| # | Holder | Shares | Value | % of shares out | Δ QoQ |
|---|---|---|---|---|---|
| 1 | Avidity Partners Management LP | 12,099,99812.1M | $49M | 10.62% | ADD 277% |
| 2 | TCG Crossover Management, LLC | 7,915,5677.9M | $33M | 6.95% | NEW† |
| 3 | Commodore Capital LP | 6,336,7826.3M | $26M | 5.56% | NEW† |
| 4 | BlackRock, Inc. | 5,348,5615.3M | $22M | 4.69% | ADD 17% |
| 5 | Opaleye Management Inc. | 4,675,0004.7M | $19M | 4.10% | ADD 295% |
| 6 | VANGUARD CAPITAL MANAGEMENT LLC | 4,378,9564.4M | $18M | 3.84% | NEW† |
| 7 | MILLENNIUM MANAGEMENT LLC | 4,046,6404.0M | $17M | 3.55% | ADD 188% |
| 8 | CITADEL ADVISORS LLC | 3,566,5043.6M | $15M | 3.13% | ADD 1219% |
| 9 | Affinity Asset Advisors, LLC | 3,164,5823.2M | $13M | 2.78% | ADD 955% |
| 10 | STATE STREET CORP | 3,132,6703.1M | $13M | 2.75% | ADD 174% |
| 11 | Balyasny Asset Management L.P. | 2,994,4603.0M | $12M | 2.63% | NEW† |
| 12 | MORGAN STANLEY | 2,983,3423.0M | $12M | 2.62% | TRIM -33% |
| 13 | Spruce Street Capital LP | 2,627,1072.6M | $11M | 2.31% | NEW† |
| 14 | GEODE CAPITAL MANAGEMENT, LLC | 1,766,9601.8M | $7M | 1.55% | ADD 25% |
| 15 | Patient Square Capital LP | 1,625,0001.6M | $7M | 1.43% | ADD 43% |
| 16 | Nicholson Wealth Management Group, LLC | 1,618,9931.6M | $7M | 1.42% | — |
| 17 | GOLDMAN SACHS GROUP INC | 1,241,8161.2M | $5M | 1.09% | ADD 677% |
| 18 | VESTOR CAPITAL, LLC | 1,098,6911.1M | $5M | 0.96% | ADD 218763% |
| 19 | Yu Fan | 1,055,4091.1M | $4M | 0.93% | NEW |
| 20 | TWO SIGMA INVESTMENTS, LP | 1,003,4741.0M | $4M | 0.88% | TRIM -16% |
| 21 | Ally Bridge Group (NY) LLC | 926,557926,557 | $4M | 0.81% | NEW |
| 22 | Nuveen, LLC | 910,221910,221 | $4M | 0.80% | TRIM -29% |
| 23 | Hills Bank & Trust Co | 872,200872,200 | $4M | 0.77% | TRIM -7% |
| 24 | Octagon Capital Advisors LP | 791,555791,555 | $3M | 0.69% | NEW |
| 25 | VANGUARD PORTFOLIO MANAGEMENT LLC | 752,033752,033 | $3M | 0.66% | NEW |
| 26 | ADAR1 Capital Management, LLC | 749,335749,335 | $3M | 0.66% | ADD 687% |
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 661,318661,318 | $3M | 0.58% | ADD 24% |
| 28 | VANGUARD FIDUCIARY TRUST CO | 566,676566,676 | $2M | 0.50% | NEW |
| 29 | NORTHERN TRUST CORP | 528,928528,928 | $2M | 0.46% | ADD 20% |
| 30 | UBS Group AG | 520,905520,905 | $2M | 0.46% | TRIM -44% |
| 31 | DIMENSIONAL FUND ADVISORS LP | 450,097450,097 | $2M | 0.40% | ADD 392% |
| 32 | WealthPlan Investment Management, LLC | 404,071404,071 | $2M | 0.35% | — |
| 33 | Seven Fleet Capital Management LP | 379,082379,082 | $2M | 0.33% | NEW |
| 34 | FMR LLC | 313,658313,658 | $1M | 0.28% | ADD 2% |
| 35 | PORTLAND INVESTMENT COUNSEL INC. | 250,000250,000 | $1M | 0.22% | — |
