% of shares outstanding suppressed: the summed institutional 13F holdings (186,329,564) exceed the cover-page shares-outstanding count for this quarter (162,308,820, as of 2026-02-13) by more than securities-lending double counting can explain (FINRA short interest 11,751,022 shares at 2026-04-30), so the share count is stale or wrong (common for annual 20-F foreign private issuers after a share issuance) and a percentage would be fabricated. Holder share counts are shown as filed.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | FMR LLC | 23,122,74823.1M | $890M | — | — |
| 2 | BlackRock, Inc. | 16,045,01416.0M | $618M | — | ADD 24% |
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 9,043,9039.0M | $348M | — | — |
| 4 | VANGUARD PORTFOLIO MANAGEMENT LLC | 7,333,3337.3M | $282M | — | NEW† |
| 5 | VANGUARD CAPITAL MANAGEMENT LLC | 6,894,9596.9M | $265M | — | NEW† |
| 6 | JANUS HENDERSON GROUP PLC | 5,965,1256.0M | $230M | — | ADD 31% |
| 7 | STATE STREET CORP | 5,663,5435.7M | $218M | — | ADD 15% |
| 8 | Fairmount Funds Management LLC | 5,503,4185.5M | $212M | — | TRIM -39% |
| 9 | RTW INVESTMENTS, LP | 5,458,6755.5M | $210M | — | TRIM -28% |
| 10 | TCG Crossover Management, LLC | 4,946,8944.9M | $190M | — | TRIM -16% |
| 11 | GOLDMAN SACHS GROUP INC | 4,434,0544.4M | $171M | — | ADD 160% |
| 12 | Kynam Capital Management, LP | 4,037,3314.0M | $155M | — | TRIM -35% |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 3,699,5193.7M | $142M | — | ADD 5% |
| 14 | WELLINGTON MANAGEMENT GROUP LLP | 3,578,6223.6M | $138M | — | ADD 32% |
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,212,8153.2M | $124M | — | ADD 25% |
| 16 | LORD, ABBETT & CO. LLC | 3,181,2703.2M | $122M | — | ADD 70% |
| 17 | Commodore Capital LP | 2,888,0072.9M | $111M | — | ADD 31% |
| 18 | Invesco Ltd. | 2,429,6292.4M | $94M | — | ADD 315% |
| 19 | Octagon Capital Advisors LP | 2,350,0002.4M | $90M | — | — |
| 20 | Holocene Advisors, LP | 2,250,1962.3M | $87M | — | ADD 91% |
| 21 | Sofinnova Investments, Inc. | 2,113,5512.1M | $81M | — | ADD 7% |
| 22 | Venrock Adviser, LLC | 2,000,0002.0M | $77M | — | — |
| 23 | D. E. Shaw & Co., Inc. | 1,868,3891.9M | $72M | — | TRIM -17% |
| 24 | Pictet Asset Management Holding SA | 1,798,7681.8M | $69M | — | ADD 1499% |
| 25 | CITADEL ADVISORS LLC | 1,714,9271.7M | $66M | — | ADD 19% |
| 26 | Siren, L.L.C. | 1,709,2791.7M | $66M | — | ADD 5% |
| 27 | MARSHALL WACE, LLP | 1,600,1681.6M | $62M | — | TRIM -4% |
| 28 | EMERALD ADVISERS, LLC | 1,588,1321.6M | $61M | — | — |
| 29 | Candriam S.C.A. | 1,516,2971.5M | $58M | — | ADD 17% |
| 30 | Woodline Partners LP | 1,509,5571.5M | $58M | — | ADD 84% |
| 31 | Point72 Asset Management, L.P. | 1,410,8261.4M | $54M | — | ADD 70% |
| 32 | SILVERARC CAPITAL MANAGEMENT, LLC | 1,314,1891.3M | $51M | — | ADD 6% |
| 33 | NORTHERN TRUST CORP | 1,245,7511.2M | $48M | — | ADD 4% |
