| 1 | 1FEDERATED HERMES, INC. | 1,765,5161.8M | $46M | 12.71% | — |
| 2 | 2FRED ALGER MANAGEMENT, LLC | 1,273,9651.3M | $33M | 9.17% | TRIM -13% |
| 3 | 3ORBIMED ADVISORS LLC | 1,196,9551.2M | $31M | 8.62% | — |
| 4 | 4JANUS HENDERSON GROUP PLC | 1,188,0601.2M | $31M | 8.56% | TRIM -17% |
| 5 | 5Affinity Asset Advisors, LLC | 1,011,8901.0M | $26M | 7.29% | ADD 2% |
| 6 | 6MPM BIOIMPACT LLC | 1,000,6821.0M | $26M | 7.21% | NEW† |
| 7 | 7ADAGE CAPITAL PARTNERS GP, L.L.C. | 950,000950,000 | $25M | 6.84% | ADD 185% |
| 8 | 8VANGUARD CAPITAL MANAGEMENT LLC | 531,692531,692 | $14M | 3.83% | NEW† |
| 9 | 9MORGAN STANLEY | 500,298500,298 | $13M | 3.60% | ADD 609% |
| 10 | 10Cable Car Capital, LP | 400,000400,000 | $10M | 2.88% | — |
| 11 | 11FMR LLC | 340,695340,695 | $9M | 2.45% | ADD 10% |
| 12 | 12MILLENNIUM MANAGEMENT LLC | 337,983337,983 | $9M | 2.43% | ADD 37% |
| 13 | 13Woodline Partners LP | 331,987331,987 | $9M | 2.39% | — |
| 14 | 14CITADEL ADVISORS LLC | 233,369233,369 | $6M | 1.68% | NEW |
| 15 | 15AWM Investment Company, Inc. | 200,000200,000 | $5M | 1.44% | TRIM -16% |
| 16 | 16SPHERA FUNDS MANAGEMENT LTD. | 184,984184,984 | $5M | 1.33% | — |
| 17 | 17MARSHALL WACE, LLP | 150,307150,307 | $4M | 1.08% | ADD 314% |
| 18 | 18Integral Health Asset Management, LLC | 150,000150,000 | $4M | 1.08% | NEW |
| 19 | 19SUSQUEHANNA INTERNATIONAL GROUP, LLP | 133,494133,494 | $3M | 0.96% | ADD 152% |
| 20 | 20GEODE CAPITAL MANAGEMENT, LLC | 125,442125,442 | $3M | 0.90% | — |
| 21 | 21Ikarian Capital, LLC | 118,972118,972 | $3M | 0.86% | TRIM -60% |
| 22 | 22STEMPOINT CAPITAL LP | 116,040116,040 | $3M | 0.84% | NEW |
| 23 | 23LORD, ABBETT & CO. LLC | 114,635114,635 | $3M | 0.83% | NEW |
| 24 | 24AMERIPRISE FINANCIAL INC | 111,788111,788 | $3M | 0.81% | TRIM -27% |
| 25 | 25Russell Investments Group, Ltd. | 91,77291,772 | $2M | 0.66% | NEW |
| 26 | 26Qube Research & Technologies Ltd | 85,96985,969 | $2M | 0.62% | ADD 167% |
| 27 | 27Candriam S.C.A. | 84,80384,803 | $2M | 0.61% | NEW |
| 28 | 28Trexquant Investment LP | 73,65173,651 | $2M | 0.53% | ADD 470% |
| 29 | 29VANGUARD FIDUCIARY TRUST CO | 72,09572,095 | $2M | 0.52% | NEW |
| 30 | 30BlackRock, Inc. | 65,92165,921 | $2M | 0.47% | ADD 2% |
| 31 | 31JANE STREET GROUP, LLC | 57,93357,933 | $2M | 0.42% | ADD 594% |
| 32 | 32STATE STREET CORP | 54,82154,821 | $1M | 0.39% | ADD 8% |
| 33 | 33J. Goldman & Co LP | 54,17454,174 | $1M | 0.39% | TRIM -11% |
| 34 | 34GOLDMAN SACHS GROUP INC | 53,47353,473 | $1M | 0.39% | TRIM -21% |