| 36 | BANK OF AMERICA CORP /DE/ | 241,924241,924 | $1M | 0.21% | TRIM -43% |
| 37 | Invesco Ltd. | 231,355231,355 | $964,750 | 0.20% | ADD 853% |
| 38 | FEDERATED HERMES, INC. | 222,142222,142 | $926,332 | 0.19% | ADD 4% |
| 39 | CITIGROUP INC | 212,131212,131 | $884,586 | 0.19% | ADD 183% |
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 186,630186,630 | $778,247 | 0.16% | ADD 129% |
| 41 | Bank of New York Mellon Corp | 185,335185,335 | $772,845 | 0.16% | — |
| 42 | Jefferies Financial Group Inc. | 183,342183,342 | $764,536 | 0.16% | NEW |
| 43 | Squarepoint Ops LLC | 169,147169,147 | $705,343 | 0.15% | NEW |
| 44 | WELLINGTON MANAGEMENT GROUP LLP | 168,223168,223 | $701,489 | 0.15% | NEW |
| 45 | Rothschild Wealth LLC | 164,821164,821 | $687,304 | 0.14% | — |
| 46 | STATE OF WISCONSIN INVESTMENT BOARD | 119,114119,114 | $496,705 | 0.10% | NEW |
| 47 | ExodusPoint Capital Management, LP | 117,051117,051 | $488,103 | 0.10% | NEW |
| 48 | VOYA INVESTMENT MANAGEMENT LLC | 115,489115,489 | $481,589 | 0.10% | ADD 982% |
| 49 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 110,800110,800 | $462,036 | 0.10% | ADD 16% |
| 50 | Trueblood Wealth Management, LLC | 99,06199,061 | $413,084 | 0.09% | TRIM -17% |
| 51 | Rafferty Asset Management, LLC | 92,81292,812 | $387,026 | 0.08% | NEW |
| 52 | RHUMBLINE ADVISERS | 77,09077,090 | $321,456 | 0.07% | — |
| 53 | Vanguard Global Advisers, LLC | 73,95073,950 | $308,372 | 0.06% | NEW |
| 54 | Creative Planning | 71,46471,464 | $298,005 | 0.06% | ADD 77% |
| 55 | Quantinno Capital Management LP | 65,49465,494 | $273,110 | 0.06% | NEW |
| 56 | Corient Private Wealth LLC | 61,86461,864 | $257,974 | 0.05% | NEW |
| 57 | Caption Management, LLC | 60,00060,000 | $250,200 | 0.05% | NEW |
| 58 | ALLIANCEBERNSTEIN L.P. | 83,47083,470 | $229,543 | 0.07% | — |
| 59 | DEUTSCHE BANK AG\ | 53,16353,163 | $221,690 | 0.05% | — |
| 60 | SIMPLEX TRADING, LLC | 42,48642,486 | $177,166 | 0.04% | NEW |
| 61 | PRICE T ROWE ASSOCIATES INC /MD/ | 42,28242,282 | $177,000 | 0.04% | ADD 42% |
| 62 | PROFUND ADVISORS LLC | 41,56741,567 | $173,334 | 0.04% | NEW |
| 63 | SYKON CAPITAL LLC | 37,93237,932 | $158,176 | 0.03% | — |
| 64 | GSA CAPITAL PARTNERS LLP | 37,31737,317 | $156,000 | 0.03% | TRIM -57% |
| 65 | AMERICAN CENTURY COMPANIES INC | 35,72235,722 | $148,961 | 0.03% | ADD 184% |
| 66 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,84134,841 | $143,091 | 0.03% | ADD 26% |
| 67 | TUDOR INVESTMENT CORP ET AL | 33,94633,946 | $141,555 | 0.03% | NEW |
| 68 | MetLife Investment Management, LLC | 33,07933,079 | $137,939 | 0.03% | ADD 98% |
| 69 | WEALTH EFFECTS LLC | 33,00033,000 | $137,610 | 0.03% | ADD 32% |