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,242,3221.2M | $48M | — | TRIM -3% |
| 35 | FRED ALGER MANAGEMENT, LLC | 1,239,7001.2M | $48M | — | ADD 12% |
| 36 | Vestal Point Capital, LP | 1,230,8881.2M | $47M | — | NEW |
| 37 | MILLENNIUM MANAGEMENT LLC | 1,192,4061.2M | $46M | — | — |
| 38 | Elmind Capital, LP | 1,170,7401.2M | $45M | — | — |
| 39 | VANGUARD FIDUCIARY TRUST CO | 1,058,0871.1M | $41M | — | NEW |
| 40 | BANK OF AMERICA CORP /DE/ | 1,043,8051.0M | $40M | — | TRIM -12% |
| 41 | EMERALD MUTUAL FUND ADVISERS TRUST | 1,028,8321.0M | $40M | — | — |
| 42 | Deep Track Capital, LP | 1,000,0001.0M | $38M | — | ADD 121% |
| 43 | First Turn Management, LLC | 947,339947,339 | $36M | — | ADD 15% |
| 44 | AMERICAN CENTURY COMPANIES INC | 890,568890,568 | $34M | — | — |
| 45 | Balyasny Asset Management L.P. | 856,598856,598 | $33M | — | TRIM -41% |
| 46 | Nuveen, LLC | 831,602831,602 | $32M | — | TRIM -11% |
| 47 | Squadron Capital Management LLC | 787,492787,492 | $30M | — | — |
| 48 | J. Goldman & Co LP | 779,570779,570 | $30M | — | ADD 77% |
| 49 | Affinity Asset Advisors, LLC | 750,000750,000 | $29M | — | ADD 114% |
| 50 | RENAISSANCE TECHNOLOGIES LLC | 706,268706,268 | $27M | — | ADD 2% |
| 51 | Redmile Group, LLC | 688,036688,036 | $26M | — | TRIM -52% |
| 52 | Burkehill Global Management, LP | 675,000675,000 | $26M | — | ADD 108% |
| 53 | VOYA INVESTMENT MANAGEMENT LLC | 664,146664,146 | $26M | — | ADD 399% |
| 54 | MORGAN STANLEY | 642,679642,679 | $25M | — | TRIM -12% |
| 55 | Saturn V Capital Management LP | 626,635626,635 | $24M | — | TRIM -49% |
| 56 | Rock Springs Capital Management LP | 624,155624,155 | $24M | — | TRIM -26% |
| 57 | Patient Square Capital LP | 596,000596,000 | $23M | — | ADD 88% |
| 58 | Ensign Peak Advisors, Inc | 572,872572,872 | $22M | — | ADD 36% |
| 59 | Fiera Capital Corp | 558,252558,252 | $21M | — | NEW |
| 60 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 449,482449,482 | $17M | — | NEW |
| 61 | Vivo Capital, LLC | 422,300422,300 | $16M | — | TRIM -82% |
| 62 | SPHERA FUNDS MANAGEMENT LTD. | 416,340416,340 | $16M | — | ADD 10% |
| 63 | Qube Research & Technologies Ltd | 394,000394,000 | $15M | — | ADD 42% |
| 64 | Russell Investments Group, Ltd. | 374,868374,868 | $14M | — | TRIM -3% |
| 65 | Bank of New York Mellon Corp | 372,796372,796 | $14M | — | — |
| 66 | ExodusPoint Capital Management, LP | 372,175372,175 | $14M | — | NEW |
| 67 | RAYMOND JAMES FINANCIAL INC | 369,715369,715 | $14M | — | — |
| 68 | KENNEDY CAPITAL MANAGEMENT LLC | 360,490360,490 | $14M | — | ADD 2% |
| 69 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 354,240354,240 | $14M | — | ADD 16% |
| 70 | Defilade Capital Management, L.P. | 352,590352,590 | $14M | — | TRIM -38% |
| 71 | Integral Health Asset Management, LLC | 350,000350,000 | $13M | — | NEW |
| 72 | Weiss Asset Management LP | 346,104346,104 | $13M | — | NEW |
