| 1 | 1JANUS HENDERSON GROUP PLC | 5,247,1515.2M | $49M | 10.54% | ADD 13% |
| 2 | 2RA CAPITAL MANAGEMENT, L.P. | 5,049,7795.0M | $47M | 10.14% | TRIM -11% |
| 3 | 3GOLDMAN SACHS GROUP INC | 4,205,4384.2M | $39M | 8.45% | TRIM -2% |
| 4 | 4BlackRock, Inc. | 4,145,3034.1M | $39M | 8.33% | — |
| 5 | 5NOVO HOLDINGS A/S | 3,650,7373.7M | $34M | 7.33% | — |
| 6 | 6BVF INC/IL | 2,879,2892.9M | $27M | 5.78% | TRIM -38% |
| 7 | 7STATE STREET CORP | 2,707,8752.7M | $25M | 5.44% | — |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 2,195,5782.2M | $20M | 4.41% | NEW† |
| 9 | 9ARMISTICE CAPITAL, LLC | 2,000,0002.0M | $19M | 4.02% | ADD 3% |
| 10 | 10ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,605,1561.6M | $15M | 3.22% | ADD 30% |
| 11 | 11FEDERATED HERMES, INC. | 1,432,2601.4M | $13M | 2.88% | TRIM -11% |
| 12 | 12Trails Edge Capital Partners, LP | 1,302,9171.3M | $12M | 2.62% | NEW† |
| 13 | 13GEODE CAPITAL MANAGEMENT, LLC | 1,065,3451.1M | $10M | 2.14% | ADD 5% |
| 14 | 14BANK OF AMERICA CORP /DE/ | 974,173974,173 | $9M | 1.96% | ADD 17% |
| 15 | 15Evergreen Quality Fund GP, Ltd. | 951,474951,474 | $9M | 1.91% | — |
| 16 | 16DEUTSCHE BANK AG\ | 708,044708,044 | $7M | 1.42% | — |
| 17 | 17RENAISSANCE TECHNOLOGIES LLC | 578,265578,265 | $5M | 1.16% | ADD 13% |
| 18 | 18Nuveen, LLC | 561,805561,805 | $5M | 1.13% | ADD 254% |
| 19 | 19VANGUARD PORTFOLIO MANAGEMENT LLC | 555,829555,829 | $5M | 1.12% | NEW |
| 20 | 20Parkman Healthcare Partners LLC | 522,577522,577 | $5M | 1.05% | ADD 4% |
| 21 | 21DIMENSIONAL FUND ADVISORS LP | 522,823522,823 | $5M | 1.05% | ADD 77% |
| 22 | 22RTW INVESTMENTS, LP | 475,737475,737 | $4M | 0.96% | — |
| 23 | 23Propel Bio Management, LLC | 380,420380,420 | $4M | 0.76% | NEW |
| 24 | 24JPMORGAN CHASE & CO | 415,655415,655 | $4M | 0.84% | ADD 49% |
| 25 | 25MORGAN STANLEY | 345,410345,410 | $3M | 0.69% | TRIM -49% |
| 26 | 26NORTHERN TRUST CORP | 342,034342,034 | $3M | 0.69% | ADD 9% |
| 27 | 27CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 328,379328,379 | $3M | 0.66% | TRIM -7% |
| 28 | 28Invesco Ltd. | 310,684310,684 | $3M | 0.62% | ADD 103% |
| 29 | 29Burkehill Global Management, LP | 275,000275,000 | $3M | 0.55% | — |
| 30 | 30VANGUARD FIDUCIARY TRUST CO | 269,295269,295 | $3M | 0.54% | NEW |
| 31 | 31RAYMOND JAMES FINANCIAL INC | 266,147266,147 | $2M | 0.53% | TRIM -44% |
| 32 | 32CITADEL ADVISORS LLC | 264,096264,096 | $2M | 0.53% | ADD 1228% |
| 33 | 33ACUTA CAPITAL PARTNERS, LLC | 242,255242,255 | $2M | 0.49% | NEW |
| 34 | 34Peapod Lane Capital LLC | 241,480241,480 | $2M | 0.49% | TRIM -10% |
