Institutional 13F holdings sum to 101.8% of shares outstanding. Readings above 100% reflect securities-lending double counting: shares on loan to short sellers are reported long by both the lending institution and the one that bought them. FINRA short interest of 9,222,491 shares (settlement 2026-04-30) accounts for the excess.
| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | RTW INVESTMENTS, LP | 6,984,8087.0M | $473M | 7.92% | ADD 247% |
| 2 | T. Rowe Price Investment Management, Inc. | 6,720,3896.7M | $455M | 7.62% | ADD 1347% |
| 3 | Decheng Capital LLC | 6,371,6696.4M | $431M | 7.22% | — |
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 5,371,2325.4M | $364M | 6.09% | TRIM -10% |
| 5 | BlackRock, Inc. | 5,064,1805.1M | $343M | 5.74% | ADD 5% |
| 6 | FMR LLC | 3,764,8443.8M | $255M | 4.27% | TRIM -12% |
| 7 | TCG Crossover Management, LLC | 3,670,2063.7M | $248M | 4.16% | — |
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,652,9803.7M | $247M | 4.14% | ADD 6% |
| 9 | VANGUARD PORTFOLIO MANAGEMENT LLC | 3,095,0983.1M | $209M | 3.51% | NEW† |
| 10 | VANGUARD CAPITAL MANAGEMENT LLC | 3,033,6253.0M | $205M | 3.44% | NEW† |
| 11 | STATE STREET CORP | 2,647,0542.6M | $179M | 3.00% | TRIM -12% |
| 12 | Foresite Capital Management VI LLC | 2,221,4742.2M | $150M | 2.52% | — |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 1,596,8641.6M | $108M | 1.81% | ADD 6% |
| 14 | Seven Fleet Capital Management LP | 1,515,1511.5M | $103M | 1.72% | — |
| 15 | FRANKLIN RESOURCES INC | 1,507,0051.5M | $102M | 1.71% | TRIM -3% |
| 16 | BANK OF AMERICA CORP /DE/ | 1,449,3641.4M | $98M | 1.64% | ADD 22% |
| 17 | DV Trading LLC | 1,439,3931.4M | $97M | 1.63% | — |
| 18 | UBS Group AG | 1,311,9781.3M | $89M | 1.49% | TRIM -32% |
| 19 | Avidity Partners Management LP | 1,288,9481.3M | $87M | 1.46% | TRIM -12% |
| 20 | GOLDMAN SACHS GROUP INC | 1,159,2391.2M | $78M | 1.31% | TRIM -12% |
| 21 | ACORN CAPITAL ADVISORS, LLC | 1,130,5011.1M | $77M | 1.28% | — |
| 22 | EcoR1 Capital, LLC | 1,102,0001.1M | $75M | 1.25% | ADD 43% |
| 23 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,064,9661.1M | $72M | 1.21% | TRIM -2% |
| 24 | Foresite Capital Management V, LLC | 1,004,0501.0M | $68M | 1.14% | — |
| 25 | Driehaus Capital Management LLC | 999,623999,623 | $68M | 1.13% | NEW |
| 26 | BRAIDWELL LP | 984,783984,783 | $67M | 1.12% | TRIM -47% |
| 27 | ORBIMED ADVISORS LLC | 948,267948,267 | $64M | 1.08% | TRIM -37% |
| 28 | ALLIANCEBERNSTEIN L.P. | 1,290,0871.3M | $54M | 1.46% | TRIM -20% |
| 29 | Clearbridge Investments, LLC | 730,283730,283 | $49M | 0.83% | ADD 4% |
| 30 | Polar Capital Holdings Plc | 704,461704,461 | $48M | 0.80% | TRIM -36% |
| 31 | FARALLON CAPITAL MANAGEMENT LLC | 674,000674,000 | $46M | 0.76% | ADD 8325% |
| 32 | Logos Global Management LP | 575,000575,000 | $39M | 0.65% | ADD 188% |
