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Clinical trials
catalyst calendar across sponsors →Studies where CL is the lead sponsor, as filed with ClinicalTrials.gov. Completion dates are the sponsor's own projected windows and are revised as a study runs. Active studies first, then completed and stopped — newest readout first within each.
105 interventional · 5 observational · 34 with posted results
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| Study | Phase | Status | Interventions | Conditions | Enrollment | Primary completion | Readout in | Updated |
|---|---|---|---|---|---|---|---|---|
| Evaluate the Efficacy of an Oral Health Behavioral Intervention in People With DiabetesNCT07619729Dental ClaimsOpen-label · Prevention | Phase 4 | Enrolling by invitation | Behavioral: Diabetes Oral Health Program · Drug: Stannous Fluoride Dentifrice, Cetylpyridinium Chloride (CPC) and Zinc Lactate Mouthwash | Diabetes Type 2, Periodontal Disease, Caries | 10,000 | 2028-01-02 | in 501 d | 2026-06-03 |
| Investigation of the Interplay Between Local Oral Inflammation, Microbiota and Systemic Immune Responses.NCT06966492Gingival Bleeding Index described by Ainamo & Bay, 1976Randomized · Triple-masked · Basic science | Phase 4 | Not yet recruiting | Drug: Stannous Fluoride Toothpaste (SnF) | Gingival Inflammation | 20 | Jun 2027 | ≤ 315 d | 2026-05-26 |
| To Assess the Efficacy of Two Brushing Regimens: in the Reduction of Established Dental Plaque and Gingivitis.NCT07605338Loe-Silness Gingival IndexRandomized · Quadruple-masked · Treatment | Phase 3 | Active, not recruiting | Drug: Colgate SNaP Total 10/10, 1.5 Taurate, Colgate Great Regular Flavor Toothpaste · Other: Flat Trimmed Extra Clean TB | Plaque, Dental, Gingivitis | 85 | Nov 2026 | ≤ 103 d | 2026-05-27 |
| Clinical Study to Evaluate Remineralization Using an in Situ Model.NCT07625670Change in integrated mineral loss (Δz)Randomized · Quadruple-masked · Other | Phase 3 | Not yet recruiting | Drug: Fluoride toothpaste containing 750 ppm MFP in a Dical base, Fluoride toothpaste containing 1450 ppm MFP in a Dical base, Fluoride-free toothpaste in a Dical base · Device: Toothbrush | Remineralization, Enamel Lesions, Enamel Subsurface Lesion | 30 | Oct 2026 | ≤ 73 d | 2026-06-04 |
| 6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum HealthNCT07414173Improvement of gum health as measured by the Gingival Index (Löe 1967) between the study groups.Randomized · Quadruple-masked · Prevention | Phase 4 | Recruiting | Other: Test Mouthrinse, Control Mouthrinse | Gingivitis, Dental Plaque Accumulation | 90 | Sep 2026 | ≤ 42 d | 2026-02-17 |
| A Study to Investigate Stannous Fluoride Containing Toothpaste on Antibacterial Effects in the Different Regions of the MouthNCT07458464Loe-SilnessRandomized · Quadruple-masked · Treatment | Phase 3 | Not yet recruiting | Drug: stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste | Plaque, Gingivitis | 100 | Sep 2026 | ≤ 42 d | 2026-07-28 |
| Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High GingivitisNCT07614490Relative abundance of Streptococcus and PorphyromonasOpen-label · Basic science | Phase 4 | Recruiting | Drug: sodium monofluorophosphate toothpaste | Gingivitis, Plaque | 100 | 2026-09-30 | in 42 d | 2026-05-29 |
| Comparative Efficacy of Different Dentin Occluding Toothpaste TechnologiesNCT07664592Change from Baseline in Dentin Hypersensitivity (1)Randomized · Quadruple-masked · Treatment | Phase 3 | Recruiting | Drug: 8% arginine + Zinc toothpaste, 5% Calcium Sodium Phosphosilicate toothpaste, 8% arginine toothpaste | Dentinal Sensitivity, Dentinal Hypersensitivity | 132 | Sep 2026 | ≤ 42 d | 2026-08-07 |
| Clinical Investigation of Oral Malodor for Max Fresh Toothpaste Containing Zinc Citrate Versus a Commercially Available Regular Fluoride ToothpasteNCT07398378Organoleptic Oral Malodor EvaluationsRandomized · Quadruple-masked · Treatment | Phase 3 | Active, not recruiting | Drug: Max Fresh Toothpaste, Colgate Cavity Protection Toothpaste | Oral Malodor | 80 | Jul 2026 | — | 2026-06-17 |
| Efficacy of a Toothpaste in Reducing Plaque, Gingivitis, and Gingival BleedingNCT07499115Modified Gingival Index (MGI_ Lobene)Randomized · Quadruple-masked · Treatment | Phase 3 | Not yet recruiting | Drug: Toothpaste containing chitosan, Colgate Cavity Protection Toothpaste | Plaque, Dental, Gingivitis | 90 | Jul 2026 | — | 2026-04-13 |
| Bacterial Reduction for a Manual Toothbrush With a 360-Degree Mouth Cleaner Design Versus a Standard ToothbrushNCT07471477measure whole mouth bacterial load (measured as LOG CFU/mL) by collecting saliva samplesRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Colgate 360 SupraClean Manual Toothbrush brush with 0.76% Na MFP, (1000 ppm F), Colgate Adult Extra Clean soft-bristle toothbrush brush with 0.76% Na MFP, (1000 ppm F) | Bacterial Load Reduction | 56 | 2026-06-06actual | — | 2026-06-12 |