| 70 | Taylor & Morgan Wealth Management, LLC | 29,00029,000 | $120,930 | 0.03% | TRIM -70% |
| 71 | JPMORGAN CHASE & CO | 29,24129,241 | $111,992 | 0.03% | ADD 4% |
| 72 | AQR CAPITAL MANAGEMENT LLC | 26,71626,716 | $111,406 | 0.02% | NEW |
| 73 | Koa Wealth Management, LLC | 25,97525,975 | $108,316 | 0.02% | — |
| 74 | WINTON GROUP Ltd | 24,30024,300 | $101,331 | 0.02% | NEW |
| 75 | MONETA GROUP INVESTMENT ADVISORS LLC | 23,70723,707 | $98,858 | 0.02% | — |
| 76 | WELLS FARGO & COMPANY/MN | 23,49123,491 | $97,957 | 0.02% | TRIM -65% |
| 77 | Hudson Bay Capital Management LP | 23,09023,090 | $96,285 | 0.02% | NEW |
| 78 | MERCER GLOBAL ADVISORS INC /ADV | 22,26922,269 | $92,862 | 0.02% | TRIM -20% |
| 79 | BNP PARIBAS FINANCIAL MARKETS | 21,66121,661 | $90,326 | 0.02% | ADD 73% |
| 80 | CIBC Asset Management Inc | 20,91720,917 | $87,224 | 0.02% | — |
| 81 | Police & Firemen's Retirement System of New Jersey | 20,78720,787 | $86,682 | 0.02% | — |
| 82 | HighTower Advisors, LLC | 20,02720,027 | $83,513 | 0.02% | TRIM -46% |
| 83 | INTECH INVESTMENT MANAGEMENT LLC | 19,50719,507 | $81,344 | 0.02% | TRIM -24% |
| 84 | Iowa State Bank | 19,06119,061 | $79,484 | 0.02% | — |
| 85 | Vontobel Holding Ltd. | 18,00018,000 | $75,060 | 0.02% | TRIM -28% |
| 86 | AXQ CAPITAL, LP | 17,04817,048 | $71,090 | 0.01% | ADD 34% |
| 87 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,68116,681 | $69,560 | 0.01% | TRIM -12% |
| 88 | Qube Research & Technologies Ltd | 15,60815,608 | $65,085 | 0.01% | TRIM -81% |
| 89 | AUCTUS ADVISORS LLC | 15,54815,548 | $64,835 | 0.01% | TRIM -51% |
| 90 | BARCLAYS PLC | 15,04915,049 | $62,754 | 0.01% | TRIM -84% |
| 91 | Virtu Financial LLC | 14,88814,888 | $62,000 | 0.01% | NEW |
| 92 | Dynamic Technology Lab Private Ltd | 14,05614,056 | $58,614 | 0.01% | NEW |
| 93 | Polymer Capital Management (US) LLC | 13,08313,083 | $54,556 | 0.01% | NEW |
| 94 | NISA INVESTMENT ADVISORS, LLC | 12,69212,692 | $52,926 | 0.01% | ADD 8966% |
| 95 | Susquehanna Portfolio Strategies, LLC | 12,52812,528 | $52,242 | 0.01% | NEW |
| 96 | Scientech Research LLC | 11,90511,905 | $49,644 | 0.01% | NEW |
| 97 | Mariner, LLC | 11,81511,815 | $49,258 | 0.01% | NEW |
| 98 | Abel Hall, LLC | 11,79411,794 | $49,181 | 0.01% | NEW |
| 99 | Tower Research Capital LLC (TRC) | 11,67511,675 | $48,685 | 0.01% | ADD 15% |
| 100 | E Fund Management Co., Ltd. | 11,66711,667 | $48,651 | 0.01% | NEW |
† a filer this large appearing as NEW usually reflects a renamed or succeeded filing entity (the old name stops filing the same quarter) — not a brand-new position.
Rows rank by the value each filer reported — 13F filers price their own positions, so a holder with fewer shares can rank just above one with more.