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 542,378542,378 | $37M | 0.61% | — |
| 34 | Candriam S.C.A. | 542,036542,036 | $37M | 0.61% | TRIM -32% |
| 35 | JPMORGAN CHASE & CO | 559,586559,586 | $36M | 0.63% | TRIM -5% |
| 36 | MORGAN STANLEY | 520,213520,213 | $35M | 0.59% | TRIM -5% |
| 37 | NORTHERN TRUST CORP | 519,669519,669 | $35M | 0.59% | ADD 8% |
| 38 | Woodline Partners LP | 492,891492,891 | $33M | 0.56% | — |
| 39 | JENNISON ASSOCIATES LLC | 476,136476,136 | $32M | 0.54% | ADD 69% |
| 40 | VANGUARD FIDUCIARY TRUST CO | 470,257470,257 | $32M | 0.53% | NEW |
| 41 | Fisher Asset Management, LLC | 465,033465,033 | $31M | 0.53% | NEW |
| 42 | Ensign Peak Advisors, Inc | 456,012456,012 | $31M | 0.52% | TRIM -14% |
| 43 | DIMENSIONAL FUND ADVISORS LP | 438,673438,673 | $30M | 0.50% | TRIM -5% |
| 44 | STEMPOINT CAPITAL LP | 411,244411,244 | $28M | 0.47% | NEW |
| 45 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 399,858399,858 | $27M | 0.45% | NEW |
| 46 | Point72 Asset Management, L.P. | 399,392399,392 | $27M | 0.45% | ADD 164% |
| 47 | Pictet Asset Management Holding SA | 398,005398,005 | $27M | 0.45% | TRIM -71% |
| 48 | Caption Management, LLC | 378,480378,480 | $26M | 0.43% | ADD 23% |
| 49 | EVENTIDE ASSET MANAGEMENT, LLC | 369,985369,985 | $25M | 0.42% | ADD 18% |
| 50 | LORD, ABBETT & CO. LLC | 340,197340,197 | $23M | 0.39% | ADD 171% |
| 51 | FIRST TRUST ADVISORS LP | 333,192333,192 | $23M | 0.38% | ADD 83% |
| 52 | AMERIPRISE FINANCIAL INC | 311,523311,523 | $21M | 0.35% | ADD 30% |
| 53 | Elmind Capital, LP | 291,800291,800 | $20M | 0.33% | TRIM -41% |
| 54 | TD Asset Management Inc | 288,756288,756 | $20M | 0.33% | ADD 55% |
| 55 | TimesSquare Capital Management, LLC | 253,708253,708 | $17M | 0.29% | TRIM -40% |
| 56 | HSBC HOLDINGS PLC | 187,765187,765 | $13M | 0.21% | NEW |
| 57 | ArrowMark Colorado Holdings LLC | 186,312186,312 | $13M | 0.21% | TRIM -24% |
| 58 | ADAR1 Capital Management, LLC | 185,699185,699 | $13M | 0.21% | TRIM -28% |
| 59 | CITADEL ADVISORS LLC | 172,815172,815 | $12M | 0.20% | TRIM -75% |
| 60 | Bank of New York Mellon Corp | 167,030167,030 | $11M | 0.19% | ADD 8% |
| 61 | SILVERARC CAPITAL MANAGEMENT, LLC | 166,349166,349 | $11M | 0.19% | TRIM -54% |
| 62 | PFM Health Sciences, LP | 165,925165,925 | $11M | 0.19% | — |
| 63 | Russell Investments Group, Ltd. | 163,172163,172 | $11M | 0.18% | ADD 14% |
| 64 | DEUTSCHE BANK AG\ | 156,454156,454 | $11M | 0.18% | ADD 4% |
| 65 | FEDERATED HERMES, INC. | 148,750148,750 | $10M | 0.17% | ADD 4150% |
| 66 | SCHRODER INVESTMENT MANAGEMENT GROUP | 156,327156,327 | $10M | 0.18% | TRIM -44% |
| 67 | Universal- Beteiligungs- und Servicegesellschaft mbH | 144,103144,103 | $10M | 0.16% | ADD 281% |
| 68 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 136,841136,841 | $9M | 0.16% | TRIM -32% |
| 69 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 136,544136,544 | $9M | 0.15% | ADD 6% |