| 73 | BNP PARIBAS FINANCIAL MARKETS | 343,082343,082 | $13M | — | ADD 72% |
| 74 | Longaeva Partners L.P. | 335,000335,000 | $13M | — | NEW |
| 75 | Hennion & Walsh Asset Management, Inc. | 326,472326,472 | $13M | — | TRIM -3% |
| 76 | DIADEMA PARTNERS LP | 322,764322,764 | $12M | — | ADD 145% |
| 77 | ORBIMED ADVISORS LLC | 322,100322,100 | $12M | — | TRIM -13% |
| 78 | Assenagon Asset Management S.A. | 295,650295,650 | $11M | — | TRIM -21% |
| 79 | SummitTX Capital, L.P. | 293,780293,780 | $11M | — | ADD 14% |
| 80 | Atika Capital Management LLC | 293,200293,200 | $11M | — | TRIM -42% |
| 81 | UBS Group AG | 291,486291,486 | $11M | — | ADD 10% |
| 82 | FEDERATED HERMES, INC. | 285,661285,661 | $11M | — | TRIM -33% |
| 83 | Exome Asset Management LLC | 278,533278,533 | $11M | — | TRIM -9% |
| 84 | Aberdeen Group plc | 272,707272,707 | $10M | — | NEW |
| 85 | AMERIPRISE FINANCIAL INC | 252,114252,114 | $10M | — | ADD 34% |
| 86 | Alyeska Investment Group, L.P. | 250,000250,000 | $10M | — | TRIM -49% |
| 87 | Nantahala Capital Management, LLC | 250,000250,000 | $10M | — | — |
| 88 | Evergreen Quality Fund GP, Ltd. | 250,000250,000 | $10M | — | — |
| 89 | NWI MANAGEMENT LP | 241,671241,671 | $9M | — | — |
| 90 | JPMORGAN CHASE & CO | 262,704262,704 | $9M | — | TRIM -34% |
| 91 | Tidal Investments LLC | 231,569231,569 | $9M | — | NEW |
| 92 | Susquehanna Portfolio Strategies, LLC | 229,755229,755 | $9M | — | — |
| 93 | Squarepoint Ops LLC | 226,259226,259 | $9M | — | ADD 45% |
| 94 | F/m Investments LLC | 226,142226,142 | $9M | — | TRIM -4% |
| 95 | SUPERSTRING CAPITAL MANAGEMENT LP | 225,158225,158 | $9M | — | TRIM -39% |
| 96 | Boxer Capital Management, LLC | 225,000225,000 | $9M | — | — |
| 97 | NEW YORK STATE COMMON RETIREMENT FUND | 223,216223,216 | $9M | — | ADD 403% |
| 98 | Hudson Bay Capital Management LP | 207,574207,574 | $8M | — | NEW |
| 99 | PEREGRINE CAPITAL MANAGEMENT LLC | 201,959201,959 | $8M | — | NEW |
| 100 | Cormorant Asset Management, LP | 200,000200,000 | $8M | — | TRIM -11% |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16.6M | 17.1M | 17.1M | 22.4M | 23.1M | 23.1M | $890M |
| BlackRock, Inc. | 8.3M | 8.2M | 8.6M | 10.4M | 13.0M | 16.0M | $618M |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2.6M | 2.6M | 2.6M | 9.1M | 9.0M | 9.0M | $348M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | — | — | — | — | — | 7.3M | $282M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 6.9M | $265M |
| JANUS HENDERSON GROUP PLC | 29K | 29K | 2.9M | 3.2M | 4.5M | 6.0M | $230M |
| STATE STREET CORP | 3.9M | 4.1M | 3.4M | 4.8M | 4.9M | 5.7M | $218M |
| Fairmount Funds Management LLC | 6.2M | 6.2M | 6.2M | 9.0M | 9.0M | 5.5M | $212M |
| RTW INVESTMENTS, LP | — | — | — | 3.5M | 7.6M | 5.5M | $210M |
| TCG Crossover Management, LLC | 7.0M | 7.0M | 7.0M | 6.8M | 5.9M | 4.9M | $190M |
| GOLDMAN SACHS GROUP INC | 865K | 989K | 1.2M | 1.7M | 1.7M | 4.4M | $171M |