| Clinical Study to Assess the Efficacy of New Toothpaste Containing SnF as Compared to Colgate Cavity Protection Toothpaste on the Reduction of Enamel ErosionNCT07442136Surface lossRandomized · Quadruple-masked · Prevention | Phase 3 | Completed | Drug: New Toothpaste Containing SnF, Fluoride Toothpaste | Enamel Erosion | 80 | 2026-06-01actual | — | 2026-07-17 |
| Efficacy of a Stannous Fluoride Toothpaste, Cetylpyridinium Chloride Mouthwash, and Battery Toothbrush Regimen in Reducing Established Dental Plaque and Gingivitis.NCT07398846Loe-Silness Gingival IndexRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: 0.454%Stannous fluoride toothpaste, 0.075% Cetylpyridinium Chloride (CPC) and 0.28% zinc lactatmouthwashe, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste, 0.022% Sodium Fluoride mouthwash | Plaque | 134 | 2026-04-29actual | — | 2026-05-22 |
| Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control MouthwashNCT07263698Modified Gingival IndexRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: cetylpyridinium chloride (CPC), zinc lactate and sodium fluoride Mouthwash, sodium fluoride Mouthwash | Gingivitis, Plaque, Dental | 80 | 2026-02-27actual | — | 2026-05-26 |
| The Efficacy of a Battery Toothbrush in the Reduction of Established Plaque and GingivitisNCT07224828Löe and Silness Gingival IndexRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Total Active Prevention Fresh Toothpaste + Colgate Total Active Prevention Battery Toothbrush, Colgate Great Regular + Total Active Prevention Battery Toothbrush, Colgate Great Regular + standard reference flat trim toothpaste | Plaque, Gingivitis | 130 | 2026-01-28actual | — | 2026-07-31 |
| Clinical Investigation of PerioGard (Test) RegimenNCT07210138Measurement of Loe-Silness Gingival Index scoreRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: PeriGuard regimen, Colgate Dental Cream regimen | Gingivitis | 80 | 2025-12-30actual | — | 2026-03-18 |
| Clinical Study to Evaluate the Tooth Whitening Efficacy of a New NextGen In-office Whitening SystemNCT07225478Whitening ImprovementsRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Beaming White, Fluoride Toothpaste · Combination product: Philips Zoom Professional Whitening Treatment, Opalescence Boost PF · Device: Soft Manual Toothbrush, CP LED, Gingival Barrier | Health Adult Subjects | 180 | 2025-12-21actual | — | 2026-01-08 |
| Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ ModelNCT07134231Microhardness changeRandomized · Quadruple-masked · Other | Phase 3 | Completed | Drug: Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base · Device: Toothbrush | Demineralization, Remineralization, Dental Cavity, Enamel Lesions | 36 | 2025-12-11actual | — | 2026-02-06 |
| Efficacy of a Toothpaste Containing Hydrogen Peroxide as Compared to a Regular Fluoride Toothpaste Without Hydrogen Peroxide in the Immediate Removal of Tooth Stains After a Single Brushing.NCT07276672Mod. Lobene Stain IndexRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Optic White Adv Sparkling White (2%HP) Toothpaste, Colgate Great Regular Flavor Toothpaste | Whitening | 80 | 2025-11-24actual | — | 2025-12-11 |
| Oothpaste Containing 8% Arginine Compared to Colgate Cavity Protection Toothpaste in Reducing Dentinal HypersensitivityNCT07257042Tactile stimulation with a Yeaple Probe. treatment Tactile and Air Blast Hypersensitivity scores. The mean Tactile and Air Blast Hypersensitivity will be computed and summarizedRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Toothpaste containing 8% Arginine, Colgate Cavity Protection Toothpaste | Hypersensitivity | 80 | 2025-11-04actual | — | 2025-12-05 |
| Comparative Efficacy of Floss and Essential Oil/CPC+Zn Mouthwashes in Reducing Dental Plaque and GingivitisNCT07029438Interproximal mean Modified Gingival Index (MGI)Randomized · Double-masked · Prevention | Phase 4 | Completed | Drug: Mouthwash, Toothpaste · Device: Floss, Toothbrush | Dental Plaque, Gingivitis | 228 | 2025-10-16actual | — | 2025-10-30 |
| To Assess the Efficacy of a Toothpaste Containing 8% Arginine as Compared to Colgate Cavity Protection Toothpaste in the Reduction of Dentinal Hypersensitivity.NCT07149376Tactile stimulation by the Yeaple ProbeRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Device: TOMs of Maine Sensitive SLS Free Xtra Fresh · Drug: Colgate Cavity protection toothpaste | Sensitivity, Tooth | 84 | 2025-10-14actual | — | 2025-11-05 |
| Hypersensitivity Reduction Efficacy: 5% Potassium Nitrate Toothpaste Compared to Colgate Cavity Protection ToothpasteNCT06956599tactile sensitivityRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: test toothpaste, Control toothpaste | Dentin Hypersensitivity | 80 | 2025-08-11actual | — | 2026-03-19 |