| 70 | Nuveen, LLC | 128,414128,414 | $9M | 0.15% | TRIM -5% |
| 71 | AQR CAPITAL MANAGEMENT LLC | 114,342114,342 | $8M | 0.13% | — |
| 72 | BNP PARIBAS FINANCIAL MARKETS | 108,039108,039 | $7M | 0.12% | ADD 12% |
| 73 | Rosalind Advisors, Inc. | 100,000100,000 | $7M | 0.11% | TRIM -67% |
| 74 | Opaleye Management Inc. | 94,80094,800 | $6M | 0.11% | TRIM -77% |
| 75 | Invesco Ltd. | 91,99491,994 | $6M | 0.10% | ADD 141% |
| 76 | Swiss National Bank | 84,40084,400 | $6M | 0.10% | — |
| 77 | RHUMBLINE ADVISERS | 71,08271,082 | $5M | 0.08% | — |
| 78 | ALPS ADVISORS INC | 68,73768,737 | $5M | 0.08% | ADD 4% |
| 79 | Rafferty Asset Management, LLC | 67,97967,979 | $5M | 0.08% | TRIM -36% |
| 80 | PICTON MAHONEY ASSET MANAGEMENT | 67,40467,404 | $5M | 0.08% | ADD 2265% |
| 81 | Blackstone Inc. | 64,12864,128 | $4M | 0.07% | NEW |
| 82 | Tidal Investments LLC | 63,16363,163 | $4M | 0.07% | NEW |
| 83 | Tema ETFs LLC | 63,16363,163 | $4M | 0.07% | ADD 75% |
| 84 | BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 57,73257,732 | $4M | 0.07% | — |
| 85 | VOYA INVESTMENT MANAGEMENT LLC | 57,29157,291 | $4M | 0.06% | ADD 31% |
| 86 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,49951,499 | $3M | 0.06% | ADD 24% |
| 87 | Aquatic Capital Management LLC | 49,62849,628 | $3M | 0.06% | NEW |
| 88 | Nantahala Capital Management, LLC | 49,44949,449 | $3M | 0.06% | TRIM -55% |
| 89 | D. E. Shaw & Co., Inc. | 46,61046,610 | $3M | 0.05% | ADD 102% |
| 90 | Informed Momentum Co LLC | 46,10246,102 | $3M | 0.05% | NEW |
| 91 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,61545,615 | $3M | 0.05% | ADD 6% |
| 92 | SummitTX Capital, L.P. | 40,57040,570 | $3M | 0.05% | TRIM -19% |
| 93 | Legal & General Group Plc | 38,00838,008 | $3M | 0.04% | TRIM -16% |
| 94 | MetLife Investment Management, LLC | 32,60432,604 | $2M | 0.04% | — |
| 95 | Lynx1 Capital Management LP | 31,59131,591 | $2M | 0.04% | — |
| 96 | PROFUND ADVISORS LLC | 30,68830,688 | $2M | 0.03% | TRIM -22% |
| 97 | Vanguard Global Advisers, LLC | 30,25630,256 | $2M | 0.03% | NEW |
| 98 | VANGUARD ASSET MANAGEMENT, Ltd | 28,94328,943 | $2M | 0.03% | NEW |
| 99 | TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 27,75327,753 | $2M | 0.03% | — |
| 100 | STATE OF WISCONSIN INVESTMENT BOARD | 26,84026,840 | $2M | 0.03% | — |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 1.7M | 1.7M | 1.7M | 1.7M | 2.0M | 7.0M | $473M |
| T. Rowe Price Investment Management, Inc. | — | — | — | — | 464K | 6.7M | $455M |
| Decheng Capital LLC | 6.4M | 6.4M | 6.4M | 6.4M | 6.4M | 6.4M | $431M |
| WELLINGTON MANAGEMENT GROUP LLP | 1.9M | 2.1M | 1.9M | 5.5M | 6.0M | 5.4M | $364M |
| BlackRock, Inc. | 4.1M | 4.4M | 4.5M | 4.6M | 4.8M | 5.1M | $343M |
| FMR LLC | 2.4M | 2.5M | 3.9M | 3.9M | 4.3M | 3.8M | $255M |
| TCG Crossover Management, LLC | 3.7M | 3.7M | 3.7M | 3.7M | 3.7M | 3.7M | $248M |