| Kynam Capital Management, LP | 9.1M | 9.1M | 8.5M | 7.9M | 6.2M | 4.0M | $155M |
| GEODE CAPITAL MANAGEMENT, LLC | 2.3M | 2.4M | 2.7M | 3.3M | 3.5M | 3.7M | $142M |
| WELLINGTON MANAGEMENT GROUP LLP | 285K | 258K | 297K | 407K | 2.7M | 3.6M | $138M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50K | 54K | 73K | 90K | 2.6M | 3.2M | $124M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD PORTFOLIO MANAGEMENT LLC | +7,333,333 | — | OPEN |
| VANGUARD CAPITAL MANAGEMENT LLC | +6,894,959 | — | OPEN |
| BlackRock, Inc. | +3,070,423 | — | ADD |
| GOLDMAN SACHS GROUP INC | +2,728,910 | — | ADD |
| Invesco Ltd. | +1,843,864 | — | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −11,514,326 | — | CLOSE |
| Fairmount Funds Management LLC | −3,500,000 | — | TRIM |
| Duquesne Family Office LLC | −2,214,470 | — | CLOSE |
| RTW INVESTMENTS, LP | −2,133,566 | — | TRIM |
| Kynam Capital Management, LP | −2,127,892 | — | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the quarter-end close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure. No licensed quarter-end close is stored for this line, so the dollar columns are withheld; share counts stand.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 304 | 186,329,564 | — | $7.2B |
| 2025-Q4 | 267 | 174,083,583 | — | $6.2B |
| 2025-Q3 | 195 | 159,299,866 | — | $2.3B |
| 2025-Q2 | 181 | 135,724,079 | — | $975M |
| 2025-Q1 | 186 | 133,518,414 | — | $800M |
| 2024-Q4 | 177 | 121,716,252 | — | $949M |
| 2024-Q3 | 161 | 121,899,020 | — | $1.3B |
| 2024-Q2 | 148 | 122,232,003 | — | $1.0B |
| 2024-Q1 | 146 | 113,039,851 | 108.8% | $760M |
| 2023-Q4 | 144 | 93,838,659 | 109.0% | $552M |
| 2023-Q3 | 135 | 90,861,414 | 106.3% | $886M |
| 2023-Q2 | 136 | 88,536,716 | — | $1.0B |
| 2023-Q1 | 136 | 75,314,184 | 107.7% | $815M |
| 2022-Q4 | 135 | 74,869,543 | 107.1% | $859M |
| 2022-Q3 | 134 | 76,362,869 | — | $1.1B |
| 2022-Q2 | 112 | 70,881,783 | — | $639M |
| 2022-Q1 | 87 | 47,816,535 | 104.4% | $358M |
| 2021-Q4 | 82 | 48,088,327 | — | $413M |
| 2021-Q3 | 73 | 36,797,725 | 92.3% | $310M |
| 2021-Q2 | 69 | 40,145,886 | 104.5% | $324M |
| 2021-Q1 | 69 | 34,467,486 | 92.7% | $303M |
| 2020-Q4 | 68 | 32,640,229 | — | $367M |
| 2020-Q3 | 35 | 40,540,947 | 106.0% | $94M |
| 2020-Q2 | 24 | 10,095,573 | 26.4% | $5M |
| 2020-Q1 | 25 | 9,097,238 | — | $4M |
| 2019-Q4 | 27 | 9,786,752 | 31.9% | $7M |
| 2019-Q3 | 36 | 12,369,111 | 40.3% | $18M |
| 2019-Q2 | 39 | 12,908,138 | 42.9% | $34M |
| 2019-Q1 | 53 | 14,233,743 | 47.3% | $62M |
| 2018-Q4 | 47 | 14,413,063 | 48.1% | $63M |
| 2018-Q3 | 48 | 15,348,799 | 51.4% | $158M |
| 2018-Q2 | 44 | 15,386,452 | 51.6% | $221M |
| 2018-Q1 | 28 | 14,245,522 | 47.7% | $186M |
| TCG Crossover GP I, LLC | 4.8% | Passive | 2025-09-30 | SEC → |
| Kynam Capital Management, LP | 4.33% | QII | 2025-12-31 | SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