| To Validate Changes in Knowledge, Attitudes and Practices (KAPs) Related to the Know Your OQ Initiative and to Understand the Readability, Comprehension and Ease of Use of the Know Your OQ QuizNCT06880458observationalKnowledge, attitudes and practices towards oral health questionnaire intervention | — | Completed | Other: Oral health education | Literacy-language Intervention | 176 | 2025-07-18actual | — | 2026-04-15 |
| Clinical Investigation of Bleeding Reduction Efficacy on Toothpaste Containing 1.05% ChitosanNCT06955871Gingival BleedingRandomized · Quadruple-masked · Prevention | Not applicable | Completed | Other: Toothpaste containing 1.05% Chitosan, Silica-based NaF Toothpaste, Toothpaste with 67% bicarbonate | Bleeding Gum, Gingivitis | 134 | 2025-06-04actual | — | 2025-08-15 |
| Dentinal Hypersensitivity Reduction Efficacy StudyNCT06960148Tactile Sensitivity using the Yeaple Electronic Force Sensing ProbeRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: CSPR Toothpaste, Colgate Dental Cream Toothpaste | Sensitivity, Tooth | 95 | 2025-05-13actual | — | 2026-03-19 |
| Clinical Study to Evaluate the Tooth Whitening EfficacyNCT06957249Tooth color measurementRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Optic White 5%HP ActivShine Toothpaste, Crest3DWhite Advanced Radiant Mint Toothpaste | Whitening | 80 | 2025-05-03actual | — | 2025-09-03 |
| Evaluation of the Anti-cavity Efficacy of Three Dentifrices Using an Intra-oral Enamel Demineralization - Remineralization In-Situ ModelNCT06732518Microhardness changeRandomized · Quadruple-masked · Other | Phase 3 | Completed | Drug: Fluoride Toothpaste, Fluoride free toothpaste in a chalk base, Fluoride free toothpaste in a PCC/RNCC base · Device: Toothbrush | Enamel Lesions, Demineralization, Tooth, Remineralization, Dental Cavity | 36 | 2025-04-24actual | — | 2025-08-06 |
| Evaluation of the Effect of a Toothpaste Containing 0.3% Chlorhexidine in Subjects With Established Dental Plaque and GingivitisNCT06732466Löe-Silness Gingival IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Chlorhexidine toothpaste, Placebo toothpaste without chlorhexidine and AmCl · Device: Toothbrush | Gingivitis, Gingivitis and Periodontal Diseases, Gingival Disease, Dental Plaque | 80 | 2025-04-15actual | — | 2025-08-06 |
| Children in the Operating Room: Kids That go Thru Operating Room Will be Given a Connected Health Toothbrush, Kids Anticavity Toothpaste and Behavioral Health Intervention to Reduce Claim CostsNCT07539064observationalClaim Cost | — | Completed | Device: Connected Toothbrush with a behavioral health intervention | Caries Active, Prevention | 93 | 2025-03-04actual | — | 2026-04-20 |
| Clinical Research Study to Assess the Efficacy of Two Brushing RegimensNCT06240481Quigley and Hein Plaque IndexRandomized · Triple-masked · Treatment | Phase 3 | Completed | Drug: Test Regimen, Control Regimen | Dental Plaque, Gingivitis | 90 | 2024-12-21actual | — | 2026-02-06 |
| Comparative Study to Evaluate the Efficacy of an Alcohol-free Mouthwash Regimen With CPC+Zn, Flossing and Brushing, and an Alcohol-based Mouthwash Regimen With Essential Oils in Reducing Plaque and Gingivitis.NCT06598072Modified Gingival IndexRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Mouthwash CPC+Zn+F, Essential oils mouthwash · Device: Dental floss | Gingival Bleeding, Plaque Induced Gingival Disease, Gingival Diseases, Gingivitis and Periodontal Diseases | 120 | 2024-12-16actual | — | 2025-04-14 |
| Clinical Study to Assess the Efficacy of Professional Tooth Whitening Maintenance SystemNCT06613347Tooth color assessmentRandomized · Quadruple-masked · Prevention | Not applicable | Completed | Other: whitening maintenance, whitening maintenance MW, negative control | Staining | 93 | 2024-12-15actual | — | 2025-05-21 |
| Clinical of Hypersensitivity Reduction Efficacy on Two ToothpastesNCT06937697tactile sensitivityRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Test toothpaste, Control toothpaste | Hypersensitivity | 87 | 2024-12-13actual | — | 2025-04-22 |
| Comparative Study of CPC+Zn Mouthwash, Dental Floss, and Essential Oils Mouthwash on Plaque and Gingivitis ReductionNCT06607263Modified Gingival IndexRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Mouthwash CPC+Zn+F, Essential oils mouthrinse, Toothpaste · Device: Dental floss, Toothbrush | Gingival Bleeding, Plaque Induced Gingival Disease, Gingivitis and Periodontal Diseases | 120 | 2024-12-09actual | — | 2025-04-14 |
| Assessing the Colgate Assist Handle Toothbrush in Individuals With Impairment of Hand Movement.NCT06632704observationaluser experience | — | Completed | Device: Colgate Toothbrush assist | Movement Disorders and Physical Impairments | 26 | 2024-12-01actual | — | 2025-04-13 |