| 35 | 35ArrowMark Colorado Holdings LLC | 202,864202,864 | $2M | 0.41% | TRIM -58% |
| 36 | 36Woodline Partners LP | 200,001200,001 | $2M | 0.40% | — |
| 37 | 37Privium Fund Management B.V. | 170,256170,256 | $2M | 0.34% | TRIM -19% |
| 38 | 38UBS Group AG | 158,120158,120 | $1M | 0.32% | TRIM -32% |
| 39 | 39Perigon Wealth Management, LLC | 146,197146,197 | $1M | 0.29% | — |
| 40 | 40Bank of New York Mellon Corp | 133,607133,607 | $1M | 0.27% | TRIM -2% |
| 41 | 41Exome Asset Management LLC | 130,564130,564 | $1M | 0.26% | NEW |
| 42 | 42TWO SIGMA INVESTMENTS, LP | 124,317124,317 | $1M | 0.25% | TRIM -63% |
| 43 | 43SUSQUEHANNA INTERNATIONAL GROUP, LLP | 124,228124,228 | $1M | 0.25% | — |
| 44 | 44ADAR1 Capital Management, LLC | 116,712116,712 | $1M | 0.23% | — |
| 45 | 45Opaleye Management Inc. | 112,291112,291 | $1M | 0.23% | NEW |
| 46 | 46WELLINGTON MANAGEMENT GROUP LLP | 108,872108,872 | $1M | 0.22% | TRIM -16% |
| 47 | 47AMERICAN CENTURY COMPANIES INC | 101,511101,511 | $945,067 | 0.20% | ADD 11% |
| 48 | 48Schonfeld Strategic Advisors LLC | 101,110101,110 | $941,332 | 0.20% | TRIM -38% |
| 49 | 49XTX Topco Ltd | 83,40583,405 | $776,501 | 0.17% | ADD 28% |
| 50 | 50Assenagon Asset Management S.A. | 83,33383,333 | $775,830 | 0.17% | TRIM -72% |
| 51 | 51Rafferty Asset Management, LLC | 71,39671,396 | $664,697 | 0.14% | TRIM -14% |
| 52 | 52Simplify Asset Management Inc. | 70,43070,430 | $655,703 | 0.14% | NEW |
| 53 | 53FMR LLC | 70,09770,097 | $652,598 | 0.14% | ADD 7% |
| 54 | 54Squarepoint Ops LLC | 62,51362,513 | $581,996 | 0.13% | TRIM -13% |
| 55 | 55RHUMBLINE ADVISERS | 54,10154,101 | $503,671 | 0.11% | — |
| 56 | 56BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,00050,000 | $465,500 | 0.10% | — |
| 57 | 57PANAGORA ASSET MANAGEMENT INC | 47,32847,328 | $440,624 | 0.10% | — |
| 58 | 58AQR CAPITAL MANAGEMENT LLC | 45,77745,777 | $426,183 | 0.09% | ADD 27% |
| 59 | 59VOYA INVESTMENT MANAGEMENT LLC | 45,35945,359 | $422,293 | 0.09% | NEW |
| 60 | 60ALLIANCEBERNSTEIN L.P. | 55,10055,100 | $413,250 | 0.11% | — |
| 61 | 61Quantinno Capital Management LP | 43,52543,525 | $405,218 | 0.09% | TRIM -6% |
| 62 | 62PRICE T ROWE ASSOCIATES INC /MD/ | 42,44742,447 | $396,000 | 0.09% | ADD 10% |
| 63 | 63JANE STREET GROUP, LLC | 39,69439,694 | $369,551 | 0.08% | TRIM -82% |
| 64 | 64Quadrature Capital Ltd | 32,52432,524 | $302,798 | 0.07% | NEW |
| 65 | 65Vanguard Global Advisers, LLC | 32,24832,248 | $300,229 | 0.06% | NEW |
| 66 | 66PROFUND ADVISORS LLC | 31,91131,911 | $297,091 | 0.06% | ADD 3% |
| 67 | 67Rangeley Capital, LLC | 31,46531,465 | $292,939 | 0.06% | TRIM -19% |
