 0.07% | NEW |
| 31 | AMERIPRISE FINANCIAL INC | 87,33587,335 | $1M | 0.07% | NEW |
| 32 | Balyasny Asset Management L.P. | 79,48979,489 | $993,613 | 0.06% | NEW |
| 33 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 74,31274,312 | $928,900 | 0.06% | NEW |
| 34 | BARCLAYS PLC | 70,89470,894 | $886,175 | 0.06% | NEW |
| 35 | HRT FINANCIAL LP | 58,76258,762 | $734,000 | 0.05% | NEW |
| 36 | Qube Research & Technologies Ltd | 50,22150,221 | $627,763 | 0.04% | NEW |
| 37 | TD Asset Management Inc | 42,86642,866 | $535,825 | 0.03% | NEW |
| 38 | Sumitomo Mitsui Trust Group, Inc. | 40,34440,344 | $504,300 | 0.03% | NEW |
| 39 | Amova Asset Management Americas, Inc. | 40,34440,344 | $499,459 | 0.03% | NEW |
| 40 | Squarepoint Ops LLC | 37,20337,203 | $465,038 | 0.03% | NEW |
| 41 | BANK OF AMERICA CORP /DE/ | 34,19634,196 | $427,450 | 0.03% | NEW |
| 42 | FEDERATED HERMES, INC. | 30,00030,000 | $375,000 | 0.02% | NEW |
| 43 | TUDOR INVESTMENT CORP ET AL | 23,83323,833 | $297,913 | 0.02% | NEW |
| 44 | IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 19,20319,203 | $240,038 | 0.01% | NEW |
| 45 | Y-Intercept (Hong Kong) Ltd | 18,36218,362 | $229,525 | 0.01% | NEW |
| 46 | VANGUARD FIDUCIARY TRUST CO | 17,45617,456 | $218,200 | 0.01% | NEW |
| 47 | Hudson Bay Capital Management LP | 16,67816,678 | $208,475 | 0.01% | NEW |
| 48 | Diametric Capital, LP | 10,49710,497 | $131,212 | 0.01% | NEW |
| 49 | Parallel Advisors, LLC | 5,5505,550 | $69,375 | 0.00% | NEW |
| 50 | ALBION FINANCIAL GROUP /UT | 4,8544,854 | $60,675 | 0.00% | NEW |
| 51 | FNY Investment Advisers, LLC | 3,0003,000 | $37,000 | 0.00% | NEW |
| 52 | CITIGROUP INC | 2,2442,244 | $28,050 | 0.00% | NEW |
| 53 | Vanguard Global Advisers, LLC | 1,2251,225 | $15,313 | 0.00% | NEW |
| 54 | WELLS FARGO & COMPANY/MN | 1,2001,200 | $15,000 | 0.00% | NEW |
| 55 | ROYAL BANK OF CANADA | 231231 | $3,000 | 0.00% | NEW |
| 56 | Avion Wealth | 100100 | $1,000 | 0.00% | NEW |
| 57 | Tower Research Capital LLC (TRC) | 11 | $12 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Flagship Pioneering, LLC | — | — | — | — | — | 62.7M | $783M |
| FMR LLC | — | — | — | — | — | 4.2M | $53M |
| Capital World Investors | — | — | — | — | — | 4.0M | $50M |
| BRAIDWELL LP | — | — | — | — | — | 3.6M | $45M |
| JPMORGAN CHASE & CO | — | — | — | — | — | 2.9M | $34M |
| PRICE T ROWE ASSOCIATES INC /MD/ | — | — | — | — | — | 2.1M | $26M |
| ARCH Venture Management, LLC | — | — | — | — | — | 1.9M | $24M |
| HarbourVest Partners LLC | — | — | — | — | — | 1.7M | $22M |
| BAKER BROS. ADVISORS LP | — | — | — | — | — | 1.4M | $18M |
| HARVARD MANAGEMENT CO INC | — | — | — | — | — | 1.1M | $14M |
| NVIDIA CORP | — | — | — | — | — | 833K | $10M |
| Siren, L.L.C. | — | — | — | — | — | 736K | $9M |
| Davern Capital Partners, LP | — | — | — | — | — | 592K | $7M |
| Alyeska Investment Group, L.P. | — | — | — | — | — | 500K | $6M |
| ARK Investment Management LLC | — | — | — | — | — | 498K | $6M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