| Efficacy of Manual Toothbrushes in Removing Tooth StainsNCT06486974Lobene Tooth Stain IndexRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: NaF, Na MFP | Tooth Discoloration | 80 | 2024-11-08actual | — | 2026-03-19 |
| Clinical Efficacy of the Combined Effect of Oral Irrigator and Chemicals (0.075% CPC)NCT06607172Löe-Silness Gingival IndexRandomized · Double-masked · Prevention | Phase 3 | Completed | Device: oral irrigator, oral irrigator · Drug: Cetylpyridinium Chloride (CPC) | Dental Plaque, Dental Plaque Induced Gingivitis, Dental Plaque and Gingivitis, Gingivitis | 30 | 2024-10-22actual | — | 2024-12-13 |
| Anti-gingivitis MouthrinseNCT06048627Whole-mouth Mean Modified Gingival Index (MGI)Randomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Amine/zinc lactate/fluoride system, negative control | Gingivitis | 90 | 2024-10-01actual | — | 2025-05-21 |
| Arginine Plaque Metabolism Pilot Clinical StudyNCT06954779Plaque collectionNon-randomized · Triple-masked · Treatment | Phase 3 | Completed | Drug: Colgate Cavity Protection, TOM's Superior Sensitivity Relief Toothpaste | Plaque, Dental | 20 | 2024-09-20actual | — | 2025-05-02 |
| Clinical Investigation to Assess the Efficacy of Manual Toothbrushes in the Reduction of Plaque and Gingivitis.NCT06565897Plaque assessmentRandomized · Quadruple-masked · Treatment | Phase 2 | Completed | Drug: Test regimen, Control regimen | Plaque, Dental, Gingivitis | 84 | 2024-09-10actual | — | 2026-03-18 |
| Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Plaque and GingivitisNCT06430060Loe-Silness Gingival Index scoreRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: zinc containing toothpaste, MFP Fluoride toothpaste | Plaque, Dental, Gingivitis | 86 | 2024-08-25actual | — | 2026-03-19 |
| The Clinical of Stannous Fluoride Toothpaste and a Newly Designed Toothbrush Compared to Colgate Cavity Protection Toothpaste and a Regular Toothbrush in Reducing Plaque and Gingivitis.NCT06427499Loe and Silness Gingival Index.Randomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: Stannous fluoride toothpaste, Colgate Cavity Protection Toothpaste | Plaque, Gingivitis | 95 | 2024-08-05actual | — | 2026-03-19 |
| Evaluation of the Know Your OQ™ Oral Health Literacy Tool in an Indian PopulationNCT06534112observationalChanges in Knowledge, Attitude, Practice (KAP) | — | Completed | — | Oral Health Literacy | 150 | 2024-06-08actual | — | 2024-08-26 |
| Clinical Research Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis.NCT06244303Quigley and Hein Plaque IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: manual Tooth Brush + Colgate Total TP (0.454% SnF, 1100 ppm F), manual toothbrush + Colgate dental cream | Gingivitis, Plaque | 82 | 2024-04-16actual | — | 2026-03-19 |
| Efficacy of a Eugenol-based Product to Improve the Quality of Toothbrushing and Relieving Gum Discomfort AreasNCT06366568Turesky Modification of the Quigley & Hein Plaque IndexRandomized · Triple-masked · Treatment | Phase 3 | Completed | Drug: fluoride toothpaste containing 1450 ppm of MFP in a PCC base and eugenol gum product, fluoride toothpaste containing 1450 ppm of MFP in a PCC base | Plaque, Dental | 86 | 2024-03-06actual | — | 2024-04-16 |
| A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old ChildrenNCT04750902results2026-07-21Incremental Subject-wise Decayed Missing or Filled Surfaces (DMFS) Score Between the Baseline and the Month 12 VisitsRandomized · Quadruple-masked · PreventionStudy Protocol ↗ · Statistical Analysis Plan ↗ | Phase 2 | Completed | Drug: 0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice, 8.0% Arginine Dentifrice | Dental Caries | 2,025 | 2024-02-28actual | — | 2026-07-21 |
| Maximal Use Study to Determine the Pharmacokinetics of L-arginine After Exaggerated Oral Use of COL101NCT06182267Arginine in bloodRandomized · Quadruple-masked · Treatment | Phase 1 | Completed | Drug: L Arginine, Sodium Fluoride | Caries,Dental | 29 | 2023-12-22actual | — | 2024-01-02 |
| Effects of Topical Hyaluronic Acid Gel on Postoperative Pain and Wound HealingNCT05821725Wound healing areaRandomized · Double-masked · Supportive care | Not applicable | Completed | Device: Hyaluronic acid, Control | Palatal Wound | 30 | 2023-11-21actual | — | 2025-11-25 |
| Clinical Study on MalodorNCT06300905Organoleptic Oral Malodor EvaluationsRandomized · Double-masked · Prevention | Phase 3 | Completed | Drug: test product, Control product | Oral Malodor | 100 | 2023-07-02actual | — | 2024-03-08 |
| Anti-bacterial Clinical Study on Teeth, Tongue, Cheek, Gum, and SalivaNCT06353165Whole mouth scores of dental plaqueRandomized · Double-masked · Prevention | Phase 3 | Completed | Drug: Stannous fluoride toothpaste, Colgate Dental Cream | Plaque, Dental | 100 | 2023-04-12actual | — | 2024-04-15 |