| Holder | 2024-Q4 | 2025-Q1 | 2025-Q2 | 2025-Q3 | 2025-Q4 | 2026-Q1 | Latest value |
|---|---|---|---|---|---|---|---|
| Avidity Partners Management LP | 2.7M | 2.2M | 1.9M | 3.0M | 3.2M | 12.1M | $49M |
| TCG Crossover Management, LLC | — | — | — | — | — | 7.9M | $33M |
| Commodore Capital LP | — | — | — | — | — | 6.3M | $26M |
| BlackRock, Inc. | 4.1M | 4.0M | 4.3M | 4.4M | 4.6M | 5.3M | $22M |
| Opaleye Management Inc. | — | — | — | — | 1.2M | 4.7M | $19M |
| VANGUARD CAPITAL MANAGEMENT LLC | — | — | — | — | — | 4.4M | $18M |
| MILLENNIUM MANAGEMENT LLC | 1.3M | 108K | 2.6M | 2.6M | 1.4M | 4.0M | $17M |
| CITADEL ADVISORS LLC | 215K | 508K | 44K | 161K | 270K | 3.6M | $15M |
| Affinity Asset Advisors, LLC | 1.3M | 2.2M | 1.1M | 300K | 300K | 3.2M | $13M |
| STATE STREET CORP | 1.1M | 1.1M | 1.1M | 1.1M | 1.1M | 3.1M | $13M |
| Balyasny Asset Management L.P. | 131K | — | — | — | — | 3.0M | $12M |
| MORGAN STANLEY | 1.1M | 1.6M | 1.6M | 2.8M | 4.5M | 3.0M | $12M |
| Spruce Street Capital LP | — | — | — | — | — | 2.6M | $11M |
| GEODE CAPITAL MANAGEMENT, LLC | 1.2M | 1.2M | 1.4M | 1.4M | 1.4M | 1.8M | $7M |
| Patient Square Capital LP | — | — | — | 349K | 1.1M | 1.6M | $7M |
Shares reported each quarter by the largest current holders. Green = added vs the prior filing, red = trimmed, grey = roughly held; a dash is a quarter with no 13F on file (a gap is skipped, not read as an exit). 13F is filed up to 45 days after quarter-end. Up to 40 quarters (10 years) available — use the selector above.
Line breaks are honest gaps — quarters with no 13F record, or a suppressed % — never interpolated. % of shares outstanding divides each quarter's as-filed 13F shares by the SEC cover-page share count dated to that same quarter (split-adjusted), not by today's count — so splits and buybacks don't move the line.
Short interest has its own tab now — open SI →
Source: SEC Form 13F — every institution manager (≥ $100M in 13F securities) reporting a long US-listed position, across ~10,250 filers over 10 years of history. 13F is long-only, US-listed, filed up to 45 days after quarter-end.
| Biggest buyers | Δ shares | Δ value | |
|---|---|---|---|
| Avidity Partners Management LP | +8,889,265 | $37M | ADD |
| TCG Crossover Management, LLC | +7,915,567 | $33M | OPEN |
| Commodore Capital LP | +6,336,782 | $26M | OPEN |
| VANGUARD CAPITAL MANAGEMENT LLC | +4,378,956 | $18M | OPEN |
| Opaleye Management Inc. | +3,490,500 | $15M | ADD |
| Biggest sellers | Δ shares | Δ value | |
|---|---|---|---|
| VANGUARD GROUP INC | −3,490,658 | $15M | CLOSE |
| MORGAN STANLEY | −1,491,180 | $6M | TRIM |
| TWO SIGMA ADVISERS, LP | −663,830 | $3M | CLOSE |
| MARSHALL WACE, LLP | −406,732 | $2M | CLOSE |
| UBS Group AG | −405,426 | $2M | TRIM |
The 2025-Q4 register is as-filed in ITS OWN share basis; every count below was rebased into the 2026-Q1 basis (no split in between, factor 1). Dollar figures value the SHARE delta at one price — the 2026-03-31 close — rather than differencing two filings' own reported values, which would mix the quarter's price move into the trade figure.
13Fs disclose LONG US-listed positions only — shorts, most derivatives, bonds and non-US listings are invisible here, and a filer's quarter-over-quarter change is not necessarily a trade (index rebalances, in-kind transfers and entity successions all read as flow).
