| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 3,836,8303.8M | $41M | 7.09% | NEW† |
| 2 | BlackRock, Inc. | 3,319,3793.3M | $35M | 6.13% | NEW† |
| 3 | Foresite Capital Management IV, LLC | 1,943,6821.9M | $21M | 3.59% | NEW† |
| 4 | Merck & Co., Inc. | 1,666,6661.7M | $18M | 3.08% | NEW† |
| 5 | Foresite Capital Management V, LLC | 1,318,9831.3M | $14M | 2.44% | NEW† |
| 6 | T. Rowe Price Investment Management, Inc. | 1,222,4871.2M | $13M | 2.26% | NEW† |
| 7 | Capital World Investors | 1,143,6371.1M | $12M | 2.11% | NEW† |
| 8 | ALLIANCEBERNSTEIN L.P. | 1,022,1881.0M | $11M | 1.89% | NEW |
| 9 | PRICE T ROWE ASSOCIATES INC /MD/ | 975,834975,834 | $10M | 1.80% | NEW |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 969,431969,431 | $10M | 1.79% | NEW |
| 11 | EcoR1 Capital, LLC | 732,606732,606 | $8M | 1.35% | NEW |
| 12 | BAKER BROS. ADVISORS LP | 555,555555,555 | $6M | 1.03% | NEW |
| 13 | SOROS CAPITAL MANAGEMENT LLC | 484,672484,672 | $5M | 0.90% | NEW |
| 14 | StepStone Group LP | 395,340395,340 | $4M | 0.73% | NEW |
| 15 | CANADA PENSION PLAN INVESTMENT BOARD | 379,024379,024 | $4M | 0.70% | NEW |
| 16 | FRANKLIN RESOURCES INC | 350,000350,000 | $4M | 0.65% | NEW |
| 17 | CITADEL ADVISORS LLC | 310,000310,000 | $3M | 0.57% | NEW |
| 18 | General Catalyst Group Management, LLC | 305,233305,233 | $3M | 0.56% | NEW |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 273,931273,931 | $3M | 0.51% | NEW |
| 20 | JANE STREET GROUP, LLC | 265,000265,000 | $3M | 0.49% | NEW |
| 21 | Ensign Peak Advisors, Inc | 200,000200,000 | $2M | 0.37% | NEW |
| 22 | WELLINGTON MANAGEMENT GROUP LLP | 185,000185,000 | $2M | 0.34% | NEW |
| 23 | MILLENNIUM MANAGEMENT LLC | 175,627175,627 | $2M | 0.32% | NEW |
| 24 | Blackstone Inc. | 168,338168,338 | $2M | 0.31% | NEW |
| 25 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 140,344140,344 | $1M | 0.26% | NEW |
| 26 | VANGUARD FIDUCIARY TRUST CO | 131,954131,954 | $1M | 0.24% | NEW |
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 131,079131,079 | $1M | 0.24% | NEW |
| 28 | GOLDMAN SACHS GROUP INC | 129,306129,306 | $1M | 0.24% | NEW |
| 29 | Comprehensive Financial Management LLC | 116,276116,276 | $1M | 0.21% | NEW |
| 30 | LMR Partners LLP | 115,000115,000 | $1M | 0.21% | NEW |
| 31 | Burkehill Global Management, LP | 115,000115,000 | $1M | 0.21% | NEW |
| 32 | UBS Group AG | 99,40899,408 | $1M | 0.18% | NEW |
| 33 | BANK OF AMERICA CORP /DE/ | 86,13486,134 | $911,298 | 0.16% | NEW |
| 34 | SEVEN GRAND MANAGERS, LLC | 80,00080,000 | $846,400 | 0.15% | NEW |
| 35 | Ghisallo Capital Management LLC | 70,00070,000 | $740,600 | 0.13% | NEW |
| 36 | TD Asset Management Inc | 57,07457,074 | $603,843 | 0.11% | NEW |
| 37 | NORTHERN TRUST CORP | 45,53145,531 | $481,718 | 0.08% | NEW |
| 38 | STATE STREET CORP | 40,15040,150 | $424,787 | 0.07% | NEW |
| 39 | Squarepoint Ops LLC | 30,97830,978 | $327,747 | 0.06% | NEW |
| 40 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,62328,623 | $302,831 | 0.05% | NEW |
| 41 | XTX Topco Ltd | 26,05626,056 | $275,672 | 0.05% | NEW |
| 42 | AXQ CAPITAL, LP | 15,40815,408 | $163,017 | 0.03% | NEW |
| 43 | MORGAN STANLEY | 15,27315,273 | $161,588 | 0.03% | NEW |
| 44 | TUDOR INVESTMENT CORP ET AL | 15,00015,000 | $158,700 | 0.03% | NEW |
| 45 | Vanguard Global Advisers, LLC | 13,74713,747 | $145,443 | 0.03% | NEW |
| 46 | VANGUARD PORTFOLIO MANAGEMENT LLC | 13,61313,613 | $144,026 | 0.03% | NEW |
| 47 | Hudson Bay Capital Management LP | 13,48013,480 | $142,618 | 0.02% | NEW |
| 48 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 10,38110,381 | $109,831 | 0.02% | NEW |
| 49 | JPMORGAN CHASE & CO | 1,3001,300 | $12,584 | 0.00% | NEW |
| 50 | Tower Research Capital LLC (TRC) | 1,1391,139 | $12,051 | 0.00% | NEW |
| 51 | Quantbot Technologies LP | 1,0981,098 | $11,617 | 0.00% | NEW |
| 52 | BARCLAYS PLC | 318318 | $3,364 | 0.00% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | — | — | — | — | — | 3.8M | $41M |
| BlackRock, Inc. | — | — | — | — | — | 3.3M | $35M |
| Foresite Capital Management IV, LLC | — | — | — | — | — | 1.9M | $21M |
| Merck & Co., Inc. | — | — | — | — | — | 1.7M | $18M |
| Foresite Capital Management V, LLC | — | — | — | — | — | 1.3M | $14M |
| T. Rowe Price Investment Management, Inc. | — | — | — | — | — | 1.2M | $13M |
| Capital World Investors | — | — | — | — | — | 1.1M | $12M |
| ALLIANCEBERNSTEIN L.P. | — | — | — | — | — | 1.0M | $11M |
| PRICE T ROWE ASSOCIATES INC /MD/ | — | — | — | — | — | 976K | $10M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 969K | $10M |
| EcoR1 Capital, LLC | — | — | — | — | — | 733K | $8M |
| BAKER BROS. ADVISORS LP | — | — | — | — | — | 556K | $6M |
| SOROS CAPITAL MANAGEMENT LLC | — | — | — | — | — | 485K | $5M |
| StepStone Group LP | — | — | — | — | — | 395K | $4M |
| CANADA PENSION PLAN INVESTMENT BOARD | — | — | — | — | — | 379K | $4M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