| Documenting Toothbrushing Experiences of Caregivers Who Care for Children With Autism Spectrum DisordersNCT05552144observationalUser experiences of hum connected toothbrush as observed by the caregiver with interviews & questionnaires. | — | Completed | Device: Hum by Colgate Smart Kids Toothbrush (battery powered) - 490000006871 | ASD I, ASD2 | 17 | 2022-11-08actual | — | 2024-03-08 |
| Effect of Mouthwash in Reducing the Symptoms Associated With Flu and Cold VirusesNCT06479226Upper Respiratory SymptomRandomized · Single-masked · Prevention | Phase 3 | Completed | Drug: cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash | Healthy | 150 | 2022-10-06actual | — | 2026-03-18 |
| Investigate a Varnish to Protect From Erosive ToothwearNCT06136754Microhardness MeasurementRandomized · Quadruple-masked · Prevention | Phase 3 | Completed | Drug: Varnishes, Fluoride | Tooth Erosion | 24 | 2022-07-27actual | — | 2023-11-18 |
| Clinical Study of Toothpaste Containing Zinc Lactate as Compared to Colgate Cavity Protection Toothpaste.NCT06563518Gingivitis AssessmentRandomized · Quadruple-masked · Treatment | Phase 2 | Completed | Drug: Meridol, Colgate Cavity Protection | Gingivitis, Plaque | 92 | 2022-07-10actual | — | 2024-08-21 |
| Clinical Study to Investigate a New Mouthwash in Reducing Plaque and Helping Prevent Gum Problems on Dental Implants Over a 6-month Period of Product UseNCT06770114Mombelli Modified Gingival IndexRandomized · Quadruple-masked · Prevention | Phase 3 | Completed | Drug: Cetylpyridinium Chloride, Zinc Lactate and Hyaluronic Acid Mouthwash, PhosFlur Mouthwash | Gingivitis | 80 | 2022-05-09actual | — | 2025-12-01 |
| 2-year Caries Clinical Study: Arginine Fluoride-Free Toothpastes vs. NaF ToothpasteNCT05560945The primary efficacy endpoint will be the incremental subject-wise Decayed Missing Filled Surfaces score after 2 year product use.Randomized · Quadruple-masked · Prevention | Phase 3 | Completed | Drug: 0.32% Sodium Fluoride Dentifrice Toothpaste, 1.5% Arginine Dentifrice, 8.0% Arginine Dentifrice | Dental Caries | 6,000 | 2022-03-12actual | — | 2022-10-03 |
| A New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum ProblemsNCT05821712Gingival inflammationRandomized · Triple-masked · Prevention | Phase 3 | Completed | Drug: 0.2% zinc lactate, 0.17% amine fluoride and 0.0275% sodium fluoride Mouthwash, 0.057% sodium fluoride Mouthwash | Plaque, Gum Disease | 80 | 2021-09-24actual | — | 2023-04-20 |
| Measurement of Viral Load Reduction in the Oral Cavity After a Regimental Use of OC Toothpaste ProductsNCT04864925Primary outcome based on reductions of viral titers in the oral cavity as determined by qRT-PCRRandomized · Triple-masked · Prevention | Phase 3 | Completed | Drug: Colgate Total Clean Mint, Tom's Botanically Bright Peppermint | Covid19 | 46 | 2021-08-25actual | — | 2022-01-18 |
| Gingivitis Reduction After Use of 0.45% Stannous Fluoride ToothpasteNCT06300866Whole-Mouth Gingivitis MeasurementRandomized · Double-masked · Prevention | Phase 3 | Completed | Drug: Test, Control | Gingivitis, Plaque, Dental | 80 | 2021-03-08actual | — | 2024-03-08 |
| Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria Saliva and Bioaerosol Contamination Phase 2NCT04717063evaluate the antibacterial efficacy of mouthwash in reducing the levels of bacteria in bioaerosols generated by dental prophylaxisRandomized · Triple-masked · Treatment | Phase 2 | Completed | Drug: Peroxyl Oral Product, Placebo | Healthy | 100 | 2020-12-30actual | — | 2021-01-20 |
| Clinical Study to Assess Therapeutic Delay and Resolution of Induced GingivitisNCT05731778Bleeding Index (BOP) and Oral Inflammatory LoadRandomized · Triple-masked · Treatment | Phase 4 | Completed | Drug: Stannous Fluoride Toothpaste, Colgate fluoride toothpaste | Gingivitis | 26 | 2020-12-22actual | — | 2023-02-16 |
| Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria in Saliva and Bioaerosol ContaminationNCT04626778Change in the Colony Forming Unit of total bacteria in saliva and in bioaerosolRandomized · Double-masked · Treatment | Phase 2 | Completed | Drug: Peroxyl Mouthwash, Placebo Mouthwash | Healthy | 100 | 2020-12-15actual | — | 2021-01-20 |
| Dentinal Hypersensitivity ReductionNCT06244290Tactile dentin hypersensitivityRandomized · Triple-masked · Treatment | Phase 3 | Completed | Drug: Colgate SNF, Sensodyne Extra Whitening, Colgate Fluoride (CDC) | Dentinal Hypersensitivity | 123 | 2020-10-21actual | — | 2026-03-18 |
| Clinical Research Study to Evaluate the Stain Removal EfficacyNCT06242769Composite Lobene Stain IndexRandomized · Triple-masked · Treatment | Phase 3 | Completed | Drug: Stannous Fluoride Toothpaste (SnF), Colgate Fluoride Toothpaste (CDC) | Tooth Stain Removal | 80 | 2020-09-14actual | — | 2024-02-05 |