| Quarter | Holders | Shares held | % shares out | Value held |
|---|---|---|---|---|
| 2026-Q1 | 138 | 85,962,381 | 75.4% | $357M |
| 2025-Q4 | 116 | 36,583,586 | 49.2% | $102M |
| 2025-Q3 | 105 | 44,182,512 | 59.5% | $152M |
| 2025-Q2 | 98 | 42,494,378 | 57.2% | $146M |
| 2025-Q1 | 112 | 45,287,736 | 61.2% | $96M |
| 2024-Q4 | 135 | 47,251,400 | 69.9% | $151M |
| 2024-Q3 | 127 | 49,130,077 | 72.9% | $655M |
| 2024-Q2 | 105 | 38,671,824 | 62.1% | $385M |
| 2024-Q1 | 104 | 251,796,540 | 42.9% | $301M |
| 2023-Q4 | 52 | 36,646,328 | 13.1% | $16M |
| 2023-Q3 | 49 | 36,512,189 | 13.0% | $10M |
| 2023-Q2 | 50 | 32,971,571 | 11.8% | $22M |
| 2023-Q1 | 42 | 27,870,958 | 10.0% | $18M |
| 2022-Q4 | 48 | 17,244,362 | 12.1% | $4M |
| 2022-Q3 | 35 | 16,087,677 | 11.3% | $4M |
| 2022-Q2 | 43 | 16,791,879 | 11.8% | $5M |
| 2022-Q1 | 39 | 15,947,741 | 11.2% | $6M |
| 2021-Q4 | 45 | 17,660,479 | 12.4% | $7M |
| 2021-Q3 | 43 | 15,836,345 | 11.2% | $10M |
| 2021-Q2 | 48 | 17,375,954 | 12.3% | $14M |
| 2021-Q1 | 57 | 18,540,460 | 13.1% | $20M |
| 2020-Q4 | 43 | 8,604,542 | 9.9% | $4M |
| 2020-Q3 | 38 | 6,758,648 | 9.8% | $4M |
| 2020-Q2 | 38 | 7,072,746 | 10.5% | $4M |
| 2020-Q1 | 37 | 7,227,193 | 10.7% | $4M |
| 2019-Q4 | 31 | 4,480,814 | 6.6% | $3M |
| 2019-Q3 | 30 | 3,694,559 | 5.5% | $1M |
| 2019-Q2 | 29 | 3,994,875 | 5.9% | $2M |
| 2019-Q1 | 32 | 4,904,233 | 7.3% | $2M |
| 2018-Q4 | 30 | 6,099,765 | 9.1% | $2M |
| 2018-Q3 | 29 | 5,761,903 | 8.6% | $3M |
| 2018-Q2 | 30 | 3,498,753 | 6.3% | $2M |
| 2018-Q1 | 32 | 3,966,910 | 7.2% | $2M |
| 2017-Q4 | 29 | 3,906,846 | 7.1% | $2M |
| 2017-Q3 | 26 | 3,601,876 | 6.5% | $2M |
| 2017-Q2 | 27 | 3,606,613 | 6.6% | $2M |
| 2017-Q1 | 26 | 3,995,938 | 7.3% | $2M |
| 2016-Q4 | 30 | 4,477,752 | 8.1% | $3M |
| 2016-Q3 | 25 | 4,057,495 | 7.4% | $3M |
| 2016-Q2 | 27 | 4,270,949 | 7.8% | $4M |
| 2016-Q1 | 24 | 4,319,412 | 7.9% | $4M |
| 2015-Q4 | 26 | 4,284,995 | 7.8% | $4M |
| 2015-Q3 | 30 | 4,291,058 | 7.8% | $6M |
| 2015-Q2 | 31 | 4,177,758 | 7.6% | $6M |
| 2015-Q1 | 27 | 3,560,455 | 6.5% | $6M |
| 2014-Q4 | 28 | 3,763,718 | 6.9% | $5M |
| 2014-Q3 | 27 | 3,331,294 | 6.1% | $6M |
| 2014-Q2 | 26 | 3,436,848 | 6.3% | $11M |
| 2014-Q1 | 25 | 2,061,736 | 5.0% | $5M |
| 2013-Q4 | 19 | 1,591,617 | 4.1% | $795,834 |
| 2013-Q3 | 18 | 2,626,681 | 6.8% | $2M |
| 2013-Q2 | 16 | 933,460 | 2.7% | $448,000 |
| 2013-Q1 | 1 | 20,000 | 0.1% | $11,000 |
| 2023-12-31 |
| SEC → |
Source: SEC Schedule 13D/13G structured XML. 13D = active intent; 13G filers report passively (Rule 13d-1(b) QII / 13d-1(c) Passive / 13d-1(d) Exempt) and are not activists. Percent and delta are the group aggregate the filing reports. Structured 13D/G coverage begins December 2024 (SEC XML mandate).