| 68 | 68Engineers Gate Manager LP | 29,40029,400 | $273,714 | 0.06% | TRIM -60% |
| 69 | 69Creative Planning | 29,16029,160 | $271,480 | 0.06% | TRIM -34% |
| 70 | 70Man Group plc | 28,98328,983 | $269,832 | 0.06% | ADD 7% |
| 71 | 71Susquehanna Portfolio Strategies, LLC | 28,49628,496 | $265,298 | 0.06% | ADD 176% |
| 72 | 72COMMONWEALTH EQUITY SERVICES, LLC | 28,27428,274 | $263,230 | 0.06% | ADD 41% |
| 73 | 73DekaBank Deutsche Girozentrale | 30,00030,000 | $261,000 | 0.06% | — |
| 74 | 74LOS ANGELES CAPITAL MANAGEMENT LLC | 27,58927,589 | $256,854 | 0.06% | ADD 145% |
| 75 | 75Virtu Financial LLC | 26,36826,368 | $245,000 | 0.05% | NEW |
| 76 | 76CITIGROUP INC | 26,18026,180 | $243,736 | 0.05% | ADD 107% |
| 77 | 77BARCLAYS PLC | 25,43725,437 | $236,818 | 0.05% | TRIM -85% |
| 78 | 78Y-Intercept (Hong Kong) Ltd | 25,42025,420 | $236,660 | 0.05% | NEW |
| 79 | 79MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 25,80925,809 | $236,539 | 0.05% | ADD 10% |
| 80 | 80Virtus Investment Advisers, LLC | 25,15425,154 | $234,184 | 0.05% | ADD 2% |
| 81 | 81STRS OHIO | 25,10025,100 | $233,681 | 0.05% | — |
| 82 | 82Peloton Wealth Strategists | 25,00025,000 | $233,000 | 0.05% | — |
| 83 | 83TRUIST FINANCIAL CORP | 25,00025,000 | $232,750 | 0.05% | — |
| 84 | 84MetLife Investment Management, LLC | 24,60124,601 | $229,035 | 0.05% | — |
| 85 | 85Kera Capital Partners, Inc. | 24,06824,068 | $224,073 | 0.05% | — |
| 86 | 86D. E. Shaw & Co., Inc. | 24,03024,030 | $223,719 | 0.05% | TRIM -79% |
| 87 | 87Mitsubishi UFJ Asset Management Co., Ltd. | 23,27023,270 | $216,644 | 0.05% | TRIM -2% |
| 88 | 88STATE OF WISCONSIN INVESTMENT BOARD | 22,95622,956 | $213,720 | 0.05% | NEW |
| 89 | 89SIMPLEX TRADING, LLC | 21,66021,660 | $201,654 | 0.04% | NEW |
| 90 | 90EntryPoint Capital, LLC | 21,60221,602 | $201,115 | 0.04% | TRIM -3% |
| 91 | 91ACADIAN ASSET MANAGEMENT LLC | 20,10920,109 | $186,000 | 0.04% | TRIM -33% |
| 92 | 92Landing Point Financial Group, LLC | 19,00019,000 | $176,890 | 0.04% | — |
| 93 | 93WELLS FARGO & COMPANY/MN | 18,30918,309 | $170,457 | 0.04% | TRIM -61% |
| 94 | 94Parallel Advisors, LLC | 17,88717,887 | $166,528 | 0.04% | — |
| 95 | 95Rockefeller Capital Management L.P. | 17,85417,854 | $166,221 | 0.04% | — |
| 96 | 96MARSHALL WACE, LLP | 16,72816,728 | $155,738 | 0.03% | TRIM -40% |
| 97 | 97Ballentine Partners, LLC | 16,35916,359 | $152,302 | 0.03% | — |
| 98 | 98Headlands Technologies LLC | 15,95615,956 | $148,550 | 0.03% | NEW |
| 99 | 99ExodusPoint Capital Management, LP | 15,52915,529 | $144,575 | 0.03% | TRIM -60% |
| 100 | 100BNP PARIBAS FINANCIAL MARKETS | 13,28313,283 | $123,665 | 0.03% | ADD 121% |