| Clinical Investigation Examining Plaque and Gingivitis Connected Toothbrush Compared to Non-Connected ToothbrushNCT04221334change in mean dental plaqueRandomized · Triple-masked · Prevention | Not applicable | Completed | Device: Electric Toothbrush · Other: oral health care application | Gingivitis, Plaque, Dental | 79 | 2019-07-03actual | — | 2020-01-09 |
| Clinical Investigation of a Toothpaste Containing Stannous Fluoride as Compared to Colgate Fluoride ToothpasteNCT04033575Gingivitis ScoresRandomized · Triple-masked · Treatment | Phase 4 | Completed | Drug: Colgate Total SF, Colgate Cavity Protection toothpaste | Gingivitis | 88 | 2019-06-06actual | — | 2022-09-27 |
| Dentin Hypersensitivity Reduction Efficacy ClinicalNCT07738198Tactile Sensitivity using the Yeaple Electronic Force Sensing ProbeRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: 0.454% stannous fluoride toothpaste, 5% potassium nitrate, 0.76% sodium monofluorophosphate | Dental Hypersensitivity | 116 | 2018-12-08actual | — | 2026-07-31 |
| Metagenomic and Metatranscriptomic Analysis of Clinical Plaque SamplesNCT05138978DNA (metagenomic) sequencesNon-randomized · Triple-masked · Basic science | Phase 2 | Completed | Drug: Colgate Maximum Cavity Protection plus Sugar Acid Neutralizer, Colgate Cavity Protection | Plaque | 34 | 2018-10-17actual | — | 2021-12-01 |
| A Clinical Study Conducted in the Bangkok, Thailand Area, to Investigate the Clinical Efficacy of a New ToothpasteNCT07223073Mean Organoleptic scores for each treatment groupRandomized · Quadruple-masked · Treatment | Phase 3 | Completed | Drug: 0.454% stannous fluoride, 0.76% sodium monofluorophosphate | Oral Malodor | 80 | 2018-01-12actual | — | 2025-10-31 |
| The Clinical Investigation of a New Toothpaste Containing Stannous Fluoride as Compared to a Commercially Available Fluoride Toothpaste in Reducing Plaque and GingivitisNCT03852056Dental Plaque ScoresRandomized · Triple-masked · Treatment | Phase 3 | Completed | Drug: MFP Fluoride toothpaste, Stannous fluoride toothpaste | Dental Plaque, Gingivitis | 98 | 2017-12-07actual | — | 2019-02-22 |
| Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.NCT07223060Supragingival calculus formation via Volpe-Manhold Calculus IndexRandomized · Quadruple-masked · Treatment | Phase 2/3 | Completed | Drug: 0.454% stannous fluoride, 0.76% sodium monofluorophosphate | Calculus, Dental | 100 | 2017-10-06actual | — | 2025-12-11 |
| Clinical Investigation of the Effects of Colgate Total Toothpaste as Compared to a Matching Placebo on Periodontal Disease and Systemic Inflammatory MarkersNCT02670135Periodontal Pocket Depth (PPD)Randomized · Double-masked · Treatment | Phase 4 | Completed | Drug: Triclosan Containing Toothpaste, Triclosan Free Toothpaste | Periodontal Disease, Systemic Inflammatory Markers | 303 | Jul 2016actual | — | 2019-02-22 |
| Assessment of Prevident Sodium Fluoride 1.1% Toothpaste Using an Intra-oral Remineralization-demineralization ModelNCT02708160Mineral Change (delta Z)Randomized · Triple-masked · Treatment | Phase 2 | Withdrawnsponsor's stated reason: Withdrawn due to business reasons | Drug: Fluoride Free toothpaste, 1.1% Fluoride toothpaste, 0.243% Fluoride toothpaste | Dental Caries | 0 | Jun 2016 | — | 2019-02-21 |
| To Determine the Ability of a New Product Formulation to Remineralize an Early Caries Lesion by an In-situ StudyNCT02388178Mineral Change (delta Z)Randomized · Triple-masked · Treatment | Phase 2 | Withdrawnsponsor's stated reason: The study was stopped due to business reasons. | Drug: Control toothpaste containing no anti-cavity ingredients, Experimental toothpaste containing fluoride and amino acid (arginine), Fluoride toothpaste containing fluoride as the anti-cavity ingredient | Dental Caries | 0 | Jul 2015 | — | 2022-09-27 |
| The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and GingivitisNCT02243046results2016-05-04Gingivitis ScoresRandomized · Double-masked · Treatment | Phase 2 | Completed | Drug: Control toothpaste, Experimental toothpaste, Active Comparator | Dental Plaque and Gingivitis | 162 | May 2015actual | — | 2019-02-25 |
| Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash)NCT02366689results2016-03-30Dental Plaque ScoresRandomized · Triple-masked · Treatment | Phase 4 | Completed | Drug: Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride only toothpaste, Cetylpyridinium chloride mouthwash, Fluoride only mouthwash | Dental Plaque, Gingivitis | 179 | Dec 2014actual | — | 2016-03-30 |