| 35 | 35WELLINGTON MANAGEMENT GROUP LLP | 29,49129,491 | $763,817 | 0.21% | NEW |
| 36 | 36ENVESTNET ASSET MANAGEMENT INC | 28,69728,697 | $743,252 | 0.21% | ADD 47% |
| 37 | 37MANGROVE PARTNERS IM, LLC | 25,70625,706 | $665,785 | 0.19% | NEW |
| 38 | 38Weil Company, Inc. | 24,76524,765 | $641,414 | 0.18% | NEW |
| 39 | 39NORTHERN TRUST CORP | 23,71223,712 | $614,141 | 0.17% | TRIM -7% |
| 40 | 40BANK OF AMERICA CORP /DE/ | 21,60621,606 | $559,595 | 0.16% | ADD 444% |
| 41 | 41Squarepoint Ops LLC | 20,75520,755 | $537,555 | 0.15% | NEW |
| 42 | 42UBS Group AG | 20,45020,450 | $529,655 | 0.15% | TRIM -18% |
| 43 | 43683 Capital Management, LLC | 20,00020,000 | $518,000 | 0.14% | TRIM -50% |
| 44 | 44Hudson Bay Capital Management LP | 19,08319,083 | $494,250 | 0.14% | ADD 15% |
| 45 | 45Balyasny Asset Management L.P. | 18,71718,717 | $484,770 | 0.13% | NEW |
| 46 | 46Quadrature Capital Ltd | 18,62218,622 | $482,310 | 0.13% | ADD 6% |
| 47 | 47Engineers Gate Manager LP | 16,42716,427 | $425,459 | 0.12% | NEW |
| 48 | 48Jain Global LLC | 15,59715,597 | $403,962 | 0.11% | TRIM -92% |
| 49 | 49TWO SIGMA INVESTMENTS, LP | 15,50915,509 | $401,683 | 0.11% | TRIM -51% |
| 50 | 50Brevan Howard Capital Management LP | 14,02014,020 | $363,118 | 0.10% | NEW |
| 51 | 51ExodusPoint Capital Management, LP | 13,74713,747 | $356,047 | 0.10% | ADD 24% |
| 52 | 52ROYAL BANK OF CANADA | 13,38913,389 | $346,000 | 0.10% | ADD 12% |
| 53 | 53BARCLAYS PLC | 13,26813,268 | $343,641 | 0.10% | TRIM -45% |
| 54 | 54AMERICAN CENTURY COMPANIES INC | 12,69912,699 | $328,904 | 0.09% | ADD 57% |
| 55 | 55ALPS ADVISORS INC | 10,20010,200 | $264,180 | 0.07% | — |
| 56 | 56Persistent Asset Partners Ltd | 6,7446,744 | $174,670 | 0.05% | TRIM -34% |
| 57 | 57Vanguard Global Advisers, LLC | 4,5004,500 | $116,550 | 0.03% | NEW |
| 58 | 58BNP PARIBAS FINANCIAL MARKETS | 3,4363,436 | $88,992 | 0.02% | TRIM -78% |
| 59 | 59SIMPLEX TRADING, LLC | 2,3122,312 | $59,880 | 0.02% | TRIM -62% |
| 60 | 60WELLS FARGO & COMPANY/MN | 502502 | $13,002 | 0.00% | — |
| 61 | 61FIFTH THIRD BANCORP | 496496 | $12,846 | 0.00% | NEW |
| 62 | 62Steward Partners Investment Advisory, LLC | 493493 | $12,769 | 0.00% | TRIM -11% |
| 63 | 63NATIONAL BANK OF CANADA /FI/ | 478478 | $12,380 | 0.00% | ADD 529% |
| 64 | 64GROUP ONE TRADING LLC | 204204 | $5,284 | 0.00% | — |
| 65 | 65ASSETMARK, INC | 4646 | $1,191 | 0.00% | TRIM -21% |
| 66 | 66SBI Securities Co., Ltd. | 1212 | $311 | 0.00% | — |
| 67 | 67JPMORGAN CHASE & CO | 88 | $211 | 0.00% | NEW |
| 68 | 68REAP Financial Group, LLC | 33 | $78 | 0.00% | — |