| PRICE T ROWE ASSOCIATES INC /MD/ | 945K | 1.0M | 2.0M | 1.6M | 3.4M | 3.7M | $247M |
| VANGUARD PORTFOLIO MANAGEMENT LLC | — | — | — | — | — | 3.1M | $209M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 3.0M | $205M |
| STATE STREET CORP | 1.9M | 2.0M | 2.2M | 2.0M | 3.0M | 2.6M | $179M |
| Foresite Capital Management VI LLC | 2.2M | 2.2M | 2.2M | 2.2M | 2.2M | 2.2M | $150M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.2M | 1.3M | 1.3M | 1.5M | 1.5M | 1.6M | $108M |
| Seven Fleet Capital Management LP | — | — | — | — | 1.5M | 1.5M | $103M |
| FRANKLIN RESOURCES INC | 1.3M | 1.3M | 1.5M | 1.5M | 1.6M | 1.5M | $102M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding uses today's share count for every quarter (the only count stored).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 233 | 89,777,080 | 101.8% | $6.0B |
| 2025-Q4 | 194 | 82,676,168 | 93.7% | $3.4B |
| 2025-Q3 | 176 | 77,876,923 | 88.3% | $3.1B |
| 2025-Q2 | 163 | 75,940,298 | 86.1% | $2.0B |
| 2025-Q1 | 142 | 70,776,673 | 80.2% | $1.7B |
| 2024-Q4 | 140 | 66,220,898 | 75.1% | $1.9B |
| 2024-Q3 | 121 | 52,214,144 | 59.2% | $2.0B |
| 2024-Q2 | 111 | 43,294,059 | 49.1% | $1.4B |
| 2024-Q1 | 96 | 38,928,787 | 44.1% | $1.7B |
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
“The information set forth in Item 3 of this Statement is incorporated herein by reference. The Reporting Persons hold the securities of the Issuer for general investment purposes. The Reporting Persons may, from time to time, depending on prevailing market, economic and other conditions, acquire additional shares of Common Stock or other securities of the Issuer, dispose of any such securities, or engage in discussions with the Issuer concerning such acquisitions or dispositions or further inves”
“Item 4 of the Schedule 13D is amended to add the following: The Reporting Persons effected an internal restructuring into a master-feeder structure, pursuant to which Seven Fleet Partners LP contributed, for no consideration, all of the 1,515,151 Shares it then held to Seven Fleet Master Fund LP on October 6, 2025 (the "Contribution Date"). Following the Contribution Date, Seven Fleet Partners LP no longer beneficially owns any securities of the Issuer and has ceased to be a reporting person wit”
“The Reporting Persons purchased the Shares based on the Reporting Persons' belief that the Shares, when purchased, were undervalued and represented an attractive investment opportunity. Depending upon overall market conditions, other investment opportunities available to the Reporting Persons, and the availability of Shares at prices that would make the purchase or sale of Shares desirable, the Reporting Persons may endeavor to increase or decrease their position in the Issuer through, among oth”
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