| The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and GingivitisNCT02193165results2015-02-06Dental Plaque ScoresRandomized · Triple-masked · Treatment | Phase 3 | Completed | Drug: triclosan/fluoride toothpaste + cetylpyridinium chloride Mouthwash, stannous fluoride toothpaste + cetylpyridinium chloride Mouthwash, fluoride toothpaste + fluoride Mouthwash | Dental Plaque, Gingivitis | 120 | Aug 2014actual | — | 2015-08-17 |
| The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the USNCT02360995results2016-03-30Dental Plaque ScoresRandomized · Triple-masked · Treatment | Phase 4 | Completed | Drug: Triclosan/fluoride toothpaste, stannous fluoride toothpaste, fluoride toothpaste, Fluoride Mouthwash, cetylpyridinium chloride Mouthwash | Dental Plaque, Gingivitis | 129 | Aug 2014actual | — | 2016-03-30 |
| Clinical Investigation to Examine Toothpaste Effect on Oral BacteriaNCT02194621results2016-04-15Anaerobic BacteriaRandomized · Double-masked · Prevention | Phase 4 | Completed | Drug: Total Flavor option 1, Total Flavor option 2, Placebo toothpaste: Crest Cavity Protection toothpaste | Oral Bacteria Levels in the Mouth | 128 | Mar 2014actual | — | 2016-04-15 |
| Six Month Plaque and Gingivitis Study Using Colgate Total ToothpasteNCT02080273results2019-05-20Dental Plaque ScoreRandomized · Triple-masked · Treatment | Phase 4 | Completed | Drug: Colgate Cavity Protection toothpaste, Colgate Total toothpaste, Parodontax toothpaste | Dental Plaque, Gingivitis | 135 | Nov 2013actual | — | 2019-05-20 |
| Compare Anti-inflammatory DentifricesNCT00762528results2012-04-03Gingival Index (GI)Randomized · Double-masked · Treatment | Phase 4 | Completed | Drug: Triclosan/Copolymer/fluoride toothpaste, Sodium monofluorophosphate toothpaste | Gingivitis | 49 | Feb 2010actual | — | 2015-09-10 |
| Periodontal Disease and Cardiovascular DiseaseNCT00763165Periodontal diseaseRandomized · Double-masked · Treatment | Phase 3 | Unknown status | Drug: Triclosan, Fluoride, Fluoride | Periodontal Diseases | 438 | Dec 2009 | — | 2008-10-02 |
| The Effect of Periodontal Treatment and the Use of Dentifrice on Glycaemic Control in DiabeticsNCT00763256results2012-04-02HbA1c Levels in BloodRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Triclosan, Fluoride, Fluoride | Periodontal Disease | 33 | Aug 2009actual | — | 2015-07-28 |
| Effectiveness of a Triclosan Containing Toothpaste in Maintaining Periodontal Health in a Type 2 Diabetic PopulationNCT00762762results2012-04-26HbA1c Levels in BloodRandomized · Single-masked · Treatment | Phase 3 | Completed | Drug: Triclosan/copolymer/fluoride, Fluoride | Periodontitis | 60 | Dec 2008actual | — | 2023-03-03 |
| The Efficacy of a Toothpaste to Reduce SensitivityNCT00763269results2010-09-17Hypersensitivity Tactile(Yeaple Probe)Randomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Triclosan, Silicon dioxide, fluoride, Triclosan, fluoride | Dentin Hypersensitivity | 626 | Dec 2008actual | — | 2012-03-07 |
| Investigate Oral Bacteria in Adult PopulationNCT00762177results2011-02-14Antimicrobial Species in Plaque(Actinomyces)Randomized · Single-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Fluoride, Triclosan, Stannous Fluoride | Oral Bacteria | 24 | Sep 2008actual | — | 2011-03-23 |
| Effect on Bacterial Glycolytic Acid Formation on PlaqueNCT00762450results2011-02-15ph of Dental Plaque After Sucrose ChallengeRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Triclosan, Fluoride, fluoride, Fluoride, triclosan, amino acid | Dental Plaque | 6 | Aug 2008actual | — | 2012-03-07 |
| Clinical Study to Evaluate the Treatment of Gingivitis of Two ToothpastesNCT00762515results2010-12-14Control Established Plaque in AdultsRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan, Fluoride | Dental Plaque | 44 | Aug 2008actual | — | 2010-12-28 |
| Clinical Study to Examine Brushing on Dental ImplantsNCT00762619results2011-01-25Mombelli Plaque Index (mPI) for Natural TeethRandomized · Single-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan, fluoride | Gingival Diseases | 105 | Aug 2008actual | — | 2011-01-25 |
| Evaluate Inflammation Caused by Gingivitis in AdultsNCT00941668results2009-07-17Level of Gingival Crevicular Fluid Interleukin - 1 (GCF IL-1) at 2 HoursRandomized · Double-masked · Treatment | Phase 4 | Completed | Drug: Triclosan/Copolymer/fluoride toothpaste, sodium monofluorophosphate toothpaste | Gingivitis | 49 | Aug 2008actual | — | 2015-08-27 |
| Clinical Efficacy of a Toothpaste on Hypersensitivity ReductionNCT01040169results2009-12-29Tooth Hypersensitity to Touch Stimuli (Tactile)Randomized · Double-masked · Treatment | Not applicable | Completed | Device: Arginine/Calcium Carbonate, Mint Prophy paste - Fluoride free | Hypersensitivity | 79 | Aug 2008actual | — | 2013-12-10 |
| Clinical Efficacy of 10% Arginine Bicarbonate Prophylaxis PasteNCT01072188results2010-02-19Hypersensitivity to Touch (Tactile)Randomized · Double-masked · Treatment | Phase 3 | Completed | Device: Arginine/Calcium Carbonate, Nupro - Fluoride Free | Hypersensitivity | 45 | Aug 2008actual | — | 2011-06-14 |
