| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Velan Capital Investment Management LP | 827,500827,500 | $4M | 9.91% | ADD 20% |
| 2 | Rubric Capital Management LP | 687,500687,500 | $4M | 8.24% | — |
| 3 | PERCEPTIVE ADVISORS LLC | 563,239563,239 | $3M | 6.75% | NEW† |
| 4 | JANE STREET GROUP, LLC | 115,721115,721 | $605,221 | 1.39% | NEW |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 85,96685,966 | $449,602 | 1.03% | NEW |
| 6 | GEODE CAPITAL MANAGEMENT, LLC | 77,05477,054 | $403,016 | 0.92% | ADD 66% |
| 7 | VANGUARD FIDUCIARY TRUST CO | 38,44638,446 | $201,073 | 0.46% | NEW |
| 8 | STATE STREET CORP | 37,97937,979 | $198,630 | 0.45% | ADD 103% |
| 9 | COMMONWEALTH EQUITY SERVICES, LLC | 35,00335,003 | $183,070 | 0.42% | NEW |
| 10 | Scientech Research LLC | 30,53430,534 | $159,693 | 0.37% | NEW |
| 11 | Stonepine Capital Management, LLC | 30,00030,000 | $156,900 | 0.36% | TRIM -96% |
| 12 | BlackRock, Inc. | 27,70927,709 | $144,918 | 0.33% | NEW |
| 13 | Virtu Financial LLC | 26,27526,275 | $137,000 | 0.31% | NEW |
| 14 | Schonfeld Strategic Advisors LLC | 19,65019,650 | $102,768 | 0.24% | NEW |
| 15 | SCOTIA CAPITAL INC. | 15,84315,843 | $82,859 | 0.19% | NEW |
| 16 | NORTHERN TRUST CORP | 14,99414,994 | $78,419 | 0.18% | NEW |
| 17 | SBI Securities Co., Ltd. | 3,5023,502 | $18,315 | 0.04% | NEW |
| 18 | UBS Group AG | 2,3432,343 | $12,254 | 0.03% | ADD 72% |
| 19 | ROYAL BANK OF CANADA | 1,6591,659 | $9,000 | 0.02% | — |
| 20 | MCGUIRE CAPITAL ADVISORS INC | 1,5001,500 | $7,845 | 0.02% | NEW |
| 21 | Tower Research Capital LLC (TRC) | 507507 | $2,652 | 0.01% | TRIM -80% |
| 22 | CITIGROUP INC | 487487 | $2,547 | 0.01% | NEW |
| 23 | Vanguard Global Advisers, LLC | 162162 | $847 | 0.00% | NEW |
| 24 | TD Waterhouse Canada Inc. | 142142 | $792 | 0.00% | — |
| 25 | DANSKE BANK A/S | 11 | $5 | 0.00% | — |
| 26 | LRI Investments, LLC | 11 | $5 | 0.00% | — |
| 27 | Dogwood Wealth Management LLC | 11 | $5 | 0.00% | — |
| 28 | Banque Cantonale Vaudoise | 33 | $0 | 0.00% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Velan Capital Investment Management LP | — | 688K | 688K | 688K | 688K | 828K | $4M |
| Rubric Capital Management LP | — | 688K | 688K | 688K | 688K | 688K | $4M |
| PERCEPTIVE ADVISORS LLC | — | — | — | — | — | 563K | $3M |
| JANE STREET GROUP, LLC | — | — | — | — | — | 116K | $605,221 |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 86K | $449,602 |
| GEODE CAPITAL MANAGEMENT, LLC | 20K | 29K | 28K | 45K | 47K | 77K | $403,016 |
| VANGUARD FIDUCIARY TRUST CO | — | — | — | — | — | 38K | $201,073 |
| STATE STREET CORP | — | — | — | — | 19K | 38K | $198,630 |
| COMMONWEALTH EQUITY SERVICES, LLC | — | 50K | 35K | 38K | — | 35K | $183,070 |
| Scientech Research LLC | — | — | — | — | — | 31K | $159,693 |
| Stonepine Capital Management, LLC | — | 688K | — | 688K | 688K | 30K | $156,900 |
| BlackRock, Inc. | — | — | — | — | — | 28K | $144,918 |
| Virtu Financial LLC | — | — | — | — | — | 26K | $137,000 |
| Schonfeld Strategic Advisors LLC | — | — | — | — | — | 20K | $102,768 |
| SCOTIA CAPITAL INC. | — | — | — | — | — | 16K | $82,859 |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | +563,239 | $3M | OPEN |
| Velan Capital Investment Management LP | +140,000 | $732,200 | ADD |
| JANE STREET GROUP, LLC | +115,721 | $605,221 | OPEN |
| VANGUARD CAPITAL MANAGEMENT LLC | +85,966 | $449,602 | OPEN |
| VANGUARD FIDUCIARY TRUST CO | +38,446 | $201,073 | OPEN |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| Stonepine Capital Management, LLC | −657,500 | $3M | TRIM |
| Nantahala Capital Management, LLC | −625,000 | $3M | CLOSE |
| DRW Securities, LLC | −134,222 | $701,981 | CLOSE |
| DIADEMA PARTNERS LP | −54,025 | $282,551 | CLOSE |
| CITADEL ADVISORS LLC | −53,630 | $280,485 | CLOSE |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 28 | 2,643,721 | 31.7% | $14M |
| 2025-Q4 | 22 | 3,052,673 | 36.6% | $4M |
| 2025-Q3 | 23 | 2,876,709 | 40.9% | $7M |
| 2025-Q2 | 20 | 2,109,933 | 30.0% | $4M |
| 2025-Q1 | 20 | 2,822,449 | 40.7% | $7M |
| 2024-Q4 | 17 | 207,514 | 6.0% | $350,112 |
| 2024-Q3 | 18 | 161,349 | 5.0% | $718,221 |
| 2024-Q2 | 17 | 150,715 | 4.7% | $645,126 |
| 2024-Q1 | 17 | 107,936 | 3.4% | $451,110 |
| 2023-Q4 | 19 | 110,873 | 3.5% | $507,245 |
| 2023-Q3 | 20 | 2,052,256 | 9.7% | $2M |
| 2023-Q2 | 22 | 2,010,615 | 9.8% | $2M |
| 2023-Q1 | 26 | 2,249,825 | 11.2% | $2M |
| 2022-Q4 | 22 | 1,633,241 | 8.4% | $3M |
| 2022-Q3 | 21 | 539,701 | 3.5% | $494,224 |
| 2022-Q2 | 24 | 1,408,268 | 9.1% | $2M |
| 2022-Q1 | 23 | 1,854,558 | 13.5% | $6M |
| 2021-Q4 | 26 | 361,546 | 2.7% | $2M |
| 2021-Q3 | 23 | 385,561 | 2.9% | $3M |
| 2021-Q2 | 18 | 261,131 | 2.0% | $1M |
| 2021-Q1 | 16 | 143,365 | 1.3% | $773,740 |
| 2020-Q4 | 12 | 214,258 | 2.0% | $910,000 |
| 2020-Q3 | 12 | 151,883 | 1.6% | $1M |
| 2020-Q2 | 10 | 16,586 | 0.2% | $81,000 |
| 2020-Q1 | 8 | 4,716 | 0.1% | $10,000 |
| 2019-Q4 | 11 | 35,508 | 0.5% | $145,000 |
| 2019-Q3 | 10 | 24,247 | 0.3% | $151,000 |
| 2019-Q2 | 9 | 39,871 | 4.4% | $280,000 |