| Clinical Study to Evaluate Dental PlaqueNCT00758290results2008-11-25Dental Plaque IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Triclosan/Fluoride, Fluoride/triclosan | Gingival Diseases | 23 | Jul 2008actual | — | 2008-11-25 |
| Compare the Clinical Efficacy of Prototype Toothpastes.NCT00761930results2010-10-20Dental PlaqueRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan and fluoride, Herbal Ingredient and fluoride | Gingival Diseases | 103 | Jun 2008actual | — | 2013-08-15 |
| Development of Clinical Method to Triclosan Retention in Plaque Following BrushingNCT00762853results2010-09-14Triclosan Concentration in Dental PlaqueRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Fluoride and triclosan | Dental Plaque | 20 | Jun 2008actual | — | 2012-02-17 |
| Train New Examiners Via Modified Gingival Margin PlaqueNCT00758563results2008-11-20Mean Gingival Plaque UnitsRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan/Fluoride | Dental Plaque | 15 | Apr 2008actual | — | 2008-11-25 |
| Evaluate Clinical Research From Commerical Oral Care ProductsNCT00759187results2008-11-18Dental Plaque IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan/Fluoride, Chlorhexidine Gluconate | Gingival Diseases | 25 | Apr 2008actual | — | 2010-03-04 |
| Collection of Gingival Crevicular Fluid From Periodontitis PatientsNCT00763048results2011-03-01Metabolite Associated With Inflammation (Cadaverine)Randomized · Single-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Fluoride, triclosan | Gingival Diseases | 39 | Apr 2008actual | — | 2011-06-14 |
| Compare the Clinical Efficacy of Prototype ToothpastesNCT00926029results2009-06-23Plaque IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan, fluoride · Other: Metal salt | Dental Plaque | 98 | Apr 2008actual | — | 2012-02-17 |
| Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral RinseNCT01024738results2009-12-03Plaque IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan, fluoride, Chlorhexidine Gluconate | Dental Plaque | 22 | Apr 2008actual | — | 2009-12-03 |
| Investigation of Dental Plaque and Gingival IndexNCT00759031results2008-11-25Gingival Margin Plaque IndexRandomized · Single-masked · Treatment | Phase 3 | Completed | Drug: Sodium Monofluorophosphate, Triclosan/Fluoride/Copolymer | Dental Plaque | 19 | Mar 2008actual | — | 2012-04-13 |
| Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.NCT00966953results2009-08-27Plaque IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan/Fluoride toothpaste, Fluoride, Fluoride · Other: antibacterial plant extract | Gingival Diseases | 25 | Jan 2008actual | — | 2009-09-22 |
| Training and Calibration of Dental ExaminersNCT00765167Dental plaqueRandomized · Single-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan, Chlorhexidine gluconate, Fluoride | Dental Plaque | 18 | Dec 2007actual | — | 2008-10-03 |
| Comparative Efficacy of a Toothpaste That Reduces Plaque and GingivitisNCT00926328results2009-06-23Gingivitis IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Triclosan, fluoride, Fluoride | Gingivitis | 120 | Dec 2007actual | — | 2013-08-15 |
| Efficacy of Salivary Bacteria and Post BrushingNCT00981825results2009-09-22CFU (Colony Forming Units)Randomized · Single-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan/Fluoride | Salivary Bacteria Levels | 22 | Dec 2007actual | — | 2011-06-14 |
| To Access the Effects of Mucositis in Adults With Dental ImplantsNCT01072201results2010-02-19Bleeding on ProbingRandomized · Single-masked · Treatment | Phase 3 | Completed | Drug: Triclosan and Fluoride, Fluoride | Mucositis | 60 | Dec 2007actual | — | 2010-10-05 |
| Clinical Study to Compare Dental Plaque ControlNCT00758394results2008-11-19Dental Plaque IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Fluoride, Triclosan/Fluoride, Triclosan/Fluoride, Triclosan/Fluoride | Dental Plaque | 29 | Nov 2007actual | — | 2013-08-15 |
| Clinical Research Study Efficacy of a Prototype Oral RinseNCT01021007results2009-11-26Gingival IndexRandomized · Double-masked · Treatment | Phase 3 | Completed | Drug: Iodine · Other: water | Dental Plaque | 67 | Nov 2007actual | — | 2009-12-01 |
| Evaluating Commercial Anti-Plaque Products and Oral RinseNCT01014143results2009-11-16Plaque IndexRandomized · Double-masked · Treatment | Phase 2 | Completed | Drug: Fluoride, Chlorhexidine digluconate, Fluoride, triclosan | Dental Plaque | 26 | Sep 2007actual | — | 2011-06-14 |
Primary completion is the date the sponsor filed with the registry — their own projection, revised whenever they revise it, unless the row is marked actual.
Source: ClinicalTrials.gov, retrieved 2026-08-19